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Preclinical Assessment of Enhanced Chemodynamic Therapy by an FeMnOx-Based Nanocarrier: Tumor-Microenvironment-Mediated Fenton Reaction and ROS-Induced Chemotherapeutic for Boosted Antitumor Activity

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ACS Applied Materials and Interfaces 2023年第48期15卷 55258-55275页

作者： dirersa, Worku Batu Kan, Tzu-Chun Getachew, Girum Wibrianto, Aswandi Ochirbat, Sonjid Rasal, Akash Chang, Jungshan Chang, Jia-Yaw Department of Chemical Engineering National Taiwan University of Science and Technology Taiwan Taipei106335 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan

In recent studies, iron-containing Fenton nanocatalysts have demonstrated significant promise for clinical use due to their effective antitumor activity and low cytotoxicity. A new approach was reported in this work utilizing cation exchange synthesis to fabricate FeMnOx nanoparticles (NPs) that boost Fenton reactions and responses to the tumor microenvironment (TME) for chemodynamic therapy (CdT) and chemotherapy (CT). Within the TME, the redox metal pair of Fe2+/Mn2+ helps break down endogenous hydrogen peroxide (H2O2) into very harmful hydroxyl radicals (•OH) while simultaneously deactivating glutathione (GSH) to boost CdT performance. To further enhance the therapeutic potential, FeMnOx NPs were encapsulated with thioketal-linked camptothecin (CPT-TK-COOH), a reactive oxygen species (ROS)-responsive prodrug, achieving a high CPT-loading capacity of up to 51.1%. Upon ROS generation through the Fenton reaction, the prodrug TK linkage was disrupted, releasing 80% of the CPT payload within 48 h. Notably, FeMnOx@CPT exhibited excellent dual-modal imaging capabilities, enabling magnetic resonance and fluorescence imaging for image-guided therapy. In vitro studies showed the cytocompatibility of FeMnOx NPs using MdA-Mb-231 and 4T1 cells, but in the presence of H2O2, they induced significant cytotoxicity, resulting in 80% cell death through CdT and CT effects. Upon intravenous administration, FeMnOx@CPT displayed remarkable tumor accumulation, which enhanced tumor suppression in xenografts through improved CdT and CT effects. Moreover, no significant adverse effects were observed in the FeMnOx NP-treated animals. In the current study, the FeMnOx@CPT anticancer platform, with its boosted •OH-producing capability and ROS-cleavable drug release, has been validated utilizing in vitro and animal studies, suggesting its capacity as a viable strategy for clinical trials. © 2023 American Chemical Society.

关键词： Chemotherapy

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Evaluating cooling tube effects on defect formation and distribution in Czochralski crystal growth

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Journal of Materials Science: Materials in Electronics 2024年第19期35卷 1315页

作者： Huang, Yi-Jen dezfoli, Amir Reza Ansari Department of Chemical and Materials Engineering National Chin-Yi University of Technology Taichung41170 Taiwan Department of Intelligent Automation Engineering National Chin-Yi University of Technology Taichung Taiwan Ph.D. Program at Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology Taichung Taiwan

The quality of silicon ingots is paramount in semiconductor manufacturing as defects profoundly influence the crystal integrity and device performance. This study investigates the impact of cooling-tube configurations on defect formation during the Czochralski process. Comprehensive modeling and simulation elucidated the intricate relationship between the presence of a cooling tube and the evaluation of point defects within silicon ingots. The results show that cooling tubes augment the axial temperature gradient and shift the point-defect behavior from vacancy-rich to interstitial-dominated regions with an increase in the axial temperature gradient of up to 1.6 times. Additionally, cooling tubes impede the formation of agglomerated defects by reducing point-defect mobility and propagation time, resulting in a reduction of the agglomerated defect count by up to 30% compared to processes without cooling tubes. Experiments validated the simulation findings, demonstrating a notable decrease in agglomerated defect counts. These insights underscore the potential of optimized cooling-tube designs for enhancing semiconductor device performance and manufacturing yield, thereby driving progress in electronics and beyond. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

关键词： Agglomeration

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Macroscopic discolorization in Quantum dot Color Converters for Microdisplay Applications

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ACS Applied Nano Materials 2024年第7期7卷 8258-8268页

作者： Lin, Chen-Te Chen, Hsueh-Shih Ph.D. Program in Prospective Functional Materials Industry College of Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing Hua University Hsinchu30013 Taiwan

