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Steric and electronic influence on Cu-Cu short contacts in β-thioketiminato tricopper(i) clusters

Dalton Transactions 2024年第31期53卷 13160-13173页

作者： Penki, Venkata Sai Sashankh Chu, Yu-Ting Chen, Hsing-Yin Sudewi, Sri Li, Chien-Hung Huang, Genin Gary Hsu, Sodio C. N. Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung80708 Taiwan International PhD Program for Science National Sun Yat-sen University Kaohsiung80424 Taiwan Department of Pharmacy Faculty of Mathematic and Natural Science Universitas Sam Ratulangi Manado95115 Indonesia Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung80708 Taiwan

A series of β-thioketiminate copper(i) complex trimers [LCuI]3 were synthesized by modifying the ligand framework with electron-withdrawing groups (F and Cl) or electron-donating groups (iPr and Me) at the N-aryl ring as well as with CF3 groups on the chelating backbone. This ligand modification significantly impacts the enhancement of Cu⋯Cu short contacts, which can be rationalized by using steric and electronic factors of the chelated ligand. We observed that this intramolecular cuprophilicity among [LCuI]3 complexes is primarily governed by the size of N-aryl ortho-substituents. These findings were well supported by X-ray crystallography, Raman spectroscopy, and Mayer bond order analysis. The electronic effects induced by the ligand modification on the LCuI fragment were investigated using CO and 2,4,6-CNC6H2Me3 as probe molecules. Corroborated by the FTIR and CV measurements, our results reveal that the β-thioketiminate SN chelators induce more pronounced changes in the electronic character of the LCuI fragment due to the presence of CF3 groups on the chelating backbone in comparison with the F or Cl substituents on the N-aryl ring. © 2024 The Royal Society of Chemistry.

关键词： Ligands

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Effects of Exercise Training on Immune-Related Genes and Pathways in the Cortex of Animal Models of Alzheimer’s Disease: A Systematic Review

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Journal of Alzheimer's Disease 2024年第4期98卷 1219-1234页

作者： Widjaya, Michael Anekson Lee, Shin-Da Cheng, Wei-Chung Wu, Bor-Tsang Graduate Institute of Biomedical Sciences College of Medicine China Medical University Taichung Taiwan Department of Physical Therapy PhD program in Healthcare Science China Medical University Taichung Taiwan Cancer Biology and Precision Therapeutics Center China Medical University Taichung Taiwan Program for Cancer Biology and Drug Discovery China Medical University Academia Sinica Taichung Taiwan Department of Senior Citizen Service Management National Taichung University of Science and Technology Taichung Taiwan

Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disease that affects the immune system due to the accumulation of amyloid-b (Ab) and tau associated molecular pathology and other pathogenic processes. To address AD pathogenesis, various approaches had been conducted from drug development to lifestyle modification to reduce the prevalence of AD. Exercise is considered a prominent lifestyle modification to combat AD. Objective: This observation prompted us to review the literature on exercise related to immune genes in the cortex of animal models of AD. We focused on animal model studies due to their prevalence in this domain. Methods: The systematic review was conducted according to PRISMA standards using Web of science (WoS) and PubMed databases. Any kind of genes, proteins, and molecular molecules were included in this systematic review. The list of these immune-related molecules was analyzed in the STRING database for functional enrichment analysis. Results: We found that 17 research studies discussed immune-related molecules and 30 immune proteins. These studies showed that exercise had the ability to ameliorate dysfunction in AD-related pathways, which led to decreasing the expression of microglia-related pathways and Th17-related immune pathways. As a result of decreasing the expression of immune-related pathways, the expression of apoptosis-related pathways was also decreasing, and neuronal survival was increased by exercise activity. Conclusions: Based on functional enrichment analysis, exercise not only could reduce apoptotic factors and immune components but also could increase cell survival and Ab clearance in cortex samples. PROSPERO ID: CRD42022326093. © 2024 – IOS Press. All rights reserved.

关键词： Alzheimer’s disease apoptosis-related pathway brain microglia-related pathway physical activity Th17-related pathway

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Synthetic investigations of the diisocyanide-bridged Cp*-cobalt rectangles

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Journal of the Chinese Chemical Society 2024年第4期71卷 376-384页

作者： Huang, Cheng-Chang Chu, Yu-Ting Huang, Yen-Chung Chang, Yu-Lun Ding, Shangwu Hsu, Sodio C. N. Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung Taiwan Department of Chemistry National Sun Yat-Sen University Kaohsiung Taiwan International PhD Program for Science National Sun Yat-Sen University Kaohsiung Taiwan

