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Any-Angle Routing Algorithm for Microfluidic Biochips Driven by Flow Path

Jisuanji Yanjiu yu Fazhan/Computer Research and Development 2025年第4期62卷 978-988页

作者： Youlin, Pan Shuai, Guo Xing, Huang Genggeng, Liu College of Computer and Data Science Fuzhou University Fuzhou350116 China Engineering Research Center of Big Data Intelligence Fuzhou University Ministry of Education Fuzhou350116 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350116 China School of Computer Science Northwestern Polytechnical University Xi’an710072 China

Continuous-flow microfluidic biochips (CFMBs) have become a hot research topic in recent years due to their ability to perform biochemical assays automatically and efficiently. For the first time, PathDriver+ takes the requirements of the actual fluid transportation into account in the design process of CFMBs and implements the actual fluid transport and removal, and plans separate flow paths for each transport task, which have been neglected in previous work. However, PathDriver+ does not take full advantage of the flexibility of CFMBs routing because it only considers the optimization of flow channel length for the global routing in the mesh model, except for the detailed routing. In addition, PathDriver+ only considers the X architecture, while the existing work shows that the any-angle routing can utilize the routing resources more efficiently and shorten the flow channel length. To address the above issues, we propose a flow path-driven arbitrary angle routing algorithm, which can improve the utilization of routing resources and reduce the flow channel length while considering the actual fluid transportation requirements. The proposed algorithm constructs a search graph based on constrained Delaunay triangulation to improve the search efficiency of routing solutions while ensuring the routing quality. Then, a Dijkstra-based flow path routing method is used on the constructed search graph to generate a routing result with a short channel length quickly. In addition, in the routing process, channel reuse strategy and intersection optimization strategy are proposed for the flow path reuse and intersection number optimization problems, respectively, to further improve the quality of routing results. The experimental results show that compared with the latest work PathDriver+, the length of channels, the number of ports used, and the number of channel intersections are significantly reduced by 33.21%, 11.04%, and 44.79%, respectively, and the channel reuse rate is i

关键词： High level synthesis

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Control Logic Routing for Continuous-Flow Microfluidic Biochips Based on Deep Reinforcement Learning

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Jisuanji Yanjiu yu Fazhan/Computer Research and Development 2025年第4期62卷 950-962页

作者： Cai, Huayang Huang, Xing Liu, Genggeng College of Computer and Data Science Fuzhou University Fuzhou350116 China Engineering Research Center of Big Data Intelligence Fuzhou University Ministry of Education Fuzhou350116 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350116 China School of Computer Science Northwestern Polytechnical University Xi’an710072 China

With the advancement of electronic design automation, continuous-flow microfluidic biochips have become one of the most promising platforms for biochemical experiments. This chip manipulates fluid samples in milliliters or nanoliters by utilizing internal microvalves and microchannels, and thus automatically performs basic biochemical experiments, such as mixing and detection. To achieve the correct bioassay function, the microvalves deployed inside the chip are usually managed by a multiplexer-based control logic, and valves receive control signals from a core input through the control channel for accurate switching. Since biochemical reactions typically require high sensitivity, the length of control paths connecting each valve needs to be reduced to ensure immediate signal propagation, and thus to reduce the signal propagation delay. In addition, to reduce the fabrication cost of chips, a vital issue to be addressed in the logic architecture design is how to effectively reduce the total channel length within the control logic. To address the above issues, we propose a deep reinforcement learning-based control logic routing algorithm to minimize the signal propagation delay and total control channel length, thereby automatically constructing an efficient control channel network. The algorithm employs the dueling deep Q-network architecture as the agent of the deep reinforcement learning framework to evaluate the tradeoff between signal propagation delay and total channel length. Besides, the diagonal channel routing is implemented for the first time for control logic, thus fundamentally improving the efficiency of valve switching operations and reducing the fabrication cost of the chip. The experimental results demonstrate that the proposed algorithm can effectively construct a high-performance and low-cost control logic architecture. © 2025 Science Press. All rights reserved.

