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Repurposing transfer learning strategy of computer vision for owl sound classification

Procedia Computer Science 2023年 216卷 424-430页

作者： Kevin William Gunawan Alam Ahmad Hidayat Tjeng Wawan Cenggoro Bens Pardamean Computer Science Department BINUS Graduate Program – Master of Computer Science Bina Nusantara University Jakarta 11480 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta 11480 Indonesia Computer Science Department School of Computer Science Bina Nusantara University Jakarta 11480 Indonesia

Accurately predicting an owl species based on its sound can be helpful for owl conservation. To build an accurate model for owl sound classification, deep learning is currently the most preferred algorithm, due to its excellent performance for modeling audio data. However, deep learning is generally underperformed for a small dataset, which is the case for recognizing scops owl sound. To overcome the issue, we proposed a transfer learning strategy, which is common for computer vision tasks, that can alleviate overfitting in a deep learning model for the owl sound classification. In our approach, we propose a neural network architecture consisting of the backbone of a EfficientNet model pre-trained on the massive ImageNet database. The model takes the sound input that has been converted as two image representations: Spectrogram and Mel Frequency Cepstral Coefficients. Our strategy enables the use of a relatively small size of pre-trained image classification model, which is widely available, for transfer learning in owl sound classification. Deploying the lightweight model in an automatic sound classifier provides a fast and accurate tool for various owl conservation purposes.

关键词： acoustics deep learning bird sound species detection transfer learning

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Context-dependent gene regulatory network reveals regulation dynamics and cell trajectories using unspliced transcripts

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Briefings in bioinformatics 2023年第2期24卷 bbac633-bbac633页

作者： Tu, Yueh-Hua Juan, Hsueh-Fen Huang, Hsuan-Cheng The Bioinformatics Program Taiwan International Graduate Program Academia Sinica Taiwan Department of Life Science Center for Computational and Systems Biology National Taiwan University Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung University Taiwan

Gene regulatory networks govern complex gene expression programs in various biological phenomena, including embryonic development, cell fate decisions and oncogenesis. Single-cell techniques are increasingly being used to study gene expression, providing higher resolution than traditional approaches. However, inferring a comprehensive gene regulatory network across different cell types remains a challenge. Here, we propose to construct context-dependent gene regulatory networks (CDGRNs) from single-cell RNA sequencing data utilizing both spliced and unspliced transcript expression levels. A gene regulatory network is decomposed into subnetworks corresponding to different transcriptomic contexts. Each subnetwork comprises the consensus active regulation pairs of transcription factors and their target genes shared by a group of cells, inferred by a Gaussian mixture model. We find that the union of gene regulation pairs in all contexts is sufficient to reconstruct differentiation trajectories. Functions specific to the cell cycle, cell differentiation or tissue-specific functions are enriched throughout the developmental process in each context. Surprisingly, we also observe that the network entropy of CDGRNs decreases along differentiation trajectories, indicating directionality in differentiation. Overall, CDGRN allows us to establish the connection between gene regulation at the molecular level and cell differentiation at the macroscopic level. © The Author(s) 2023.

关键词： Gaussian mixture model gene regulatory network single-cell RNA sequencing trajectory analysis

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Influence of conformational change of chain unit on the intrinsic negative thermal expansion of polymers

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Chinese Chemical Letters 2021年第4期32卷 1515-1518页

作者： Qiangsheng Sun Ke Jin Yuhui Huang Jia Guo Thanyada Rungrotmongkol Phornphimon Maitarad Changchun Wang State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science Fudan UniversityShanghai 200433.China Biocatalyst and Environmental Biotechnology Research Unit Department of BiochemistryFaculty of Science and Program in Bioinformatics and Computational BiologyGraduate SchoolChulalongkom UniversityBangkok 10330Thailand Research Center of Nano Science and Technology Shanghai UniversityShanghai 200444China

Negative thermal expansion(NTE) behavior has roused wide interest for the control of thermomechanical properties of functional *** NTE behaviors have been found in kinds of compounds,it remains challenging for polymers to achieve intrinsic NTE *** this work,we systematically studied the conformational change of dibenzocyclooctadiene(DBCOD) derivatives between chair(C) and twist-boat(TB) forms based on density-functional theo ry(DFT) calculations,and found clear evidence of the relationship between the structure of DBCOD units and the thermal contraction behavior of the related *** order to obtain the polymer with NTE property,two conditions should be met for the thermal contracting DBCOD related units as follows:(i) the TB conformation can turn into C conformation as the temperature increases,and(ii) the volume of C conformation is smaller than that of TB *** rule should offer a guidance to exploration of the new intrinsic NTE polymers in the future.

