检索结果-内蒙古大学图书馆

Phage Display–Selected Peptides: Research and Clinical Applications in Cancer Imaging

Journal of Peptide Science 2025年第7期31卷 e70034页

作者： Cimen, Atike Nur Porsuk, Melis Hazal Kutlu, Ozlem Cetinel, Sibel Sabanci University Nanotechnology Research and Application Center (SUNUM) Istanbul Turkey Molecular Biology Genetics and Bioengineering Program Faculty of Engineering and Natural Sciences Sabanci University Istanbul Turkey

Phage display has emerged as a groundbreaking technique for discovering novel biomolecules with significant applications in cancer diagnosis and therapy. This technique employs genetically engineered bacteriophages to display diverse libraries of peptides on their coat proteins, enabling the identification of candidates through a biopanning process targeting specific cancer markers. Biomolecules identified via phage display are widely used as molecular tools, often labeled with imaging agents or conjugated to nanoparticles for noninvasive tumor imaging. This review provides a comprehensive overview of recent advancements in phage display applications in cancer research over the past 5 years and prominent examples of clinical studies. The analysis underscores the potential of phage display to deliver diagnostic and therapeutic biomolecules, highlighting its promise for future clinical implementation in cancer imaging. © 2025 European Peptide Society and John Wiley & Sons Ltd.

关键词： cancer imaging peptide phage display

来源：评论

学校读者我要写书评

暂无评论

Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

引用

National Science Review 2024年第1期11卷 94-106页

作者： Yuqing Sun Haixin Yu Shaoqing Han Ruoxi Ran Ying Yang Yongling Tang Yuhao Wang Wenhao Zhang Heng Tang Boqiao Fu Boshi Fu Xiaocheng Weng Song-Mei Liu Hexiang Deng Shuang Peng Xiang Zhou College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers-Ministry of Education Wuhan University Department of Digestive Surgical Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Clinical Laboratory Center for Gene Diagnosis and Program of Clinical Laboratory Zhongnan Hospital of Wuhan University College of Chemistry and Materials Science Hubei Engineering University Department of Pharmacology School of Pharmacy China Medical University Taikang Center for Life and Medical Sciences Wuhan University Department of Hematology Zhongnan Hospital of Wuhan University

Cell-free RNA(cf RNA) allows assessment of health, status, and phenotype of a variety of human organs and is a potential biomarker to non-invasively diagnose numerous diseases. Nevertheless, there is a lack of highly efficient and bias-free cf RNA isolation technologies due to the low abundance and instability of cf ***, we developed a reproducible and high-efficiency isolation technology for different types of cell-free nucleic acids(containing cf RNA and viral RNA) in serum/plasma based on the inclusion of nucleic acids by metal-organic framework(MOF) materials, which greatly improved the isolation efficiency and was able to preserve RNA integrity compared with the most widely used research kit method. Importantly, the quality of cf RNA extracted by the MOF method is about 10-fold that of the kit method, and the MOF method isolates more than three times as many different RNA types as the kit method. The whole transcriptome mapping characteristics of cf RNA in serum from patients with liver cancer was described and a cf RNA signature with six cf RNAs was identified to diagnose liver cancer with high diagnostic efficiency(area under curve = 0.905 in the independent validation cohort) using this MOF method. Thus, this new MOF isolation technique will advance the field of liquid biopsy, with the potential to diagnose liver cancer.

关键词： MOF circulating cell-free RNA biomarker liver cancer diagnosis

来源：评论

学校读者我要写书评

暂无评论

Camera-based Motion Correction for PET/MR Brain Imaging

Camera-based Motion Correction for PET/MR Brain Imaging

引用

2022 IEEE Nuclear Science Symposium, Medical Imaging Conference, and Room Temperature Semiconductor Detector Conference, IEEE NSS MIC RTSD 2022

作者： Fisher, Jonathan Groll, Andrew Kim, Chris C. Innes, Derek Levin, Craig S. Stanford University Department of Electrical Engineering CA United States Molecular Imaging Program Stanford University Department of Radiology CA United States Stanford University Department of Computer Science CA United States Stanford University Physics Electrical Engineering and Bioengineering Department of Radiology CA United States

