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Publisher Correction: Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

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Nature communications 2019年第1期10卷 2459页

作者： Peer Aramillo Irizar Sascha Schäuble Daniela Esser Marco Groth Christiane Frahm Steffen Priebe Mario Baumgart Nils Hartmann Shiva Marthandan Uwe Menzel Jule Müller Silvio Schmidt Volker Ast Amke Caliebe Rainer König Michael Krawczak Michael Ristow Stefan Schuster Alessandro Cellerino Stephan Diekmann Christoph Englert Peter Hemmerich Jürgen Sühnel Reinhard Guthke Otto W Witte Matthias Platzer Eytan Ruppin Christoph Kaleta Research Group Medical Systems Biology Institute of Experimental Medicine Christian-Albrechts-University Kiel D-24105 Kiel Germany. Jena University Language and Information Engineering Lab Friedrich-Schiller-University Jena D-07743 Jena Germany. GerontoSys JenAge Consortium D-07745 Jena Germany. Genome Analysis Lab Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Hans Berger Department of Neurology Jena University Hospital D-07747 Jena Germany. Systems Biology and Bioinformatics Group Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll-Institute D-07745 Jena Germany. Biology of Ageing Lab Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Molecular Genetics Lab Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Imageing Facility Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Integrated Research and Treatment Center Center for Sepsis Control and Care (CSCC) Jena University Hospital D-07747 Jena Germany. Network Modeling Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute D-07745 Jena Germany. Institute for Medical Informatics and Statistics Christian-Albrechts-University Kiel D-24105 Kiel Germany. Energy Metabolism Laboratory Swiss Federal Institute of Technology (ETH) Zurich Schwerzenbach/Zürich CH-8603 Switzerland. Department of Bioinformatics Friedrich-Schiller-University Jena D-07743 Jena Germany. Laboratory of Neurobiology Scuola Normale Superiore University of Pisa I-56100 Pisa Italy. Molecular Biology Lab Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Faculty of Biology and Pharmacy Friedrich-Schiller-University Jena D-07743 Jena Germany. Biocomputing Lab Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Department of Computer Science and Center for Bioinformatics and Computational Biology University of Maryland College Park M

The original version of this Article contained an error in the spelling of the author Jule Müller, which was incorrectly given as Julia Müller. Additionally, in Fig. 4a, the blue-red colour scale for fold change in ageing/disease regulation included a blue stripe in place of a red stripe at the right-hand end of the scale. These errors have been corrected in both the PDF and HTML versions of the Article.

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Research on Prediction Method for Pivotal Indicator of Hospital Medical Quality Using Decision Tree

Research on Prediction Method for Pivotal Indicator of Hospi...

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2015 6th IEEE International Conference on Software Engineering and Service science(ICSESS 2015)

作者： Liujian Chen Lujia Bi Huayou Si Jilin Zhang Yongjian Ren Key Laboratory of Complex System Modeling and Simulation Ministry of Education Department of Computer Science and Technology Hangzhou Dianzi University Department of Information First Hospital of Jiaxing

Indicators of medical quality is the main basis of medical quality evaluation, predictive analyzing the indicators by using data mining technology, we can find and solve the problems of hospital quality management more timely. The study, basing on the medical homepage records, analyzes the key indicators of the hospital medical quality by decision tree C4.5 algorithm. Decision tree is a prediction model which can assist hospital to make related decision on medical quality management issues. By using decision tree C4.5 algorithm with appropriate modification, a high quality model of decision tree can be made. It can not only do the statistic of medical quality indicators, but also predict the indicators with high relative accuracy to improve hospital’s medical quality management.

