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Physicochemical properties of lard oil and rubber seed oil blends and their comprehensive characterization

Chinese Journal of Chemical engineering 2024年第11期75卷 1-13页

作者： Amonrat Thangthong Wuttichai Roschat Phongsakorn Pholsupho Aekkaphon Thammayod Sunti Phewphong Tappagorn Leelatam Preecha Moonsin Boonyawan Yoosuk Pathompong Janetaisong Vinich Promarak Program of Environment Science Faculty of Science and TechnologySakon Nakhon Rajabhat UniversityMueang DistrictSakon Nakhon 47000Thailand Biomass Energy Research Laboratory Center of Excellence on Alternative EnergyResearch and Development InstitutionSakon Nakhon Rajabhat UniversityMueang DistrictSakon Nakhon 47000Thailand Program of Chemistry Faculty of Science and TechnologySakon Nakhon Rajabhat UniversityMueang DistrictSakon Nakhon 47000Thailand Innovation in Chemistry for Community Research Unit Faculty of Science and TechnologySakon Nakhon Rajabhat UniversityMueang DistrictSakon Nakhon 47000Thailand Appropriated Technology Center Faculty of Science and TechnologySakon Nakhon Rajabhat UniversityMueang DistrictSakon Nakhon 47000Thailand Program of Chemistry Faculty of ScienceUbon Ratchathani Rajabhat UniversityMueang DistrictUbon Ratchathani 34000Thailand National Energy Technology Center(ENTEC) 114 Thailand Science ParkPhahonyothin RoadKlong LuangPathumthani 12120Thailand Department of Material Science and Engineering School of Molecular Science&EngineeringVidyasirimedhi Institute of Science and TechnologyWangchanRayong 21210Thailand

This research investigates the potential of blending complementary lard oil with rubber seed oil as feedstock for biodiesel *** seed oil,obtained through hexane extraction using the Soxhlet method,contains the major fatty acids of oleic acid(C_(18:1)),palmitic acid(C_(16:0)),linoleic acid(C_(18:2)),and stearic acid(C_(18:0)),while rubber seed oil primarily consists of linoleic acid(C_(18:2)),oleic acid(C_(18:1)),linolenic acid(C_(18:3)),palmitic acid(C_(16:0)),and stearic acid(C_(18:0)).The least acid value of lard oil(0.55 mg KOH/g)can benefit of reducing soap formation of rubber seed oil during transesterification process in biodiesel production due to its substantial-high acid value(16.28 mg KOH/g).Blending at ratios below 80:20 volume ratio produced biodiesel exceeding 85%,utilizing CaO as a *** oil demonstrated a higher reaction rate constant(11.88×10^(-3)min^(-1))than rubber seed oil(2.11×10^(-3)min^(-1)),indicating a significant difference in *** acid value and free fatty acids in rubber seed oil correlated with lower reaction *** a mixture ratio below 80:20 volume ratio optimized reaction rates during biodiesel *** obtained from blends below 80:20 volume ratio met ASTM D6751 and EN 14214 standards,demonstrating suitability for bio-auto *** drawbacks of using rubber seed oil as a raw material for biodiesel production are overcome by blending with lard oil,giving rise to expanding renewable energy options for rural communities,community enterprises,and large-scale biodiesel production.

关键词： Biodiesel oil Rubber seed oil Lard oil High free fatty acid Physicochemical properties Liquid biofuels

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A high mobility air-stable n-type organic small molecule semiconductor with high UV-visible-to-NIR photoresponse

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Light(Science & Applications) 2022年第9期11卷 2140-2146页

作者： YING-SHI GUAN JING QIAO YINGYING LIANG HARI KRISHNA BISOYI CHAO WANG WEI XU DAOBEN ZHU QUAN LI Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast University211189 NanjingChina Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of Sciences100190 BeijingChina Advanced Materials and Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State UniversityKentOH 44242USA

