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检索条件"机构=Memphis Joint Program in Biomedical Engineering"

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memphis Center for biomedical engineering in pediatrics: graduate biomedical engineering education with a clinical orientation

Memphis Center for Biomedical Engineering in pediatrics: gra...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： M.R. Newnan J. Buchanan R. Danish E.C. Eckstein Joint Graduate Program in Biomed. Eng. Memphis Univ. TN USA Joint Graduate Program in Biomedical Engineering University of Memphis and University of Tennessee Health Science Center USA

The memphis Center for biomedical engineering in Pediatrics is an educational and research program that applies biomedical engineering to children's health care. The program involves biomedical engineering and related engineering departments and academic and clinical medical programs in memphis. Students and faculty from these institutions carry out clinically related research in applying instrumentation, imaging, radiation, computation and rehabilitation engineering to children's health care. The Center has laboratory facilities in the Children's Foundation Research Center at LeBonheur Children's Medical Center and currently has clinical studies involving pediatric neurology, neonatal intensive care, gait analysis, critical care instrumentation, and diagnostic measurements. The Center links the facilities of the science and engineering departments of the universities with the memphis programs in clinical pediatrics.

关键词： biomedical engineering biomedical engineering education Pediatrics biomedical imaging Medical services Medical diagnostic imaging Instruments biomedical computing Laboratories Nervous system

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Ventricular wall thickness and volume during hemodynamic collapse produced by AC leakage current

Ventricular wall thickness and volume during hemodynamic col...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： B.K. Hoffmeister B.S. Sheals A.L. de Jongh R.A. Malkin Department of Physics Rhodes College Memphis TN USA Joint Program in Biomedical Engineering University of Memphis and University of Tennessee Health Science Center Memphis TN USA

Medical equipment can unintentionally allow the flow of power line current through the patient causing complete hemodynamic collapse without fibrillation. This study tests the hypothesis that static wall thickening accompanies AC induced collapse via an isovolumic state. In 3 dogs, we delivered AC current stimulation ranging from 10-160 Hz and 10-1000 /spl mu/A to the right ventricle. A steerable, quadripolar catheter was placed in the apex of the left ventricle and deflected towards the basal region to measure left ventricular volume. Two dimensional, short-axis ultrasound images of the LV endocardial walls were recorded to measure wall thickness. Our results indicate that wall thickness during collapse is significantly greater than during systole (/spl Delta/ thickness =11.7/spl plusmn/12 mm, p<0.001) and diastole (/spl Delta/ thickness=23.6/spl plusmn/13 mm, p<0.001). In addition, the volume of the left ventricle is significantly smaller during collapse than the average volume during normal sinus rhythm (/spl Delta/ impedance=0.152/spl plusmn/0.006 no units, p<0.001).

关键词： Hemodynamics Leakage current Ultrasonic variables measurement biomedical equipment Testing Dogs Catheters Volume measurement Ultrasonic imaging Thickness measurement

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Left ventricular volume changes after defibrillation

Left ventricular volume changes after defibrillation

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： A.L. de Jongh B.S. Sheals D.K. Chau B.K. Hoffmeister R.A. Malkin Joint Graduate Program in Biomedical Engineering University of Memphis and University of Tennessee Health Science Center Memphis TN USA Department of Physics Rhodes College Memphis TN USA

A previous study has shown that the cross-sectional area of the left ventricular cavity (LV) increases immediately after defibrillation, suggesting that the defibrillation shock may cause relaxation. Since a single area slice may not reflect the entire myocardium, we wanted to test the relaxation hypothesis by evaluating volume. Ten to twenty defibrillation shocks were delivered in each of six dogs. A catheter was placed in the LV to measure intraventricular volume (IVV). Ultrasound images of the LV were recorded simultaneously with IVV. LV cavity area increased 13% (p<0.001) and IVV increased 4% (p<0.001) post-shock. Our results confirm that the heart is relaxing after defibrillation.