关键词： Negative thermal expansion Conformational change Polyarylamides Density-functional theory Dibenzocyclooctadiene

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GranatumX:A Community-engaging, Modularized, and Flexible Webtool for Single-cell Data Analysis

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Genomics, Proteomics & bioinformatics 2021年第3期19卷 452-460页

作者： David G.Garmire Xun Zhu Aravind Mantravadi Qianhui Huang Breck Yunits Yu Liu Thomas Wolfgruber Olivier Poirion Tianying Zhao Cédric Arisdakessian Stefan Stanojevic Lana X.Garmire Department of Electrical Engineering&Computer Science University of MichiganAnn ArborMI 48109USA Epidemiology Program University of Hawaii Cancer CenterHonoluluHI 96813USA Department of Biostatistics University of MichiganAnn ArborMI 48109USA Department of Computational Medicine and Bioinformatics University of MichiganAnn ArborMI 48105USA Molecular Biosciences and Bioengineering Graduate Program University of Hawaii at ManoaHonoluluHI 96822USA

We present GranatumX,a next-generation software environment for single-cell RNA sequencing(scRNA-seq)data *** is inspired by the interactive webtool *** enables biologists to access the latest scRNA-seq bioinformatics methods in a web-based graphical *** also offers software developers the opportunity to rapidly promote their own tools with others in customizable *** architecture of GranatumX allows for easy inclusion of plugin modules,named Gboxes,which wrap around bioinformatics tools written in various programming languages and on various *** can be run on the cloud or private servers and generate reproducible *** is a community-engaging,flexible,and evolving software ecosystem for scRNA-seq analysis,connecting developers with bench *** is freely accessible at http://***/granatumx/app.

关键词： Single-cell RNA sequencing Analysis Pipeline Webtool Module

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Mass cytometry uncovers a distinct peripheral immune profile and upregulated CD38 expression in patients with hidradenitis suppurativa

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Cellular & Molecular Immunology 2023年第8期20卷 972-975页

作者： Peter Dimitrion Iltefat Hamzavi Congcong Yin Jugmohit Toor Kalpana Subedi Namir Khalasawi Angela Miller Richard Huggins Indra Adrianto Jesse Veenstra Gautham Vellaichamy Aakash Hans Steven Daveluy Mohammad Athar Wilson Liao Henry Lim David Ozog Li Zhou Qing-Sheng Mi Center for Cutaneous Biology and Immunology Research Department of DermatologyHenry Ford Health SystemDetroitMI48202USA Immunology Research Program Henry Ford Cancer InstituteHenry Ford Health SystemDetroitMI48202USA Cancer Biology Graduate Program School of MedicineWayne State UniversityDetroitMI48202USA Center for Bioinformatics Department of Public Health SciencesHenry Ford Health SystemDetroitMI48202USA Department of Dermatology Wayne State University School of MedicineDetroitMI48202USA University of Alabama at Birmingham(UAB)Research Center of Excellence in Arsenicals Department of DermatologyUniversity of Alabama at BirminghamBirminghamALUSA Department of Dermatology University of California San FranciscoSan FranciscoCAUSA Department of Biochemistry Microbiologyand ImmunologySchool of MedicineWayne State UniversityDetroitMI48202USA

Hidradenitis suppurativa(HS)is a chronic inflammatory skin disease with a worldwide prevalence of 0.3–4.0%,wherein abscesses and dermal sinus tracts form in intertriginous skin[1].HS remains poorly treated due to a l... 详细信息

关键词： CD38 patients pathogenesis

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A Diversity Inventory Monitoring System of Riparian Vegetation 4

A Diversity Inventory Monitoring System of Riparian Vegetati...