关键词： Deep reinforcement learning

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Unsupervised Multivariate Time Series Anomaly Detection by Feature Decoupling in Federated Learning Scenarios

IEEE Transactions on Artificial Intelligence

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IEEE Transactions on Artificial Intelligence 2025年

作者： He, Yifan Ding, Xi Tang, Yateng Guan, Jihong Zhou, Shuigeng Fudan University School of Computer Science Shanghai200433 China Shanghai Key Laboratory of Intelligent Information Processing Shanghai200433 China Tencent Weixin Group Guangzhou510308 China Tongji University Department of Computer Science and Technology Shanghai201804 China Ministry of Education Key Laboratory of Embedded System and Service Computing Tongji University Shanghai200092 China

Anomalies are usually regarded as data errors or novel patterns previously unseen, which are quite different from most observed data. Accurate detection of anomalies is crucial in various application scenarios. This paper focuses on unsupervised anomaly detection from Multivariate Time Series (MTS), as real-world data collected from sources such as wearable devices, medical equipment and industrial machines typically manifest as MTS and are often unlabeled. Anomaly detection in MTS represents a data-driven challenge that traditionally requires substantial centralized data for training models. However, in practice, data are frequently distributed among multiple institutions, with privacy concerns restricting unrestricted access. To address these issues, we introduce Feature Decoupling Federated Learning (FDFL), an approach designed to collaboratively train a representation learning network over multiple clients for unsupervised anomaly detection in MTS. Unlike previous methods that simply integrate MTS anomaly detection algorithms with federated learning strategies, FDFL specifically addresses heterogeneity among clients by decoupling the representation network into shared and private branches through a contrastive learning mechanism. This method aggregates shared parameters during each federated round while maintaining client-specific private parameters locally. Additionally, we develop a self-attention block that integrates the representations derived from both shared and private parameters to reconstruct MTS and identify anomalies based on reconstruction errors. Extensive experiments conducted on three publicly available datasets demonstrate that FDFL outperforms existing algorithms in most cases, highlighting the effectiveness and superiority of our proposed method in MTS anomaly detection. © 2020 IEEE.

关键词： Federated learning

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Reliable Multi-Modal Object Re-Identification via Modality-Aware Graph Reasoning

arXiv

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arXiv 2025年

作者： Wan, Xixi Zheng, Aihua Wang, Zi Jiang, Bo Tang, Jin Ma, Jixin Information Materials and Intelligent Sensing Laboratory of Anhui Province Anhui Provincial Key Laboratory of Security Artificial Intelligence School of Artificial Intelligence Anhui University Hefei230601 China School of Biomedical Engineering Anhui Medical University Key Laboratory of Intelligent Computing & Signal Processing Ministry of Education Anhui University Hefei China Anhui Provincial Key Laboratory of Multimodal Cognitive Computation School of Computer Science and Technology Anhui University Hefei230601 China School of Computing and Mathematical Sciences University of Greenwich LondonSE10 9LS United Kingdom

Multi-modal data provides abundant and diverse object information, crucial for effective modal interactions in Re-Identification (ReID) tasks. However, existing approaches often overlook the quality variations in local features and fail to fully leverage the complementary information across modalities, particularly in the case of low-quality features. In this paper, we propose to address this issue by leveraging a novel graph reasoning model, termed the Modality-aware Graph Reasoning Network (MGRNet). Specifically, we first construct modality-aware graphs to enhance the extraction of fine-grained local details by effectively capturing and modeling the relationships between patches. Subsequently, the selective graph nodes swap operation is employed to alleviate the adverse effects of low-quality local features by considering both local and global information, enhancing the representation of discriminative information. Finally, the swapped modality-aware graphs are fed into the local-aware graph reasoning module, which propagates multimodal information to yield a reliable feature representation. Another advantage of the proposed graph reasoning approach is its ability to reconstruct missing modal information by exploiting inherent structural relationships, thereby minimizing disparities between different modalities. Experimental results on four benchmarks (RGBNT201, Market1501-MM, RGBNT100, MSVR310) indicate that the proposed method achieves state-of-the-art performance in multi-modal object ReID. The code for our method will be available upon acceptance. Copyright © 2025, The Authors. All rights reserved.

