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Subnational mapping of HIV incidence and mortality among individuals aged 15–49 years in sub-Saharan Africa, 2000–18: a modelling study

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The Lancet HIV 2021年第6期8卷 e363-e375页

作者： Sartorius, Benn VanderHeide, John D. Yang, Mingyou Goosmann, Erik A. Hon, Julia Haeuser, Emily Cork, Michael A. Perkins, Samantha Jahagirdar, Deepa Schaeffer, Lauren E. Serfes, Audrey L. LeGrand, Kate E. Abbastabar, Hedayat Abebo, Zeleke Hailemariam Abosetugn, Akine Eshete Abu-Gharbieh, Eman Accrombessi, Manfred Mario Kokou Adebayo, Oladimeji M. Adegbosin, Adeyinka Emmanuel Adekanmbi, Victor Adetokunboh, Olatunji O. Adeyinka, Daniel Adedayo Ahinkorah, Bright Opoku Ahmadi, Keivan Ahmed, Muktar Beshir Akalu, Yonas Akinyemi, Oluwaseun Oladapo Akinyemi, Rufus Olusola Aklilu, Addis Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Noore Alamneh, Alehegn Aderaw Alanzi, Turki M. Alemu, Biresaw Wassihun Alhassan, Robert Kaba Ali, Tilahun Alipour, Vahid Amini, Saeed Ancuceanu, Robert Ansari, Fereshteh Anteneh, Zelalem Alamrew Anvari, Davood Anwer, Razique Appiah, Seth Christopher Yaw Arabloo, Jalal Asemahagn, Mulusew A. Asghari Jafarabadi, Mohammad Asmare, Wondwossen Niguse Atnafu, Desta Debalkie Atout, Maha Moh'd Wahbi Atreya, Alok Ausloos, Marcel Awedew, Atalel Fentahun Ayala Quintanilla, Beatriz Paulina Ayanore, Martin Amogre Aynalem, Yared Asmare Ayza, Muluken Altaye Azari, Samad Azene, Zelalem Nigussie Babar, Zaheer-Ud-Din Baig, Atif Amin Balakrishnan, Senthilkumar Banach, Maciej Bärnighausen, Till Winfried Basu, Sanjay Bayati, Mohsen Bedi, Neeraj Bekuma, Tariku Tesfaye Bezabhe, Woldesellassie M. Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Pankaj Bhattacharyya, Krittika Bhutta, Zulfiqar A. Bibi, Sadia Bikbov, Boris Birhan, Tsegaye Adane Bitew, Zebenay Workneh Bockarie, Moses John Boloor, Archith Brady, Oliver J. Bragazzi, Nicola Luigi Briko, Andrey Nikolaevich Briko, Nikolay Ivanovich Burugina Nagaraja, Sharath Butt, Zahid A. Cárdenas, Rosario Carvalho, Felix Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Chowdhury, Mohiuddin Ahsanul Kabir Chu, Dinh-Toi Cook, Aubrey J. Cormier, Natalie Maria Cowden, Richard G. Culquichicon, Carlos Dagnew, Baye Dahlawi, Saad M.A. D Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford United Kingdom Malaria Atlas Project University of Oxford Oxford United Kingdom The George Institute for Global Health University of Oxford Oxford United Kingdom Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Insights Program Bill and Melinda Gates Foundation Seattle WA United States Global Programs Medical Teams International Seattle WA United States Department of Pediatric Newborn Medicine Brigham and Women's Hospital Boston MA United States Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Pediatric Chronic Kidney Disease Research Center Tehran University of Medical Sciences Tehran Iran Department of Environmental Health Engineering Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Public Health Arba Minch University Arba Minch Ethiopia Department of Medical Laboratory Sciences Arba Minch University Arba Minch Ethiopia College of Medicine and Health Science Arba Minch University Arba Minch Ethiopia Department of Nursing Arba Minch University Arba Minch Ethiopia Department of Biomedical Sciences Arba Minch University Arba Minch Ethiopia Department of Public Health Debre Berhan University Debre Brehan