关键词： Defibrillation Electric shock Myocardium Testing Volume relaxation Dogs Catheters Volume measurement Ultrasonic variables measurement Ultrasonic imaging

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The effects of in utero cocaine-exposure on the heart rate and heart rate variability of near and full term infants following orthostatic stress

The effects of in utero cocaine-exposure on the heart rate a...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： V. John M.R. Neuman A.J. Talati University of Memphis and University of Tennessee Joint Program in Biomedical Engineering Memphis TN USA Department of Pediauics and ObIGyn University of Tennessee Health Science Center Memphis TN USA

To understand the effects of in utero cocaine exposure on the developing fetus, we studied the heart rate and the heart rate variability in near and full term cocaine-exposed infants in quiet sleep supine and following orthostatic stress. We studied 21 cocaine-exposed and 23 control infants within 120 hours of birth. Two 30-minute segments of the electrocardiogram (ECG) were recorded and analyzed in the time and frequency domain; the first with the supine infant, horizontal followed by the infant in a 25/spl deg/ head-up tilt. The cocaine-exposed group, as compared with the control group, had a trend toward an increase in heart rate in the horizontal position and a significant increase in heart rate following the tilt in the cocaine-exposed group. The frequency components of the heart rate were lower in the horizontal position and increased following the orthostatic stress. These results are consistent with the known pharmacological actions of cocaine and demonstrate the dangers of cocaine abuse during pregnancy.

关键词： Heart rate Heart rate variability Pediatrics Stress Sleep Electrocardiography Frequency domain analysis Spectral analysis Wavelet analysis Fetus

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Development of transient outward K/sup +/ current to simulate ventricular action potentials of spontaneously hypertensive rats

Development of transient outward K/sup +/ current to simulat...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： S. Padmala W.R. Giles S.S. Demir Joint Graduate Program in Biomedical Engineering University of Memphis and University of Tennessee Health Science Center Memphis USA Department of Physiology and Biophysics University of Calgary Calgary Canada

We extended our adult rat ventricular myocyte model to formulate the effects of hypertrophy in spontaneously hypertensive rats (SHR). Membrane capacitance is increased by 53% and the density of transient outward current (I/sub t/) is decreased by 35% in SHR but its voltage dependence and kinetics are unchanged when compared to those of normal rats. We simulated the ventricular action potential of SHR by incorporating these changes into our rat model. Action potential duration (APD) is prolonged when compared to that of normal rat. APD/sub 90/ (90% repolarization) and APD/sub 50/ (50% repolarization) of SHR are increased by 64% and 105% respectively when compared to those of normal rats. Peak overshoot of AP in SHR is increased by 7% and upstroke velocity is decreased by 6%.

关键词： Hypertension Rats Voltage Biomembranes Capacitance biomedical engineering Equivalent circuits Calcium Physiology Biophysics

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Assessment of the efficacy of tissue factor pathway inhibitor (TFPI) immobilized on glass slides to inhibit factor Xa under flow conditions

Assessment of the efficacy of tissue factor pathway inhibito...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： A. Chandiwal A.E. Mast C.L. Hall Joint Program in Biomedical Engineering University of Memphis TN Research and Pathology Services Veterans Affairs Medical Center Memphis TN IIT Pritzker Institute of Medical Engineering Chicago IL USA

The purpose of the present study was to assess the efficacy of tissue factor pathway inhibitor (TFPI) immobilized on glass slides to inhibit factor Xa (FXa) under well defined flow conditions. Employing a parallel plate flow chamber, FXa was perfused over TFPI coated or uncoated glass slides. Wall shear rates of 50, 100, 400, and 1200 s/sup -1/ were tested and the effluent was collected and assayed for FXa. Experiments were also carried out to determine the retention of adsorbed TFPI on the glass surfaces. FXa flux was calculated for the various shear rates used during the apparent steady state regime. There was a significant difference between these flux values in the untreated versus TFPI treated glass slides at all the shear rates (p<0.05). Increasing, the mass of adsorbed TFPI also significantly increased this inhibition. There was no measurable loss of adsorbed TFPI from the glass slides for all the conditions studied.

关键词： Inhibitors Glass Effluents biomedical engineering Surface treatment Loss measurement Pathology Testing biomedical measurements Regulators

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Simulation-based teaching and learning for electrophysiology by iCell

Simulation-based teaching and learning for electrophysiology...

