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A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis

Bioactive Materials 2023年第2期20卷 271-285页

作者： Mengna Li Jing-Wei Xu Jiayong Li Wei Wang Chenqi Luo Haijie Han Zhi-Kang Xu Ke Yao Eye Center Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009PR China Zhejiang Provincial Key Laboratory of Ophthalmology Hangzhou310009PR China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027PR China

Postoperative endophthalmitis(POE)has been the most threatening complication after cataract surgery,which perhaps can be solved by the antibiotic-loaded intraocular lens(IOL).However,most drug-loaded IOLs demonstrate insufficient drug quantity,short release time,increased implantation-related difficulties or other noticeable *** prevent POE and to address these deficiencies,a drug-loaded copolymer IOL,prepared from poly(urethane acrylate)prepolymer,isobornyl methacrylate(IBOMA),N-vinyl-2-pyrrolidone(NVP),Irgacure 819,RUVA-93,and gatifloxacin(GAT),was rapidly fabricated via photocuring and by using a 3D-printed *** composite displayed an outstanding and controllable GAT release behavior in vitro,a high light transmittance,and a moderate refractive ***,it demonstrated improved strain stress and elongation compared with the reference commercial acrylic IOL *** vivo tests demonstrated satisfying released drug concentration at the early treatment *** vitro and in vivo studies further confirmed the remarkable bacterial inhibition and prevention of POE by the proposed IOL,which also displayed good *** findings suggested that the GAT-loaded IOL could be a promising implant to prevent and cure POE,also the proposed methods could inspire more designs for various medical applications.

关键词： Photocuring Drug delivery intraocular lens 3D printing Postoperative endophthalmitis Gatifloxacin

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Microstructure Evolution and Strain Softening of Carbon Black Filled Natural Rubber Vulcanizates

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Chinese Journal of Polymer Science 2023年第12期41卷 1947-1957,I0010页

作者： Xuan-Yu Shi Shi-Hao Sun Li Yang Jun Zhong Xiao-Feng Yu Zheng Xu Min Zuo Yi-Hu Song Qiang Zheng Ministry of Education Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030001China

Incorporation of carbon black(CB)in natural rubber(NR)enhances the Mullins effect and Payne effect of their vulcanizates,but the strain softening mechanisms and the microstructure evolution in the vulcanizates have not been clearly concluded so *** investigate the Mullins effect and Payne effect of CB filled NR vulcanizates by using cyclic tensile tests at different temperatures and dynamic rheological measurements combined with simultaneous electric *** cyclic stretching,the normalized recovery hysteresis energy and accumulative softening energy for NR/CB vulcanizates with different loadings can be both superimposed on a master curve,indicating that the Mullins effect is mainly dominated by the rubber *** irreversible simultaneous resistance evolution also reveals that the structural evolution of nanoparticles(NPs)network is not directly related to the Mullins ***,the extension of linear viscoelastic region and the hysteresis of Payne effect for filled vulcanizates subjected to cyclic stretching indicate the destruction of CB aggregated structure and the interfacial layers between CB and rubber chains during cyclic *** investigation would be illuminating for the microstructure evolution and strain softening of rubber nanocomposites under harsh service conditions.

关键词： Mullins effect Payne effect Conductive connected network Nanocomposites

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Nanomaterial‑Based Repurposing of Macrophage Metabolism and Its Applications

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Nano-Micro Letters 2024年第11期16卷 494-528页

作者： Tingting Meng Danfeng He Zhuolei Han Rong Shi Yuhan Wang Bibo Ren Cheng Zhang Zhengwei Mao Gaoxing Luo Jun Den Institute of Burn Research Southwest HospitalState Key Laboratory of Trauma and Chemical PoisoningArmy Medical UniversityChongqing 400038People’s Republic of China Department of Breast Surgery Gansu Provincial HospitalLanzhouGansu 730030People’s Republic of China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease ***(NMs)have been engineered to monitor macrophage metabolism,enabling the evaluation of disease progression and the replication of intricate physiological signal *** achieve this either directly or by delivering regulatory signals,thereby mapping phenotype to effector functions through metabolic repurposing to customize macrophage fate for ***,a comprehensive summary regarding NM-mediated macrophage visualization and coordinated metabolic rewiring to maintain phenotypic equilibrium is currently *** review aims to address this gap by outlining recent advancements in NM-based metabolic *** initially explore the relationship between metabolism,polarization,and disease,before delving into recent NM innovations that visualize macrophage activity to elucidate disease onset and fine-tune its fate through metabolic remodeling for macrophage-centered ***,we discuss the prospects and challenges of NM-mediated metabolic immunotherapy,aiming to accelerate clinical *** anticipate that this review will serve as a valuable reference for researchers seeking to leverage novel metabolic intervention-matched immunomodulators in macrophages or other fields of immune engineering.

