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A polymyxin B loaded hypoxia-responsive liposome with improved biosafety for efficient eradication of bacterial biofilms

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Nano Research 2024年第9期17卷 8325-8336页

作者： Fang Liu Lingyun Zou Yongcheng Chen Zuolong Liu Yue Huang Qiao Jin Jian Ji MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Transvascular Implantation Devices The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310009China

Biofilm-associated bacterial infection brings serious threats to global public health owing to serious antibiotic *** is urgently needed to develop innovative strategies to combat biofilm-associated bacterial *** stand out as the last line of defense against Gram-negative ***,serious nephrotoxicity of polymyxins severely limits their clinical ***,a hypoxia-responsive liposome is designed as the nanocarrier of polymyxin B(PMB)to combat biofilms developed by Gram-negative bacteria.A metronidazole modified lipid(hypoxia-responsive lipid(HRLipid))is synthesized to fabricate hypoxia-responsive liposomes(HRLip).PMB loaded hypoxia-responsive liposomes(HRL-PMB)is then prepared to mitigate the nephrotoxicity of PMB while preserving its excellent bactericidal ***-PMB shows very low hemolysis and cytotoxicity due to liposomal encapsulation of *** can be readily released from HRL-PMB in response to hypoxic biofilm microenvironment,exerting its bactericidal activity to realize biofilm *** excellent in vivo antibiofilm ability of HRL-PMB is confirmed by a Pseudomonas aeruginosa infected zebrafish model and a *** pneumonia infection ***,HRL-PMB can greatly reduce the nephrotoxicity of PMB after intravenous *** hypoxia-sensitive liposomes held great promise to improve the biosafety of highly toxic antibiotics while preserving their intrinsic bactericidal ability,which may provide an innovative strategy for combating biofilm-associated infections.

关键词： bacterial biofilm hypoxia liposome polymyxin B nephrotoxicity

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CO_(2)-Sourced Poly(chloropropylene carbonate) with High Flame-Retardant Performance

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Chinese Journal of Polymer Science 2025年第1期43卷 110-119,I0010页

作者： Yue Gong Xiao-Feng Zhu Guan-Wen Yang Meng Ma Xu Wang Jie Xu Xin Shu Guang-Peng Wu MOE Key Laboratory of Macromolecular Synthesis and Functionalization Key Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058China Zhejiang Key Laboratory of Plastic Modification and Processing Technology College of Materials Science and EngineeringZhejiang University of Technology Hangzhou 310014China Shanxi Coal Chemical Industry Technology Research Institute Co Ltd.Xi'an 710100China

The alternating copolymer of CO_(2) with epoxide is a green plastic that can efficiently transform CO_(2) into valuable chemicals. Despite the significant advances made, the restricted practical application of CO_(2)-sourced polycarbonates due to their lack of functionality has hindered field development. We successfully demonstrated the flame retardancy of poly(chloropropylene carbonate) (PCPC), a perfectly alternating copolymer of epichlorohydrin (ECH) and CO_(2). This was prepared at a 200-gram scale using a high-efficacy tetranuclear organoborane catalyst. PCPC’s excellent flame-retardant performance has been proven by both the vertical combustion test (UL94 V-0) and the limiting oxygen index (LOI) value (29.1%). The underlaid flame-retardant mechanism of PCPC was clearly elucidated. As a result, we confirmed that the generated cyclic carbonates and concurrently released flame-retardant chlorine radicals, hydrogen chloride, and CO_(2) during combustion render PCPC an excellent flame retardant. Furthermore, we investigated the practicability of PCPC as a halogen-rich polymeric flame retardant by blending it with commercial bisphenol A polycarbonate (BPA-PC). PCPC upgraded the flame retardancy rating of BPA polycarbonate from V-2 to V-0 even with a mere 1 wt% addition. It is our hope that this result will prove useful in future developments of advanced CO_(2)-sourced polymeric materials.

