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作者： Li, Gang Wang, Xiao-Yuan Wang, Ji-Bo Sun, Lin-Yan School of Management Xi'An Jiaotong University Xi'an 710049 China State Key Laboratory for Manufacturing Systems Engineering Xi'an 710054 China Key Laboratory of the Ministry of Education on Process Control and Efficiency Xi'An Jiaotong University Xi'an 710049 China School of Science Shenyang Aerospace University Shenyang 110136 China

In this paper we consider flow shop scheduling problems with a time-dependent learning effect. The time-dependent learning effect of a job on a machine is assumed to be a function of the total normal processing time of the jobs scheduled in front of the job on the machine. The objective is to minimize one of the five regular performance criteria namely, the total completion time, the makespan, the total weighted completion time, the total weighted discounted completion time, and the sum of the quadratic job completion times. We present heuristic algorithms by using the optimal permutations for the special cases of the corresponding single machine scheduling problems. We also analyze the worst-case bound of the proposed heuristic algorithms. © 2012 Elsevier B.V. All rights reserved.

关键词： Heuristic algorithms

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Analysis of software licensing mode and compatibility choice with network externality

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Xitong Gongcheng Lilun yu Shijian/System engineering Theory and Practice 2015年第12期35卷 3047-3055页

作者： Zhang, Xiao-Juan Zhang, Sheng-Hao School of Management Xi'an Jiaotong University Xi'an710049 China Key Lab. of the Ministry of Education for Process Control & Efficiency Engineering Xi'an Jiaotong University Xi'an710049 China State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Xi'an710049 China

With network externality, two licensing modes-perpetual licensing mode and Softwareas-a-Service mode, and four compatibility choices-no compatibility, backward compatibility, forward compatibility and backward & forward compatibility, are considered. Consumers' purchasing decision and the vendor's pricing strategy are examined through two-stage models under each combination of licensing mode and compatibility choice. The results show that backward & forward compatibility maximizes the vendor's revenue under perpetual licensing mode, and any of no compatibility, backward compatibility and backward & forward compatibility may maximize the vendor's profit with software development costs under different compatibility choices. Under Software-as-a-Service mode, the compatibility choice has no impact on the vendor's revenue, and no compatibility maximizes the vendor's profit. When revenue maximization is the vendor's concern, perpetual licensing mode is superior to Software-as-a-Service mode;when profit maximization is the vendor's objective, Software-as-a-Service mode usually becomes better than perpetual licensing mode. © 2015, Systems engineering Society of China. All right reserved.

关键词： Profitability

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Diosgenin alleviates neuropathic pain based on the enhancement of autophagy and promotion of M2 polarization

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International immunopharmacology 2025年 159卷 114936页

作者： Shuli Man Yaxue Zhou Xinghao Zhang Xiaoqin Tang Lu Xie Long Ma Wenyuan Gao State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial Microbiology Ministry of Education Tianjin Key Laboratory of Industry Microbiology National and Local United Engineering Lab of Metabolic Control Fermentation Technology China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry College of Biotechnology Tianjin University of Science & Technology Tianjin 300457 China. Electronic address: msl@***. State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial Microbiology Ministry of Education Tianjin Key Laboratory of Industry Microbiology National and Local United Engineering Lab of Metabolic Control Fermentation Technology China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry College of Biotechnology Tianjin University of Science & Technology Tianjin 300457 China. Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency School of Pharmaceutical Science and Technology Faculty of Medicine Tianjin University Tianjin 300072 China. Electronic address: biochemgao@***.