An organic semiconductor with high carrier mobility and efficient light absorption over a wide spectral range is of the most important yet challenging material for constructing a broadband responsive organic ***,the development of such organic semiconductors,especially for air-stable n-type organic small molecule semiconductors,is still at an early *** we report the fabrication of high-performance n-type semiconducting crystalline nanosheets and the development of air-stable field-effect transistors,phototransistors,with high response over a broad *** n-type small molecule semiconductor is assembled into a crystalline nanosheet based on the solvent-phase interfacial self-assembly method.N-type field-effect transistors with high electron mobility are fabricated and their electrical performances exhibit excellent air ***,the demonstrated phototransistors exhibit an ultrahigh responsivity over a wide spectral range from 365 to 940 nm,with a maximum photoresponsivity of 9.2×10^(5) AW-1 and specific detectivity of 5.26×10^(13) Jones,which is the best performance among the reported n-type organic small molecule-based phototransistors.

关键词： high visible crystalline

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Multilocus sequence typing of Treponema pallidum in male patients with genital ulcers in a public sexually transmitted infections clinic: a new allele and almost complete macrolide resistance

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Anais Brasileiros de Dermatologia 2025年第3期100卷 569-573页

作者： Esteves, Leonardo Souza Grassi, Vera Mileide Trivellato Grassi, Liliane Trivellato Nicola, Maria Rita Castilhos Silva, Marcia Susana Nunes Rossetti, Maria Lucia Rosa Ramos, Mauro Cunha Laboratory of Molecular Biology Applied to Microbacteria Fundação Oswaldo Cruz RJ Rio de Janeiro Brazil Program in Cellular and Molecular Biology Applied to Health Sciences Universidade Luterana do Brasil RS Canoas Brazil Biomedical Engineering Universidade Luterana do Brasil RS Canoas Brazil Sanitary Dermatology Outpatient Unit Secretaria Estadual de Saúde RS Porto Alegre Brazil DNTech - Development of New Technologies LTDA Agência Estadual de Pesquisa Desenvolvimento e Inovação do Rio Grande do Sul / Financiadora de Estudos e Projetos RS Porto Alegre Brazil Postgraduate Program Faculdade de Biologia Celular e Molecular Aplicada à Saúde Universidade Luterana do Brasil RS Canoas Brazil

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Mechano-responsive hydrogel for direct stem cell manufacturing to therapy

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Bioactive Materials 2023年第6期24卷 387-400页

作者： Yufeng Shou Ling Liu Qimin Liu Zhicheng Le Khang Leng Lee Hua Li Xianlei Li Dion Zhanyun Koh Yuwen Wang Tong Ming Liu Zheng Yang Chwee Teck Lim Christine Cheung Andy Tay Department of Biomedical Engineering National University of Singapore117583Singapore Institute for Health Innovation&Technology National University of Singapore117599Singapore School of Civil Engineering and Architecture Wuhan University of Technology430070WuhanChina NUS Tissue Engineering Program National University of Singapore117510Singapore Lee Kong Chian School of Medicine Nanyang Technological University636921Singapore School of Mechanical and Aerospace Engineering Nanyang Technological University639798Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)138648Singapore Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of Singapore119288Singapore Mechanobiology Institute National University of Singapore117411Singapore

Bone marrow-derived mesenchymal stem cell(MSC)is one of the most actively studied cell types due to its regenerative potential and immunomodulatory *** cell expansion methods using 2D tissue culture plates and 2.5D microcarriers in bioreactors can generate large cell numbers,but they compromise stem cell potency and lack mechanical preconditioning to prepare MSC for physiological loading expected in *** overcome these challenges,in this work,we describe a 3D dynamic hydrogel using magneto-stimulation for direct MSC manufacturing to *** our technology,we found that dynamic mechanical stimulation(DMS)enhanced matrix-integrinβ1 interactions which induced MSCs spreading and *** addition,DMS could modulate MSC biofunctions including directing MSC differentiation into specific lineages and boosting paracrine activities(e.g.,growth factor secretion)through YAP nuclear localization and FAK-ERK *** our magnetic hydrogel,complex procedures from MSC manufacturing to final clinical use,can be integrated into one single platform,and we believe this‘all-in-one’technology could offer a paradigm shift to existing standards in MSC therapy.