关键词： Carbon dioxide Ring-Opening polymerization Organocatalysis Sustainable materials Flame-retardant polymer

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Alternating Copolymerization of Epoxides and Isothiocyanates to Diverse Functional Polythioimidocarbonates and Related Block Polymers

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Chinese Journal of Chemistry 2023年第23期41卷 3311-3318页

作者： Xiao-Feng Zhu Xin-Yu Lu Cheng-Kai Xu Yu-Bo Fang Guan-Wen Yang Wei Li Jingdai Wang Guang-Peng Wu MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiang310027 China Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhouZhejiang310027 China

synthesis of diverse polythioimidocarbonates via ring-opening copolymerization of epoxides and isothiocyanates catalyzed by organoboron catalyst was reported *** aromatic and aliphatic isothiocyanates underwent successful copolymerization with terminal and internal epoxides,allowing for the precise tuning of the performance of the resultant copolymers over a broad *** wide scope of available isothiocyanates and epoxides enables the direct construction of sulfur-containing functional polymers featuring both high glass transition temperature and refractive ***,it was observed that aromatic isothiocyanates polymerize much faster than aliphatic ones,and the reactivity difference facilitated the one-step synthesis of block polymers from mixed aromatic isothiocyanates,aliphatic isothiocyanates and epoxides due to the preferential incorporation of aromatic isothiocyanates over the aliphatic analogues during their alternating copolymerization with *** produced polythioimidocarbonates can be used as positive resists for electron beam lithography(sensitivity of 130μC/cm^(2) and contrast of 1.53 for poly(CHO-alt-EITC)).Coupling with their high refractive index(1.58—1.68),polythioimidocarbonates might find functional applications in *** results render ring-opening copolymerization of epoxides and isothiocyanates a facile route to enrich functional polymer library.

关键词： Ring-opening copolymerization Metal-free catalysis Sulfur-containing polymers Block polymers Electron beam lithography High refractive index

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ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation

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Bioactive Materials 2023年第1期19卷 38-49页

作者： Lulu Jin Zhixin Zhu Liangjie Hong Zhefeng Qian Fang Wang Zhengwei Mao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China b The MOE Frontier Science Center for Brain Research and Brain-Machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou310058China

Ischemic stroke is an acute and serious cerebral vascular disease,which greatly affects people’s health and brings huge economic burden to ***,as important innate immune components in central nervous system(CNS),are double-edged swords in the battle of nerve injury,considering their polarization between pro-inflammatory M1 or anti-inflammatory M2 *** mobility group box 1(HMGB1)is one of the potent pro-inflammatory mediators that promotes the M1 polarization of microglia.18β-glycyrrhetinic acid(GA)is an effective intracellular inhibitor of HMGB1,but of poor water solubility and dose-dependent *** overcome the shortcomings of GA delivery and to improve the efficacy of cerebral ischemia therapy,herein,we designed reactive oxygen species(ROS)responsive polymer-drug conjugate nanoparticles(DGA)to manipulate microglia polarization by suppressing the translocation of nuclear *** presented excellent therapeutic efficacy in stroke mice,as evidenced by the reduction of infarct volume,recovery of motor function,suppressed of M1 microglia activation and enhanced M2 activation,and induction of ***,our work demonstrates a close association between HMGB1 and microglia polarization,suggesting potential strategies for coping with inflammatory microglia-related diseases.

关键词： HMGB1 Microglia M1/M2 phenotype Polymer-drug conjugates Drug delivery Ischemic stroke

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Strain Softening of Styrene-Isoprene-Styrene Copolymers under Large Amplitude Oscillatory Shear for Clarifying Payne Effect in Rubbers and Their Nanocomposites

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Chinese Journal of Polymer Science 2023年第1期41卷 153-165页

作者： Xin-Peng Fan Yi-Hu Song Qiang Zheng Wan-Jie Wang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Shanxi-Zheda Institute of New Materials and Chemical Engineering Taiyuan030000China College of Materials Science and Engineering Henan Key Laboratory of Advanced Nylon Materials and ApplicationZhengzhou UniversityZhengzhou450001China

