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Modifying BiVO4 as a photocatalyst for water oxidation using constant-duration alkaline-etched post treatments

New Journal of Chemistry 2023年第2期48卷 569-577页

作者： Hsu, Chuan-Chih Chuang, Kai-Jie Huang, Hsiao-Wen Pan, Bo-Jin Chen, Hung-Ming Husain, Sadang Yougbaré, Sibidou Hsiao, Yu-Cheng Wu, Yung-Fu Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Gingen Technology Co. Ltd. Rm. 7 10F. No. 189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia /Nanoro Ouagadougou03 Burkina Faso International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan

BiVO4 with suitable band edges and a small band gap is considered an efficient photocatalyst for the oxygen evolution reaction (OER), but short charge-transfer lengths limit its photocatalytic ability. Increasing active sites can essentially enhance oxidation reactions and photocatalytic ability. The alkaline etching technique can refine the surface properties of BiVO4 by introducing oxygen vacancies and possibly establishing a heterojunction, but suitable alkaline etching methods are rarely discussed. In this study, three alkaline etching methods, including hydrothermal, soaking, and electrodeposition processes, are first applied for a constant duration to tailor the surface properties of BiVO4 as a photocatalyst for the OER. Alkaline-etched BiVO4 prepared using hydrothermal and soaking processes shows better photocatalytic abilities due to the generation of additional oxygen vacancies, while poor photocatalytic ability is found for that fabricated using electrodeposition due to the formation of less photocatalytic VO2. The highest photocurrent density of 2.38 mA cm−2 is obtained at 1.23 V versus a reversible hydrogen electrode in an electrolyte without a hole scavenger for the BiVO4 etched in the hydrothermal process, while the untreated BiVO4 presents a photocurrent density of 0.58 mA cm−2. A photocurrent retention of 92.3% is achieved after 5000 seconds of continuous illumination. The study supplies blueprints for establishing effective alkaline etching methods for enhancing the photocatalytic ability of BiVO4, with the exception of time costs. © 2024 The Royal Society of Chemistry.

关键词： Charge transfer

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Freeze-dried jaboticaba(Myrciaria jaboticaba)peel powder,a rich source of anthocyanins and phenolic acids,mitigates inflammation-driven colorectal cancer in mice

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Food Bioscience 2023年第3期53卷 1060-1071页

作者： Roberto de Paula do Nascimento Julia Soto Rizzato Gabriele Polezi Amanda Maria Tomazini Munhoz Moya Milena Ferreira Silva Ana Paula da Fonseca Machado Gilberto Carlos Franchi Junior Renata Galhardo Borguini Manuela Cristina Pessanha de Araújo Santiago Ana Paula Ribeiro Paiotti JoséAires Pereira Carlos Augusto Real Martinez Mario Roberto Marostica Junior Laboratory of Nutrition and Metabolism(LANUM) Department of Food Science and Nutrition(DECAN)School of Food Engineering(FEA)University of Campinas(UNICAMP)CampinasSPBrazil Laboratory of Food Nutritionand HealthDepartment of Food Science and Nutrition(DECAN)School of Food Engineering(FEA)University of Campinas(UNICAMP)CampinasSPBrazil Laboratory of Cellular and Behavioral Pharmacology Federal University of São Paulo(UNIFESP)Diadema CampusDiademaSPBrazil Integrated Research Center for Onco-Hematological Childhood Diseases School of Medical Sciences(FCM)University of Campinas(UNICAMP)CampinasSPBrazil Brazilian Agricultural Research Corporation(EMBRAPA) Embrapa Food TechnologyRio de JaneiroRJBrazil Laboratory of Hepatology Molecular Applied-Discipline of GastroenterologyFederal University of S˜ao Paulo(UNIFESP)S˜ao Paulo CampusS˜ao PauloSPBrazil Postgraduate Program in Health Sciences S˜ao Francisco University(USF)Bragança Paulista CampusBragança PaulistaSPBrazil