关键词： Mesenchymal stem cell Dynamic mechanical stimulation Magnetic hydrogel Stem cell manufacturing Cell therapy

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Alkyl-thiophene-alkyl linkers to construct double-cable conjugated polymers for single-component organic solar cells

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Chinese Chemical Letters 2024年第1期35卷 542-546页

作者： Wenbin Lai Safakath Karuthedath Chengyi Xiao Lei Meng Frédéric Laquai Weiwei Li Yongfang Li Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Beijing Advanced Innovation Center for Soft Matter Science and Engineering&State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China King Abdullah University of Science and Technology(KAUST) KAUST Solar Center(KSC)Physical Sciences and Engineering Division(PSE)Material Science and Engineering Program(MSE)Thuwal 23955-6900Kingdom of Saudi Arabia University of Chinese Academy of Sciences Beijing 100049China Institute of Materials Research Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

In this work,semirigid linkers of the alkyl-thiophene-alkyl structure are developed to construct double-cable *** alkyl units,propyl(C3H6),hexyl(C6H12),and dodecyl(C12H24),are applied as semirigid linkers,yielding three double-cable polymers:PBC6-T,PBC12-T,and PBC24-T,***12-T which uses C6H12-thiophene-C6H12 linkers is found to exhibit the best device efficiency of 5.56%,while PBC6-T and PBC24-T with shorter or longer linkers yield device efficiencies of only 2.65%and 1.09%in single-component organic solar cells(SCOSCs).Further studies reveal that PBC12-T exhibits higher crystallinity and improved charge transport,resulting in better *** work provides an approach to construct double-cable conjugated polymers with long alkyl linkers,and it shows the importance of the linker length for the photovoltaic performance of SCOSCs.

关键词： Double-cable conjugated polymer Single-component organic solar cell Crystallinity Semirigid linkers Alkyl-thiophene-alkyl

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Safety,dosimetry,and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors:From preclinical testing to first-in-human study

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Acta Pharmaceutica Sinica B 2025年第2期15卷 707-721页

作者： Wei Guo Xuejun Wen Yuhang Chen Tianzhi Zhao Jia Liu Yucen Tao Hao Fu Hongjian Wang Weizhi Xu Yizhen Pang Liang Zhao Jingxiong Huang Pengfei Xu Zhide Guo Weibing Miao Jingjing Zhang Xiaoyuan Chen Haojun Chen Department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of Radiopharmaceuticalsthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China School of Clinical Medicine Fujian Medical UniversityFuzhou 350005China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 138667Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 138667Singapore Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 138667Singapore Department of Nuclear Medicine the First Affiliated HospitalFujian Medical UniversityFuzhou 350005China Department of Nuclear Medicine National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350212China Fujian Key Laboratory of Precision Medicine for Cancer the First Affiliated HospitalFujian Medical UniversityFuzhou 350005China

Peptide receptor radionuclide therapy(PRRT)with radiolabeled SSTR2 agonists is a treatment option that is highly effective in controlling metastatic and progressive neuroendocrine tumors(NETs).Previous studies have shown that an SSTR2 agonist combined with albumin binding moiety Evans blue(denoted as^(177)Lu-EB-TATE)is characterized by a higher tumor uptake and residence time in preclinical models and in patients with metastatic *** study aimed to enhance the in vivo stability,pharmacokinetics,and pharmacodynamics of^(177)Lu-EB-TATE by replacing the maleimide-thiol group with a polyethylene glycol chain,resulting in a novel EB conjugated SSTR2-targeting radiopharmaceutical,^(177)Lu-LNC1010,for *** preclinical studies,^(177)Lu-LNC1010 exhibited good stability and SSTR2-binding affinity in AR42J tumor cells and enhanced uptake and prolonged retention in AR42J tumor ***,we presented the first-in-human dose escalation study of^(177)Lu-LNC1010 in patients with advanced/metastatic NETs.^(177)Lu-LNC1010 was well-tolerated by all patients,with minor adverse effects,and exhibited significant uptake and prolonged retention in tumor lesions,with higher tumor radiation doses than those of^(177)*** PRRT efficacy results showed an 83%disease control rate and a 42%overall response rate after two^(177)Lu-LNC1010 treatment *** encouraging findings warrant further investigations through multicenter,prospective,and randomized controlled trials.