To illustrate mechanisms of Payne effect in rubbers and their nanocomposites experiencing large amplitude oscillatory shear(LAOS),comparison studies were performed in styrene-isoprene-styrene(SIS)copolymers and their selectively crosslinked materials at temperatures below and above glass transition temperature of the polystyrene(PS)*** was found that under periodic dynamic shear,the strain softening is reversible when the polyisoprene(PI)phase,either crosslinked or not,is restricted by hard PS domains but it shows hysteresis once the PS domains *** strain softening can happen at the time scale of intrinsic Rouse relaxation of elastically active network *** stress of strain softening scales with number density of elastically active network strands,a simple relation being verified not only in the selectively crosslinked SIS copolymers but also in PI gum vulcanizates and carbon black filled PI *** effect is traditionally used to term strain softening of highly filled rubber vulcanizates under LAOS deformation while evidenced herein is that the Payne effect of highly filled rubber vulcanizates shares the mechanism being common to the strain softening of SIS copolymers.

关键词： Large amplitude oscillatory shear SIS Rubber nanocomposites Strain softening

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Influence of Liquid Isoprene Rubber on Strain Softening of Carbon Black Filled Isoprene Rubber Nanocomposites

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Chinese Journal of Polymer Science 2021年第7期39卷 887-895页

作者： Feng-Yi Hou Yi-Hu Song Qiang Zheng MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

The reinforcement of rubbers by nanoparticles is always accompanied with enhanced dissipation of mechanical energy upon large *** for solving the contradiction between improving reinforcement and reducing energy dissipation for rubber nanocomposites have not been well *** carbon black(CB)filled isoprene rubber(IR)/liquid isoprene rubber(LR)blend nanocomposites with similar crosslink density(ve)are prepared and influence of LR on the strain softening behaviors including Payne effect under large amplitude shear deformation and Mullins effect under cyclic uniaxial deformation is *** introduction of LR could improve the frequency sensitivity of loss modulus and reduce critical strain amplitude for Payne effect and loss modulus at the low ***,tuning ve and LR content allows reducing mechanical hysteresis in Mullins effect without significant impact on the mechanical *** investigation is illuminating for manufacturing nanocomposite vulcanizates with balanced mechanical hysteresis and reinforcement effect.

关键词： Rubber nanocomposites Stress softening Mechanical hysteresis Liquid rubber

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Recent Advances on Surface-modified Biomaterials Promoting Selective Adhesion and Directional Migration of Cells

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Chinese Journal of Polymer Science 2021年第7期39卷 815-823页

作者： Chen-Xi Tu Chang-You Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

The surfaces and interfaces of biomaterials interact with the biological systems in multi-scale levels,and thereby influence the biological functions and comprehensive performance in vitro and in *** particular,a surface promoting the selective adhesion and directional migration of desired types of cells in complex environment is extremely important in the repair and regeneration of tissues such as peripheral nerve and blood vessel,and long-term application of intracorporal devices such as intravascular ***,surface modification of biomaterials is a facile and effective method to achieve the desired cell-biomaterials *** this short review,recent advances on the surface modification of biomaterials to regulate selective cell adhesion and migration are briefly *** particular,the surface properties of biomaterials are manipulated via the convenient introduction of amino groups to the ester-based polymers,the formation of polyelectrolyte multilayers,and the fabrication of topology and gradient cues,etc.,followed by the association of chemical and biological signals such as collagen,heparin,hyaluronic acid,peptides and cell growth *** selective adhesion and directional migration of various types of cells such as endothelial cells(ECs),smooth muscle cells(SMCs),hepatocytes and Schwann cells(SCs)are achieved over the competitive counterpart cells by the use of cell-resisting substances and cell-selective motifs on gradient substrates in most *** advances on cell behaviors in three-dimensional(3D)ceH-extracellular matrix(ECM)-mimicking substrates are also reviewed.

