检索结果-内蒙古大学图书馆

IEEE Symposium on Nuclear Science (NSS/MIC)

作者： Y. Pan J. Fisher C. Wang C. Levin Applied Physics Stanford University Stanford California United States of America Electrical Engineering Stanford University Stanford California United States of America Rad/Molecular Imaging Program Stanford University Stanford California United States of America Radiology Physics Bioengineering Stanford University Stanford California United States of America

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

This paper proposes a geometry-based attenuation correction method for phantom PET scans using emission data alone. The method reconstructs the phantom image without attenuation and scatter correction, registers the image with the known phantom, and calculates the intersection of every line of response (LOR) with the registered phantom geometry. Knowing the attenuation per LOR allows us to manipulate the list-mode emission data accordingly and generate a list-mode data file with an enhanced number of coincidences per LOR according to the estimated *** approach yielded promising results when applied to a Hoffman brain phantom study using the second-generation PETcoil insert scanner. The intensity line profile generated by summing the signal intensity along the transverse and coronal axes looked more like the expected line profile without scatter correction, as expected. This approach can be easily generalized to any other phantoms and scanners.

关键词： Neuroimaging Geometry Microwave integrated circuits Semiconductor detectors Phantoms Attenuation Imaging phantoms

来源：评论

学校读者我要写书评

暂无评论

Electronic Readout for a 100 ps CTR PET Detector with 24:1 Multiplexing Ratio of Timing Channels

Electronic Readout for a 100 ps CTR PET Detector with 24:1 M...

引用

IEEE Symposium on Nuclear Science (NSS/MIC)

作者： Shirin Pourashraf Andrea Gonzalez-Montoro Derek Innes Joshua W. Cates Craig S. Levin Department of Radiology Stanford University Stanford CA USA Applied Nuclear Physics Program Lawrence Berkeley National Laboratory Berkeley CA USA Departments of Radiology Bioengineering Physics and Electrical Engineering Molecular Imaging Program Stanford University Stanford CA USA

We have designed a novel electronic readout with 24:1 multiplexing ratio of the timing channels that achieves 100 ps coincidence time resolution. The detector layer units comprise 2×4 arrays of 3×3×10 mm 3 "LGSO" crystals side-coupled to 6×4 arrays of 3×3 mm 2 SiPMs. To achieve low power dissipation and scalability of this readout design, its effective area is implemented in only 13.3 mm using compact and power efficient electronic components. The measured CTR of the 24:1 multiplexed timing channels (or 8:1 LVDS signals) was 107.0 ± 3.6 ps FWHM using a 22 Na point-source and a very low timing jitter FPGA-based TDC.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Integrating Chain-of-Thought and Retrieval Augmented Generation Enhances Rare Disease Diagnosis from Clinical Notes

arXiv

引用

arXiv 2025年

作者： Wu, Da Wang, Zhanliang Nguyen, Quan Wang, Kai Raymond G. Perelman Center for Cellular and Molecular Therapeutics Children's Hospital of Philadelphia PhiladelphiaPA19104 United States Applied Mathematics and Computational Science Graduate Program University of Pennsylvania PhiladelphiaPA19104 United States Bioengineering Graduate Program University of Pennsylvania PhiladelphiaPA19104 United States Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania PhiladelphiaPA19104 United States