Neuropathic pain has serious impacts on the quality of people's life. Diosgenin extracted from yams has shown significant potential in the treatment of nervous system diseases. To investigate the potential mechanism of diosgenin fighting against neuropathic pain, we established a chronic compression injury (CCI) model. The pain-related behaviors were determined by Von Frey, hot plate, and sciatic nerve index test. As a result, diosgenin significantly lowered the pain threshold, improved the sciatic nerve index, and decreased the damage of sciatic nerve structure in CCI model mice. It increased the protein levels of LC3-II and Beclin-1, the number of the lysosomes, decreased the protein level of P62 and the number of the autophagosomes, and therefore activated autophagy. Diosgenin also inhibited the proliferation of microglia cells and the translocation of NF-κB p65, while promoting promoted M2 polarization of microglia cells. Autophagy inhibitor like chloroquine inhibited the M2 polarization of microglia cells, and reversed the therapeutic effect of diosgenin. All in all, diosgenin alleviated neuropathic pain in CCI mice based on the enhancement of autophagy and the promotion of M2 polarization.

关键词： Autophagy Diosgenin Microglia Neuropathic pain

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Highly active N,O-doped hierarchical porous carbons for high-energy supercapacitors

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Chinese Chemical Letters 2020年第5期31卷 1226-1230页

作者： Ziyang Zhou Hui Duan Zhiwei Wang Yaokang Lv Wei Xiong Dazhang Zhu Liangchun Li Mingxian Liu Lihua Gan Shanghai Key Lab.of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji UniversityShanghai 200092China State Key Laboratory of Pollution Control and Resources Reuse Shanghai Institute of Pollution Control and Ecological SecuritySchool of Environmental Science and EngineeringTongji UniversityShanghai 200092China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China School of Chemistry and Environmental Engineering Key Laboratory for Green Chemical Process(Ministry of Education)Hubei Key Lab.of Novel Reactor&Green Chemical TechnologyWuhan Institute of TechnologyZhengzhou 450001China College of Chemistry and Molecular Engineering Zhengzhou UniversityWuhan 430205China

Highly active N,O-doped hierarchical porous carbons(NOCs)are fabricated through the in-situ polymerization and pyrolysis of o-tolidine and ***-prepared NOCs have a variety of faradaic-active species(N-6,N-5 and O-I),high ion-accessible platform(1799 m^2/g)and hierarchically micro-meso-macro porous ***,the resultant NOC electrode delivers an advantageous specific capacitance(311 F/g),with a pseudocapacitive contribution of 37%in a threeelectrode configuration,and an enhanced energy output of 18.0 Wh/kg@350 W/kg owing to the enlarged faradaic effect in an aqueous redox-active ***,a competitive energy density(74.9 Wh/kg)and high-potential durability(87.8%)are achieved in an ionic liquid(EMIMB F4)-assembled *** study sheds light on a straightforward avenue to optimize the faradaic activity and nanoarchitecture for advanced supercapacitors.

关键词： N.O-doped carbon Hierarchical porous structure Faradaic activity Supcrcapacitor High energy density

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The Optimization and Integration of the Transportation and Inventory Cost Based on Time in Supply Chain Logistics System

The Optimization and Integration of the Transportation and I...

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International Conference on Logistics engineering and Intelligent Transportation Systems (LEITS)

作者： Yongfei Li Qin Su Tongzheng Li School of Management State Key Laboratory for Manufacturing Systems Engineering The Key Laboratory of the Ministry of Education for Process Control & Efficiency Engineering Xi''an Jiaotong University Xi'an China

This paper puts forth a model of the transportation and inventory integration and optimization problem based on system and optimal theory which we take into account the antinomy relationship of transportation and inventory and the antinomy relationship of inventory and stock-out in supply chain logistics system. We consider that the resources available and the total time of inventory and transportation are *** the transportation process, transportation cost, transportation time and transportation capacity may vary between the two adjacent nodes for the reason of the transfer among various transportation modes. When the mode of the transportation is changed, we need consider the transshipment time and transshipment *** issue is a multi-transportation option network question under the normal distribution of the minimum total cost which consists of transportation cost, inventory cost, stock-out cost and time cost. In this paper, we comparatively study and specifically calculate the minimum total transportation and inventory cost in several different cases. Our paper shows that the result is not only more reasonable and effective than other models which can be seen in the appendix but also more in line with the actual situation of the supply chain logistics system. We can get our purpose that we may have a certain referential significance to reduce the total cost and raise the total profit of the supply chain logistics system.