This study explores the utilization of 1,4-diisocyanobenzene as a linear bridging ligand for the assembly of organometallic CpCo or Cp*Co complexes. Overcoming solubility challenges, the synthesis of organometallic Cp* cobalt complexes incorporating bridging 1,4-diisocyanobenzene ligands was successfully achieved, while similar CpCo complexes were not attainable. The presented approach encompasses investigations into both stepwise and self-assembly synthetic pathways, leading to the construction of a rectangular tetranuclear complex [(Cp*CoI)₄(μ-1,4-CNC₆H₄NC)₄](OTf)₄ (3). Through single-crystal x-ray diffraction and spectroscopic techniques such as infrared, nuclear magnetic resonance, and electrospray ionization-mass spectrometry, the cobalt-isocyanides complexes were characterized. © 2024 The Chemical Society Located in Taipei & Wiley-VCH GmbH.

关键词： 1,4-diisocyanobenzene cobalt Cp cyclic voltammetry self-assembly

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Universal nanocomposite coating with antifouling and redox capabilities for electrochemical affinity biosensing in complex biological fluids

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Nanoscale Horizons 2024年第5期9卷 843-852页

作者： Bharti, Aditya Manu Rakesh Kumar, R.K. Chuang, Cheng-Hsin Shaikh, Muhammad Omar International PhD Program for Science National Sun Yat-sen University Kaohsiung80424 Taiwan Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung80424 Taiwan Department of Chemical Engineering National Taiwan University Taipei City10617 Taiwan Institute of Biomedical Engineering and Nanomedicine National Healthcare Research Institutes Miaoli County350 Taiwan National Sun Yat-sen University Kaohsiung80424 Taiwan Sustainability Science and Management Program Tunghai University Taichung407224 Taiwan

Electrochemical affinity biosensors have the potential to facilitate the development of multiplexed point-of-care diagnostics in complex biological fluids. However, their commercial viability has been hindered by challenges such as electrode biofouling and the lack of inherent redox properties. To address this unmet need, we have developed a universal nanocomposite coating which is unique in its ability to not only allow oriented conjugation of the biorecognition element but also specific detection directly in complex biological fluids like serum and urine owing to its built-in antifouling and redox capabilities, thus improving suitability for point of care testing. This multifunctional coating comprises a 3D porous crosslinked bovine serum albumin matrix for oriented conjugation and antifouling properties with embedded graphene nanosheets modified with amino-ferrocene for enhanced conductivity and mediator-free biosensing. The coating showed minimal signal degradation despite prolonged exposure to 1% bovine serum albumin, artificial urine and untreated human serum for up to 30 days. To demonstrate its utility, we fabricated and tested proof-of-concept electrochemical immunosensors for bladder cancer protein biomarkers, specifically interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF). The practical feasibility was highlighted by the excellent sensitivity and specificity observed for IL-8 and VEGF with a limit of detection of 41 pg mL−1 and 67 pg mL−1, respectively. Consequently, this universal nanocomposite-based electrochemical biosensing platform can be extended to the point of care testing of a broad spectrum of biomarkers present in complex biological fluids, thus enabling reliable and early diagnostics. © 2024 The Royal Society of Chemistry

关键词： Biomarkers

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Recent advances in nanomaterials-based optical sensors for detection of various biomarkers (inorganic species, organic and biomolecules)

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Luminescence 2023年第7期38卷 954-998页

作者： Harshita Wu, Hui-Fen Kailasa, Suresh Kumar Department of Chemistry Sardar Vallabhbhai National Institute of Technology Gujarat Surat India Department of Chemistry National Sun Yat-Sen University Kaohsiung Taiwan School of Pharmacy College of Pharmacy Kaohsiung Medical University Kaohsiung Taiwan Institute of Medical Science and Technology National Sun Yat-Sen University Kaohsiung Taiwan International PhD Program for Science National Sun Yat-Sen University Kaohsiung Taiwan

This review briefly emphasizes the different detection approaches (electrochemical sensors, chemiluminescence, surface-enhanced Raman scattering), functional nanostructure materials (quantum dots, metal nanoparticles, metal nanoclusters, magnetic nanomaterials, metal oxide nanoparticles, polymer-based nanomaterials, and carbonaceous nanomaterials) and detection mechanisms. Furthermore, the emphasis of this review is on the integration of functional nanomaterials with optical spectroscopic techniques for the identification of various biomarkers (nucleic acids, glucose, uric acid, oxytocin, dopamine, ascorbic acid, bilirubin, spermine, serotonin, thiocyanate, Pb2+, Cu2+, Hg2+, F−, peptides), and cancer biomarkers (mucin 1, prostate specific antigen, carcinoembryonic antigen, CA15-3, human epidermal growth factor receptor 2, C-reactive protein, and interleukin-6). Analytical characteristics of nanomaterials-based optical sensors are summarized in the tables, providing the insights of nanomaterials-based optical sensors for biomarkers detection. Finally, the opportunities and challenges of nanomaterials-based optical analytical approaches for the detection of various biomarkers (inorganic, organic, biomolecules, peptides and proteins) are discussed. © 2022 John Wiley & Sons Ltd.