Quantum dot color converters (QdCCs) currently have the unsolved problems of photostability and discolorization in appearance after long-term operation in microdisplays. Instead of polymer-to-carbon conversion and/or impurity precipitation, the macroscopic bright-yellow-to-dark-brown discolorization is determined by microscopic interfacial chemical reactions of the Qd-ligand-polymer system. The phenomenon has been confirmed to be related to multiple factors, including chemical transformation of the Qd shell and partial degradation of the polymer, resulting in increased optical reflectance and reduced photoluminescence (PL) intensity in QdCCs. Our finding suggests that the photoexcitation of Qds in the polymer matrix should lead to detached surface ligands along with photocatalytic reactions, oxidizing the Qd shell together with degrading the polymer chains. © 2024 The Authors. Published by American Chemical Society

关键词： Color

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design Method for Wafer dicing Machine Base Based on Calculations 9

Design Method for Wafer Dicing Machine Base Based on Calcula...

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9th International Conference on Mechanical engineering, Materials, and Automation Technology, MMEAT 2023

作者： Tai, Au-Zou Fang, Jiunn Ph.D. Program of Mechanical and Aeronautical Engineering Feng Chia University Taichung40724 Taiwan Department of Aerospace and Engineering Feng Chia University Taichung City Taiwan

ISBN: (纸本)9781510668584

In recent years, the role of semiconductor industry has become crucial for development in various countries. The semiconductor industry mainly consists of three parts: silicon material production, integrated circuit wafer manufacturing, and integrated circuit packaging. This paper focuses on the analysis of the cutting structure of the backend equipment wafer dicing machine in the integrated circuit packaging process. Currently, the mainstream wafer dicing machines utilize two types of cutting methods: laser cutting and mechanical cutting. While laser cutting is necessary for certain materials due to the generation of debris, mechanical cutting using diamond saw blades still offers significant cost savings. In order to achieve optimal design for mechanical wafer dicing machines, this paper presents a design process specifically tailored for such machines that used of mechanical cutting method, taking the example of a vibration-isolated base for a 6-inch wafer dicing machine. © 2023 SPIE.

关键词： Integrated circuit design

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Machine-learning-based sampling inspection under OQC capacity for real-time quality monitoring in the TFT-LCd industry

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International Journal of Production Research 2025年第6期63卷 2090-2113页

作者： Shih, Ming-Sung Chen, James C. Chen, Tzu-Li Chiang, Chih-Hsiung Hsu, Ching-Lan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu Taiwan Department of Industrial Engineering and Engineering Management National Tsing Hua University Hsinchu Taiwan Graduate Institute of Intelligent Manufacturing Technology National Taiwan University of Science and Technology Taipei Taiwan Division of Quality Control AUO Corporation Taichung Taiwan

In the thin film transistor-liquid crystal display (TFT-LCd) industry, the competition is fierce, and the external failure cost is high. To improve the quality of released products, sampling inspection under outgoing quality control (OQC) is conducted before products are released. Owing to the variety and complexity of inspection items, the task must be carried out manually while realising automation is difficult. Traditional random sampling inspection is limited by sampling quantity, manpower, and material resources. To effectively improve acceptable quality levels, this paper proposes a quality predictive monitoring framework tailored to the production and inspection characteristics of the TFT-LCd industry. This framework includes real-time automatic quality monitoring based on an optimal machine learning prediction model with two-phase feature creation, and it also addresses OQC inspection capacity constraints. Experimental results show the prediction performance based on proposed model is better than the traditional random sampling process. In practice, superior average outgoing quality improves by more than 70% at the same sampling level. In addition, the features of the process can be further controlled and managed based on the prediction model to monitor the key parameters in real time and respond to abnormalities quickly, thereby further improving the quality of released products. © 2024 Informa UK Limited, trading as Taylor & Francis Group.

关键词： Liquid crystal displays

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A High-step-down Converter with Negative Output Voltage 11

A High-step-down Converter with Negative Output Voltage

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11th International Conference on Power Electronics - ECCE Asia, ICPE 2023-ECCE Asia

作者： Yau, Yeu-Torng Luu, Thanh-phu. National Chin-Yi University of Technology Ph.D. Program Ptoeecs Taichung Taiwan National Chin-Yuuuuuuui University of Technology Department of Electrical Engineering Taichung Taiwan

ISBN: (纸本)9788957083505

This paper proposes a new high step-down converter with negative voltage output, which has the following advantages: (1) Compared to conventional buck-boost or SEPIC converters, the proposed converter operates with zero voltage turn-on function. (2) The voltage gain of this circuit does not contain non-linear components, and the control is simple and can be driven by existing buck control ICs. (3) due to the dC blocking capacitor between the output and input terminals, the high voltage at the input will not pass through to the output when the converter fails to be controlled. The load is protected. Finally, a prototype is completed and the proposed method is verified to be feasible. © 2023 The Korean Institute of Power Electronics.