ISBN: (纸本)9781665488723

In this work, we evaluated the performance of a camera-based rigid body motion correction solution in PET studies. We compared the image quality obtained by reconstructing a static phantom scan to those obtained by reconstructing a moving phantom scan with and without applying motion correction. Our suggested solution uses a camera to track a 3D marker attached to the object to be imaged (in this work, a resolution phantom). This data was incorporated in the multiple acquisition frames (MAF) image reconstruction algorithm to compensate for motion. While we got multiple spatially shifted replicas of the resolution phantom in the motion study's reconstructed image when motion correction was not applied, the motion-corrected image was comparable to the static image, with some degradation in spatial resolution (3.2-4.2 vs. 2.8-3.2 mm) and lower peak to valley ratio (indicating lower contrast to noise ratio). The context of the results presented is in PET/MR imaging, but in principle, this motion compensation method could be used in any type of medical imaging modality. © 2022 IEEE.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Dynamic changes of fatty acids and (R)-dichlorprop toxicity in Arabidopsis thaliana: correlation, mechanism, and implications

引用

Environmental Science and Pollution Research 2024年第43期31卷 55522-55534页

作者： Li, Jun Zhang, Qiushui Chen, Hui Xu, Dongmei Chen, Zunwei Wen, Yuezhong MOE Key Laboratory of Environmental Remediation & amp Ecosystem Health College of Environmental and Resource Sciences Zhejiang University Hangzhou310058 China College of Science and Technology Ningbo University Ningbo315211 China Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province College of Biological and Environmental Engineering Zhejiang Shuren University Hangzhou310015 China Program in Molecular and Integrative Physiological Sciences Department of Environmental Health Harvard University T.H. Chan School of Public Health BostonMA02115 United States

Plant fatty acids (FAs) are critical components of lipids and play an important role in coping with pollution-induced stress. However, the relationship between the fluctuating changes of FAs and the toxic effects of pollutants is not clear. Here, we analyzed and identified 19 FAs, namely 14 medium and long chain fatty acids (MLCFAs) and 5 very long chain fatty acids (VLCFAs). First, a positive correlation between plant biomass and LCFA content was observed. Changes in unsaturation were inversely related to cell membrane permeability, which serves as an indicator of the toxic effects. In particular, the use of herbicides led to a reduction in total FA content, but caused a significant increase in free fatty acids (FFAs), which facilitate oxidative stress. In addition, supplementation with exogenous FAs, particularly linoleic and alpha-linolenic acids, effectively alleviated the toxic inhibition. (R)-dichlorprop causes abnormal FA metabolism that can be reversed by ferrostatin-1, a ferroptosis inhibitor. Under (R)-dichlorprop exposure, the balance of FA unsaturation in plants is disrupted by inhibition of FA desaturase activity, ultimately leading to ferroptosis and disruption of cell membrane integrity. This study aims to enhance the understanding of the ecotoxic effects of herbicides by examining changes in FAs. The findings will provide a scientific basis for controlling environmental risks associated with hazardous substances. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Cell membranes

来源：评论

学校读者我要写书评

暂无评论

Maximum Likelihood Estimation for LOR Identification of Positron + Prompt Gamma Ray Emitters in Multiplexed PET (mPET)

Maximum Likelihood Estimation for LOR Identification of Posi...

引用

IEEE Symposium on Nuclear Science (NSS/MIC)

作者： S. J. Zou G. Chinn C. S. Levin Electrical Engineering Stanford University Stanford California United States of America Stanford University Radiology Stanford California United States of America Electrical Engineering Bioengineering Physics Molecular Imaging Program Stanford University Radiology Stanford California United States of America

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

For many diseases applications, it is beneficial to simultaneously observe multiple biomarkers at a time. However, current PET systems are unable to image multiple tracers in one session due to annihilation photons being indistinguishable across radiotracers. However with the utilization of one or more positron emitting radionuclides that also emit a prompt gamma (positron + prompt gamma ray emitter), the latter signal can be used to unmix the tracer signals and facilitate multiplex PET or mPET. With the use of prompt-gamma-positron emitters, an issue arises with the correct identification of the two annihilation photons in a triple photon coincidence. In this work, we present a maximum likelihood estimation (MLE) framework that uses spatial, timing, and energy information to return the most probable line of response (LOR). We validate our method using simulated data. Results indicate we can achieve > 99% accuracy at identifying the correct LOR for a 22 Na source.