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23rd Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Demir, Semahat S. Joint Biomedical Engineering Program University of Memphis 330 Engineering Technology Building Memphis TN 38152-3210 United States

An interactive cell modeling web site, iCell (http://***/icell/), that integrates research and education, was developed as a simulation-based teaching and learning tool for electrophysiology. The site consists of JAVA applets representing models of various cardiac cells and neurons, and provides simulation data of their bioelectric activities at cellular level. Each JAVA-based model allows the user to go through menu options to change model parameters, run and view simulation results. The site also has a glossary section for the scientific terms. iCell has been used as a teaching and learning tool for four graduate courses at the joint biomedical engineering program of University of memphis and University of Tennessee. This modeling tool was also used as a collaboration site among our colleagues interested in simulations of cell membrane activities. Scientists from the fields of biosciences, engineering, life sciences and medical sciences in USA, Canada, China, Brazil, England, Ireland, the Netherlands, New Zealand, Spain and Turkey have tested and utilized iCell as a simulation-based teaching, learning and collaboration environment. The platform-independent software, iCell, provides us with an interactive and user-friendly teaching and learning tool, and also a collaboration environment for electrophysiology to be shared over the Internet.

关键词： Computational models Simulation data Single cell membrane models

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Left ventricular geometry immediately following defibrillation-strength shocks

Left ventricular geometry immediately following defibrillati...

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Computers in Cardiology (CinC)

作者： V. Ramanathan B. Hoffmeister A. de Jongh Joint Graduate Program in Biomedical Engineering University of Tennessee Health Science Center USA Department of Physics Rhodes College Memphis USA

A previous 2D ultrasound study (R.A. Malkin et al., 2001) suggested that there is relaxation of the myocardium after defibrillation. However, that 2D study could not measure activity occurring within the first 33 ms following the shock. Thus, the objective of our study is to determine the left ventricular (LV) geometry during this period. Biphasic defibrillation shocks were delivered to seven dogs. 1D short-axis ultrasound images of the LV cavity were acquired, the boundary of the anterior and posterior endocardial walls was extracted and the distance between them computed from 32 ms before to 32 ms after the shock. The normalized mean pre- and post-shock slopes were 0.2 /spl plusmn/ 2.2 and 3.3 /spl plusmn/ 7.9 %/10 ms, respectively. The post-shock LV diameter slope is positive in the first 32 ms following both successful and unsuccessful defibrillation shocks (p<0.05). Therefore, our results confirm that the bulk of the myocardium is relaxing immediately after a defibrillation shock.

关键词： Geometry Electric shock Defibrillation Ultrasonic imaging Pulse measurements Myocardium Ultrasonic variables measurement biomedical measurements Dogs Sampling methods

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Inducibility of Ventricular Arrhythmias in a Rat Model of Cardiac Fibrosis

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Journal of Investigative Medicine 2001年第1_SUPPL_PART_3期52卷 259页

作者： S. C. Marak A. L. de Jongh Curry T. A. Williams R. A. Malkin Y. Sun Joint Graduate Program in Biomedical Engineering University of Memphis and University of Tennessee Health Science Center Memphis TN

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Thin- and thick-film structures for miniature biomedical sensors

Thin- and thick-film structures for miniature biomedical sen...

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International Conference on Microtechnologies in Medicine and Biology

作者： M.R. Neuman E. Lindner A. Cristalli R.E. Gyurcsanyi K. Cheema M. Pandolf Joint Program in Biomedical Engineering University of Memphis and University of Tennessee USA

Physical and chemical miniature biomedical sensors fan be fabricated using thin- and thick-film technology. Devices such as biopotential electrodes; temperature, force, and compliant strain gauge sensors; and ion-selective electrodes have been designed, constructed, and applied to biomedical problems. Sometimes there are advantages to depositing non-conventional materials, thicker films, and thin- thick-film hybrid structures in fabricating biomedical sensors.

关键词： Biosensors Chemical technology biomedical electrodes Temperature sensors Chemical sensors Force sensors Capacitive sensors Chemical and biological sensors Biological materials biomedical materials

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