Background: High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods: In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to estimate HIV prevalence at the second administrative level in 44 countries in sub-Saharan Africa for 2000–18 and sought data on the number of individuals on antiretroviral therapy (ART) by second-level administrative unit. We then modified the Estimation and Projection Package (EPP) to use these HIV prevalence and treatment estimates to estimate HIV incidence and mortality by second-level administrative unit. Findings: The estimates suggest substantial variation in HIV incidence and mortality rates both between and within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater difference in estimated HIV incidence between the second-level administrative units with the lowest and highest estimated incidence levels. Across all 44 countries in 2018, HIV incidence ranged from 2·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and HIV mortality ranged from 0·8 (0·7–0·9) in Mauritania to 676·5 (513·6–888·0) deaths per 100 000 people in Lesotho. Variation in both incidence and mortality was substantially greater at the subnational level than at the national level and the highest estimated rates were accordingly higher. Among second-level administrative units, Guijá District, Gaza Province, Mozambique,

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Human genetic and immunological determinants of critical COVID-19 pneumonia

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四川生理科学杂志 2021年第11期43卷 1947-1947页

作者： Qian Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Department of Pediatrics Necker Hospital for Sick Children Paris France Howard Hughes Medical Institute Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine Institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San Raffaele Telethon Institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA Department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. Lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine Department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia School of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain Department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic Department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology Department Cliniques Universitaires Saint-Luc Brussels Belgium Institut de Recherche Expérimentale et Clinique (IREC) Université Catholique de Louvain Brussels Belgium

SARS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLR3 and X-linked TLR7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.

关键词： pneumonia critical cases

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Author Correction: Multiplexed droplet single-cell RNA-sequencing using natural genetic variation

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Nature biotechnology 2020年第11期38卷 1356页

作者： Hyun Min Kang Meena Subramaniam Sasha Targ Michelle Nguyen Lenka Maliskova Elizabeth McCarthy Eunice Wan Simon Wong Lauren Byrnes Cristina M Lanata Rachel E Gate Sara Mostafavi Alexander Marson Noah Zaitlen Lindsey A Criswell Chun Jimmie Ye Department of Biostatistics and Center for Statistical Genetics University of Michigan School of Public Health Ann Arbor Michigan USA. hmkang@umich.edu. Biological and Medical Informatics Graduate Program University of California San Francisco San Francisco California USA. Institute for Human Genetics (IHG) University of California San Francisco San Francisco California USA. Institute for Computational Health Sciences University of California San Francisco San Francisco California USA. Department of Epidemiology and Biostatistics University of California San Francisco San Francisco California USA. Department of Bioengineering and Therapeutic Sciences University of California San Francisco San Francisco California USA. Medical Scientist Training Program (MSTP) University of California San Francisco San Francisco California USA. Department of Microbiology and Immunology University of California San Francisco San Francisco California USA. Diabetes Center University of California San Francisco San Francisco California USA. Innovative Genomics Institute University of California Berkeley Berkeley California USA. Department of Neurology University of California San Francisco San Francisco California USA. Developmental and Stem Cell Biology Graduate Program University of California San Francisco San Francisco California USA. Department of Medicine University of California San Francisco San Francisco California USA. Rosalind Russell/Ephraim P Engleman Rheumatology Research Center University of California San Francisco San Francisco California USA. Department of Statistics University of British Columbia Vancouver British Columbia Canada. UCSF Helen Diller Family Comprehensive Cancer Center University of California San Francisco San Francisco California USA. Chan Zuckerberg Biohub San Francisco California USA. Lung Biology Center University of California San Francisco San Francisco California USA. Department of Orofacial Sciences Universi

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease

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Nature communications 2018年第1期9卷 4333页