关键词： Buck-Boost converter

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Energy-efficient and Accurate Object detection design on an FPGA Platform

Energy-efficient and Accurate Object Detection Design on an ...

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2022 IET International Conference on engineering Technologies and Applications, IET-ICETA 2022

作者： Chen, Kuan-Hung Su, Chun-Wei Wang, Jen-He Feng Chia University Department of Electronic Engineering Taichung Taiwan PH.D. Program of Electronical and Communications Engineering Department of Electronic Engineer

ISBN: (数字)9781665491389

ISBN: (纸本)9781665491389

With the innovation of hardware equipment, the development of artificial intelligence has broken through the limitations of the past. Neural networks have been continuously deepened to improve the accuracy of detection, so that the parameters have increased with a direct proportional rate. In this way, however, high energy consumption has been induced which obstacles the deployment of AI algorithms on portable devices. Therefore, the design of neural network must consider not only detection accuracy but also energy efficiency. In this paper, we analyzed energy consumption, detection accuracy and execution speed of our neural network model as well as the state-of-the-art models based on an FPGA platform called ZCU-102. We adopt the performance index from Low Power Computer Vision (LPCV) challenge which considers power dissipation, mean Average Precision (mAP) and Frames Per Second (FPS) at the same time to evaluate these models in an overall point of view. Agilev4 can achieve 59.9% of mAP@50 on MS COCO test-dev2017 datasets. If the input frame resolution is turned into 416 × 416, the processing frame rate can reach 20.7 FPS on ZCU-102. Compared with the state-of-the-art models, the LPCV score of Agilev4-416 is 1475. S which is 1.56 times of that of YOLOv4-416. © 2022 IEEE.

关键词： Field programmable gate arrays (FPGA)

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engineering H2O2 Self-Supplying Platform for Xdynamic Therapies via Ru-Cu Peroxide Nanocarrier: Tumor Microenvironment-Mediated Synergistic Therapy

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ACS Applied Materials and Interfaces 2024年第19期16卷 24172-24190页

作者： dirersa, Worku Batu Kan, Tzu-Chun Chang, Jungshan Getachew, Girum Ochirbat, Sonjid Kizhepat, Shamsa Wibrianto, Aswandi Rasal, Akash Chen, Hung-An Ghule, Anil Vithal Chou, Tzung-Han Chang, Jia-Yaw Department of Chemical Engineering National Taiwan University of Science and Technology Taipei106335 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Green Nanotechnology Laboratory Department of Chemistry Shivaji University Kolhapur416004 India Department of Chemical and Materials Engineering National Yunlin University of Science and Technology Yunlin64002 Taiwan

Of the most common, hypoxia, overexpressed glutathione (GSH), and insufficient H2O2 concentration in the tumor microenvironment (TME) are the main barriers to the advancment of reactive oxygen species (ROS) mediated Xdynamic therapies (X = photo, chemodynamic, chemo). Maximizing Fenton catalytic efficiency is crucial in chemodynamic therapy (CdT), yet endogenous H2O2 levels are not sufficient to attain better anticancer efficacy. Specifically, there is a need to amplify Fenton reactivity within tumors, leveraging the unique attributes of the TME. Herein, for the first time, we design RuxCu1-xO2-Ce6/CPT (RCpCCPT) anticancer nanoagent for TME-mediated synergistic therapy based on heterogeneous Ru-Cu peroxide nanodots (RuxCu1-xO2 Nds) and chlorine e6 (Ce6), loaded with ROS-responsive thioketal (TK) linked-camptothecin (CPT). The Ru-Cu peroxide Nds (RCp Nds, x = 0.50) possess the highest oxygen vacancy (OV) density, which grants them the potential to form massive Lewis’s acid sites for peroxide adsorption, while the dispersibility and targetability of the Nds were improved via surface modification using hyaluronic acid (HA). In TME, RCpCCPT degrades, releasing H2O2, Ru2+/3+, and Cu+/2+ ions, which cooperatively facilitate hydroxyl radical (•OH) formation and deactivate antioxidant GSH enzymes through a cocatalytic loop, resulting in excellent tumor therapeutic efficacy. Furthermore, when combined with laser treatment, RCpCCPT produces singlet oxygen (1O2) for PdT, which induces cell apoptosis at tumor sites. Following ROS generation, the TK linkage is disrupted, releasing up to 92% of the CPT within 48 h. In vitro investigations showed that laser-treated RCpCCPT caused 81.5% cell death from PdT/CdT and chemotherapy (CT). RCpCCPT in cancer cells produces red-blue emission in images of cells taking them in, which allows for fluorescence image-guided Xdynamic treatment. The overall results show that RCp Nds and RCpCCPT are more biocompatible and have excellent Xdynamic the