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4th International Conference on Cybernetics and Intelligent System, ICORIS 2022

作者： Putra, Dian Pratama Nugraha, Nanda Satya Suparyanto, Teddy Hidayat, Alam Ahmad Sudigyo, Digdo Pardamean, Bens STIPER Agricultural Institute Faculty of Agricultural Technology Yogyakarta55282 Indonesia STIPER Agricultural Institute Yogyakarta Faculty of Agricultural Technology Faculty of Forestry Yogyakarta55282 Indonesia Bina Nusantara University Bioinformatics and Data Science Research Center Jakarta11480 Indonesia Bina Nusantara University BINUS Graduate Program - Master of Computer Science Computer Science Department Jakarta11480 Indonesia

ISBN: (纸本)9781665453950

To strengthen conservation efforts for preserving biodiversity in a conservation area, forest inventory is important to understand the natural succession process in the area and to establish a monitoring strategy. Further, tree inventory aims to monitor the output yielded in the area. More specifically, the tree inventory in the watershed area plays a key role to achieve Sustainable Development Goals (SDG), especially in riparian zones which are also vital parts of green zones in forests. However, the traditional inventory approach is time-consuming and laborious therefore the development of an expert system to assist in inventory monitoring is required. In this study, we develop a monitoring system via a mobile application to collect, analyze and visualize tree inventory data. The application includes algorithms required to compute tree biodiversity, distribution, and richness for the given input of the data of all tree species in a conservation area. For the model validation stage, we compare the traditional inventory approach with our proposed application-based approach to compute diversity inventory in two riparian locations: Klaten Conservation Park and Wonosobo Conservation Park. After the three-day data collection in the areas, we obtain that the accuracy of reading data of our proposed system can achieve more than 90% in comparison with the manual approach. This demonstrates that the system can assist forestry workers to perform more efficient tree inventories in different locations. © 2022 IEEE.

关键词： Biodiversity

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Characterization of Antioxidative Flavonoids in Wild and Cultivated Soybean by Ion-Filtering Strategy-Combined Lc-Hrmsn Analysis

SSRN

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SSRN 2024年

作者： No, Kyoung Tai Kim, Kwan Joong Cho, Min Hyung Lee, Sangwon Ha, Jang-Ho Chu, Sung-June Chung, Gyuhwa Kim, Dae-Ok Bioinformatics & Molecular Design Research Center Incheon21983 Korea Republic of Department of Biotechnology Chonnam National University Yeosu59626 Korea Republic of Graduate School of Biotechnology Kyung Hee University Yongin17104 Korea Republic of Interdisciplinary Graduate Program Department of Integrative Biotechnology & Translational Medicine Yonsei University Incheon21983 Korea Republic of Yonsei University Korea Republic of

To profiling flavonoids in wild soybean (WB;Glycine soja Sieb & Zucc.) and cultivated soybean (CB;Glycine max (L.) Merr.), liquid chromatography-high resolution mass spectrometry (LC-HRMS), antioxidant assays, and chemometrics method were used. Total 70 flavonoids were tentatively identified with ion filter strategies containing precursor ion list, mass defect filter, nitrogen rule filter, and diagnostic ion filter from 20,999 features in WB and CB. Semi-quantification result revealed that WB has 1.4-, 93.1-, 6.3-, and 1.9-fold higher contents in isoflavone, flavan, procyanidin, and flavone than that of CB. In antioxidant assays, WB showed 1.89- to 5.83-fold higher antioxidant capacities than CB in four antioxidant capacity assays. In orthogonal partial least squares discriminant analysis, WB and CB were clearly classified, and 31 characteristic flavonoids were identified by variable importance in projection. Furthermore, epicatechin and procyanidins of WB showed significantly positive correlation with antioxidant capacities by Pearson's correlation. © 2024, The Authors. All rights reserved.

关键词： Flavonoids

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Trends, Opportunities, and Challenges in Detecting Depressive Disorders Through Mobile Devices: A Review 2

Trends, Opportunities, and Challenges in Detecting Depressiv...

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2nd International Conference on Computer System, Information Technology, and Electrical Engineering, COSITE 2023

作者： Elwirehardja, Gregorius Natanael Isnan, Mahmud Perbangsa, Anzaludin Samsinga Muchtar, Kahlil Pardamean, Bens Computer Science Department School of Computer Science Bina Nusantara University Jakarta11480 Indonesia Mahmud Isnan Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Information System Department School of Information Systems Bina Nusantara University Jakarta11480 Indonesia Department of Electrical and Computer Engineering Universitas Syiah Kuala Banda Aceh23111 Indonesia Computer Science Department BINUS Graduate Program-Master of Computer Science Bina Nusantara University Jakarta11480 Indonesia