关键词： Multiplexing Maximum likelihood estimation Microwave integrated circuits Semiconductor detectors Gamma-rays Positrons Timing

来源：评论

学校读者我要写书评

暂无评论

Motion Correction for Cardiac PET via Parametric Image Optical Flow

Motion Correction for Cardiac PET via Parametric Image Optic...

引用

IEEE Symposium on Nuclear Science (NSS/MIC)

作者： S. J. Zou G. Chinn C. S. Levin Electrical Engineering Stanford University Stanford California United States of America Radiology Stanford University Stanford California United States of America Radiology Electrical Engineering Bioengineering Physics Molecular Imaging Program Stanford University Stanford California United States of America

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

Motion correction (MC) is crucial in cardiac positron emission tomography (PET) to mitigate artifacts caused by cardiac, respiratory, and body motion. Motion correction not only improves image quality also leads to accurate quantification of cardiac health. In this study, we explore the effectiveness of optical flow based motion correction for gated cardiac PET. We present a novel method of joint estimation and denoising of parametric *** also present preliminary results of parametric image based optical flow MC, a novel MC method. By jointly denoising and estimating parametric images we see a $\lt4 \mathrm{~dB}$ increase in PSNR for Patlak $K$ image compared to no denoising and see at least a 1 dB PSNR gain with our MC method over all noise scenarios.

关键词： Image quality Microwave integrated circuits Semiconductor detectors Noise reduction Noise Estimation Logic gates

来源：评论

学校读者我要写书评

暂无评论

Bacterial Mobility and Motility in Porous Media Mimicked By Microspheres

SSRN

引用

SSRN 2022年

作者： Shrestha, Diksha Ou, Jun Rogers, Ariel Jereb, Amani Wang, Yong Department of Physics Cell and Molecular Graduate Program Materials Science and Engineering Program University of Arkansas FayettevilleAR72701 United States Department of Environmental Resources Engineering Mechanical Engineering Program California State Polytechnic University Humboldt ArcataCA95521 United States

Bacterial motion in porous media are essential for their survival, proper functioning, and variousapplications. Here we investigated the motion of Escherichia coli bacteria in microsphere-mimicked porousmedia. We observed reduced bacterial velocity and enhanced directional changes of bacteria as the densityof microspheres increased, while such changes happened mostly around the microspheres and due to thecollisions with the microspheres. More importantly, we established and quantified the correlation betweenthe bacterial trapping in porous media and the geometric confinement imposed by the microspheres. In addition,numerical simulations showed that the active Brownian motion model in the presence of microspheresresulted in bacterial motion that are consistent with the experimental observations. Our study suggested thatit is important to distinguish the ability of bacteria to move easily – bacterial mobility – from the abilityof bacteria to move independently – bacteria motility. Our results showed that bacterial motility remainssimilar in porous media, but bacterial mobility was significantly affected by the pore-scale confinement. © 2022, The Authors. All rights reserved.

关键词： Microspheres

来源：评论

学校读者我要写书评

暂无评论

Efficient synthesis method of CsPbBr3/Al2O3 composite powders for scalable production: Augmented green emission and thermal stability

引用

Journal of Industrial and engineering Chemistry 2025年

作者： Kim, Seok-Hun Shin, Weon Ho Oh, Jong-Min Kim, Sang-Wook Kim, Sunghoon Center for Brain Busan 21 Plus Program Dong-Eui University Busan47340 Korea Republic of Department of Electronic Materials Engineering Kwangwoon University Seoul01897 Korea Republic of Department of Molecular Science and Technology Ajou University Suwon16499 Korea Republic of

