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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2

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四川生理科学杂志 2022年第7期44卷 1299-1299页

作者： Jonathan E Pekar Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA 92093 USA Department of Biomedical Informatics University of California San Diego La Jolla CA 92093 USA Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA 92037 USA Department of Computer Science and Engineering University of California San Diego La Jolla CA 92093 USA Department of Mathematics University of California San Diego La Jolla CA 92093 USA Department of Ecology and Evolutionary Biology University of Arizona Tucson AZ 85721 USA W. Harry Feinstone Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA New York City Public Health Laboratory New York City Department of Health and Mental Hygiene New York NY 11101 USA Department of Microbiology Institute for Viral Diseases Biosafety Center College of Medicine Korea University Seoul South Korea BK21 Graduate Program Department of Biomedical Sciences Korea University College of Medicine Seoul 02841 Republic of Korea National Public Health Laboratory National Centre for Infectious Diseases Singapore Malaysia Genome and Vaccine Institute Jalan Bangi 43000 Kajang Selangor Malaysia Department of Medicine University of California San Diego La Jolla CA 92093 USA Department of Microbiology and Immunology School of Medicine Tulane University New Orleans LA 70112 USA Zalgen Labs Frederick MD 21703 USA Global Virus Network (GVN) Baltimore MD 21201 USA Sydney Institute for Infectious Diseases School of Life and Environmental Sciences and School of Medical Sciences The University of Sydney Sydney NSW 2006 Australia Institute of Evolutionary Biology University of Edinburgh King’s Buildings Edinburgh EH9 3FL UK Department of Biomathematics David Geffen School of Medicine Un

Understanding the circumstances that lead to pandemics is important for their prevention. Here, we analyze the genomic diversity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in the coronavirus disease 2019 (COVID-19) pandemic. We show that SARS-CoV-2 genomic diversity before February 2020 likely comprised only two distinct viral lineages, denoted A and B. Phylodynamic rooting methods, coupled with epidemic simulations, reveal that these lineages were the result of at least two separate cross-species transmission events into humans. The first zoonotic transmission likely involved lineage B viruses around 18 November 2019 (23 October-8 December), while the separate introduction of lineage A likely occurred within weeks of this event.

关键词： epidemiology likely acute

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Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h

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Cancer cell international 2023年第1期23卷 45页

作者： Kuan-Yi Lee Chia-Ming Liu Li-Han Chen Chien-Yueh Lee Tzu-Pin Lu Li-Ling Chuang Liang-Chuan Lai Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan. Institute of Fisheries Science College of Life Science National Taiwan University Taipei Taiwan. Department of Life Science College of Life Science National Taiwan University Taipei Taiwan. Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University Taichung Taiwan. Institute of Epidemiology and Preventive Medicine Department of Public Health National Taiwan University Taipei Taiwan. School of Physical Therapy and Graduate Institute of Rehabilitation Science College of Medicine Chang Gung University Taoyuan Taiwan. lchuang@gap.cgu.edu.tw. Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan. lchuang@gap.cgu.edu.tw. Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan. llai@ntu.edu.tw. Bioinformatics and Biostatistics Core Center of Genomic and Precision Medicine National Taiwan University Taipei Taiwan. llai@ntu.edu.tw.

BACKGROUND:Breast cancer is a prevalent disease in women, with high prevalence worldwide. The hypoxic microenvironment of solid tumors develops during the progress of carcinogenesis and leads to greater malignancy and treatment resistance. Recently, accumulating evidence indicates that non-coding RNAs, such as circular RNAs (circRNAs), play a pivotal role in altering cellular functions. However, the underlying mechanisms of circRNAs in breast cancer are still unclear. Therefore, the purpose of this study was to investigate the role of a tumor-suppressive circRNA, circAAGAB, in breast cancer by assuming down-regulation of circAAGAB under hypoxia and the properties of a tumor suppressor. METHODS:Firstly, circAAGAB was identified from expression profiling by next generation sequencing. Next, the stability of circAAGAB increased by interacting with the RNA binding protein FUS. Moreover, cellular and nuclear fractionation showed that most circAAGAB resided in the cytoplasm and that it up-regulated KIAA1522, NKX3-1, and JADE3 by sponging miR-378 h. Lastly, the functions of circAAGAB were explored by identifying its down-stream genes using Affymetrix microarrays and validated by in vitro assays. RESULTS:The results showed that circAAGAB reduced cell colony formation, cell migration, and signaling through p38 MAPK pathway, as well as increased radiosensitivity. CONCLUSION:These findings suggest that the oxygen-responsive circAAGAB acts as a tumor suppressor in breast cancer, and may contribute to the development of a more specific therapeutic regimen for breast cancer.