关键词： Transportation Supply chains Cities and towns Optimization Transforms Mathematical model

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Online balance strategy on byproduct gas in iron and steel industry

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Xitong Gongcheng Lilun yu Shijian/System engineering Theory and Practice 2013年第6期33卷 1486-1491页

作者： Cao, Yong-Feng Xu, Yin-Feng School of Management Xi'an Jiaotong University Xi'an 710049 China Ministry of Education Key Lab. for Intelligent Networks and Network Security Xi'an Jiaotong University Xi'an 710049 China The MOE Key Lab. for Process Control and Efficiency Engineering Xi'an Jiaotong University Xi'an 710049 China

This paper develops a new framework for the analysis of byproduct gas supply in iron and steel industry. Based on the online theory, this paper studies the online balance assignment problem of the byproduct gas. In the production process, the online decision maker makes decisions to balance the supply of byproduct gas in the online case. Under some reasonable assumptions, the paper constructs a balance assignment model of the byproduct gas to solve the balance range unknown problem. First, this researcher attempts to analyze the special nature of the offline case and the characteristics of the online case under different scenes. Then the paper designs an online balance strategy with a competitive ratio of (1+3M/m)/4 without the knowledge of supply interval. This study provides some ideas and theories for the balance assignment and use of the byproduct in manufacture industry.

关键词： Steelmaking

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The effect of environmental uncertainty on supply chain integration in Chinese manufacturing industry

The effect of environmental uncertainty on supply chain inte...

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International Conference on Services Systems and Services Management, ICSSSM

作者： Dehui Xu Li Zhao Gang Li Linyan Sun School of Management The State Key Laboratory on Mechanic Manufacturing System Engineering The Key Laboratory of the Ministry of Education on Process Control and Efficiency Engineering Xi''an Jiaotong University Xi'an China

ISBN: (纸本)9781424464852;9781424464876

Supply chain integration nowadays is considered as an important approach to building and sustaining advantages. Many previous empirical researches focus on the effect of supply chain integration on the firms' performance, yet, the antecedence of supply chain integration is still largely unknown. This paper investigates the relationship between environmental uncertainty (including demand uncertainty, supply uncertainty and technology uncertainty) and supply chain integration (including customer integration, supplier integration and internal integration) with 139 samples from Chinese manufacturing industry. The results reveal both supply uncertainty and technology uncertainty significantly influence supply chain integration; the effect of supply uncertainty is negative, while that of technology uncertainty is positive. However, demand uncertainty just has a significant effect on internal integration. The relationship between demand uncertainty and external integration (including customer integration and supplier integration) is mediated by the internal integration.

关键词： Uncertainty Supply chains Manufacturing industries Costs Collaboration Supply chain management Environmental management engineering management Manufacturing systems Systems engineering and theory

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Robust scheduling of a two-stage hybrid flow shop with uncertain interval processing times

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International Journal of Production Research 2016年第12期54卷 p3706-3717页

作者： Feng, Xin Zheng, Feifeng Xu, Yinfeng School of Management Xi'an Jiaotong University Xi'an China State Key Lab for Manufacturing Systems Engineering Xi'an China Ministry of Education Key Lab for Process Control and Efficiency Engineering Xi'an China Glorious Sun School of Business and Management Donghua University Shanghai P.R. China

This paper studies the makespan minimisation scheduling problem in a two-stage hybrid flow shop. The first stage has one machine and the second stage hasmidentical parallel machines. Neither the processing time nor probability distribution of the processing time of each job is uncertain. We propose a robust (min–max regret) scheduling model. To solve the robust scheduling problem, which is NP-hard, we first derive some properties of the worst-case scenario for a given schedule. We then propose both exact and heuristic algorithms to solve this problem. In addition, computational experiments are conducted to evaluate the performance of the proposed algorithms. [ABSTRACT FROM AUTHOR]

关键词： hybrid flow shop scheduling makespan minimisation min–max regret min–max regret uncertain processing times