关键词： Radiolabeled somatostatin analog Neuroendocrine tumor Evans blue ^(177)Lu-LNC1010 Peptide receptor radionuclide therapy First-in-human dose escalation study

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Strongly Confined Atomic Excitation Localization in a Weakly-Driven Atom-Waveguide Interface

arXiv

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arXiv 2024年

作者： Chung, Shao-Hung Chen, Wei Jen, H.H. Institute of Atomic and Molecular Sciences Academia Sinica Taipei10617 Taiwan Department of Physics Center for Quantum Science and Engineering National Taiwan University Taipei10617 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taiwan Physics Division National Center for Theoretical Sciences Taipei10617 Taiwan

An atomic array coupled to a photonic crystal waveguide forms a strongly coupled quantum interface, exhibiting various intriguing collective features of quantum dynamics. Here we consider a homogeneous atomic array and theoretically investigate its steady-state distribution when the incident fields drive the atoms from both sides at asymmetric angles. This effectively creates an interface shared by two zones of atoms under different driving angles. This setup introduces a competition between photon-mediated dipole-dipole interactions and the directionality of coupling, while differences of the travelling phases from the incident angles further influence the overall steady-state behavior. Under this asymmetric driving scheme, the presence of strongly confined localization can be identified, where localization can occur either at the interface or at one of edges. Additionally, we examine the size effect on the atomic localization, deriving an empirical formula to predict parameter regimes that favor interfaced localization. We also consider a defect-driving scheme, where a third zone is created by undriven atoms under symmetric travelling phases. This results in strongly confined single-site excitation localization, which can be explained through analytical solutions under the reciprocal coupling. Finally, we propose several methods for precise control of multiple single-site localizations under the defect-driving scheme. Our results provide insights into driven-dissipative quantum systems with nonreciprocal couplings and pave the way for quantum simulation of exotic many-body states relevant to quantum information applications. Copyright © 2024, The Authors. All rights reserved.

关键词： Photonic crystals

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Nanoparticle-based sustained drug delivery for the treatment of ocular neovascular diseases

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ACTA OPHTHALMOLOGICA 2024年第Sup279期102卷

作者： Durak, Saliha Kutlu, Ozlem Cetinel, Sibel Nanotechnology Research and Application Center (SUNUM) Sabanci University Istanbul Turkey Faculty of Engineering and Natural Sciences Molecular Biology Genetics and Bioengineering Program Sabanci University Istanbul Turkey

Aims/Purpose: Nanoparticles have shown great potential as a drug delivery system for the treatment of neovascular ocular diseases characterized by the growth of abnormal blood vessels in the retina. The current standard of therapy for neovascular ocular diseases involves administering monoclonal antibody-based anti-VEGF drugs via intravitreal injections on a periodic basis. The short half-lives of these drugs necessitate frequent injections, which can limit the effectiveness of the treatments. Hence, there is a need to develop new approaches for enhanced bioavailability and sustained and long-lasting delivery of anti-VEGF drugs. The aim of this study was to utilize poly (glycerol sebacate) (PGS) nanoparticles to achieve an extended release of anti-VEGF (anti-vascular endothelial growth factor) drugs, with the objective of reducing the frequency of intravitreal injections required for treatment. Methods: Double emulsion solvent evaporation method was utilized for the synthesis of PGS nanoparticles. Nanoparticle size and polydispersity index (PDI) were determined with dynamic light scattering method. Results: Nanoparticles were synthesized with a size of approximately 150 nm and PDI less than 0.3. The encapsulation efficiency of nanoparticles loaded with anti-VEGF drugs was found to be 74%. The 30% drug release from nanoparticles in the first 2 months indicates that nanoparticles are a promising candidate for sustained drug release applications. Cell-viability studies showed that anti-VEGF drug-loaded nanoparticles did not exhibit toxicity to ARPE-19 cells, but they did exhibit anti-angiogenesis properties by inhibiting the growth of HUVEC cells in a concentration-dependent manner. Conclusions: The development of new-generation materials for the storage and preservation of anti-VEGF drugs, as well as their enhancement with prolonged release, will considerably improve the efficacy of long-term treatment strategies for ocular neovascular diseases.