Background: Several studies show that large language models (LLMs) struggle with phenotype-driven gene prioritization for rare diseases. These studies typically use Human Phenotype Ontology (HPO) terms to prompt foundation models like GPT and LLaMA to predict candidate genes. However, in real-world settings, foundation models are not optimized for domain-specific tasks like clinical diagnosis, yet inputs are unstructured clinical notes rather than standardized terms. How LLMs can be instructed to predict candidate genes or disease diagnosis from unstructured clinical notes remains a major challenge. Methods: We introduce RAG-driven CoT and CoT-driven RAG, two methods that combine Chain-of-Thought (CoT) and Retrieval Augmented Generation (RAG) to analyze clinical notes. A five-question CoT protocol mimics expert reasoning, while RAG retrieves data from sources like HPO and OMIM (Online Mendelian Inheritance in Man). We evaluated these approaches on rare disease datasets, including 5,980 Phenopacket-derived notes, 255 literature-based narratives, and 220 in-house clinical notes from Children’s Hospital of Philadelphia. Results: We found that recent foundations models, including Llama 3.3-70B-Instruct and DeepSeek-R1-Distill-Llama-70B, outperformed earlier versions such as Llama 2 and GPT-3.5. We also showed that RAG-driven CoT and CoT-driven RAG both outperform foundation models in candidate gene prioritization from clinical notes;in particular, both methods with DeepSeek backbone resulted in a top-10 gene accuracy of over 40% on Phenopacket-derived clinical notes. RAG-driven CoT works better for high-quality notes, where early retrieval can anchor the subsequent reasoning steps in domain-specific evidence, while CoT-driven RAG has advantage when processing lengthy and noisy notes. Conclusions: Integrating CoT and RAG enhances LLMs’ understanding of clinical notes in the context of rare disease diagnosis, and can facilitate various downstream medical tasks. © 2025, CC

关键词： Chains

来源：评论

学校读者我要写书评

暂无评论

Biomass-Based Discrete Furan Oligomers as Materials for Electrochromic Devices

引用

ACS Sustainable Chemistry and Engineering 2024年第1期12卷 459-469页

作者： Atayde, Eduardo C. Fong, Guan-Lun Yeh, Jyun-Yi Matsagar, Babasaheb M. Wang, Yu-Cheng Chen, De-Chian Peng, Chi-How Li, Yi-Pei Yamauchi, Yusuke Ho, Kuo-Chuan Wu, Kevin C.-W. Molecular Science and Technology Program Taiwan International Graduate Program (TIGP-MST) Academia Sinica No. 128 Sec. 2 Academia Road Taipei 11529 Taiwan Department of Chemistry National Tsing Hua University No. 101 Sec. 2 Kuang-Fu Road Hsinchu 30013 Taiwan Department of Chemical Engineering National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei 10617 Taiwan Sustainable Chemical Science and Technology Program Taiwan International Graduate Program (TIGP-SCST) Academia Sinica No. 128 Sec. 2 Academia Road Taipei 11529 Taiwan School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensl Brisbane 4072 QLD Australia Department of Materials Process Engineering Graduate School of Engineering Nagoya University Nagoya 464-8603 Japan Institute of Polymer Science and Engineering National Taiwan University No.1 Sec. 4 Roosevelt Rd. Taipei 10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University No. 135 Yuandong Rd. Taoyuan 320 Taiwan

Electrochromic devices (ECDs) are materials that can undergo reversible changes in transmittance when exposed to different applied potentials. While many conjugated heterocyclic oligomers, such as oligothiophenes, have been developed for this purpose, there is no reported study on the use of discrete oligomeric furans as ECD materials. In this work, we introduce a furan trimer that can be utilized as a discrete electrochromic material, which transitions from light yellow to red and has a very high coloration efficiency of 1940 cm²/C at 507 nm. We propose that the reversible π-stack formation of the oligomer radical cations is behind this phenomenon, as evidenced by both experimental and computational results. The derivability of this oligomer from biomass and its facile synthesis make it an interesting alternative for other existing organic electrochromic materials. © 2023 American Chemical Society

关键词： electrochromism furan oligomer hydroxyalkylation−alkylation reaction solvatochromism π-stacks

来源：评论

学校读者我要写书评

暂无评论

Integrating computational and experimental insights into osmolyte-driven activation of Geobacillus kaustophilus L-asparaginase for acrylamide mitigation