This study aimed to characterize the peel of jaboticaba(Myrciaria jaboticaba(Vell.)***)by spectropho-tometry and chromatography,and investigate its effects on mice with inflammation-driven colorectal cancer(CRC).Freeze-dried jaboticaba peel(FDJP)showed a high antioxidant capacity in vitro,and to be mostly a source of cyanidin-3-O-glucoside,gallic acid,and ellagic *** the animal bioassay,FDJP added at 5%in the diet during 114 days completely abolished the formation of adenocarcinoma,which had an incidence of 75%in the non-treated *** consuming FDJP showed low histology damage regarding inflammatory infiltrate,edema,and crypt *** significantly reduced the colonic levels of proinflammatory markers interleukin-1beta and cyclooxygenase-2,and demonstrated a probability to decrease the expressions of inducible nitric oxide synthase and nuclear factor kappa *** summary,FDJP mitigated CRC,possibly by avoiding trig-gering *** benefit may come from its rich content in anthocyanins and phenolic acids.

关键词： Brazil Carcinogenesis Colitis Cyanidin-3-O-Glucoside Flavonoid Fruit

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Comment on: “Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors”

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Journal of Pharmaceutical Analysis 2023年第9期13卷 958-959页

作者： Cuicui Li Xiaoyuan Chen Jingjing Zhang Department of Diagnostic Radiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore117599Singapore Department of Nuclear Medicine Beijing Friendship Hospital Affiliated to Capital Medical UniversityBeijing100050China Nanomedicine Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingapore117597Singapore Departments of Surgery Chemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore119074Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnologyand Research(A*STAR)61 Biopolis DriveProteosSingapore138673Singapore

In the ever-evolving landscape of cancer research and treatment,the quest for novel and non-invasive imaging techniques has become crucial for accurate diagnosis and effective *** study[1]successfully developed a good manufacturing practices(GMP)grade ^(89)Zr-labeled anti-Claudin18.2(CLDN18.2)recombinant humanized antibody TST001.^(89)Zr-DFO-TST001 exhibited high radiochemical purity(>99%)and specific activity(24.15±1.34 GBq/mmol).It demonstrated good specificity and rapid tumor accumulation in vivo and in *** immuno-PET imaging,it enables non-invasive visualization and quantification of CLDN18.2 expression level in CLDN18.2-positive gastrointestinal tumor models.

关键词： CLDN1 gastrointestinal diagnosis

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Photoelectrochemical X-Ray Absorption Spectroscopy of Graphene/Si Heterojunction Platform with Multifunctional Atomic Bridging Layer for Efficient Solar-Powered Co2 Conversion

SSRN

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SSRN 2025年

作者： Wu, Heng-Liang Wu, Po-Hsien Chen, Hsuan-Yu Yu, Sheng-Yu Chang, Chen Liu, Tsung-Hsin Song, Ruo-Nong Lin, Jr-Wen Cyue, Zih-Wei Chan, Kwun-Man Chen, Cheng-Ying Chan, Ting-Shan Chen, Jeng-Lung Pao, Chih Wen Chen, Chun-Wei Department of Materials Science and Engineering National Taiwan University Taipei106319 Taiwan Center for Condensed Matter Sciences National Taiwan University Taipei106319 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei106319 Taiwan Academia Sinica Taipei11529 Taiwan Department of Optoelectronics and Materials Technology National Taiwan Ocean University Keelung202301 Taiwan National Synchrotron Radiation Laboratory Research Center Hsinchu300092 Taiwan Center of Atomic Initiative for New Materials National Taiwan University Taipei10617 Taiwan Department of Chemistry National Taiwan University Taipei106319 Taiwan

