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Improved camptothecin encapsulation and efficacy by environmentally sensitive block copolymer/chitosan/fucoidan nanoparticles for targeting lung cancer cells

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International Journal of Biological Macromolecules 2024年第Part2期277卷 133901页

作者： Don, Trong-Ming Hong, Yu-Ting Jheng, Pei-Ru Chuang, Er-Yuan Huang, Yi-Cheng Department of Chemical and Materials Engineering Tamkang University New Taipei City Taiwan College of Life Sciences Department of Food Science National Taiwan Ocean University Keelung Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering International PhD Program in Biomedical Engineering Taipei Medical University Taipei Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University–Wan Fang Hospital Taipei Taiwan

In this study, thermo-sensitive poly(N-isopropyl acrylamide) (PNP) was polymerized with pH-sensitive poly(acrylic acid) (PAA) to prepare a PAA-b-PNP block copolymer. Above its cloud point, the block copolymer self-assembled into nanoparticles (NPs), encapsulating the anticancer drug camptothecin (CPT) in situ. Chitosan (CS) and fucoidan (Fu) further modified these NPs, forming Fu-CPT-NPs to enhance biocompatibility, drug encapsulation efficiency (EE), and loading content (LC), crucially facilitating P-selectin targeting of lung cancer cells through a drug delivery system. The EE and LC reached 82 % and 3.5 %, respectively. According to transmission electron microscope observation, these Fu-CPT-NPs had uniform spherical shapes with an average diameter of ca. 250 nm. They could maintain their stability in a pH range of 5.0–6.8. In vitro experimental results revealed that the Fu-CPT-NPs exhibited good biocompatibility and had anticancer activity after encapsulating CPT. It could deliver CPT to cancer cells by targeting P-selectin, effectively increasing cell uptake and inducing cell apoptosis. Animal study results showed that the Fu-CPT-NPs inhibited lung tumor growth by increasing tumor cell apoptosis without causing significant tissue damage related to generating reactive oxygen species in lung cancer cells. This system can effectively improve drug-delivery efficiency and treatment effects and has great potential for treating lung cancer. © 2024 Elsevier B.V.

关键词： Nanoparticles

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Growth of Gd0.3ca2.7co3.82cu0.18o9-Δ-Bace0.6zr0.2y0.2o3-Δ Bulk Heterojunction Cathode Interlayer by Pulsed Laser Deposition for Enhancing Protonic Solid Oxide Fuel Cell Performance

SSRN

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SSRN 2023年

作者： Umer, Muhammad Abdullah Cheng, Cheng-Yang Lai, Bo-Ruei Tseng, Chung-Jen Chen, Szu-Yuan Lee, Sheng-Wei Molecular Science and Technology program Taiwan International Graduate Program Academia Sinica Taipei City106923 Taiwan Department of Physics National Central University Taoyuan City320317 Taiwan Institute of Atomic and Molecular Sciences Academia Sinica Taipei City106923 Taiwan Institute of Materials Science and Engineering National Central University Taoyuan City320317 Taiwan Department of Mechanical Engineering National Central University Taoyuan City320317 Taiwan Department of Chemical and Materials Engineering National Central University Taoyuan City320317 Taiwan

The triple-conducting (e-/H+/O2-) oxides have been extensively studied as the most promising cathode materials for protonic solid oxide fuel cells (P-SOFCs) because of their excellent catalytic activity at lower operating temperatures. However, direct application of these cathode materials by brush-painting or screen-printing provides limited contact area with the underlying electrolyte layer, resulting in high cathode ohmic and polarization resistances. In this study, it is demonstrated that a bulk heterojunction Gd0.3Ca2.7Co3.82Cu0.18O9-δ (GCCCO)-BaCe0.6Zr0.2Y0.2O3-δ (BCZY) layer with a domain width of ~5 nm can be grown by pulsed laser deposition (PLD) via spontaneous phase separation. Such a nanocomposite interlayer between spin-coated BCZY electrolyte and brush-painted GCCCO cathode can effectively increases the interfacial area between the two distinct phases and facilitates proton transport across the interface. This electrode design reduces the ohmic resistance by 0.35 Ω cm2 and the polarization resistance by a factor of three, thus significantly boosting the cell performance. © 2023, The Authors. All rights reserved.

