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Study of Novel Photodetectors and Electronics to Enhance Coincidence Time Resolution of BGO-based PET Detectors

Study of Novel Photodetectors and Electronics to Enhance Coi...

2022 IEEE Nuclear Science Symposium, Medical Imaging Conference, and Room Temperature Semiconductor Detector Conference, IEEE NSS MIC RTSD 2022

作者： Gonzalez-Montoro, Andrea Pourashraf, Shirin Cates, Joshua W Levin, Craig S Stanford University Department of Radiology StanfordCA94305 United States Lawrence Berkeley National Laboratory Applied Nuclear Physics Program BerkeleyCA94720 United States Stanford University Departments of Radiology Molecular Imaging Program Bioengineering Physics and Electrical Engineering CA94305 United States

ISBN: (纸本)9781665488723

Developing high sensitivity multiparametric medical imaging tools constitutes one of the main research topics in radionuclide *** time-of-flight positron emission tomography (TOF-PET) scanners have shown potential in this context. One of the most attractive solutions that have been proposed to improve the coincidence time resolution (CTR) of TOF-PET scanners includes exploiting the small population of promptly emitted light photons (i.e., Cherenkov photons). Bismuth germanate (BGO) is a legacy detection material for PET which exhibits a moderate Cherenkov yield. which new advancements in ultra-violet (UV) light sensitive photosensor technologies and associated detection techniques can exploit for fast timing. It has been demonstrated that exploiting the BGO-Cherenkov component may simultaneously facilitate high 511 keV photon detection sensitivity with excellent CTR, thus enabling high sensitivity, low cost TOF-PET systems. Accessing the timing information from these Cherenkov photons requires enhanced photodetector technology combined with low noise and fast readout electronics, as well as specific data post-processing *** this summary, we report the CTR evaluation of different length BGO crystals coupled to UV enhanced SiPMs and custom designed electronics. Average CTR values of 156 ± 6, 188 ± 5, 228 ± 8 and 297 ± 8 ps CTR FWHM have been achieved for 3 × 3 × 3, × 5, × 10, and × 15 mm3 BGO crystal with chemically processed surface finishes. © 2022 IEEE.

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Rational effect of CuSe2phase with octadecyl amine modified reduced graphene composite for dual-mode sensing of environmental hazardous anthelminthic drug in aquatic and biological samples

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Journal of Environmental Chemical engineering 2023年第1期11卷

作者： Hwa, Kuo-Yuan Ganguly, Anindita Santhan, Aravindan Department of Molecular Science and Engineering National Taipei University of Technology Taipei Taiwan International Graduate Program in Energy and Optoelectronic Materials National Taipei University of Technology Taipei Taiwan

The increasing usage of antihelminthic drug mebendazole (MEB) in humans and livestock poses serious threat and is considered a significant environmental pollutant. Hence, monitoring the MEB residues in environmental samples, and human fluids is essential to decrease the ecological risk and improve the health of humans. In this work, copper selenide (CuSe2) nano/microspheres were hydrothermally synthesized and ultrasonically treated with rGO surface modified with ODA alkyl amine (rGO-ODA). The optical, structural, morphological, and functional analysis were performed which revealed the CuSe2 in marcasite phase, orthorhombic pattern with Pnnm space group, and substantial composite formation. The morphological studies revealed sphere structure of the CuSe2 and wrinkled sheets of rGO-ODA. A sensor that detects MEB using the cyclic voltammetry (CV), differential pulse voltammetry (DPV) and UV-Vis absorbance techniques was developed. For DPV analysis, the sensor exhibited a very low value for limit of detection 13.55 nM and a sensitivity of 9.4871 μA M-1cm-2. For UV-Vis, the sensor demonstrated a very low limit of detection 22.3 nM. The use of this sensor was validated in real-time analysis with aquatic and biological real samples. The results suggested > 90% of analyte recovery and enhanced efficiency for MEB detection with a potential for commercialization in future. © 2022 Elsevier Ltd.