The facile integration and stability of Si-based photoelectrode architectures are the remaining challenges in the photoelectrochemical (PEC) conversion of CO2 to fuels. In this work, the single-atomic-layer graphene is used as a functional bridging layer to integrate both Si photocathodes and photoanodes, which enable the direct electrodeposition of metal-based electrocatalysts (Cu, Ag and InSn alloys) and a semiconductor-based catalyst (NiFe-LDH) on the graphene/Si heterojunction electrodes for PEC CO2 reduction and O2 evolution reaction, respectively. Photoelectrochemical X-ray absorption spectroscopy results show that the electrodeposited catalysts on the graphene layer are active and leads to efficient transport of photogenerated electrons from Si junctions to electrocatalysts. We demonstrate a PEC device with a full-cell configuration consisting of InSn/graphene/Si heterojunction photocathode and NiFe-LDH/graphene/Si heterojunction photoanode, exhibiting a reduced photovoltage of ~1080 mV compared to the electrochemical counterparts. A self-powered overall PEC CO2 reduction with a promising solar-to-fuel conversion efficiency of 3.2% can be obtained by integrating the graphene/Si heterojunction photocathode and photoanode with a Si photovoltaic. By combining the inherent chemical inertness of graphene with its role as an atomic bridging layer, the facile integration of Si photoelectrodes with various catalysts presents a promising platform for stable and efficient solar-to-fuel conversion. © 2025, The Authors. All rights reserved.

关键词： X ray absorption spectroscopy

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Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state

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细胞研究（英文版） 2023年第9期33卷 712-726页

作者： Peng Wang Xupeng Liu Ziyue Yao Yu Chen Lanfang Luo Kun Liang Jun-Hao Elwin Tan Min-Wen Jason Chua Yan-Jiang Benjamin Chua Shilin Ma Liping Zhang Wenwu Ma Shuqing Liu Wenhua Cao Luyao Guo Lu Guang Yuefan Wang He Zhao Na Ai Yun Li Chunwei Li Ruiqi Rachel Wang Bin Tean Teh Lan Jiang Kang Yu Ng Shyh Chang Institute of Zoology Chinese Academy of SciencesBeijingChina Beijing.Institute for Stem Cell and Regenerative Medicine Institute for Stem Cell and RegenerationChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina NUS Graduate School for Integrative Sciences and Engineering National University of SingaporeSingaporeSIngapore institute of Molecular and Cell Biology Genome Institute of SingaporeAgency for Science Technology and ResearchSingaporeSingapore Laboratory of Cancer Therapeutics Program in Cancer and Stem Cell BiologyDuke-National University of Singapore Medical SchoolSingaporeSingapore Laboratory of Cancer Epigenome Division of Medical ScienceNational Cancer Centre SingaporeSingaporeSingapore University of Chinese Academy of Sciences BeijingChina CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijingChina Department of Clinical Nutrition Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijingChina Institute of Zoology Chinese Academy of SciencesBeijingChina Beijing.Institute for Stem Cell and Regenerative Medicine Institute for Stem Cell and RegenerationChinese Academy of SciencesBeijingChina Laboratory of Cancer Therapeutics Program in Cancer and Stem Cell BiologyDuke-National University of Singapore Medical SchoolSingaporeSingapore Laboratory of Cancer Epigenome Division of Medical ScienceNational Cancer Centre SingaporeSingaporeSingapore CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijingChina

During homeostasis and after injury,adult muscle stem cells(MuSCs)activate to mediate muscle ***,much remains unclear regarding the heterogeneous capacity of MuSCs for self-renewal and ***,we show that Lin28a is expressed in embryonic limb bud muscle progenitors,and that a rare reserve subset of Lin28a+Pax7-skeletal MuSCs can respond to injury at adult stage by replenishing the Pax7+MuSC pool to drive muscle *** with adult Pax7+MuSCs,Lin28a+MuSCs displayed enhanced myogenic potency in vitro and in vivo upon *** epigenome of adult Lin28a+MuSCs showed resemblance to embryonic muscle *** addition,RNA-sequencing revealed that Lin28a+MuSCs co-expressed higher levels of certain embryonic limb bud transcription factors,telomerase components and the p53 inhibitor Mdm4,and lower levels of myogenic differentiation markers compared to adult Pax7+MuSCs,resulting in enhanced self-renewal and stress-response ***,conditional ablation and induction of Lin28a+MuSCs in adult mice revealed that these cells are necessary and sufficient for efficient muscle ***,our findings connect the embryonic factor Lin28a to adult stem cell self-renewal and juvenile regeneration.