关键词： Immunomodulatory nanomaterial Macrophage polarization Macrophage metabolic reprogramming Immune engineering

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Trilayered Fibrous Dressing with Wettability Gradient for Spontaneous and Directional Transport of Massive Exudate and Wound Healing Promotion

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Advanced Fiber Materials 2023年第2期5卷 574-587页

作者： Lei Liu Hengqiu Sun Jiaming Zhang Bingjie Xu Yujie Gao Dongming Qi Zhengwei Mao Jindan Wu MOE Key Laboratory of Advanced Textile Materials&Manufacturing Technology Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Pediatric Surgery Taizhou Women and Children’s Hospital of Wenzhou Medical UniversityTaizhou 318000China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Excessive exudate at wound sites increases treatment difficulty and severely decelerates the healing *** wound exu-date management,dressings with unidirectional liquid transport capability have exhibited enormous ***,it remains challenging to improve the one-way liquid transport ***,a trilayered fibrous dressing is constructed by sequentially electrospinning polyurethane(PU)and polyvinylidene fluoride(PVDF)onto cotton *** hot pressing,a stable wettability gradient is formed across the PVDF/PU/cotton dressing due to the melting and bridging of PU *** trilayered dressing exhibited rapid unidirectional transport with water penetrating from the hydrophobic side to the hydrophilic side in 6 *** hydrostatic pressure from the hydrophilic side to the hydrophobic side is 569%higher than that from the hydrophobic side to the hydrophilic side,indicating that the dressing has a profound unidirectional *** vivo experiments demonstrates that the trilayered dressing can accelerate the wound healing process,especially in the early stages of wound occurrence,by quickly draining the excessive *** study provides a new method to construct wound dressings with wettability gradients,which are advantageous for efficient exudate removal.

关键词： Trilayered fibrous dressing Exudate pumping PU nanofibers Wettability gradient Wound healing

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Facile Amination of Poly(Ethyl Methacrylate) Film and its Surface Properties

SSRN

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SSRN 2024年

作者： Zhao, Yu Xue, Yunyun Wang, Chuyao Zhao, Zihao Cui, Ronglu Zhu, Baoku Zhejiang University China MOE Key Laboratory of Macromolecular Synthesis and Functionalization China

Polymethacrylate and its derivates are widely used in food industry and biomedical applications for their plasticity, biocompatibility and optical transparency. However, the susceptibility to bacterial growth on their surfaces limit their use. Herein, polyethyleneimine (PEI), as a kind of well-known polycation, was grafted onto poly(ethyl methacrylate) (PEMA) with a facile one-step method to improve the antibacterial properties of PEMA films. PEI-modified PEMA films exhibited obvious improvements in bactericidal abilities against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Furthermore, how PEI was grafted onto PEMA films was investigated. Both ammonolysis and electrostatic interaction were believed to anchor PEI onto PEMA. Overall, PEI-grafted PEMA films prepared with simple one-step method exhibit effective antibacterial properties and good biocompatibilities, which has the potential to be applied in biomedical devices and other industries. © 2024, The Authors. All rights reserved.

关键词： Biocompatibility

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Improving Thermal-oxidative Aging Resistance of Styrene-butadiene Rubber by Antioxidant Loaded Silica Aerogel

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Chinese Journal of Polymer Science 2024年第8期42卷 1198-1209页

作者： Xue-Fei Ping Yu Wang Lu Liu Fu-Yong Liu Hong-Wei He Pi Wang Wen-Wen Yu Qiang Zheng College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058China

The antioxidant N-isopropyl-N'-phenyl-p-phenylenediamine(4010NA)was dissolved in ethanol and impregnated into silica aerogel(SAG)via vacuum-pressure cycles,yielding composite particles(A-N)with enhanced sustained-release and reinforcing *** effect of A-N on the mechanical properties and thermal-oxidative aging resistance of styrene-butadiene rubber(SBR)vulcanizates was *** and BET assessments indicated that the loading efficiency of 4010NA in SAG reached 14.26%within ethanol's solu bility *** A-N into SBR vulcanizates significantly elevated tensile strength by 17.5%and elongation at break by 41.9%over those with fumed silica and ***,A-N notably enhanced the thermal-oxidative aging resistance of *** aging for 96 h at 100℃,the tensile strength and elongation at break of SBR with A-N sustained 70.09%and 58.61%of their initial values,respectively,with the retention rate of elongation at break being 62.8%higher than that of SBR with fumed silica and free *** study revealed that A-N composite particles significantly inhibited the crosslinking in SBR's molecular chains,reducing hardening and embrittlement during later thermal-oxidative aging stages.