关键词： Breast cancer Hypoxia Radiosensitivity Tumor suppressor circAAGAB miRNA sponge p38 MAPK

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Persistence and dynamic structures of diverse cephalosporinase genes in nontyphoidal Salmonella in cross-sectional surveillance in Taiwan

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International Journal of Antimicrobial Agents 2023年第4期62卷 106944-106944页

作者： Lee, Yuarn-Jang Chang, Yu-Chu Lee, I-Hui Ho, Kuo-Hao Fang, Shiuh-Bin Lauderdale, Tsai-Ling Chen, Ting-Wen Chen, Ku-Chung Huang, Chih-Hung Huang, Tzu-Wen Division of Infectious Diseases Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Division of Infectious Diseases Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Biochemistry and Molecular Cell Biology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Microbiology and Immunology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan Division of Pediatric Gastroenterology and Hepatology Department of Pediatrics Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Department of Medical Research Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Department of Pediatrics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Master Program in Clinical Pharmacogenomics and Pharmacoproteomics College of Pharmacy Taipei Medical University Taipei Taiwan National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Zhunan Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Chemical Engineering and Biotechnology Institute of Chemical Engineering National Taipei University of Technology Taipei Taiwan

Objectives: Nontyphoidal Salmonella (NTS) is a major foodborne pathogen causing from acute gastroenteritis to bacteraemia, particularly in paediatric and elderly patients. Antimicrobial resistance of NTS, especially resistance to extended-spectrum cephalosporins, has emerged over the past decades. Methods: Thirteen NTS isolates resistant to ceftriaxone or cefotaxime were collected from a teaching hospital in Taipei, and another three from a tertiary hospital, in New Taipei City, Taiwan, from September 2018 to December 2019. Ten other archived isolates from 2000 to 2017 were also obtained. Complete genomes of the 26 isolates were obtained. Serovars, sequence types, resistomes, genetic relatedness, and sequence comparison of plasmids were analyzed. Results: Serogroups B, C2 and E were significantly associated with ampicillin resistance. Over 90% of these 26 isolates are susceptible to carbapenems and colistin. Genomic epidemiology of these isolates shows that bla_CMY-2-harbouring isolates in different serovars were prevalent over two decades, presumably resulting from highly mobile IncI1 plasmid harbouring bla_CMY-2. One type of the IncI1 plasmids contained a mobile element, IS26, which might be involved in the acquisition of antimicrobial resistance genes. Two emerging serovars, S. Goldcoast ST358 harbouring bla_CTX-M-55 on IncHI2 plasmids and S. Anatum ST64 harbouring bla_DHA-1 on IncA/C₂ plasmids persisted in Taiwan, possibly through the clonal spread. Integration of complete or partial plasmid sequences into host chromosomes or multiplications of the antimicrobial resistance genes also appears to be mediated by IS26, in the two emerging clones. Conclusion: The dynamic movement of cephalosporinase genes mediated by IS26 in NTS is of great concern. © 2023 The Authors

关键词： Amplification Chromosome integration Epidemiology Foodborne pathogen Insertion sequence Whole-genome sequencing

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Erratum to: Genetic analysis of Down syndrome-associated heart defects in mice

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Human Genetics 2011年第5期130卷 633-633页