关键词： Modal analysis

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The structural analysis of protein sequences based on the quasi-amino acids code

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Chinese Physics B 2009年第1期18卷 363-369页

作者：朱平唐旭清徐振源 School of Science Jiangnan University Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education Anhui University

Proteomics is the study of proteins and their interactions in a cell. With the successful completion of the Human Cenome Project, it comes the postgenome era when the proteomics technology is emerging. This paper studies protein molecule from the algebraic point of view. The algebraic system （∑, ＋, ＊） is introduced, where ∑ is the set of 64 codons. According to the characteristics of （∑, ＋, ＊）, a novel quasi-amino acids code classification method is introduced and the corresponding algebraic operation table over the set ZU of the 16 kinds of quasi-amino acids is established. The internal relation is revealed about quasi-amino acids. The results show that there exist some very close correlations between the properties of the quasi-amino acids and the codon. All these correlation relationships may play an important part in establishing the logic relationship between codons and the quasi-amino acids during the course of life origination. According to Ma F et al （2003 J. Anhui Agricultural University 30 439）, the corresponding relation and the excellent properties about amino acids code are very difficult to observe. The present paper shows that （ZU, ＋,×） is a field. Furthermore, the operational results display that the eodon tga has different property from other stop codons. In fact, in the mitochondrion from human and ox genomic codon, tga is just tryptophane, is not the stop codon like in other genetic code, it is the case of the Chen W C et al （2002 Acta Biophysiea Siniea 18（1） 87）. The present theory avoids some inexplicable events of the 20 kinds of amino acids code, in other words it solves the problem of ＇the 64 codon assignments of mRNA to amino acids is probably completely wrong＇ proposed by Yang （2006 Progress in Modern Biomedicine 6 3）.

关键词： algebraic operation quasi-amino acids code protein sequences structural analysis

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An Optimization Algorithm for Service Composition Based on an Improved FOA

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Tsinghua Science and Technology 2015年第1期20卷 90-99页

作者： Yiwen Zhang Guangming Cui Yan Wang Xing Guo Shu Zhao the School of Computer Science and Technology Key Laboratory of Intelligent Computing and Signal Processing Ministry of Education Anhui University

Large-scale service composition has become an important research topic in Service-Oriented computing（SOC）. Quality of Service（Qo S） has been mostly applied to represent nonfunctional properties of web services and to differentiate those with the same functionality. Many studies for measuring service composition in terms of Qo S have been completed. Among current popular optimization methods for service composition, the exhaustion method has some disadvantages such as requiring a large number of calculations and poor scalability. Similarly,the traditional evolutionary computation method has defects such as exhibiting slow convergence speed and falling easily into the local optimum. In order to solve these problems, an improved optimization algorithm, WS FOA（Web Service composition based on Fruit Fly Optimization Algorithm） for service composition, was proposed, on the basis of the modeling of service composition and the FOA. Simulated experiments demonstrated that the algorithm is effective, feasible, stable, and possesses good global searching ability.

关键词： service composition Fruit Fly Optimization Algorithm（FOA） Quality of Service（QoS） index

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MR-IDPSO: A Novel Algorithm for Large-Scale Dynamic Service Composition

引用

Tsinghua Science and Technology 2015年第6期20卷 602-612页

作者： Yanping Zhang Zihui Jing Yiwen Zhang School of Computer Science and Technology Key Laboratory of Intelligent Computing and Signal ProcessingMinistry of EducationAnhui University

In the era of big data, data intensive applications have posed new challenges to the field of service composition. How to select the optimal composited service from thousands of functionally equivalent services but different Quality of Service(Qo S) attributes has become a hot research in service computing. As a consequence,in this paper, we propose a novel algorithm MR-IDPSO(Map Reduce based on Improved Discrete Particle Swarm Optimization), which makes use of the improved discrete Particle Swarm Optimization(PSO) with the Map Reduce to solve large-scale dynamic service composition. Experiments show that our algorithm outperforms the parallel genetic algorithm in terms of solution quality and is efficient for large-scale dynamic service composition. In addition,the experimental results also demonstrate that the performance of MR-IDPSO becomes more better with increasing number of candidate services.

关键词： Map Reduce service composition Quality of Service(

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Uncertainty-aware Superpoint Graph Transformer for Weakly Supervised 3D Semantic Segmentation

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IEEE Transactions on Fuzzy Systems 2025年

作者： Fan, Yan Wang, Yu Zhu, Pengfei Hui, Le Xie, Jin Hu, Qinghua Tianjin University College of Intelligence and Computing Tianjin300350 China Ministry of Education of the People's Republic of China Engineering Research Center of City Intelligence and Digital Governance China Haihe Laboratory of Itai Tianjin China Northwestern Polytechnical University School of Electronics and Information Shaanxi Key Laboratory of Information Acquisition and Processing China Nanjing University of Science and Technology Pca Lab Key Lab of Intelligent Perception and Systems for High-Dimensional Information of Ministry of Education China Nanjing University State Key Laboratory for Novel Software Technology Nanjing China