关键词： Biomaterials Surface modification Gradient Cell migration Cell selectivity

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The relief of hypoxic microenvironment using an O_(2) self-sufficient fluorinated nanoplatform for enhanced photodynamic eradication of bacterial biofilms

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Nano Research 2022年第2期15卷 1636-1644页

作者： Lingyun Zou Dengfeng Hu Fanjin Wang Qiao Jin Jian Ji MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Hypoxia,an important characteristic of bacterial biofilms,can hinder the generation of reactive oxygen species(ROS)in photodynamic therapy(PDT),leading to reduced therapeutic efficacy of *** order to address this issue,fluorinated liposome was fabricated as an oxygen-sufficient nanoplatform for enhanced photodynamic eradication of bacterial *** liposomes(denoted as Lip-Ce6-PFH@O_(2))were prepared by co-encapsulation of O_(2) carrier perfluorohexane(PFH)and photosensitizer chlorin e6(Ce_(6)).Lip-Ce6-PFH@O_(2) could achieve efficient biofilm penetration due to the positively charged *** hypoxic microenvironment of biofilms would then be relieved,leading to the generation of more ROS under laser ***,the bactericidal capability of PDT could be significantly improved because of the co-delivered O_(2) carrier ***-Ce6-PFH@O_(2) exhibited much better antibiofilm ability than that of Lip-Ce6 both in vitro and in ***,Lip-Ce6-PFH@O_(2) also effectively alleviated inflammation symptoms and accelerated wound healing in the mice *** general,this study provides a new paradigm to enhance the therapeutic efficacy of PDT for efficient biofilm eradication.

关键词： biofilm hypoxia perfluorohexane liposome photodynamic therapy

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Bioactive Hydrogels with Pro-coagulation Effect for Hemostasis

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Chinese Journal of Chemistry 2024年第1期42卷 87-103,I0004页

作者： Quanshi Guo Yihang Ding Lisha Yu Zongrui Tong Zhengwei Mao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiang 310058China Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310009China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province HangzhouZhejiang 310009China

Hemostatic hydrogels are widely applied for wound management of damaged tissues,traumatic wounds,and surgical *** hydrogels composed of bioactive components,including fibrin and thrombin,showed great promise in the clinic due to their good pro-coagulation *** the expanding knowledge of cascade reaction of blood coagulation and emerging bioactive substances,massive bioactive hydrogels consisting of peptides,hemocoagulase,polyphosphate(polyP),etc.,have been developed as effective hemostatic *** on the coagulation process and mechanism,we summarize the role of reported bioactive hydrogels in hemostasis in this *** conclude the key points in the coagulation process,including activation of coagulation factors,fibrinogen polymerization,etc.,then discuss how to design bioactive hydrogels to accelerate coagulation targeted to these ***,we conclude the progress and propose a perspective of bioactive hydrogels with a pro-coagulation effect for hemostasis.

关键词： Hemostasis Biological activity Biomaterials Enzyme catalysis Composites

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Healing the degradable organic–inorganic heterointerface for highly efficient and stable organic solar cells

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InfoMat 2022年第2期4卷 162-170页

作者： Yangdan Tao Haoran Liu Di Wang Feng Zhao Zeng Chen Haiming Zhu Hongzheng Chen Chang-Zhi Li State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhouChina Department of Chemistry Zhejiang UniversityHangzhouChina

The heterointerface between the contacted organic and inorganic semiconductors critically affects the charge extraction,hence overall performance of organic optoelectronics,especially for organic solar cells(OSCs).Herein,we develop an effective interfacial strategy that simultaneously boosts the chemical,electric,and electronic properties of the organic–inorganic heterointerface of the derived OSCs,through implanting conjugated molecules as selfassemble monolayers(SAMs)to metal oxide nanoparticles(MO NPs).As results,SAM passivated zinc oxide nanoparticles(ZnO NPs)as electron transport layers(ETLs)not only enable the best performed OSCs containing MO ETLs,but also exhibit the most desirable thickness insensitive features(up to 300 nm).In addition,SAM-ZnO ETLs help also substantially improving the photostability of the derived ***,this work can be beneficial to the further development of high-performance and cost-effective OSCs.

关键词： charge extraction organic-inorganic heterointerface organic solar cells photostability

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