作者： Liu, Chunhong Morishima, Masae Yu, Tao Matsui, Sei-Ichi Zhang, Li Fu, Dawei Pao, Annie Costa, Alberto C. Gardiner, Katheleen J. Cowell, John K. Nowak, Norma J. Parmacek, Michael S. Liang, Ping Baldini, Antonio Yu, Y. Eugene Children’s Guild Foundation Down Syndrome Research Program Department of Cancer Genetics Roswell Park Cancer Institute Buffalo USA Department of Anatomy and Developmental Biology Department of Pediatric Cardiology Tokyo Women’s Medical University Tokyo Japan Division of Clinical Pharmacology and Toxicology Department of Medicine University of Colorado School of Medicine Aurora USA Department of Pediatrics Intellectual and Developmental Disability Research Center Human Medical Genetics and Neuroscience Programs University of Colorado Denver Aurora USA MCG Cancer Center School of Medicine Medical College of Georgia Augusta USA New York State Center of Excellence in Bioinformatics and Life Sciences Buffalo USA Department of Cellular and Molecular Biology Roswell Park Division of Graduate School State University of New York at Buffalo Buffalo USA University of Pennsylvania Cardiovascular Institute Philadelphia USA Department of Biological Sciences Brock University St. Catharines Canada Institute of Biosciences and Technologies Texas A&M University Houston USA Institute of Genetics and Biophysics National Research Council Naples Italy

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Correction to: Authors’ Reply to Letter to the Editor: Continued improvement to genetic diversity indicator for CBD

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Conservation Genetics 2021年第4期22卷 537-539页

作者： Laikre, Linda Hohenlohe, Paul A. Allendorf, Fred W. Bertola, Laura D. Breed, Martin F. Bruford, Michael W. Funk, W. Chris Gajardo, Gonzalo González-Rodríguez, Antonio Grueber, Catherine E. Hedrick, Philip W. Heuertz, Myriam Hunter, Margaret E. Johannesson, Kerstin Liggins, Libby MacDonald, Anna J. Mergeay, Joachim Moharrek, Farideh O’Brien, David Ogden, Rob Orozco-terWengel, Pablo Palma-Silva, Clarisse Pierson, Jennifer Paz-Vinas, Ivan Russo, Isa-Rita M. Ryman, Nils Segelbacher, Gernot Sjögren-Gulve, Per Waits, Lisette P. Vernesi, Cristiano Hoban, Sean Division of Population Genetics Department of Zoology Stockholm University Stockholm Sweden Institute for Bioinformatics and Evolutionary Studies Department of Biological Sciences University of Idaho Moscow USA Division of Biological Sciences University of Montana Missoula USA City College of New York New York USA College of Science and Engineering Flinders University Bedford Park Australia School of Biosciences Cardiff University Cardiff Wales UK Graduate Degree Program in Ecology Department of Biology Colorado State University Fort Collins USA Universidad de Los Lagos Lab Genetics Aquaculture & Biodiversity Osorno Chile Instituto de Investigaciones en Ecosistemas y Sustentabilidad Universidad Nacional Autónoma de México Morelia Mexico School of Life and Environmental Sciences Faculty of Science The University of Sydney Sydney Australia School of Life Sciences Arizona State University Tempe USA INRAE Univ. Bordeaux Biogeco Cestas France U.S. Geological Survey Wetland and Aquatic Research Center Gainesville USA Department of Marine Sciences University of Gothenburg Tjärnö Strömstad Sweden School of Natural and Computational Sciences Massey University Auckland New Zealand The John Curtin School of Medical Research/Research School of Biology The Australian National University Acton Australia Research Institute for Nature and Forest Geraardsbergen Belgium Aquatic Ecology Evolution and Conservation KULeuven Leuven Belgium Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark Faculty of Biological Sciences Tarbiat Modares University Tehran Iran Scottish Natural Heritage Inverness UK Royal (Dick) School of Veterinary Studies and the Roslin Institute University of Edinburgh Midlothian UK Department of Plant Science Institute of Biology University of Campinas Campinas Brazil Australian Wildlife Conservancy Subiaco East Australia Laboratoire Evolution & Div

A correction to this paper has been published: https://***/10.1007/s10592-021-01376-9

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Erratum: Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58)

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Journal of biomedical science 2015年第1期22卷 60页