Weakly supervised 3D semantic segmentation has successfully mitigated the labor-intensive and time-consuming task of annotating 3D point clouds. However, reliably utilizing the minimal point-wise annotations for unlabeled data in complex and large-scale scenes is still challenging, such as only 20 points labeled in 2 million points. To tackle this challenge, we propose a new Uncertainty-aware Superpoint Graph Transformer (UaSGT) framework that utilizes minimal annotations for unlabeled data learning through reliable long-range supervision propagation from labeled superpoints to unlabeled superpoints. First, we propose a superpoint graph transformer to achieve long-range supervision propagation along the attention-based fuzzy subsets defined on superpoints. The attention-based fuzzy subset measures the membership of unlabeled superpoints to clusters centered on labeled superpoints. Second, we employ an uncertainty-aware membership rectification technique on the fuzzy subset to ensure reliable propagation among superpoints within the same category. This technique integrates an uncertainty prediction module to mask the influence of unreliable membership and a spatial prior refinement module to reduce uncertainty in intra-class membership degrees. Finally, experimental results on two large-scale benchmarks S3DIS and ScanNet-V2 demonstrate the superiority of our approach compared to the state-of-the-art with at least 90% annotation reduction, and our method also achieves comparable performance to fully supervised methods with less than 0.1% labeled points. Our code is available at https://***/fanyan0411/UaSGT. © 2025 IEEE.

关键词： Semantic Segmentation

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D-FGNAE: Decentralized Federated Graph Normalized AutoEncoder 19th

D-FGNAE: Decentralized Federated Graph Normalized AutoEncode...

引用

19th CCF Conference on Computer Supported Cooperative Work and Social computing, ChineseCSCW 2024

作者： Liang, Yuting Cai, Weixin Guo, Kun College of Computer and Data Science Fuzhou University Fuzhou350108 China Engineering Research Center of Big Data Intelligence Ministry of Education Fuzhou350108 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350108 China

ISBN: (纸本)9789819623723

Graphs widely exist in real-world, and Graph Neural Networks (GNNs) have exhibited exceptional efficacy in graph learning in diverse fields. With the strengthening of data privacy protection worldwide in recent years, Federated graph neural networks (FedGNNs) have gained increasing attention in academia and industry owing to their ability to train the model in a collaborative manner while complying with the privacy protection regulations. However, in federated learning, the non-independent and identically distributed (non-IID) problem of local data possessed by multiple participants can significantly undermine model accuracy. We propose a new Decentralized Federated Graph Normalized AutoEncoder (D-FGNAE). First, the model is designed as a decentralized federated learning framework with dynamically assigned tripartite roles. This design eliminates the fixed server role found in traditional federated learning, enhances system fault tolerance, avoids single points of failure, and protects model privacy. Second, the splitting and correcting of calculation by layer in the model, along with the special design of the normalization layer, effectively tackle the non-IID problem in both the structural and attribute aspects. Experimental results on real-world networks demonstrate the effectiveness of D-FGNAE, which can achieve nearly the same accuracy as the centralized model. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Federated learning

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Community-Aware Heterogeneous Graph Contrastive Learning 19th

Community-Aware Heterogeneous Graph Contrastive Learning

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19th CCF Conference on Computer Supported Cooperative Work and Social computing, ChineseCSCW 2024

作者： Li, Xinying Wu, Ling Guo, Kun College of Computer and Data Science Fuzhou University Fuzhou350108 China Engineering Research Center of Big Data Intelligence Ministry of Education Fuzhou350108 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350108 China

ISBN: (纸本)9789819623723

Recently, heterogeneous graph contrastive learning, which can mine supervision signals from the data, has attracted widespread attention. However, most existing methods employ random data augmentation strategies to construct contrastive views, which may destroy the semantic information in heterogeneous graphs. Moreover, they often select positive and negative samples based solely on node-level proximity and overlook hard samples that are difficult to distinguish from anchors. To solve the above problems, we propose a Community-Aware Heterogeneous Graph Contrastive Learning model called CAHGCL. In particular, we design an adaptive data augmentation strategy to construct views, including feature augmentation and topology augmentation. To improve the quality of samples, we propose a dynamic sample weighting strategy based on node similarity and community information, capable of identifying both hard positive samples and hard negative samples. Finally, we introduce community-level contrast to improve community cohesion. Extensive experiments and analyses demonstrate that CAHGCL consistently outperforms state-of-the-art baselines on three datasets. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Contrastive Learning

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