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Pt_(1)/Ni_(6)Co_(1)layered double hydroxides/N-doped graphene for electrochemical non-enzymatic glucose sensing by synergistic enhancement of single atoms and doping

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Nano Research 2023年第1期16卷 318-324页

作者： Baojun Long Peiyu Cao Yuanmeng Zhao Qianqian Fu Yan Mo Yueming Zhai Juejing Liu Xingyi Lyu Tao Li Xiaofeng Guo Changsheng Shan Minghua Zeng Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Chemistry and Chemical EngineeringHubei UniversityWuhan 430062China Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China The Institute for Advanced Studies(IAS) Wuhan UniversityWuhan 430072China Material Science and Engineering Program Washington State UniversityPullmanWA 99164USA Department of Chemistry and Alexandra Navrotsky Institute for Experimental Thermodynamics Washington State UniversityPullmanWA 99164USA X-ray Science Division Argonne National LaboratoryArgonneIL 60439USA Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA

The development of novel single-atom catalysts is important for highly efficient electrochemical catalysis and *** this work,a novel Pt single atoms(SAs)supported on Ni_(6)Co_(1)layered double hydroxides/nitrogen-doped graphene(Pt_(1)/Ni_(6)Co_(1)LDHs/NG)was constructed for electrochemical enzyme-free catalysis and sensing towards *** loading of Pt single atoms increases with doping of Co atoms that generate more anchoring sites for Pt *** resulting Pt_(1)/Ni_(6)Co_(1)LDHs/NG exhibits low oxidative potential of 0.440 V with high sensitivity of 273.78μA·mM^(−1)·cm^(−2)toward glucose,which are 85 mV lower and 15 times higher than those of Ni(OH)_(2),***_(1)/Ni_(6)Co_(1)LDHs/NG also shows excellent selectivity and great stability during 5-week *** and experimental results show that the boosted performance of Pt_(1)/Ni_(6)Co_(1)LDHs/NG originates from its stronger binding energy with glucose and the synergistic effect of Pt SAs,Co doping,and *** work provides a general strategy of designing highly active SACs for extending their application in electrochemical sensing.

关键词： single-atom catalysts electrochemical sensor layered double hydroxides nitrogen-doped graphene synergistic effect

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Targeting multiple signaling pathways:the new approach to acute myeloid leukemia therapy

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Signal Transduction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna LCarter Katie Hege Jay Yang Hasini AKalpage Yongwei Su Holly Edwards Maik Hüttemann Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering Laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Division of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AML)is the most common form of acute leukemia in adults and the second most common form of acute leukemia in *** this,very little improvement in survival rates has been achieved over the past few *** is partially due to the heterogeneity of AML and the need for more targeted therapeutics than the traditional cytotoxic chemotherapies that have been a mainstay in therapy for the past 50 *** the past 20 years,research has been diversifying the approach to treating AML by investigating molecular pathways uniquely relevant to AML cell proliferation and *** we review the development of novel therapeutics in targeting apoptosis,receptor tyrosine kinase(RTK)signaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has been an impressive effort into better understanding the diversity of AML cell characteristics and here we highlight important preclinical studies that have supported therapeutic development and continue to promote new ways to target AML *** addition,we describe clinical investigations that have led to FDA approval of new targeted AML therapies and ongoing clinical trials of novel therapies targeting AML survival *** also describe the complexity of targeting leukemia stem cells(LSCs)as an approach to addressing relapse and remission in AML and targetable pathways that are unique to LSC *** comprehensive review details what we currently understand about the signaling pathways that support AML cell survival and the exceptional ways in which we disrupt them.

关键词： myeloid approach approval

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