关键词： Biomarkers

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Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT

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Cancer Gene Therapy 2024年第6期31卷 807-815页

作者： Kuo, Ying-Yu Huo, Chieh Li, Chia-Yang Chuu, Chih-Pin Institute of Cellular and System Medicine National Health Research Institutes Miaoli County Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Medical Research Kaohsiung Medical University Kaohsiung Taiwan PhD Program for Aging and Graduate Institute of Basic Medical Science China Medical University Taichung City Taiwan Biotechnology Center National Chung Hsing University Taichung City Taiwan Department of Life Sciences National Central University Taoyuan City Taiwan

Androgen receptor (AR) splice variant 7 (AR-V7) is capable to enter nucleus and activate downstream signaling without ligand. AR-V7 assists the tumor growth, cancer metastasis, cancer stemness, and the evolvement of therapy-resistant prostate cancer (PCa). We discovered that caffeic acid phenethyl ester (CAPE) can repress the expression and downstream signaling of AR-V7 in PCa cells. CAPE blocked the gene transcription, nuclear localization, and protein abundance of AR-V7. CAPE inhibited the expression of U2AF65, SF2 and hnRNPF, which were splicing factors for AR-V7 intron. Additionally, CAPE decreased protein stability of AR-V7 and enhanced the proteosome-degradation of AR-V7. We observed that CDK1 and AKT regulated the expression and stability of AR-V7 via phosphorylation of Ser81 and Ser213, respectively. CAPE decreased the expression of CDK1 and AKT. Overexpression of CDK1 restored the abundance of AR-V7 in CAPE-treated PCa cells. Overexpression of AR-V7, AKT or CDK1 rescued the proliferation of PCa cells under CAPE treatment. Intraperitoneal injection of 10 mg/kg CAPE retarded the growth of 22Rv1 xenografts in nude mice and suppressed the protein levels of AR-V7, CDK1 and AKT in 22Rv1 xenografts. Our study provided the rationale of applying CAPE for inhibition of AR-V7 in prostate tumors. (Figure presented.). © The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.

关键词： Drug development Prostate cancer

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Ellagic acid protects against angiotensin II-induced hypertrophic responses through ROS-mediated MAPK pathway in H9c2 cells

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Environmental Toxicology 2024年第5期39卷 3253-3263页

作者： Lee, Ya-Che Jou, Yeong-Chin Chou, Wan-Ching Tsai, Kun-Ling Shen, Cheng-Huang Lee, Shin-Da Department of Urology Ditmanson Medical Foundation Chiayi Christian Hospital Chia-Yi City Taiwan Department of Urology St. Martin De Porres Hospital Chia-Yi City Taiwan Department of Health and Nutrition Biotechnology College of Medical and Health Science Asia University Taichung City Taiwan Department of Physical Therapy College of Medicine National Cheng Kung University Tainan City Taiwan Institute of Allied Health Science College of Medicine National Cheng Kung University Tainan City Taiwan Department of Biomedical Sciences National Chung Cheng University Chia-Yi Min Hsiung Taiwan Department of Physical Therapy College of Medical and Health Science Asia University Taichung City Taiwan Department of Physical Therapy PhD program in Healthcare Science China Medical University Taichung Taiwan

The early myocardial response of hypertension is an elevation of angiotensin-II (Ang-II) concentration, leading to heart failure and cardiac hypertrophy. This hypertrophic event of the heart is mediated by the interaction of Ang type 1 receptors (AT-R1), thereby modulating NADPH oxidase activity in cardiomyocytes, which alters redox status in cardiomyocytes. Ellagic acid (EA) has anti-inflammatory and anti-oxidative capacities. Thus, EA has potential preventive effects on cardiovascular diseases and diabetes. In the last decades, because the protective effect of EA on Ang-II-induced hypertrophic responses is unclear, this study aims to investigate the protective effect of EA in cardiomyocytes. H9c2 cells were treated to Ang-II 1 μM for 24 h to induce cellular damage. We found that EA protected against Ang-II-increased cell surface area and pro-hypertrophic gene expression in H9c2. EA reduced Ang-II-caused AT-R1 upregulation, thereby inhibiting oxidative stress NADPH oxidase activation. EA mitigated Ang-II-enhanced p38 and extracellular-signal-regulated kinase (ERK) phosphorylation. Moreover, EA treatment under Ang-II stimulation also reversed NF-κB activity and iNOS expression. This study shows that EA protects against Ang-II-induced myocardial hypertrophy and attenuates oxidative stress through reactive oxygen species-mediated mitogen-activated protein kinase signaling pathways in H9c2 cells. Thus, EA may be an effective compound for preventing Ang-II-induced myocardial hypertrophy. © 2024 Wiley Periodicals LLC.