ISBN: (纸本)9798350343069

Depressive Disorders (DD) is one of the most prevalent mental disorders in the world that may lead to suicide cases. To prevent the latter, ubiquitous early detection systems may be effective. Recent studies have since researched the development of such systems by exploiting several forms of data, including video, audio, Ecological Momentary Assessments (EMA), and passive sensing data using sensors embedded in mobile devices. To summarize the trends, opportunities, and existing challenges in this field, this study reviewed 15 papers to answer four research questions. EMA was the most popular data to be used in this task, but other approaches, such as using video, audio, and typing behaviors, may be considered due to the subjectivity of EMA. These data were typically recorded using smartphones and analyzed using Machine Learning (ML). However, most of the developed systems had yet to be implemented. Overall, it was concluded that further studies may need to explore usages of more objective data in multimodal approaches as well as consider using Mobile Cloud Computing (MCC) to deploy these systems to provide more effective and efficient diagnoses. Future studies must also take into account the existing challenges of the data and infrastructures, such as the weaknesses of several data types, limitations of mobile devices, as well as the challenges of diagnosis approaches. © 2023 IEEE.

关键词： Machine learning

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OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems

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Advanced Intelligent Systems 2025年第3期7卷

作者： Chen, Po-Yuan Ko, Tai-Ming Institute of Bioinformatics and Systems Biology College of Engineering Bioscience National Yang Ming Chiao Tung University Hsinchu300 Taiwan Bioinformatics Program Institute of Statistical Science Taiwan International Graduate Program Academia Sinica Taipei115 Taiwan Institute of Biomedical Sciences Academia Sinica Taipei115 Taiwan Institute of Statistical Science Academia Sinica Taipei115 Taiwan Department of Biological Science and Technology College of Engineering Bioscience National Yang Ming Chiao Tung University Hsinchu300 Taiwan National Yang Ming Chiao Tung University Hsinchu300 Taiwan School of Pharmacy College of Pharmacy Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung807 Taiwan

Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) and antioxidants, plays a pivotal role in inflammatory responses associated with both chronic diseases and acute injuries. In this study, OXidative Stress PREDictor (OxSpred), a supervised learning model tailored to accurately annotate the oxidative stress state of innate immune cells at the single-cell level, is introduced. Compared to the traditional gene-set-variation-analysis-based enrichment method, OxSpred demonstrates superior accuracy with an area under the receiver operating characteristic curve of 0.89 and offers interpretable embeddings with significant biological relevance. Using the predicted ROS states, precise elucidation and interpretation of the roles of novel innate immune cell subtypes can be achieved. Overall, OxSpred enhances the utility of single-cell transcriptomic datasets by providing a robust in silico method for determining intracellular oxidative stress states, thereby enriching the understanding of innate immune cell functions during inflammation. © 2024 The Author(s). Advanced Intelligent Systems published by Wiley-VCH GmbH.

关键词： Cells

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Predicting drug response through tumor deconvolution by cancer cell lines

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Patterns 2024年第4期5卷 100949页

作者： Hsu, Yu-Ching Chiu, Yu-Chiao Lu, Tzu-Pin Hsiao, Tzu-Hung Chen, Yidong Bioinformatics Program Taiwan International Graduate Program National Taiwan University Taipei115 Taiwan Bioinformatics Program Institute of Statistical Science Taiwan International Graduate Program Academia Sinica Taipei115 Taiwan Institute of Health Data Analytics and Statistics Department of Public Health College of Public Health National Taiwan University Taipei100 Taiwan Greehey Children's Cancer Research Institute University of Texas Health San Antonio San AntonioTX78229 United States Department of Medicine School of Medicine University of Pittsburgh PittsburghPA15261 United States UPMC Hillman Cancer Center University of Pittsburgh PittsburghPA15232 United States Department of Medical Research Taichung Veterans General Hospital Taichung40705 Taiwan Department of Population Health Sciences University of Texas Health San Antonio San AntonioTX78229 United States

Large-scale cancer drug sensitivity data have become available for a collection of cancer cell lines, but only limited drug response data from patients are available. Bridging the gap in pharmacogenomics knowledge between in vitro and in vivo datasets remains challenging. In this study, we trained a deep learning model, Scaden-CA, for deconvoluting tumor data into proportions of cancer-type-specific cell lines. Then, we developed a drug response prediction method using the deconvoluted proportions and the drug sensitivity data from cell lines. The Scaden-CA model showed excellent performance in terms of concordance correlation coefficients (>0.9 for model testing) and the correctly deconvoluted rate (>70% across most cancers) for model validation using Cancer Cell Line Encyclopedia (CCLE) bulk RNA data. We applied the model to tumors in The Cancer Genome Atlas (TCGA) dataset and examined associations between predicted cell viability and mutation status or gene expression levels to understand underlying mechanisms of potential value for drug repurposing. © 2024 The Authors

关键词： Tumors

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