作者： Chuan-Pin Yang Chi-Wu Chiang Chang-Han Chen Yi-Chao Lee Mei-Hsiang Wu Yi-Huan Tsou Yu-San Yang Wen-Chang Chang Ding-Yen Lin Institute of Bioinformatics and Biosignal Transduction College of Bioscience and Biotechnology National Cheng Kung University Tainan 70101 Taiwan ROC. Institute of Molecular Medicine College of Medicine National Cheng Kung University Tainan 70101 Taiwan ROC. Infectious Diseases and Signaling Research Center National Cheng Kung University Tainan 70101 Taiwan ROC. Center for Translational Research in Biomedical Sciences Kaohsiung Chang Gung Memorial Hospital Kaohsiung 83301 Taiwan ROC. Department of Applied Chemistry National Chi Nan University Puli Nantou 54561 Taiwan ROC. Center for Neurotrauma and Neuroregeneration Taipei Medical University Taipei 11031 Taiwan ROC. Program for Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan ROC. Department of Pharmacology College of Medicine National Cheng Kung University Tainan 70101 Taiwan ROC. Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei 11031 Taiwan ROC. Institute of Bioinformatics and Biosignal Transduction College of Bioscience and Biotechnology National Cheng Kung University Tainan 70101 Taiwan ROC. lindy@mail.ncku.edu.tw. Department of Pharmacology College of Medicine National Cheng Kung University Tainan 70101 Taiwan ROC. lindy@mail.ncku.edu.tw. Infectious Diseases and Signaling Research Center National Cheng Kung University Tainan 70101 Taiwan ROC. lindy@mail.ncku.edu.tw. Institute for Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan ROC. lindy@mail.ncku.edu.tw.

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Glycyrrhizic acid conjugates with amino acid methyl esters target the main protease, exhibiting antiviral activity against wild-type and nirmatrelvir-resistant SARS-CoV-2 variants

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Antiviral research 2024年 227卷 105920页

作者： Uyen Nguyen Phuong Le Yu-Jen Chang Chih-Hao Lu Yeh Chen Wen-Chi Su Shao-Ting Chao Lia A Baltina Svetlana F Petrova Sin-Rong Li Mien-Chie Hung Michael M C Lai Lidia A Baltina Cheng-Wen Lin Graduate Institute of Biological Science and Technology China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan. The Ph.D. Program of Biotechnology and Biomedical Industry China Medical University Taichung Taiwan. The Ph.D. Program of Biotechnology and Biomedical Industry China Medical University Taichung Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan. Department of Food Science and Biotechnology National Chung Hsing University Taichung 402 Taiwan. Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan. Ufa Institute of Chemistry Ufa Federal Research Center of the Russian Academy of Sciences Russia. Department of Laboratory Medicine China Medical University Hospital Taichung 404327 Taiwan. Research Center for Cancer Biology China Medical University Taichung 404327 Taiwan Center for Molecular Medicine China Medical University Hospital Taichung 404327 Taiwan. Institute of Molecular Biology Academia Sinica Taipei 115201 Taiwan. Ufa Institute of Chemistry Ufa Federal Research Center of the Russian Academy of Sciences Russia. Electronic address: baltina@anrb.ru. Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan. Electronic address: cwlin@mail.cmu.edu.tw.

COVID-19 pandemic is predominantly caused by SARS-CoV-2, with its main protease, Mpro, playing a pivotal role in viral replication and serving as a potential target for inhibiting different variants. In this study, potent Mpro inhibitors were identified from glycyrrhizic acid (GL) derivatives with amino acid methyl/ethyl esters. Out of the 17 derivatives semisynthesized, Compounds 2, 6, 9, and 15, with methionine methyl esters, D-tyrosine methyl esters, glutamic acid methyl esters, and methionines in the carbohydrate moiety, respectively, significantly inhibited wild-type SARS-CoV-2 Mpro-mediated proteolysis, with IC50 values ranging from 0.06 μM to 0.84 μM. They also demonstrated efficacy in inhibiting trans-cleavage by mutant Mpro variants (Mpro_P132H, Mpro_E166V, Mpro_P168A, Mpro_Q189I), with IC50 values ranging from 0.05 to 0.92 μM, surpassing nirmatrelvir (IC50: 1.17-152.9 μM). Molecular modeling revealed stronger interactions with Valine166 in the structural complex of Mpro_E166V with the compounds compared to nirmatrelvir. Moreover, these compounds efficiently inhibited the post-entry viral processes of wild-type SARS-CoV-2 single-round infectious particles (SRIPs), mitigating viral cytopathic effects and reducing replicon-driven GFP reporter signals, as well as in vitro infectivity of wild-type, Mpro_E166V, and Mpro_Q189I SRIPs, with EC50 values ranging from 0.02 to 0.53 μM. However, nirmatrelvir showed a significant decrease in inhibiting the replication of mutant SARS-CoV-2 SRIPs carrying Mpro_E166V (EC50: >20 μM) and Mpro_Q189I (EC50: 13.2 μM) compared to wild-type SRIPs (EC50: 0.06 μM). Overall, this study identifies four GL derivatives as promising lead compounds for developing treatments against various SARS-CoV-2 strains, including Omicron, and nirmatrelvir-resistant variants.