关键词： Copper compounds

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PFAS compounds PFOA and Gen X are teratogenic to sea urchin embryos

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Developmental Biology 2025年 525卷 139-154页

作者： Lion, Alexandra T. Bodine, Sophie M. McCutcheon, Kelley R. Ghogale, Mayank Chandragiri, Santhan Abayawardena, Deema Shrestha, Bikram D. Descoteaux, Abigail Alvarez, Kathryn Balkman, J'nesse A. Cocke, Breelyn Wikramanayake, Athula H. Schlezinger, Jennifer Wong, Joyce Y. Prakash, Vivek N. Bradham, Cynthia A. Molecular Biology Cell Biology and Biochemistry Program Boston University Boston MA United States Biology Department Boston University Boston MA United States Bioinformatics Program Boston University Boston MA United States Department of Physics University of Miami Coral Gables FL United States Department of Biology University of Miami Coral Gables FL United States Biological Design Center College of Engineering Boston University Boston MA United States Environmental Health Boston University Boston MA United States Department of Biomedical Engineering Boston University Boston MA United States Department of Marine Biology and Ecology University of Miami Miami FL United States

Per-and polyfluorinated substances (PFAS) are synthetic compounds used in the production of fluoropolymer coatings found in products such as non-stick pans, clothing, cosmetics, and food packaging. These highly persistent molecules are known as “forever chemicals” since they neither degrade environmentally nor break down enzymatically within biological systems. PFAS compounds readily contaminate water sources, and as a result, certain PFAS molecules have bioaccumulated in exposed species including humans. The purpose of this study was to define the effect of two PFAS molecules, the ostensibly more toxic perfluorooctanoic acid (PFOA) and the more recent, reportedly safer chemical hexafluoropropylene oxide dimer acid (Gen X), on the development of Lytechinus variegatus sea urchin embryos. We examined the effects of PFOA and Gen X on development and patterning using morphological analysis, immunostaining, HCR-FISH, and Particle Image Velocimetry (PIV). The results show that both PFAS compounds are teratogenic to sea urchin embryos. PFOA and Gen X each function at different intervals during development and provoke distinct phenotypic and gene expression outcomes. Despite beliefs that Gen X would be a safer alternative, our findings indicate that Gen X has earlier and more severe effects on endomesoderm and dorsal-ventral axis specification, neural development and function, and pattern formation compared to PFOA. These results illustrate the dangerous teratogenic potential of environmentally accumulating PFAS like Gen X, underscoring the negative ecological implications that accompany continuing commercial and industrial use of PFAS in the absence of remediation strategies. © 2025 Elsevier Inc.

关键词： Cilia Gen X Neural PFOA Teratogen

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Electronic Readout for a 100 ps CTR PET Detector with 24:1 Multiplexing Ratio of Timing Channels

Electronic Readout for a 100 ps CTR PET Detector with 24:1 M...

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2022 IEEE Nuclear Science Symposium, Medical Imaging Conference, and Room Temperature Semiconductor Detector Conference, IEEE NSS MIC RTSD 2022

作者： Pourashraf, Shirin Gonzalez-Montoro, Andrea Innes, Derek Cates, Joshua W. Levin, Craig S. Stanford University Department of Radiology StanfordCA94305 United States Lawrence Berkeley National Laboratory Applied Nuclear Physics Program BerkeleyCA94720 United States Stanford University Molecular Imaging Program Departments of Radiology Bioengineering Physics and Electrical Engineering StanfordCA94305 United States

ISBN: (纸本)9781665488723

We have designed a novel electronic readout with 24:1 multiplexing ratio of the timing channels that achieves 100 ps coincidence time resolution. The detector layer units comprise 2×4 arrays of 3×3×10 mm3 "LGSO"crystals side-coupled to 6×4 arrays of 3×3 mm2 SiPMs. To achieve low power dissipation and scalability of this readout design, its effective area is implemented in only 13.3 mm using compact and power efficient electronic components. The measured CTR of the 24:1 multiplexed timing channels (or 8:1 LVDS signals) was 107.0 ± 3.6 ps FWHM using a22Na point-source and a very low timing jitter FPGA-based TDC. © 2022 IEEE.

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Novel Circuit Design for a 3D Position Sensitive Scintillation TOF-PET Detector that Achieves ~100 ps CTR

Novel Circuit Design for a 3D Position Sensitive Scintillati...