关键词： Oxidative stress

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Demethoxymurrapanine, an indole-naphthoquinone alkaloid, inhibits the proliferation of oral cancer cells without major side effects on normal cells

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Environmental Toxicology 2024年第3期39卷 1221-1234页

作者： Chuang, Ya-Ting Yen, Ching-Yu Shiau, Jun-Ping Chang, Fang-Rong Duh, Chang-Yih Sung, Ping-Jyun Chen, Kuan-Liang Tsai, Yi-Hong Tang, Jen-Yang Jeng, Jiiang-Huei Sheu, Jyh-Horng Chang, Hsueh-Wei Department of Biomedical Science and Environmental Biology PhD Program in Life Sciences College of Life Science Kaohsiung Medical University Kaohsiung Taiwan School of Dentistry Taipei Medical University Taipei Taiwan Department of Oral and Maxillofacial Surgery Chi-Mei Medical Center Tainan Taiwan Division of Breast Oncology and Surgery Department of Surgery Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung Taiwan National Museum of Marine Biology and Aquarium Pingtung Taiwan Department of Pharmacy and Master Program College of Pharmacy and Health Care Tajen University Pingtung Taiwan School of Post-Baccalaureate Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Radiation Oncology Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan School of Dentistry College of Dental Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Dentistry Kaohsiung Medical University Hospital Kaohsiung Taiwan Department of Dentistry National Taiwan University Hospital Taipei Taiwan Department of Medical Research China Medical University Hospital China Medical University Taichung Taiwan Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung Taiwan Center for Cancer Research Kaohsiung Medical University Kaohsiung Taiwan

Antioral cancer drugs need a greater antiproliferative impact on cancer than on normal cells. Demethoxymurrapanine (DEMU) inhibits proliferation in several cancer cells, but an in-depth investigation was necessary. This study evaluated the proliferation-modulating effects of DEMU, focusing on oral cancer and normal cells. DEMU (0, 2, 3, and 4 μg/mL) at 48 h treatments inhibited the proliferation of oral cancer cells (the cell viability (%) for Ca9-22 cells was 100.0 ± 2.2, 75.4 ± 5.6, 26.0 ± 3.8, and 15.4 ± 1.4, and for CAL 27 cells was 100.0 ± 9.4, 77.2 ± 5.9, 57.4 ± 10.7, and 27.1 ± 1.1) more strongly than that of normal cells (the cell viability (%) for S-G cells was 100.0 ± 6.6, 91.0 ± 4.6, 95.0 ± 2.6, and 95.8 ± 5.5), although this was blocked by the antioxidant N-acetylcysteine. The presence of oxidative stress was evidenced by the increase of reactive oxygen species and mitochondrial superoxide and the downregulation of the cellular antioxidant glutathione in oral cancer cells, but these changes were minor in normal cells. DEMU also caused greater induction of the subG1 phase, extrinsic and intrinsic apoptosis (annexin V and caspases 3, 8, and 9), and DNA damage (γH2AX and 8-hydroxy-2-deoxyguanosine) in oral cancer than in normal cells. N-acetylcysteine attenuated all these DEMU-induced changes. Together, these data demonstrate the preferential antiproliferative function of DEMU in oral cancer cells, with the preferential induction of oxidative stress, apoptosis, and DNA damage in these cancer cells, and low cytotoxicity toward normal cells. © 2023 Wiley Periodicals LLC.