引用

Journal of molecular Liquids 2025年 423卷

作者： Özdemir, F.İnci Servili, Burak Demirtaş, Özge Şükür, Gözde Tülek, Ahmet Yildirim, Deniz Gebze Technical University Department of Molecular Biology and Genetics Kocaeli Gebze41400 Turkey Kadir Has University of Science and Engineering Bioinformatics and Genetics Program İstanbul Fatih35430 Turkey Iğdır University Postgraduate Education Institute Department of Bioengineering and Sciences Iğdır Merkez76000 Turkey Cukurova University Faculty of Ceyhan Engineering Department of Chemical Engineering Adana Ceyhan01950 Turkey

Osmolytes play a critical role in enhancing the stability and activity of enzymes for industrial applications. This study systematically investigated the effects of various osmolytes on the activity, optimal pH, temperature, stability, metal ion effects, storage, and acrylamide mitigation performance of L-asparaginase from the thermophilic Geobacillus kaustophilus (GkASNase). The experimental findings were further supported by computationally integrated tools such as homology modeling, docking, and molecular dynamics (MD) simulations. Among the selected osmolytes (maltose, sorbitol, trehalose, glycine, and sucrose), GkASNase showed the highest stability during 30 days of storage in the presence of maltose and arginine. Maltose increased GkASNase activity approximately 2-fold at 37 °C and 55 °C. In the presence of osmolytes, the Km values of GkASNase decreased and the Vmax values increased compared to controls at 37 °C and 55 °C. In the presence of osmolytes, the acrylamide mitigation performance of GkASNase increased by 1.7-fold in a 15 min reaction. The computational analysis indicates that L-asparagine as substrate enhances protein compactness and stability, while arginine as osmolyte increases flexibility and optimizes water distribution around the enzyme. These findings provide novel insights into enzyme stabilization that have implications for therapeutic and biotechnological applications. © 2025 Elsevier B.V.

关键词： Maltose

来源：评论

学校读者我要写书评

暂无评论

Scaling Ipsc Production in Different 3d Platforms in Suspension Culture for Their Use in Allogeneic Regenerative Therapies

SSRN

引用

SSRN 2024年

作者： Freire-Flores, Danton Kawles, Nyna Caviedes, Pablo Andrews, Barbara A. Asenjo, Juan A. Centre for Biotechnology and Bioengineering Faculty of Physical and Mathematical Sciences Universidad de Chile Beaucheff 851 Santiago8370448 Chile Department of Chemical Engineering Biotechnology and Materials Universidad de Chile Beaucheff 851 Santiago8370448 Chile Program of Molecular and Clinical Pharmacology ICBM Faculty of Medicine University of Chile Independencia 1027 Santiago8379482 Chile

Human induced pluripotent stem cells (iPSCs) exhibit significant potential for advancing regenerative medical treatments due to their pluripotency and proliferation capacity. However, the large-scale production required for allogeneic therapies necessitates efficient and scalable culture systems. Conventional 2D culture techniques are inadequate for this, driving interest for innovative bioreactor-based expansion techniques such as microcarrier-based or suspension aggregate cultures. In this study, we compare iPSC expansion and quality in microcarrier and aggregate cultures in spinner flasks, aiming to ascertain which 3D growth configuration yields superior cell mass while maintaining cellular product quality. We demonstrated comparable expansion of iPSCs on Cytodex 1 and Cultisphere G microcarriers, as well as in aggregates by day 6 in culture, achieving a final cell density of 2.6*10^6 cells/ml and 5.67*10^6 cells/ml on microcarriers respectively, and 9.76*10^6 cells/ml in aggregates, yielding 4- and 9-fold expansion on microcarriers and 15-fold in aggregates. The efficiency in the recovery of iPSCs in single-cell form was over 91.5% for all cultures. iPSCs cultured on microcarriers and as aggregates exhibit OCT3/4, SSEA4, TRA-1-60, and SOX2 pluripotency marker expression, as well as retention of differentiation potential into three germinal layers. This work supports the utilization of microcarriers and aggregates as an efficient 3D expansion platform for suspension cultures of iPSCs, in the quest to further scale production in larger stirred-tank bioreactor systems. © 2024, The Authors. All rights reserved.