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2022 IEEE Nuclear Science Symposium, Medical Imaging Conference, and Room Temperature Semiconductor Detector Conference, IEEE NSS MIC RTSD 2022

作者： Pourashraf, Shirin Zhao, Zhixiang Innes, Derek Gonzalez-Montoro, Andrea Cates, Joshua W. Levin, Craig S. Stanford University Department of Radiology StanfordCA94305 United States Lawrence Berkeley National Laboratory Applied Nuclear Physics Program BerkeleyCA94720 United States Stanford University Molecular Imaging Program Departments of Radiology Bioengineering Physics and Electrical Engineering StanfordCA94305 United States The School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China

ISBN: (纸本)9781665488723

We have built a scalable mixed-signal readout circuit for a 3D position sensitive PET detector that achieves ~100 ps FWHM CTR. For this work we used individual 3×3×3 mm3 and 3×3×10 mm3 LGSO crystals, as well as 2×4 arrays of 3×3×10 mm3 crystals side-coupled to arrays of 3.16×3.16 mm2 SiPMs. The preliminary results verify that the CPLD is able to resolve 3D interaction positions along the array with © 2022 IEEE.

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Topographical variations influence mesenchymal stem cell-derived extracellular vesicles and paracrine factors for chondrocyte chondrogenesis

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Osteoarthritis and Cartilage 2025年第6期33卷 796-797页

作者： Christopher J. Chong Justin Koh Vinitha Denslin Yingnan Wu Zheng Yang Biochemistry and Chemistry La Trobe Institute for Molecular Science Bundoora Victoria Australia Life Sciences Institute National University of Singapore NUS Tissue Engineering Program Singapore Singapore Department of Orthopaedic Surgery National University of Singapore Singapore Singapore

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Elevated temperature-driven coordinative reconstruction of an unsaturated single-Ni-atom structure with low valency on a polymer-derived matrix for the electrolytic oxygen evolution reaction

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Nanoscale 2024年第15期16卷 7467-7479页

作者： Patil, Rahul Rajput, Anubha Matsagar, Babasaheb M. Chen, Norman C. R. Ujihara, Masaki Salunkhe, Rahul R. Yadav, Praveen Wu, Kevin C.-W. Chakraborty, Biswarup Dutta, Saikat Electrochemical Energy & Sensor Research Laboratory Amity Institute of Click Chemistry Research & Studies Amity University Noida India Department of Chemistry Indian Institute of Technology New Delhi India Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taiwan National Taiwan University Taiwan Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei Taiwan Materials Research Laboratory Department of Physics Indian Institute of Technology Jammu India Synchrotron X-ray Facility Raja Ramanna Centre for Advanced Technology Rajendra Nagar Madhya Pradesh 452013 Indore India

A high-temperature pyrolysis-controlled coordination reconstruction resulted in a single-Ni-atom structure with a Ni-Nx-C structural unit (x = N atom coordinated to Ni). Pyrolysis of Ni-phen@ZIF-8-RF at 700 °C resulted in NiNP-NC-700 with predominantly Ni nanoparticles. Upon elevating the pyrolysis temperature from 700 to 900 °C, a coordination reconstruction offers Ni-Nx atomic sites in NiSA-NC-900. A combined investigation with X-ray absorption spectroscopy, X-ray photoelectron spectroscopy, and soft X-ray L3-edge spectroscopy suggests the stabilization of low-valent Niδ+ (0 −2 was achieved. The cell potential recorded with Pt(−)/(+)NiSA-NC-900/NF was much lower than that obtained for other cells, i.e., Pt(−)/NF and NF(−)/(+)NF, which enhances the potentials of low-valent NiSAs for insightful understanding of the OER. At a constant applied potential of 1.61 V (vs. RHE) for 12 h, an small increase in current for initial 0.6 h followed by a constant current depicts the fair stability of catalyst for 12 h. Our results offer an insightful angle into the OER with a coordinatively reconstructed single-Ni-atom structure at lower valency ( © 2024 The Royal Society of Chemistry.

关键词： Reaction kinetics

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Resolving p53 to Create Clinically-Relevant Mutation Models

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 1087-1090页

作者： Solares, Maria J. Jonaid, G.M. Kelly, Deborah F. Molecular Cellular Integrative Biosciences Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States Department of Biomedical Engineering Pennsylvania State University University Park PA United States Center for Structural Oncology Pennsylvania State University University Park PA United States Bioinformatics and Genomics Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States

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Polarization-driven dynamic laser speckle analysis for characterizing breast cancer cells 36

Polarization-driven dynamic laser speckle analysis for chara...