关键词： Pulsed laser deposition

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Revisiting the Temperature Dependence of Protein Diffusion inside Bacteria: Validity of the Stokes-Einstein Equation

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Physical Review Letters 2022年第1期129卷 018101-018101页

作者： Asmaa A. Sadoon William F. Oliver Yong Wang Department of Physics University of Arkansas Fayetteville Arkansas 72701 USA Materials Science and Engineering Program University of Arkansas Fayetteville Arkansas 72701 USA Department of Physics University of Thi-Qar Nassiriya 64001 Iraq Cell and Molecular Biology Program University of Arkansas Fayetteville Arkansas 72701 USA

Although the transport and mixing of proteins and other molecules inside bacteria rely on the diffusion of molecules, many aspects of the molecular diffusion in bacterial cytoplasm remain unclear or controversial, including how the diffusion-temperature relation follows the Stokes-Einstein equation. In this study, we applied single-particle tracking photoactivated localization microscopy to investigate the diffusion of histonelike nucleoid structuring (HNS) proteins and free dyes in bacterial cytoplasm at different temperatures. Although the diffusion of HNS proteins in both live and dead bacteria increased at higher temperatures and appeared to follow the Arrhenius equation, the diffusion of free dyes decreased at higher temperatures, questioning the previously proposed theories based on superthermal fluctuations. To understand the measured diffusion-temperature relations, we developed an alternative model, in which the bacterial cytoplasm is considered as a polymeric network or mesh. In our model, the Stokes-Einstein equation remains valid, while the polymeric network contributes a significant term to the viscosity experienced by the molecules diffusing in bacterial cytoplasm. Our model was successful in predicting the diffusion-temperature relations for both HNS proteins and free dyes in bacteria. In addition, we systematically examined the predicted diffusion-temperature relations with different parameters in the model, and predicted the possible existence of phase transitions.

关键词： Anomalous diffusion Diffusion Intracellular transport Network diffusion Proteins

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GranatumX:A Community-engaging, Modularized, and Flexible Webtool for Single-cell Data Analysis

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Genomics, Proteomics & Bioinformatics 2021年第3期19卷 452-460页

作者： David G.Garmire Xun Zhu Aravind Mantravadi Qianhui Huang Breck Yunits Yu Liu Thomas Wolfgruber Olivier Poirion Tianying Zhao Cédric Arisdakessian Stefan Stanojevic Lana X.Garmire Department of Electrical Engineering&Computer Science University of MichiganAnn ArborMI 48109USA Epidemiology Program University of Hawaii Cancer CenterHonoluluHI 96813USA Department of Biostatistics University of MichiganAnn ArborMI 48109USA Department of Computational Medicine and Bioinformatics University of MichiganAnn ArborMI 48105USA Molecular Biosciences and Bioengineering Graduate Program University of Hawaii at ManoaHonoluluHI 96822USA

We present GranatumX,a next-generation software environment for single-cell RNA sequencing(scRNA-seq)data *** is inspired by the interactive webtool *** enables biologists to access the latest scRNA-seq bioinformatics methods in a web-based graphical *** also offers software developers the opportunity to rapidly promote their own tools with others in customizable *** architecture of GranatumX allows for easy inclusion of plugin modules,named Gboxes,which wrap around bioinformatics tools written in various programming languages and on various *** can be run on the cloud or private servers and generate reproducible *** is a community-engaging,flexible,and evolving software ecosystem for scRNA-seq analysis,connecting developers with bench *** is freely accessible at http://***/granatumx/app.