关键词： Muscle stem cells Regeneration

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Correction: Materials laboratories of the future for alloys, amorphous, and composite materials (MRS Bulletin, (2025), 50, 2, (190-207), 10.1557/s43577-024-00846-y)

引用

MRS Bulletin 2025年 1-2页

作者： Banerjee, Sarbajit Meng, Y. Shirley Minor, Andrew M. Zhang, Minghao Zaluzec, Nestor J. Chan, Maria K.Y. Seidler, Gerald McComb, David W. Agar, Joshua Mukherjee, Partha P. Melot, Brent Chapman, Karena Guiton, Beth S. Klie, Robert F. McCue, Ian D. Voyles, Paul M. Robertson, Ian Li, Ling Chi, Miaofang Destino, Joel F. Devaraj, Arun Marquis, Emmanuelle A. Segre, Carlo U. Liu, Huinan H. Yang, Judith C. Momeni, Kasra Misra, Amit Abdolrahim, Niaz Medvedeva, Julia E. Cai, Wenjun Sehirlioglu, Alp Dizbay-Onat, Melike Mehta, Apurva Graham-Brady, Lori Maruyama, Benji Rajan, Krishna Warner, Jamie H. Taheri, Mitra L. Kalinin, Sergei V. Reeja-Jayan, B. Schwarz, Udo D. Simon, Sindee L. Brown, Craig M. Department of Chemistry and Department of Materials Science & Engineering Texas A & M University College Station United States Pritzker School of Molecular Engineering The University of Chicago Chicago United States Department of Materials Science & Engineering University of California Berkeley Berkeley United States National Center for Electron Microscopy Molecular Foundry Lawrence Berkeley National Laboratory Berkeley United States Center for Nanoscale Materials Argonne National Laboratory Lemont United States Department of Physics University of Washington Seattle United States Department of Materials Science & Engineering The Ohio State University Columbus United States Department of Mechanical Engineering and Mechanics Drexel University Philadelphia United States School of Mechanical Engineering Purdue University West Lafayette United States Department of Chemistry University of Southern California Los Angeles United States Department of Chemistry Stony Brook University The State University of New York Stony Brook United States Department of Chemistry University of Kentucky Lexington United States Department of Physics University of Illinois at Chicago Chicago United States Department of Materials Science & Engineering Northwestern University Evanston Bangladesh Department of Materials Science & Engineering University of Wisconsin–Madison Madison United States Department of Materials Science and Engineering University of Pennsylvania Philadelphia United States Department of Mechanical Engineering and Materials Science Duke University Durham United States Department of Chemistry Creighton University Omaha United States Physical and Computational Sciences Directorate Pacific Northwest National Laboratory Richland United States Department of Materials Science & Engineering University of Michigan–Ann Arbor Ann Arbor United States Department of Physics Illinois Institute of Technology Chicago United States Department of Bioengineering and the Mater

This article was updated to correct Minghao Zhang’s affiliation from "Pritzker School of molecular Engineering, The University of Chicago, Chicago, USA" to "Pritzker School of molecular Engineering, The University of Chicago, Chicago, USA;Argonne National Laboratory, Lemont, USA." Argonne National Laboratory was left off the original publication. © The Author(s) 2025.

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Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics

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Journal of molecular Cell Biology 2020年第6期12卷 462-476页

作者： Ruoying Yu Huihui Wu Hazrat Ismail Shihao Du Jun Cao Jianyu Wang Tarsha Ward Fengrui Yang Ping Gui Mahboob Ali Lingluo Chu Fei Mo Qi Wang Youjun Chu Jianye Zang Yun Zhao Mingliang Ye Guowei Fang Peng RChen Zhen Dou Xinjiao Gao Wenwen Wang Xing Liu Xuebiao Yao MOE Key Laboratory for Cellular Dynamics&Anhui Key Laboratory for Chemical Biology CAS Center for Excellence in Molecular Cell ScienceHefei National Science Center for Physical Sciences at Microscale&University of Science and Technology of ChinaHefei 230027China BUCM-MSM-USTC Joint Program on Global Health Equity Beijing University of Chinese MedicineBeijing 100029China Department of Physiology Morehouse School of MedicineAtlantaGA 30310USA Harvard Medical School BostonMA 02115USA Dalian Institute for Physical Chemistry Dalian 116023China Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China