关键词： Styrene-butadiene rubber Silica aerogel Loading modification Thermal-oxidative aging

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Surface and Interface Engineering for Advanced Nanofiltration Membranes

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Chinese Journal of Polymer Science 2022年第2期40卷 124-137页

作者： Bian-Bian Guo Cheng-Ye Zhu Zhi-Kang Xu Ministry of Education Key Laboratory of Macromolecular Synthesis and FunctionalizationKey Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Nanofiltration has been attracting great attention in alleviating the global water crisis because of its high efficiency,mild operation,and strong *** decades,it remains a challenge to break the upper limit of performance and establish the formation-structureproperty relationship for nanofiltration *** feature article summarizes our recent progress in the preparation of high-performance thin-film composite(TFC)nanofiltration membranes,focusing on the mussel-inspired deposition method and the optimized interfacial polymerization(IP).By accelerating the oxidation of polydopamine and equilibrating the rate of aggregation and deposition processes,the mussel-inspired deposition method realizes the rapid and uniform formation of selective coatings or *** deposition systems endow the selective layer with rich chemical structures and easy post-functionalization,highlighting its potential in water *** for optimizing the conventional IP,the rapid polycondensation of amine and acid chloride groups is slowed down to enable the controllability of IP at the water-organic *** homogeneity and integrity of the TFC membranes are improved by constructing a uniform reaction platform and introducing a viscous medium to control the amine diffusion,which facilitates the water permeability and promotes the separation *** have proposed a series of practical strategies for improving TFC membranes and might provide more inspiration for other nanofiltration techniques.

关键词： Nanofiltration Thin-film composite membranes Mussel-inspired deposition Interfacial polymerization

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Unveiling new anti-inflammatory mechanisms of nanomaterials

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National Science Review 2023年第12期10卷 40-42页

作者： Zhen Gu College of Pharmaceutical Sciences National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang University Liangzhu Laboratory Jinhua Institute of Zhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University

Inflammasome activation is instrumental in clearance of pathogens and damaged cells, playing a pivotal role in maintaining host homeostasis. Nonetheless, it is important to note that inflammasome activation can also be a primary driving factor in autoimmune disease and metabolic dysregulation, encompassing conditions such as Alzheimer’s disease, colitis, type 2 diabetes, gout, and atherosclerosis [1].

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Tuning the Excited State of Tetradentate Pd(ll) and Pt(ll) Complexes through Benzannulated N-Heteroaromatic Ring and Central Metal

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Chinese Journal of Chemistry 2022年第2期40卷 223-234页

作者： Guijie Hua Guo Xiaoli Fang Yun-Fang Yang Yulu Sun Weiwei Lou Qisheng Zhang Yuanbin She College of Chemical Engineering Zhejiang University of TechnologyHangzhouZhejiang 310014China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiang 310027China

A series of tetra de ntate Pd(ll)and Pt(ll)complexes containing fused 5/6/6 metallocycles with phe nyl/V-heteroaromatic ben-zo[d]imidazole(pbiz),benzo[d]oxazole(pboz)or benzo[d]thiazole(pbthz)-containing ligands was *** studies by experiments and theoret:ical calculations reveal that both the central metal and the benzannulated A/-heteroaromatic ring have sig-n ificant in flue nee on the electrochemical,photophysical and excited-state properties of the Pd(ll)and Pt(ll)*** identical condition,compared to pb/z-based Pd(ll)and Pt(ll)complexes,the corresponding metal complexes with pboz and pbthz-containing ligand show significant red-shift emission spectra.

关键词： Semiconductors Luminescence Platinum and Palladium Energy conversion OLED

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ROS-responsive&scavenging NO nanomedicine for vascular diseases treatment by inhibiting endoplasmic reticulum stress and improving NO bioavailability

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Bioactive Materials 2024年第7期37卷 239-252页

作者： Jian Li Jvhong Zhang Pengcheng Yu Han Xu Meihui Wang Zhebin Chen Bo Yu Jing Gao Qiao Jin Fan Jia Jian Ji Guosheng Fu Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhou310016PR China MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhouPR China

Vascular diseases seriously threaten human life and *** delivery of nitric oxide(NO)represents an effective approach for maintaining vascular homeostasis during pathological ***,the overproduction of reactive oxygen species(ROS)at vascular injury sites would react with NO to produce damaging peroxynitrite(ONOO􀀀)species and limit the therapeutic effect of ***,we design a ROS-responsive NO nanomedicine(t-PBA&NO NP)with ROS scavenging ability to solve the dilemma of NO-based therapy.t-PBA&NO NP targets NO and anti-oxidant ethyl caffeate(ECA)to the injury sites via collagen IV homing *** ROS-triggered ROS depletion and ECA release potently alleviate local oxidative stress via ROS scavenging,endoplasmic reticulum and mitochondrial *** subsequently maximizes vascular modulation effects of NO,without production of harmful compounds,reactive nitrogen species(RNS).Therefore,it significantly increases competitiveness of human umbilical vein endothelial cells(HUVECs)over human aortic smooth muscle cells(HASMCs)both in vitro and in *** strategy proved effective in inducing faster re-endothelialization,inhibiting neointimal formation and restoring vascular *** synergy between ROS depletion and NO therapy served as a new inspiration for the treatment of cardiovascular diseases and other ROS-associated illnesses.

关键词： Cardiovascular diseases Nitric oxide Reactive oxygen species Endoplasmic reticulum stress Nanomedicine

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