关键词： Glycyrrhizic acid derivative Inhibitor Mpro Nirmatrelvir-resistant variant Omicron SARS-CoV-2

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The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic

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四川生理科学杂志 2022年第7期44卷 1246-1246页

作者： Michael Worobey Department of Ecology and Evolutionary Biology University of Arizona Tucson AZ 85721 USA Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA 92037 USA W. Harry Feinstone Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore MD 21205 USA Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA 92093 USA Department of Biomedical Informatics University of California San Diego La Jolla CA 92093 USA Department of Human Genetics University of Utah School of Medicine Salt Lake City UT 84112 USA Vaccine and Infectious Disease Organization University of Saskatchewan Saskatoon SK S7N 5E3 Canada Center for Global Health Science and Security Georgetown University Washington DC 20057 USA Department of Zoology University of Oxford Oxford OX1 3SZ UK Wildlife Conservation Research Unit Department of Zoology The Recanati-Kaplan Centre University of Oxford Oxford OX13 5QL UK Pandemic and Disaster Preparedness Centre Erasmus University Medical Center 3015 CE Rotterdam Netherlands Department of Viroscience Erasmus University Medical Center 3015 CE Rotterdam Netherlands Department of Biostatistics Fielding School of Public Health University of California Los Angeles Los Angeles CA 90095 USA Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA Department of Computational Medicine David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA Department of Medicine University of California San Diego La Jolla CA 92093 USA Department of Microbiology Immunology and Transplantation Rega Institute for Medical Research KU Leuven 3000 Leuven Belgium Global Virus Network (GVN) Baltimore MD 21201 USA MRC-University of Glasgow Center for Virus Research Glasgow G61 1QH UK Tulane University School of Medicine Department of Microbiology and Immu

Understanding how severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged in 2019 is critical to preventing zoonotic outbreaks before they become the next *** Huanan Seafood Wholesale Market in Wuhan,China,was identified as a likely source of cases in early reports but later this conclusion became *** show the earliest known COVID-19 cases from December 2019,including those without reported direct links,were geographically centered on this *** report that live SARS-CoV-2 susceptible mammals were sold at the market in late 2019 and,within the market,SARS-CoV-2-positive environmental samples were spatially associated with vendors selling live mammals.

关键词： Market likely Wuhan

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Erratum to: Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin

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Genome Medicine 2014年第7期6卷 1-1页

作者： Hakan Alakus Kristen Jepsen Yang Dai Angelo Arias Kelly A Frazer Olivier Harismendy Michele L Babicky Evangeline S Mose Andrew M Lowy Pradipta Ghosh Richard B Schwab Shawn Yost Michael R Peterson Michael L Samuels Division of Genome Information Sciences Department of Pediatrics and Rady Children’s Hospital University of California San Diego La Jolla CA USA Department of General Visceral and Cancer Surgery University of Cologne Köln Germany Moores UCSD Cancer Center University of California San Diego La Jolla CA USA Clinical and Translational Science Institute University of California San Diego La Jolla CA USA Institute for Genomic Medicine University of California San Diego La Jolla CA USA Division of Surgical Oncology Department of Surgery University of California San Diego La Jolla CA USA Department of Medicine University of California San Diego La Jolla CA USA Bioinformatics Graduate Program University of California San Diego La Jolla CA USA Department of Pathology University of California San Diego La Jolla CA USA RainDance Technologies Lexington MA USA

No abstract.

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