Faithful segregation of mitotic chromosomes requires bi-orientation of sister chromatids, which relies on the sensing of correct attachments between spindle microtubules and kinetochores. Although the mechanisms underlying PLK1 activation have been extensively studied, the regulatory mechanisms that couple PLK1 activity to accurate chromosome segregation are not well understood. In particular, PLK1 is implicated in stabilizing kinetochore–microtubule attachments, but how kinetochore PLK1 activity is regulated to avoid hyperstabilized kinetochore–microtubules in mitosis remains elusive. Here, we show that kinetochore PLK1 kinase activity is modulated by SET7/9 via lysine methylation during early mitosis. The SET7/9-elicited dimethylation occurs at the Lys191 of PLK1, which tunes down its activity by limiting ATP utilization. Overexpression of the non-methylatable PLK1 mutant or chemical inhibition of SET7/9 methyltransferase activity resulted in mitotic arrest due to destabilized kinetochore–microtubule attachments. These data suggest that kinetochore PLK1 is essential for stable kinetochore–microtubule attachments and methylation by SET7/9 promotes dynamic kinetochore–microtubule attachments for accurate error correction. Our findings define a novel homeostatic regulation at the kinetochore that integrates protein phosphorylation and methylation with accurate chromosome segregation for maintenance of genomic stability.

关键词： mitosis PLK1 kinase SET7/9 methylation kinetochore-microtubule attachment

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TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation

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Nature Communications 2023年第1期14卷 3050-3050页

作者： Chen, Yu-Hsuan Chen, Han-Hsiun Wang, Won-Jing Chen, Hsin-Yi Huang, Wei-Syun Kao, Chien-Han Lee, Sin-Rong Yeat, Nai Yang Yan, Ruei-Liang Chan, Shu-Jou Wu, Kuen-Phon Chen, Ruey-Hwa Institute of Biological Chemistry Academia Sinica Taipei 115 Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Taipei 112 Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan Institute of Biochemical Sciences College of Life Science National Taiwan University Taipei 106 Taiwan Chemical Biology and Molecular Biophysics Program Taiwan International Graduate Program Academia Sinica Taipei 115 Taiwan Department of Chemistry National Tsing Hua University Hsinchu 300 Taiwan

Activation of tumor-intrinsic innate immunity has been a major strategy for improving immunotherapy. Previously, we reported an autophagy-promoting function of the deubiquitinating enzyme TRABID. Here, we identify a critical role of TRABID in suppressing anti-tumor immunity. Mechanistically, TRABID is upregulated in mitosis and governs mitotic cell division by removing K29-linked polyubiquitin chain from Aurora B and Survivin, thereby stabilizing the entire chromosomal passenger complex. TRABID inhibition causes micronuclei through a combinatory defect in mitosis and autophagy and protects cGAS from autophagic degradation, thereby activating the cGAS/STING innate immunity pathway. Genetic or pharmacological inhibition of TRABID promotes anti-tumor immune surveillance and sensitizes tumors to anti-PD-1 therapy in preclinical cancer models in male mice. Clinically, TRABID expression in most solid cancer types correlates inversely with an interferon signature and infiltration of anti-tumor immune cells. Our study identifies a suppressive role of tumor-intrinsic TRABID in anti-tumor immunity and highlights TRABID as a promising target for sensitizing solid tumors to immunotherapy. © 2023, The Author(s).

关键词： Mitosis Cancer microenvironment Tumour immunology Macroautophagy

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Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy

Nature Cancer

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Nature Cancer 2024年第3期5卷 400-419页