关键词： Oxidation

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Synthesis of Methotrexate-Loaded dumbbell-Shaped Titanium dioxide/Gold Nanorods Coated with Mesoporous Silica and decorated with Upconversion Nanoparticles for Near-Infrared-driven Trimodal Cancer Treatment

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ACS Applied Materials and Interfaces 2023年第28期15卷 33335-33347页

作者： dash, Pranjyan Thirumurugan, Senthilkumar Tseng, Ching-Li Lin, Yu-Chien Chen, Sung-Lung dhawan, Udesh Chung, Ren-Jei Taipei10608 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei110 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Taipei10608 Taiwan

This study prepared dumbbell-shaped titanium dioxide (TiO2)/gold nanorods (AuNRs) coated with mesoporous silica shells (mS) (AuNRs-TiO2@mS). Methotrexate (MTX) was further loaded into the AuNRs-TiO2@mS, and then upconversion nanoparticles (UCNPs) were decorated to form AuNRs-TiO2@mS-MTX: UCNP nanocomposites. TiO2 is used as an intense photosensitizer (PS) to produce cytotoxic reactive oxygen species (ROS), leading to photodynamic therapy (PdT). Concurrently, AuNRs exhibited intense photothermal therapy (PTT) effects and photothermal conversion efficiency. In vitro results suggested that these nanocomposites can kill oral cancer cells (HSC-3) without toxicity through irradiation of NIR laser, owing to the synergistic effect. The in vivo studies indicated that these nanocomposites exhibited excellent antitumor effects through synergistic PdT/PTT/chemotherapy under a near-infrared (NIR) 808 nm laser irradiation. Thus, these AuNRs-TiO2@mS: UCNP nanocomposites have great potential to undergo deep tissue penetration with enhanced synergistic effects through NIR-triggered light for cancer treatment. © 2023 American Chemical Society

关键词： Titanium dioxide

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Overcoming the Blood-Brain Tumor Barrier with docetaxel-Loaded Mesoporous Silica Nanoparticles for Treatment of Temozolomide-Resistant Glioblastoma

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ACS Applied Materials and Interfaces 2024年第17期16卷 21722-21735页

作者： Hsu, Tsung-I Chen, Yi-Ping Zhang, Rong-Lin Chen, Zih-An Wu, Cheng-Hsun Chang, Wen-Chang Mou, Chung-Yuan Chan, Hardy Wai-Hong Wu, Si-Han Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei110 Taiwan International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei110 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Nano Targeting & Therapy Biopharma Inc. Taipei110 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei110 Taiwan Department of Chemistry National Taiwan University Taipei106 Taiwan

While temozolomide (TMZ) has been a cornerstone in the treatment of newly diagnosed glioblastoma (GBM), a significant challenge has been the emergence of resistance to TMZ, which compromises its clinical benefits. Additionally, the nonspecificity of TMZ can lead to detrimental side effects. Although TMZ is capable of penetrating the blood-brain barrier (BBB), our research addresses the need for targeted therapy to circumvent resistance mechanisms and reduce off-target effects. This study introduces the use of PEGylated mesoporous silica nanoparticles (MSN) with octyl group modifications (C8-MSN) as a nanocarrier system for the delivery of docetaxel (dTX), providing a novel approach for treating TMZ-resistant GBM. Our findings reveal that C8-MSN is biocompatible in vitro, and dTX@C8-MSN shows no hemolytic activity at therapeutic concentrations, maintaining efficacy against GBM cells. Crucially, in vivo imaging demonstrates preferential accumulation of C8-MSN within the tumor region, suggesting enhanced permeability across the blood-brain tumor barrier (BBTB). When administered to orthotopic glioma mouse models, dTX@C8-MSN notably prolongs survival by over 50%, significantly reduces tumor volume, and decreases side effects compared to free dTX, indicating a targeted and effective approach to treatment. The apoptotic pathways activated by dTX@C8-MSN, evidenced by the increased levels of cleaved caspase-3 and PARP, point to a potent therapeutic mechanism. Collectively, the results advocate dTX@C8-MSN as a promising candidate for targeted therapy in TMZ-resistant GBM, optimizing drug delivery and bioavailability to overcome current therapeutic limitations. © 2024 The Authors. Published by American Chemical Society.

关键词： Tumors

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