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Optical Interactions with Tissue and Cells XXXVI 2025

作者： Abbasian, Vahid Rad, Vahideh Farzam Ahmadvand, Davoud Darafsheh, Arash Department of Radiation Oncology Washington University School of Medicine in St. Louis St. LouisMO63110 United States Imaging Science Program McKelvey School of Engineering Washington University in St. Louis St. LouisMO63130 United States Department of Molecular Imaging Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences Tehran Iran

ISBN: (纸本)9781510683822

The study of breast cancer cells is essential to advance our knowledge of tumor biology and therapeutic strategies. Optical techniques, particularly polarimetric imaging, have significantly enhanced our understanding of cancer cells, but conventional methods face challenges in capturing and interpreting polarization characteristics. Coherent light sources offer high-contrast imaging but introduce speckle noise, while incoherent sources reduce noise but lack contrast and polarization distinction. To address these issues, we integrated polarimetric imaging with dynamic laser speckle analysis (DLSA), a method that extracts information from intensity variations in the speckle pattern. The polarization-driven DLSA maintains laser advantages while transforming challenges into opportunities. This approach involves capturing a series of intensity images under different polarization modulations and then analyzing sequence-based variations in the resultant speckle pattern across the polarimetric images. In this study, we extend the approach to the microscopy domain and apply it to MCF7 breast cancer cell samples, showing the potential of this novel technique as a robust and label-free diagnostic tool. © 2025 SPIE.

关键词： Laser beams

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Myocardial transcriptomic and proteomic landscapes across the menopausal continuum in a murine model of chemically induced accelerated ovarian failure

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Physiological Genomics 2025年第7期57卷 409-430页

作者： Lopez-Pier, Marissa A. Marino, Vito A. Vazquez-Loreto, Andrea C. Skaria, Rinku S. Cannon, Danielle K. Hoyer-Kimura, Christina H. Solomon, Alice E. Lipovka, Yulia Doubleday, Kevin Pier, Maricela Chu, Meinsung Mayfield, Rachel Behunin, Samantha M. Hu, Tianjing Langlais, Paul R. McKinsey, Timothy A. Konhilas, John P. Department of Physiology University of Arizona Tucson AZ United States Sarver Molecular Cardiovascular Research Program University of Arizona Tucson AZ United States Department of Biomedical Engineering University of Arizona Tucson AZ United States Department of Endocrinology University of Arizona Tucson AZ United States College of Medicine University of Arizona Tucson AZ United States Department of Cellular and Molecular Medicine University of Arizona Tucson AZ United States Department of Chemistry-Biology University of Sonora Hermosillo Mexico Division of Cardiology and Consortium for Fibrosis Research & Translation Department of Medicine University of Colorado Anschutz Medical Campus Aurora CO United States

Risk of cardiovascular disease (CVD) in women increases with the menopausal transition. Using a chemical model (4-vinylcyclohexene diepoxide;VCD) of accelerated ovarian failure, we previously demonstrated that menopausal females are more susceptible to CVD compared with peri-or premenopausal females like humans. Yet, the cellular and molecular mechanisms underlying this shift in CVD susceptibility across the pre-to peri-to menopause continuum remain understudied. In this work using the VCD mouse model, we phenotyped cellular and molecular signatures from hearts at each hormonally distinct stage that included transcriptomic, proteomic, and cell biological analyses. The transcriptional profile of premenopausal hearts clustered separately from perimenopausal and menopausal hearts, which clustered more similarly. Proteomics also revealed hormonal clustering;perimenopausal hearts grouped more closely with premenopausal than menopausal hearts. Both proteomes and transcriptomes showed similar trends in genes associated with atherothrombosis, contractility, and impaired nuclear signaling between pre-, peri-, and menopausal murine hearts. Further analysis of posttranslational modifications (PTMs) showed hormone-dependent shifts in the phosphoproteome and acetylome. To further interro-gate these findings, we triggered pathological remodeling using angiotensin II (Ang II). Phosphorylation of AMP-activated protein kinase (AMPK) signaling and histone deacetylase (HDAC) activity were found to be dependent on hormonal status and Ang II stimulation. Finally, knockdown of anti-inflammatory regulatory T cells (Treg) exacerbated Ang II-dependent fibrosis implicating HDAC-mediated epi-genetic suppression of Treg activity. Taken together, we demonstrated unique cellular and molecular profiles underlying the cardiac phenotype of pre-, peri-, and menopausal mice supporting the necessity to study CVD in females across the hormonal transition. NEW & NOTEWORTHY Cycling and perimenopausal fem

关键词： 4-vinylcyclohexenediepoxide AMP-activated protein kinase heart disease menopause proteomics

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