Metal halide perovskites (MHPs) have gained significant attention for their exceptional optoelectronic properties, particularly in displays. However, their practical utility is severely limited by their intrinsic instability, including poor thermal stability, photostability, and susceptibility to moisture-induced degradation. This study introduces scalable synthesis of CsPbBr3/Al2O3 green-emitting phosphors, using submicron Al2O3 as a support, comparing mechanochemical reaction (MRM) and dissolution-evaporation (DEM) methods. DEM is the optimal route, enabling the formation of monoclinic CsPbBr3/Al2O3 with high photoluminescence quantum yield (PLQY) and enhanced stability. The influence of the CsPbBr3 to Al2O3 mass ratio on PLQY was quantitatively analyzed using the Halder-Wagner method, which indirectly calculated crystallite size and its correlation with PLQY. The composite demonstrated exceptional thermal stability, maintaining over 90 % of its initial PL intensity after 200 °C exposure for 15 days and showed excellent photostability, maintaining nearly its initial luminous efficiency under the currents of 20 mA and 70 mA for 10000-seconds. When integrated as a green phosphor in a white LED package with K2SiF6:Mn+4 as a red phosphor, it achieved a luminous efficiency of 25 lm W−1 and a color gamut of 112.4 % NTSC. These results highlight the potential of CsPbBr3/Al2O3 composites for cost-effective, stable, and high-performance optoelectronic applications. © 2025 The Korean Society of Industrial and engineering Chemistry

关键词： Perovskite

来源：评论

学校读者我要写书评

暂无评论

PET-derived bis(2-hydroxyethyl) terephthalate as a new linker source for solvent-free and hydrothermal synthesis of BDC-based MOFs

引用

Materials Today Nano 2024年 25卷

作者： Krisbiantoro, Philip Anggo Kuo, Tzu-Jung Chang, Yu-Chia Liao, Weisheng Sun, Jih-Peng Yang, Chun-Yen Kamiya, Yuichi Shieh, Fa-Kuen Chen, Chia-Chin Wu, Kevin C.-W Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei11529 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Faculty of Environmental Earth Science Hokkaido University Nishi 5 Kita 10 Kita-ku Sapporo060-0810 Japan Department of Chemistry National Central University Taoyuan32001 Taiwan Center of Atomic Initiative for New Materials National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taoyuan Taiwan

To date, the high cost of organic linkers and the energy-consuming synthesis processes remain two of the main challenges for the commercialization of metal-organic frameworks (MOFs). Herein, we demonstrate that polyethylene terephthalate (PET)-derived bis(2-hydroxyethyl) terephthalate (BHET) is a new linker source that enables the facile solvent-free and hydrothermal synthesis of BDC-based MOFs. Using BHET as a linker source, UiO-66(Zr) was rapidly synthesized via a solvent-free "grind and bake" technique, while Ca-BDC and Ba-BDC were easily obtained by using hydrothermal synthesis. We found that the hydrolysis of BHET to terephthalate anion (BDC2−) over proton produced from the hydrolysis/clustering of Zr precursor and hydroxyl anion produced from the dissolution of M(OH)2 (M = Ca or Ba) was the key to the crystal growth of solvent-free synthesized UiO-66(Zr) and hydrothermally synthesized M-BDC (M = Ca or Ba), respectively. While the as-synthesized UiO-66(Zr) was highly active for the esterification of lactic acid (LA) with ethanol (EtOH), Ca-BDC and Ba-BDC exhibited remarkable electrochemical performance for lithium storage. Our strategy provides a major step towards realizing the idea of a more facile, green, and low-cost synthesis of PET-derived MOFs compared to prior arts applicable for catalysis and energy applications. © 2024

关键词： Lithium-ion batteries

来源：评论

学校读者我要写书评

暂无评论

Metagenomics vs metaproteomics: A review of their application on anaerobic digestion in biogas generation

引用

Bioresource Technology Reports 2023年 24卷

作者： Lam, Tze-Kang Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan Institute of Biological Chemistry Academia Sinica Taipei Taiwan Chemical Biology and Molecular Biophysics Program Taiwan International Graduate Program Academia Sinica Taipei Taiwan Department of Chemistry National Taiwan University Taipei Taiwan

Understanding the workings of anaerobic digestion in the production of biogas from carbon waste has been an issue for many scientists. Recently, advancement in techniques finally paved the way in providing a solution for these issues. Metagenomics which aimed in the understanding on the microbial community was initially developed;continual interest had led to the development of metaproteomics which could identify the functional roles of the microorganisms. For biogas production, anaerobic digestion can also be viewed as a series of well-known biochemistry metabolic pathways accomplished by various syntrophic and competitive interactions within each specific microbial community. With the increasing knowledge in application of metagenomics and metaproteomics techniques, biochemist and engineers are able to effective adopt their unique specialized tools and means in achieving the objectives of their research. Successful integration will lead to more useful adoption of the fields leading to increase biogas quality and quantity. © 2023

关键词： Anaerobic digestion

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：