作者： Rebecca Aron Pasquale Pellegrini Edward W Green Daniel C Maddison Kwadwo Opoku-Nsiah Jinny S Wong Aaron C Daub Flaviano Giorgini Steven Finkbeiner Center for Systems and Therapeutics & Taube/Koret Center for Neurodegenerative Disease Gladstone Institutes 1650 Owens St. 94158 San Francisco CA USA. Taube-Koret Center for Neurodegenerative Disease 94158 San Francisco CA USA. Yumanity Therapeutics 02139 Cambridge MA USA. Department of Genetics and Genome Biology College of Life Sciences University of Leicester Adrian Building University Road LE1 7RH Leicester UK. DKFZ 69120 Heidelberg Germany. Graduate Program in Chemistry and Chemical Biology Department of Pharmaceutical Chemistry University of California-San Francisco 94158 San Francisco CA USA. Center for Systems and Therapeutics & Taube/Koret Center for Neurodegenerative Disease Gladstone Institutes 1650 Owens St. 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu. Taube-Koret Center for Neurodegenerative Disease 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Biomedical Sciences University of California-San Francisco 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Neuroscience University of California-San Francisco 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu. Graduate Program in Medical Scientist Training Program University of California-San Francisco 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu. Department of Neurology and Physiology University of California-San Francisco 94158 San Francisco CA USA. sfinkbeiner@gladstone.ucsf.edu.

The original version of this Article incorrectly gave a publication date of 8 October 2018; this should have been 28 September 2018. This has now been corrected in the PDF and HTML versions of the Article.

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Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

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Journal of neuroinflammation 2018年第1期15卷 169页

作者： Megan F Duffy Timothy J Collier Joseph R Patterson Christopher J Kemp Kelvin C Luk Malú G Tansey Katrina L Paumier Nicholas M Kanaan D Luke Fischer Nicole K Polinski Olivia L Barth Jacob W Howe Nishant N Vaikath Nour K Majbour Omar M A El-Agnaf Caryl E Sortwell Department of Translational Science and Molecular Medicine Michigan State University 400 Monroe Avenue NW Grand Rapids MI 49503-2532 USA. Neuroscience Graduate Training Program Michigan State University Grand Rapids MI USA. Mercy Health Hauenstein Neuroscience Medical Center Grand Rapids MI USA. Center for Neurodegenerative Disease Research Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Physiology Emory University School of Medicine Atlanta GA USA. MD/PhD Program Michigan State University Grand Rapids MI USA. Neurological Disorders Research Center Qatar Biomedical Research Institute (QBRI) Hamad Bin Khalifa University (HBKU) Education City Qatar. Life Sciences Division College of Science and Engineering Hamad Bin Khalifa University (HBKU) Education City Qatar. Department of Translational Science and Molecular Medicine Michigan State University 400 Monroe Avenue NW Grand Rapids MI 49503-2532 USA. caryl.sortwell@hc.msu.edu. Mercy Health Hauenstein Neuroscience Medical Center Grand Rapids MI USA. caryl.sortwell@hc.msu.edu.

After publication of the original article [1] it was noted that the name of author, D. Luke Fisher, was erroneously typeset in both the PDF and online formats of the manuscript as Luke D. Fisher.

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Analytical strategies for studying stem cell metabolism

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Frontiers in Biology 2015年第2期10卷 141-153页

作者： James M. Arnold William T. Choi Arun Sreekumar Mirjana Maletic-Savatic Department of Molecular and Cell Biology Baylor College of Medicine Houston TX 77030 USA Program in Developmental Biology and Medical Scientist Training Program Baylor College of Medicine Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital Houston TX 77030 USA Departments of Pediatrics-Neurology and Neuroscience and Program in Structural and Computational Biology and Molecular Biophysics Baylor College of Medicine Houston TX 77030 USA

Owing to their capacity for self-renewal and pluripotency, stem cells possess untold potential for revolutionizing the field of regenerative medicine through the development of novel therapeutic strategies for treating cancer, diabetes, cardiovascular and neurodegenerative diseases. Central to developing these strategies is improving our understanding of biological mechanisms responsible for governing stem cell fate and self-renewal. Increasing attention is being given to the significance of metabolism, through the production of energy and generation of small molecules, as a critical regulator of stem cell functioning. Rapid advances in the field of metabolomics now allow for in-depth profiling of stem cells both in vitro and in vivo, providing a systems perspective on key metabolic and molecular pathways which influence stem cell biology. Understanding the analytical platforms and techniques that are currently used to study stem cell metabolomics, as well as how new insights can be derived from this knowledge, will accelerate new research in the field and improve future efforts to expand our understanding of the interplay between metabolism and stem cell biology.