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Combined control of fluid adsorption capacity and initial permeability on coal permeability

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International Journal of Coal Science & Technology 2022年第6期9卷 127-137页

作者： Xiaolei Liu Jianping Wei Guoying Wei Caifang Wu Cao Liu Xiaoming Ni State Key Laboratory Cultivation Base for Gas Geology and Gas Control Henan Polytechnic University454000 JiaozuoHenanChina College of Safety Science and Engineering Henan Polytechnic University454000 JiaozuoHenanChina State Collaborative Innovation Center of Coal Work Safety and Clean-efficiency Utilization 454000 JiaozuoHenanChina Key Laboratory of Coalbed Methane Resource and Reservoir Formation Process Ministry of EducationSouth Jiefang Road221008 XuzhouJiangsuChina Collaborative Innovation Center of Coalbed Methane(Shale Gas)in Central Plains Economic Zone 454000 JiaozuoChina

The variations of strain and permeability of coal were systematically studied through the physical simulation of N2 and water *** effects of fluid adsorption capacity and initial permeability on strain,permeability and the dominant effect of pore pressure were *** adsorption strain and strain rate of coal during water injection are significantly higher than those during N2 *** edge of free adsorption exists in the early phase of N2 and water injection,which is related to fluid *** this boundary,the strain rate and pore pressure are ***,the injec-tion time of initial stage accounts for about 20%of the total injection time,but the strain accounts for 70%of the total *** water injection,this boundary is about half of water saturation of ***,the influence of pore pressure on permeability is complex,which is controlled by adsorption capacity and initial permeability of *** the initial permeability is large enough,the effect of adsorption strain on permeability is relatively weak,and the promoting effect of pore pressure on fluid migration is ***,the permeability increases with increasing pore *** the initial permeability is relatively low,the pore pressure may have a dominant role in promoting fluid migration for the fluid with weak adsorption ***,for the fluid with strong adsorption capacity,the adsorption strain caused by pore pressure may play a leading role,and the permeability reduces first and then ascends with increasing pore pressure.

关键词： Initial permeability Adsorption capacity Free adsorption Pore pressure Coal strain

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Rhizoma paridis saponins protected against liver injury in diethylnitrosamine-induced mice

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Traditional Medicine Research 2023年第2期8卷 7-12页

作者： Chen Luo Jing-Wen Yao Shu-Li Man Wen-Yuan Gao Key Laboratory of Industrial Microbiology Ministry of Education/Tianjin Key Laboratory of Industry Microbiology/National and Local United Engineering Lab of Metabolic Control Fermentation Technology/College of BiotechnologyTianjin University of Science&TechnologyTianjin 300457China Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China

Background:Diethylnitrosamine,one of food additives,possessed a strong carcinogenic effect in *** paridis saponins,as the main active components of Paris polyphylla,have a good anti-cancer effect in our previous *** verify their inhibitory effect on diethylnitrosamine-induced liver cancer,we carried out this ***:We established diethylnitrosamine-induced mouse hepatocarcinoma models to evaluate antitumor of Rhizoma paridis ***,gas chromatography-mass spectrometry was applied to analyze the metabolites in the urine and serum ***:Rhizoma paridis saponins alleviated diethylnitrosamine-induced *** the one hand,Rhizoma paridis saponins down-regulated the levels of liver function markers,such as alanine aminotransferase,aspartate transaminase and alpha *** the other hand,Rhizoma paridis saponins reduced metabolic disorders by increasing fructose and mannose metabolism,and decreasing pentose and glucuronate interconversion,inositol phosphate metabolism,and the process of saturated fatty acids transforming to unsaturated fatty acids,which based on the regulating mRNA expression of glucose transporter type 4,lactate dehydrogenase A,fatty acid synthetas,acetyl-CoA carboxylase and apolipoprotein ***:Rhizoma paridis saponins has the potential application to inhibit chemical-induced hepatocarcinogenesis in the future.

关键词： Rhizoma paridis saponins liver injury diethylnitrosamine metabolites

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