关键词： medical quality data mining decision tree C4.5

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Corrigendum to “Ontological anti-patterns: Empirically uncovered error-prone structures in ontology-driven conceptual models” [Data Knowl. Eng. 99 (September 2015) 72–104]

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Data & Knowledge Engineering 2016年 101卷 42-42页

作者： Tiago Prince Sales Giancarlo Guizzardi Ontology and Conceptual Modeling Research Group (NEMO) Computer Science Department Federal University of Espírito Santo (UFES) Vitória ES Brazil

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Proton dynamics in protein mass spectrometry

arXiv

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arXiv 2017年

作者： Li, Jinyu Lyu, Wenping Rossetti, Giulia Konijnenberg, Albert Natalello, Antonino Ippoliti, Emiliano Orozco, Modesto Sobott, Frank Grandori, Rita Carloni, Paolo College of Chemistry Fuzhou University Fuzhou350002 China Computational Biomedicine Institute for Advanced Simulation IAS-5 Institute of Neuroscience and Medicine INM-9 Forschungszentrum Jülich Jülich Germany Faculty of Mathematics Computer Science and Natural Sciences RWTH-Aachen University Aachen52056 Germany Cyprus Institute Computat Based Sci & Technol Res Ctr Aglantzia Nicosia2121 Cyprus Department of Hematology Oncology Hemostaseology and Stem Cell Transplantation Faculty of Medicine RWTH Aachen University Aachen Germany Forschungszentrum Jülich JülichD-52425 Germany Biomolecular & Analytical Mass Spectrometry group Department of Chemistry University of Antwerp Antwerpen Belgium Department of Biotechnology and Biosciences University of Milano-Bicocca Piazza della Scienza 2 Milan20126 Italy Barcelona Institute of Science and Technology Baldiri Reixac 10 Barcelona08028 Spain Departament de Bioquímica i Biomedicina Facultat de Biologia Universitat de Barcelona Avgda Diagonal 647 Barcelona08028 Spain Astbury Centre for Structural Molecular Biology University of Leeds LeedsLS2 9JT United Kingdom School of Molecular and Cellular Biology University of Leeds LS2 9JT United Kingdom JARA-HPC Jülich52425 Germany

Native electrospray ionization/ion mobility-mass spectrometry (ESI/IM-MS) allows an accurate determination of low-resolution structural features of proteins. Yet, the presence of proton dynamics, observed already by us for DNA in the gas phase, and its impact on protein structural determinants, have not been investigated so far. Here, we address this issue by a multi-step simulation strategy on a pharmacologically relevant peptide, the N-terminal residues of amyloid- β peptide (Aβ(1-16)). Our calculations reproduce the experimental maximum charge state from ESI-MS and are also in fair agreement with collision cross section (CCS) data measured here by ESI/IM-MS. Although the main structural features are preserved, subtle conformational changes do take place in the first ~0.1 ms of dynamics. In addition, intramolecular proton dynamics processes occur on the ps-timescale in the gas phase as emerging from quantum mechanics/molecular mechanics (QM/MM) simulations at the B3LYP level of theory. We conclude that proton transfer phenomena do occur frequently during fly time in ESI-MS experiments (typically on the ms timescale). However, the structural changes associated with the process do not significantly affect the structural determinants. Copyright © 2017, The Authors. All rights reserved.

关键词： Mass spectrometry

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Optimizing Border Patrol Operations Using Unmanned Aerial Vehicles

Optimizing Border Patrol Operations Using Unmanned Aerial Ve...

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International Conference on Information Technology: New Generations (ITNG)

作者： Doina Bein Wolfgang Bein Ashish Karki Bharat B. Madan Department of Computer Science University of Nevada Las Vegas Las Vegas USA Dept. of Modeling Simulation and Visualization Eng Old Dominion University Norfolk USA

The most common approach for border patrol operations is the use of human personnel and manned ground vehicles, which is expensive, at times inefficient and sometimes even hazardous to people involved. A better approach would be using Unmanned Aerial Vehicles (UAVs) in combination with such ground sensors. This would help improve the overall effectiveness of the surveillance system as a UAV could first scan the alert area before sending in personnel and vehicles, if deemed necessary. We propose border surveillance using multiple Unmanned Aerial Vehicles (UAVs) in combination with alert stations consisting of Unattended Ground Sensors (UGSs) along the border line/fence. Upon detecting an event, an alert would be triggered by any UGS. We simulate this process by reading probability data for different timestamps from a text file. And, based on utility values of each station, two UAVs decide on which alert station to service.