关键词： Single-cell RNA sequencing Analysis Pipeline Webtool Module

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Optical coherence tomography angiography reveals retinal microvascular changes in patients with multiple sclerosis without optic neuritis

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ACTA OPHTHALMOLOGICA 2022年第Sup275期100卷

作者： Popa-Cherecheanu, Alina Bostan, Mihai Chua, Jacqueline Sim, Yin Ci Tan, Bingyao Bujor, Inna Garhofer, Gerhard Schmetterer, Leopold Ophthalmology Carol Davila University of Medicine and Pharmacy Ophthalmology Emergency University Hospital Singapore Eye Research Institute Singapore National Eye Centre Singapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical School National University of Singapore SERI-NTU Advanced Ocular Engineering (STANCE) Singapore School of Chemical and Biological Engineering Nanyang Technological University Singapore Department of Clinical Pharmacology Medical University Vienna Center for Medical Physics and Biomedical Engineering Medical University Vienna Institute of Molecular and Clinical Ophthalmology Basel Switzerland

Purpose: Retinal imaging has attracted much interest as a non‐invasive low‐budget biomarker for neurological diseases such as multiple sclerosis (MS). Optical coherence tomography angiography (OCTA) is a functional extension of OCT and allows for the non‐invasive visualization of the retinal and choroidal microvasculature. We investigated retinal microvasculature changes in patients with relapsing–remitting MS (RRMS) without history of optic neuritis (ON) and compared them to a healthy control ***: The study was performed in a prospective, case–control design, including 58 participants (n = 100 eyes) with RRMS without ON and 78 age‐ and sex‐matched control participants (n = 136 eyes). OCTA images of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) were obtained using a commercial OCTA system (Zeiss Cirrus HD‐5000 Spectral‐Domain OCT with AngioPlex OCTA, Carl Zeiss Meditec, Dublin, CA). Perfusion density (PD) and foveal avascular zone (FAZ) features (area and circularity) in both the SCP and DCP, as well as flow deficit in the CC were used as outcome ***: MS patients showed significantly increased PD in SCP (p = 0.003) and decreased PD in DCP (p < 0.001) as compared to controls when data were corrected for confounders. A significant difference was also noted when large vessels (LV) in the SCP were removed from the PD calculation (p = 0.004). Deep FAZ was significantly larger (p = 0.005) and less circular (p < 0.001) in the eyes of MS patients compared to healthy controls. Neither LV, PD or FAZ features in the SCP, nor flow deficits in the CC showed any statistically significant differences between the MS patients and the controls (p > 0.186).Conclusions: Our study shows that MS patients have microvascular changes in the macular parafoveal retina even without ON. They show increased PD in SCP and decreased PD in DCP. To which degree retinal biomarkers

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Integrated omics analysis on the bacterial community in the anaerobic digestion of chicken manure materials in biogas production farm

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Bioresource Technology Reports 2023年 22卷

作者： Lam, Tze-Kang Yu, Chang-Ping Wu, Shih-Hsiung Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan Institute of Biological Chemistry Academia Sinica Taipei Taiwan Chemical Biology and Molecular Biophysics Program Taiwan International Graduate Program Academia Sinica Taipei Taiwan Department of Chemistry National Taiwan University Taipei Taiwan

The overall effectiveness of anaerobic digestion is affected by the initial three phases as a result of substrates created for the methanogens to take in. In this study, the bacterial composition of the various chambers in the anaerobic digestion of chicken manure was investigated. Diversity of the microbial community for chicken manure was relatively simpler, consisting mainly of Lactobacillus, compared to the main digestion chambers with a more complex community. Chicken manure only has hydrolysis phase occurring, while the main digesters have the first three phases of anaerobic digestion concurrently occurring. A comparison of the metagenomics versus metaproteomics analysis revealed that the main difference was in the percentage of unknown microorganisms. The quantity of volatile fatty acids detected in each respective chamber suggested the effectiveness of the microorganisms in assimilating the metabolites. Successful integration of these study modes would present a better understanding on anaerobic digestion of complex systems. © 2023