关键词： Tanks (containers)

来源：评论

学校读者我要写书评

暂无评论

Design of Modular Readout Electronics for Cadmium Zinc Telluride (CZT) PET Imaging of the Plants Rhizosphere

Design of Modular Readout Electronics for Cadmium Zinc Tellu...

引用

IEEE Symposium on Nuclear Science (NSS/MIC)

作者： Muhammad Nasir Ullah Andrew Groll Derek Innes Shiva Abbaszadeh Craig S. Levin Department of Radiology Stanford University California USA Department of Radiology and Molecular Imaging Program at Stanford (MIPS) Stanford University California USA Department of Electrical and Computer Engineering University of California Santa Cruz Santa Cruz California USA Departments of Radiology Electrical Engineering Bioengineering Physics Molecular Imaging Program at Stanford MIPS) Stanford University Stanford California USA

To study and quantify the dynamic behavior of a plant’s soil-root interface (rhizosphere), we are developing a hybrid positron emission tomography-computed tomography (PET-CT) system to obtain in situ 3D images to help in modeling the Earth System Model (ESM) in a precise manner. ESM integrates the relevant aspects of the earth system to study the state of climate under various of conditions. The proposed system aims to understand the complex bi-directional flow of carbon in the rhizosphere by quantitatively measuring 11 C concentration. The rhizosphere imaging requires the creation of a PET system with high sensitivity and excellent spatial resolution; a dual panel geometry of cadmium zinc telluride (CZT) detectors with fine electrodes is being refined and scaled to a 4-panel system to answer the demands. This work focuses on the development, evaluation, and integration of the critical intermediate board (IB) needed to support approximately 5 thousand channels in the CZT PET system and provide modularity to the system. A Rigid-Flex PCB approach is adopted to design the IB. The rigid region will provide firm mechanical support for direct placement of the necessary electronic components and connectors, and the flex region will help to align the subsequent readout boards at the backend of the IB while maintaining the dense packing fraction at front-end where the CZT crystals are connected. Three CZT module (each module comprising of 2-crystals of 39x39 x5 mm 3 sandwiched in anode-cathode-cathode-anode configuration) along with 1-mm thick mechanical support on either side of modules will be directly attached to two IBs which forms one tray to modularize the entire system. This modularized design will help to assemble and dissemble the system in an efficient way and minimize the chance of damaging the crystal assemblies. This new IB design will address the troubleshooting/repairing experience and modularity issues that were taking significant amount of time and energy

关键词：

来源：评论

学校读者我要写书评

暂无评论

The minimum dataset for rare diseases in Brazil: A systematic review protocol

The minimum dataset for rare diseases in Brazil: A systemati...

引用

2021 International Conference on ENTERprise Information Systems, CENTERIS 2021 / ProjMAN 2021 - International Conference on Project MANagement / HCist 2021 and International Conference on Health and Social Care Information Systems and Technologies 2021

作者： Bernardi, Filipe Andrade Yamada, Diego Bettiol De Oliveira, Bibiana Mello Lima, Vinicius Costa Félix, Têmis Maria Alves, Domingos Bioengineering Postgraduate Program University of São Paulo São Carlos Brazil Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto Brazil Postgraduate Program in Genetics and Molecular Biology Federal University of Rio Grande Do sul Porto Alegre Brazil Medical Genetics Service Porto Alegre Clinics Hospital Porto Alegre Brazil

The Minimum Data Set (MDS) can be used for subsidiarity decision-making and health planning. Besides, this strategy allows to identify obligatory points that must be adjusted to achieve sustainable management in the planning and development of relevant Health Information Systems for public health. Specifically, in the context of rare diseases, the MDS strategy can be very valuable. This systematic review will focus on research using MDS for rare diseases in several databases. We seek to answer the question: "What is the minimum data set used in registries for rare diseases?" Some outcomes of interests specific for MDS will involve information about epidemiology, clinical procedures, and therapeutic resources among other features. We hope that by standardizing data through a careful analysis of evidence from different sources of a common format, with shared specifications and structures, we can help in the methodological transparency and reproducibility of results in the context of rare disease research. © 2021 Elsevier B.V. All rights reserved.