关键词： stem cell metabolism NMR mass spectrometry MRS flux analysis

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CCR5- and CXCR4-tropic HIVs infect CD4 + hematopoietic stem and progenitor cells in vitro and in optimally treated people

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Journal of Virus Eradication 2015年 1卷 33-34页

作者： N. Sebastian V. Terry F. Taschuk L.A. McNamara A. Onafuwa-Nuga J. Riddell D. Bixby K.L. Collins Cellular and Molecular Biology Graduate Program University of Michigan Medical School USA Medical Scientist Training Program University of Michigan Medical School USA Department of Internal Medicine University of Michigan Medical School USA Department of Microbiology and Immunology University of Michigan Medical School USA

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Application of generalized linear models to investigate functional synaptic coupling and synchrony in an animal model of schizophrenia

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BMC neuroscience 2015年第1期16卷 1-2页

作者： Jennifer L Zick Rachael K Blackman Matthew V Chafee Theoden I Netoff Graduate Program in Neuroscience University of Minnesota Minneapolis MN 55455 USA Medical Scientist Training Program (MD/PhD) University of Minnesota Minneapolis MN 55455 USA Brain Sciences Center VA Medical Center Minneapolis MN 55417 USA Department of Biomedical Engineering University of Minnesota Minneapolis MN 55455 USA

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4D-FLOW IN THE CEREBRAL ARTERIES PROVIDES UNIQUE INFORMATION ABOUT CEREBROVASCULAR HEALTH BEYOND ISCHEMIC LESION BURDEN AND SIGNIFICANTLY PREDICTS COGNITIVE OUTCOMES

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Alzheimer's & Dementia 2017年第7期13卷 P117-P119页

作者： Sara Elizabeth Berman Lindsay R. Clark Leonardo A. Rivera Cynthia M. Carlsson Patrick Turski Howard A. Rowley Sanjay Asthana Oliver Wieben Sterling C. Johnson Neuroscience Training Program University of Wisconsin Madison WI USA University of Wisconsin School of Medicine and Public Health Medical Scientist Training Program Madison WI USA Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin-Madison Madison WI USA Geriatric Research Education and Clinical Center W.S. Middleton Memorial Veterans Hospital Madison WI USA Wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA University of Wisconsin School of Medicine and Public Health Madison WI USA Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA

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PM296. SORCS2 regulates alcohol withdrawal severity and excitatory synaptic transmission

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International Journal of Neuropsychopharmacology 2016年第SUPPL_1期19卷 5-6页

作者： Smith, Andrew H. Bolcho, Ulrik Phokaew, Chureerat Ovesen, Peter L. Yeo, Seungeun Jensen, Kevin P. Diazgranados, Nancy Zhao, Hongyu Farrer, Lindsay A. Goldman, David Glerup, Simon Kranzler, Henry R. Nykjær, Anders Gelernter, Joel Interdepartmental Neuroscience Program and Medical Scientist Training Program Yale School of Medicine Division of Human Genetics Department of Psychiatry VA CT Healthcare Center and Yale School of Medicine The Lundbeck Foundation Research Center MIND Danish Research Institute of Translational Neuroscience DANDRITE - Nordic EMBL Partnership for Molecular Medicine Department of Biomedicine Aarhus University DK-8000 Aarhus C Denmark Laboratory of Neurogenetics National Institute on Alcohol Abuse and Alcoholism Office of the Clinical Director National Institute on Alcohol Abuse and Alcoholism National Institutes of Health Bethesda MD 20892 USA Department of Biostatistics Yale School of Public Health Departments of Medicine (Biomedical Genetics) Neurology and Ophthalmology School of Medicine and Departments of Biostatistics and Epidemiology School of Public Health Boston University Boston MA 02118 USA Department of Psychiatry Perelman School of Medicine University of Pennsylvania and Corporal Michael J. Crescenz VAMC Philadelphia Pennsylvania 19104 USA Department of Neuroscience Mayo Clinic Jacksonville 32224 Florida USA Departments of Genetics and Neurobiology Yale School of Medicine Yale University New Haven Connecticut 06510 USA

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