关键词： Anaerobic digestion

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Polarization-driven dynamic laser speckle analysis for brain neoplasms differentiation

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Light(Advanced Manufacturing) 2024年第4期5卷 31-44页

作者： Vahid Abbasian Vahideh Farzam Rad Parisa Shamshiripour Davoud Ahmadvand Arash Darafsheh Department of Radiation Oncology Washington University School of Medicine in St.LouisSt.LouisMO 63110USA Imaging Science Program McKelvey School of EngineeringWashington University in St.LouisSt.LouisMO 63130USA Department of Physics Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Department of Molecular Imaging Faculty of Advanced Technologies in MedicineIran University of Medical SciencesTehranIran Faculty of Medicine Iran University of Medical SciencesTehranIran

Early diagnosis of brain tumors is often hindered by non-specific symptoms,particularly in eloquent brain regions where open surgery for tissue sampling is *** limitation increases the risk of misdiagnosis due to tumor heterogeneity in stereotactic ***-free diagnostic methods,including intraoperative probes and cellular origin analysis techniques,hold promise for improving diagnostic *** offers valuable information on the polarization properties of biomedical samples,yet it may not fully reveal specific structural *** interpretative scope of polarimetric data is sometimes constrained by the limitations of existing decomposition *** the other hand,dynamic laser speckle analysis(DLSA),a burgeoning technique,not only does not account for the polarimetric attributes but also is known for tracking only the temporal activity of the dynamic *** study bridges these gaps by synergizing conventional polarimetric imaging with DLSA for an indepth examination of sample polarization *** effectiveness of our system is shown by analyzing the collection of polarimetric images of various tissue samples,utilizing a variety of adapted numerical and graphical statistical post-processing methods.

关键词： Polarimetric imaging Dynamic laser speckle analysis Cancerous tissue Brain neoplasm Label-free diagnostics

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Quantitative Analysis of Sodium Metal Deposition and Interphase in Na Metal Batteries

arXiv

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arXiv 2023年

作者： Sayahpour, Baharak Li, Weikang Bai, Shuang Lu, Bingyu Han, Bing Chen, Yu-Ting Deysher, Grayson Parab, Saurabh Ridley, Phillip Raghavendran, Ganesh Nguyen, Long Hoang Bao Zhang, Minghao Meng, Ying Shirley Materials Science and Engineering Program University of California San DiegoCA92093 United States Department of NanoEngineering University of California San DiegoCA92093 United States Pritzker School of Molecular Engineering University of Chicago ChicagoIL60637 United States

Sodium-ion batteries exhibit significant promise as a viable alternative to current lithium-ion technologies owing to their sustainability, low cost per energy density, reliability, and safety. Despite recent advancements in cathode materials for this category of energy storage systems, the primary challenge in realizing practical applications of sodium-ion systems is the absence of an anode system with high energy density and durability. Although Na metal is the ultimate anode that can facilitate high-energy sodium-ion batteries, its use remains limited due to safety concerns and the high-capacity loss associated with the high reactivity of Na metal. In this study, titration gas chromatography is employed to accurately quantify the sodium inventory loss in ether- and carbonate-based electrolytes. Uniaxial pressure is developed as a powerful tool to control the deposition of sodium metal with dense morphology, thereby enabling high initial coulombic efficiencies. In ether-based electrolytes, the Na metal surface exhibits the presence of a uniform solid electrolyte interphase layer, primarily characterized by favorable inorganic chemical components with close-packed structures. The full cell, utilizing a controlled electroplated sodium metal in ether-based electrolyte, provides capacity retention of 91.84% after 500 cycles at 2C current rate and delivers 86 mAh/g discharge capacity at 45C current rate, suggesting the potential to enable Na metal in the next generation of sodium-ion technologies with specifications close to practical requirements. © 2023, CC BY-NC-ND.