关键词： Public health

来源：评论

学校读者我要写书评

暂无评论

The minimum dataset for rare diseases in Brazil: a systematic review protocol

引用

Procedia Computer Science 2022年 196卷 439-444页

作者： Filipe Andrade Bernardi Diego Bettiol Yamada Bibiana Mello de Oliveira Vinicius Costa Lima Têmis Maria Félix Domingos Alves Bioengineering Postgraduate Program University of São Paulo São Carlos Brazil Ribeirao Preto Medical School University of Sao Paulo Ribeirao Preto Brazil Postgraduate Program in Genetics and Molecular Biology Federal University of Rio Grande do Sul Porto Alegre Brazil Medical Genetics Service Porto Alegre Clinics Hospital Porto Alegre Brazil

关键词： Rare diseases Minimum data set Public Health Digital Health Review protocol

来源：评论

学校读者我要写书评

暂无评论

Early Postoperative Conjunctival Complications Leading to Exposure of Surgically Implanted CorNeat EverPatch Devices

引用

Ophthalmology 2025年第7期132卷 799-814页

作者： Kanter, Jacob Garkal, Atul Cardakli, Nur Pitha, Ian Sabharwal, Jasdeep Schein, Oliver D. Ramulu, Pradeep Y. Parikh, Kunal S. Johnson, Thomas V. Glaucoma Center of Excellence Wilmer Eye Institute Johns Hopkins University School of Medicine Baltimore Maryland United States Center for Nanomedicine Wilmer Eye Institute Johns Hopkins University School of Medicine Baltimore Maryland United States Moran Eye Center University of Utah Salt Lake City Utah United States North Bay Eye Associates Petaluma CA United States Cornea Division Wilmer Eye Institute Johns Hopkins University School of Medicine Baltimore Maryland United States Center for Bioengineering Innovation & Design Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore Maryland United States Cellular and Molecular Medicine Program Johns Hopkins University School of Medicine Baltimore Maryland United States

Purpose: To compare the early exposure and surgical revision rates between a new synthetic tissue substitute (CorNeat EverPatch) with that of human donor cornea after placement onto the scleral surface during ophthalmic surgery and study the biomaterial properties of the synthetic patch material. Design: Retrospective comparison study and biomaterial analyses of new and explanted synthetic patch material. Participants: All consecutive patients who underwent ophthalmic surgery with implantation of the CorNeat EverPatch at the Wilmer Eye Institute (occurring from February through August 2024) and a comparison group who underwent ophthalmic surgery with implantation of irradiated donor cornea, matched 1:2 with patients receiving EverPatch for age, type of glaucoma, and surgeon. Methods: Retrospective review of clinical electronic medical records of patients who underwent surgery at the Wilmer Eye Institute. Materials characterization of EverPatch, including morphologic features, surface roughness, wettability, thermal stability, elemental analysis, and physical properties. Main Outcome Measures: Early exposure (within 5 months of surgery) and surgical revision rates after CorNeat EverPatch or irradiated human donor cornea implantation during ophthalmic surgery. Results: Thirty patients undergoing ophthalmic surgery in 2024 received EverPatch implantation during primary tube shunt placement (n = 27), tube shunt revision (n = 2), or covering of exposed suture used for scleral fixation of an intraocular lens (n = 1). During the early postoperative period, the rate of EverPatch exposure was 48.3% and the rate of surgical revision was 27.9%. In case-matched control participants (n = 58), the rate of patch graft exposure was 1.7% (P < 0.0001) and the rate of surgical revision was 1.7% (P < 0.0001). EverPatch devices constituted a randomly aligned fibrous mesh with an average fiber diameter of 1.36 ± 0.78 μm, surface roughness of 1.3 ± 0.1 μm, pore size of 3.7 ± 0.4 μm^2<

关键词： conjunctiva Electrospinning Glaucoma surgery Patch graft Tube shunt

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：