关键词： Oxidative stress

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Rational Design of Ultrastable Conjugated Microporous Polymers Based on Pyrene and Perylene Units as High-Performance Organic Electrode Materials for Supercapacitor Applications

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ACS Applied Energy Materials 2023年第15期6卷 8277-8287页

作者： Singh, Poonam Nagendra Mohamed, Mohamed Gamal Chaganti, Swetha V. Sharma, Santosh U. Ejaz, Moshin Lee, Jyh-Tsung Kuo, Shiao-Wei Department of Materials and Optoelectronic Science Center for Functional Polymers and Supramolecular Materials National Sun Yat-Sen University Kaohsiung804 Taiwan Department of Chemistry Faculty of Science Assiut University Assiut71515 Egypt Department of Chemistry National Sun Yat-Sen University Kaohsiung80424 Taiwan International PhD Program for Science National Sun Yat-Sen University Kaohsiung80424 Taiwan Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung807 Taiwan

We successfully synthesized three perylene dianhydride (PDI)-based conjugated microporous polymers (CMPs), namely, Py-Ph-Pery, TPE-Ph-Pery, and TPA-Ph-Pery CMPs, through a Suzuki-Miyaura coupling reaction. The precursors used in the reaction contained brominated compounds of pyrene (Py), tetraphenylethylene (TPE), triphenylamine (TPA), and 1,4-benzeneboronic acid, which were coupled with redox-active PDI unit. To evaluate the thermal stability, molecular structure, and porosity properties of the synthesized CMPs, we conducted an examination of their Brunauer-Emmett-Teller isotherm, along with spectroscopic and microscopic analyses. These CMPs demonstrated moderate thermal stability based on thermogravimetric analysis. In terms of electrochemical performance, the Py-Ph-Pery CMP exhibited a high capacitance of 300 F g-1 (measured at 0.5 A g-1), indicating its excellent capacitive properties. Furthermore, the Py-Ph-Pery CMP displayed exceptional cycle stability at 10 A g-1, retaining more than 93% of its capacity over 5000 cycles. The findings illustrate the potential of these CMPs for reliable and durable energy storage applications. Additionally, we utilized synthesized CMPs to assess the electrochemical characteristics of a symmetric coin supercapacitor. The results further validate the suitability of these CMPs for practical electrical energy storage applications, highlighting their significant promise. © 2023 American Chemical Society.

关键词： Supercapacitor

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Hepatitis B surface antigen loss in chronic hepatitis B patients with low-viral-load

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Journal of Gastroenterology and Hepatology (Australia) 2024年第11期39卷 2327-2331页

作者： Jang, Tyng-Yuan Batsaikhan, Batbold Chen, Yo-Chia Dai, Chia-Yen PhD Program of Environmental and Occupational Medicine and Graduate Institute of Clinical Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Department of Internal Medicine Pingtung Hospital Ministry of Health and Welfare Ping-Tung Taiwan Department of Internal Medicine Institute of Medical Sciences Mongolian National University of Medical Sciences Ulaanbaatar Mongolia Department of Biological Science and Technology National Pingtung University of Science and Technology Pingtung Taiwan College of Professional Studies National Pingtung University of Science and Technology Pingtung Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung Taiwan

Background and Aim: Among low viral load (DNA of hepatitis B virus (HBV) was 10 IU/mL vs 2.3 log10 IU/mL;P = 0.003), and higher proportion of prior NAs-treated history. Logistic regression analysis revealed ... 详细信息

Background and Aim: Among low viral load (DNA of hepatitis B virus (HBV) was < 2000 IU/mL), the factor of the loss of hepatitis B surface antigen (HBsAg) remained elusive. Methods: The retrospective study recruited patients with chronic hepatitis B (CHB) who were negative low for hepatitis B e-antigen (HBeAg), had a low viral load, and experienced HBsAg loss during follow-up. CHB patients with low-viral load but without consequent HBsAg loss were also enrolled at the ratio of 1:4. The factors contributing to HBsAg loss were analyzed. Results: A total of 80 patients were recruited for the current study, with a mean age of 63.9 years and 61.3% being male. Among them, 62.5% patients (50/80) were treated with potent nucleoside/nucleotide analogues (NAs) during the follow-up period. Additionally, 12.5% patients (10/80) had a prior history of NAs treatment before enrolment. During the follow-up, HBsAg loss occurred in 17 patients (21.3%). Compared with patients without HBsAg loss, those with HBsAg loss were younger (57.9 years vs 65.5 years;P = 0.01), had lower HBV DNA levels (1.3 log₁₀ IU/mL vs 2.3 log₁₀ IU/mL;P = 0.003), and higher proportion of prior NAs-treated history. Logistic regression analysis revealed that the factors associated with factors associated with HBsAg loss were age < 60 years (OR/CI: 3.95/1.15–13.60, P = 0.03), prior NAs-treated history (OR/CI: 7.59/1.42–40.51, P = 0.01) and current NAs-treated (OR/CI: 0.19/0.05–0.71, P = 0.01). Conclusions: In the study, older age and prior NAs were positively associated with HBsAg loss, and current NAs was negatively associated with HBsAg loss. Additionally, some patients experienced HBsAg loss during the NAs therapy. © 2024 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

关键词： HBeAg HBsAg HBV NAs viral load

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