关键词： Sensors Probabilistic logic Monitoring Decision making Animals Unmanned aerial vehicles

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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC NEUROscience 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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Erratum to: A novel revenue optimization model to address the operation and maintenance cost of a data center

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Journal of Cloud Computing 2016年第1期5卷 1-1页

作者： Snehanshu Saha Jyotirmoy Sarkar Avantika Dwivedi Nandita Dwivedi Anand M. Narasimhamurthy Ranjan Roy Shrisha Rao Center for Applied Mathematical Modeling and Simulation (CAMMS) & Department of Computer Science and Engineering PESIT-BSC Bangalore India GE Healthcare Bangalore India BITS Pilani Hyderabad India State Resource Centre Chattisgarh India IIIT Bangalore Bangalore India

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OntoUML Lightweight Editor: A Model-Based Environment to Build, Evaluate and Implement Reference Ontologies

OntoUML Lightweight Editor: A Model-Based Environment to Bui...

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International Workshop on Enterprise Distributed Object Computing, EDOCW

作者： John Guerson Tiago Prince Sales Giancarlo Guizzardi João Paulo A. Almeida Computer Science Department Ontology & Conceptual Modeling Research Group (NEMO) Vitoria ES Brazil Universidade Federal do Espirito Santo Vitoria ES BR

Enterprise information systems are increasingly being conceived as a combination of existing systems and to work as a part of an ecosystem of software products. This change demands methods and tools to deal with the challenging semantic interoperability issues. OntoUML is a well-founded modeling language that allows modelers to formalize world-views in a technologically neutral way, aiding in the solution of such interoperability challenges. In this paper, we present an overview of the OntoUML Lightweight Editor (OLED), our model-based environment to build, evaluate and implement OntoUML models, alongside with its main features and application scenarios.

关键词： Unified modeling language Ontologies Organic light emitting diodes OWL Accidents Biological system modeling Vehicles

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Model checking CSL for markov population models 12

Model checking CSL for markov population models

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12th International Workshop on Quantitative Aspects of Programming Languages and Systems, QAPL 2014

作者： Spieler, David Hahn, Ernst Moritz Zhang, Lijun Modeling and Simulation Group Computer Science Department Saarland University Saarbrücken Germany State Key Laboratory of Computer Science Institute of Software Chinese Academy of Sciences Beijing China

Markov population models (MPMs) are a widely used modelling formalism in the area of computational biology and related areas. The semantics of a MPM is an infinite-state continuous-time Markov chain. In this paper, we use the established continuous stochastic logic (CSL) to express properties of Markov population models. This allows us to express important measures of biological systems, such as probabilistic reachability, survivability, oscillations, switching times between attractor regions, and various others. Because of the infinite state space, available analysis techniques only apply to a very restricted subset of CSL properties. We present a full algorithm for model checking CSL for MPMs, and provide experimental evidence showing that our method is effective. © 2014 D. Spieler, E. M. Hahn & L. Zhang.

关键词： Model checking

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Security modeling and analysis of a self-cleansing intrusion tolerance technique

Security modeling and analysis of a self-cleansing intrusion...

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International Symposium on Information Assurance and Security (IAS)

作者： Iman El Mir Dong Seong Kim Abdelkrim Haqiq Computer Networks Mobility and Modeling laboratory FST Hassan 1st University Settat Morocco Department of Computer Science and Software Engineering University of Canterbury New Zealand E-NGN Research Group

ISBN: (纸本)9781467387163

Since security is increasingly the principal concern in the conception and implementation of software systems, it is very important that the security mechanisms are designed so as to protect the computer systems against cyber attacks. An Intrusion Tolerance Systems play a crucial role in maintaining the service continuity and enhancing the security compared with the traditional security. In this paper, we propose to combine a preventive maintenance with existing intrusion tolerance system to improve the system security. We use a semi-Markov process to model the system behavior. We quantitatively analyze the system security using the measures such as system availability, Mean Time To Security Failure and cost. The numerical analysis is presented to show the feasibility of the proposed approach.

关键词： Markov processes Servers Numerical models computer architecture Preventive maintenance computer crime

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