关键词： Ethers

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Challenges in Developing MOF-Based Membranes for Gas Separation

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Langmuir 2023年第8期39卷 2871-2880页

作者： Kang, Dun-Yen Lee, Jong Suk Department of Chemical Engineering National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei10617 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei10617 Taiwan Center of Atomic Initiative for New Materials National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei10617 Taiwan Department of Chemical and Biomolecular Engineering Sogang University Baekbeom-ro 35 Seoul4107 Korea Republic of Institute of Emergent Materials Sogang University 35 Baekbeom-ro Seoul4107 Korea Republic of

Metal-organic frameworks (MOFs) are promising candidates for membrane gas separation. MOF-based membranes include pure MOF membranes and MOF-based mixed matrix membranes (MMMs). This Perspective discusses the challenges for the next stage of the development of MOF-based membranes based on research conducted in the past decade. We focused on three major issues associated with pure MOF membranes. First, some MOF compounds have been overstudied, despite the availability of numerous MOFs. Second, gas adsorption and diffusion in MOFs are often independently investigated. The correlation between adsorption and diffusion has seldom been discussed. Third, we identify the importance of characterizing the gas distribution in MOFs to understand the structure-property relationships for gas adsorption and diffusion in MOF membranes. For MOF-based MMMs, engineering the MOF-polymer interface is essential for achieving the desired separation performance. Various approaches to modify the MOF surface or polymer molecular structure have been proposed to improve the MOF-polymer interface. Herein, we present defect engineering as a facile and efficient approach for engineering the MOF-polymer interfacial morphology and its extended application for various gas separations. © 2023 American Chemical Society.

关键词： Organometallics

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Mussel-Inspired and Bioclickable Peptide Engineered Surface to Combat Thrombosis and Infection

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Research 2022年第3期2022卷 91-104页

作者： Xiaohui Mou Hongbo Zhang Hua Qiu Wentai Zhang Ying Wang Kaiqin Xiong Nan Huang Hélder A.Santos Zhilu Yang Affiliated Dongguan Hospital Southern Medical UniversityDongguanGuangdong 523059China Guangdong Provincial Key Laboratory of Shock and Microcirculation GuangzhouGuangdong 510080China Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Pharmaceutical Sciences Laboratory Åbo Akademi UniversityTurku Biosciences CenterUniversity of Turku andÅbo Akademi University20520 TurkuFinland State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200438China Department of Biomedical Engineering and W.J.Kolff Institute for Biomedical Engineering and Materials Science University Medical Center Groningen/University of GroningenAnt.Deusinglaan 19713 AV GroningenNetherlands Drug Research Program Division of Pharmaceutical Chemistry and TechnologyFaculty of PharmacyUniversity of HelsinkiFI-00014 HelsinkiFinland

Thrombosis and infections are the two major complications associated with extracorporeal circuits and indwelling medical devices,leading to significant mortality in *** address this issue,here,we report a biomimetic surface engineering strategy by the integration of mussel-inspired adhesive peptide,with bio-orthogonal click chemistry,to tailor the surface functionalities of tubing and *** by mussel adhesive foot protein,a bioclickable peptide mimic(DOPA)4-azidebased structure is designed and grafted on an aminated tubing robustly based on catechol-amine ***,the dibenzylcyclooctyne(DBCO)modified nitric oxide generating species of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid(DOTA)chelated copper ions and the DBCO-modified antimicrobial peptide(DBCO-AMP)are clicked onto the grafted surfaces via bio-orthogonal *** combination of the robustly grafted AMP and Cu-DOTA endows the modified tubing with durable antimicrobial properties and ability in long-term catalytically generating NO from endogenous snitrosothiols to resist adhesion/activation of platelets,thus preventing the formation of ***,this biomimetic surface engineering technology provides a promising solution for multicomponent surface functionalization and the surface bioengineering of biomedical devices with enhanced clinical performance.

关键词： DOTA generating Engine

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