作者： Huang, Yu-Kai Cheng, Wei-Chung Kuo, Ting-Ting Yang, Juan-Cheng Wu, Yang-Chang Wu, Heng-Hsiung Lo, Chia-Chien Hsieh, Chih-Ying Wong, Sze-Ching Lu, Chih-Hao Wu, Wan-Ling Liu, Shih-Jen Li, Yi-Chuan Lin, Ching-Chan Shen, Chia-Ning Hung, Mien-Chie Lin, Jaw-Town Yeh, Chun-Chieh Sher, Yuh-Pyng Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Cancer Biology and Precision Therapeutics Center China Medical University Taichung Taiwan Ph.D. Program for Cancer Biology and Drug Discovery China Medical University and Academia Sinica Taichung Taiwan School of Chinese Medicine College of Chinese Medicine China Medical University Taichung Taiwan Graduate Institute of Integrated Medicine College of Chinese Medicine China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology College of Medical and Health Science Asia University Taichung Taiwan Center for Molecular Medicine China Medical University Hospital Taichung Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Taipei Taiwan National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Miaoli Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Biological Science and Technology China Medical University Taichung Taiwan Division of Hematology and Oncology China Medical University Hospital Taichung Taiwan Genomics Research Center Academia Sinica Taipei Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine E-Da Hospital Kaohsiung Taiwan Department of Medicine School of Medicine China Medical University Taichung Taiwan Department of Surgery Organ Transplantation Center China Medical University Hospital Taichung Taiwan Institute of Biochemistry and Molecular Biology China Medical University Taichung Taiwan

Kirsten rat sarcoma virus (KRAS) signaling drives pancreatic ductal adenocarcinoma (PDAC) malignancy, which is an unmet clinical need. Here, we identify a disintegrin and metalloproteinase domain (ADAM)9 as a modulator of PDAC progression via stabilization of wild-type and mutant KRAS proteins. Mechanistically, ADAM9 loss increases the interaction of KRAS with plasminogen activator inhibitor 1 (PAI-1), which functions as a selective autophagy receptor in conjunction with light chain 3 (LC3), triggering lysosomal degradation of KRAS. Suppression of ADAM9 by a small-molecule inhibitor restricts disease progression in spontaneous models, and combination with gemcitabine elicits dramatic regression of patient-derived tumors. Our findings provide a promising strategy to target the KRAS signaling cascade and demonstrate a potential modality to enhance sensitivity to chemotherapy in PDAC. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.

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Monolayer indium selenide: an indirect bandgap material exhibits efficient brightening of dark excitons

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npj 2D Materials and Applications 2024年第1期8卷 12页

作者： Paylaga, Naomi Tabudlong Chou, Chang-Ti Lin, Chia-Chun Taniguchi, Takashi Watanabe, Kenji Sankar, Raman Chan, Yang-Hao Chen, Shao-Yu Wang, Wei-Hua Molecular Science Technology Program Taiwan International Graduate Program Academia Sinica Taipei 10617 Taiwan National Central University Taoyuan Zhongli 320317 Taiwan Institute of Atomic and Molecular Sciences Academia Sinica Taipei 10617 Taiwan Research Center for Materials Nanoarchitectonics National Institute for Materials Science 1-1 Namiki Tsukuba 305-0044 Japan Research Center for Electronic and Optical Materials National Institute for Materials Science 1-1 Namiki Tsukuba 305-0044 Japan Institute of Physics Academia Sinica Taipei 115201 Taiwan Physics Division National Center of Theoretical Sciences Taipei 10617 Taiwan Center of Atomic Initiative for New Materials National Taiwan University Taipei 10617 Taiwan Center for Condensed Matter Sciences National Taiwan University Taipei 10617 Taiwan

Atomically thin indium selenide (InSe) exhibits a sombrero-like valence band, leading to distinctive excitonic behaviors. It is known that the indirect band gap of atomically thin InSe leads to a weak emission from the lowest-energy excitonic state (A peak). However, the A peak emission of monolayer (ML) InSe was observed to be either absent or very weak, rendering the nature of its excitonic states largely unknown. Intriguingly, we demonstrate that ML InSe exhibits pronounced PL emission because of the efficient brightening of the momentum-indirect dark excitons. The mechanism is attributed to acoustic phonon-assisted radiative recombination facilitated by strong exciton-acoustic phonon coupling and extended wavefunction in momentum space. Systematic analysis of layer-, power-, and temperature-dependent PL demonstrates that a carrier localization model can account for the asymmetric line shape of the lowest-energy excitonic emission for atomically thin InSe. Our work reveals that atomically thin InSe is a promising platform for manipulating the tightly bound dark excitons in two-dimensional semiconductor-based optoelectronic devices. © The Author(s) 2024.

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