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Multiomic Mapping of Copy Number and Structural Variation on Chromosome 1 (Chr1) Highlights Multiple Recurrent Disease Drivers

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BLOOD 2021年第Sup1期138卷 721-721页

作者： Blaney, Patrick Boyle, Eileen M. Wang, Yubao Ghamlouch, Hussein Choi, Jinyoung Williams, Louis James, Stoeckle Siegel, Ariel Razzo, Beatrice Braunstein, Marc Kaminetzky, David Arbini, Arnaldo A. Bruno, Benedetto Corre, Jill Montes, Lydia Auclair, Daniel Davies, Faith E. Tsirigos, Aristotelis Rustad, Even H. Maura, Francesco Landgren, Ola Bauer, Michael A. Walker, Brian Morgan, Gareth Perlmutter Cancer Center NEW YORK UNIVERISITY New York NY Perlmutter Cancer Center New York University Langone Health New York NY Perlmutter Cancer Center Myeloma Research Program New York NY NYU Langone Health Myeloma Research Program Perlmutter Cancer Center NYU Grossman School of Medicine New York NY Myeloma Research Program Laura and Isaar Perlmutter Cancer Center NEW YORK UNIVERSITY New York NY Laura & Isaac Perlmutter Cancer Center NEW YORK UNIVERSITY SCHOOL OF MEDICINE New York NY Myeloma Research Program NYU Permutter's cancer center New-York NY Myeloma Research Program NYU Langone's Perlmutter Cancer Center New York NY Myeloma Research Program Perlmutter Cancer Center NYU Langone Health New York NY Blood and Marrow Transplantation and Cellular Therapy New York University Langone Health New York NY Unité de Génomique du Myélome IUCT- Oncopole Toulouse France Hematology department CHU Amiens Amiens France The MMRF Norwalk CT Perlmutter Cancer Center NYU Langone Health New York NY Applied Bioinformatics Laboratories NYU Langone New York NY Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway Myeloma Program Sylvester Comprehensive Cancer Center Miami Department of Biomedical Informatics University of Arkansas for Medical Sciences Little Rock AR Division of Hematology Oncology Melvin and Bren Simon Comprehensive Cancer Center Indianapolis IN NYU Langone Health New York University School of Medicine New York NY

Introduction Copy number abnormalities (CNA) and structural variants (SV) are crucial to driving cancer progression and in multiple myeloma (MM). Chr1 CNA are seen in up to 40% of cases and associate with poor prognosis. Variants include deletions, gains, translocations and complex SV events such as chromothripsis (CT), chromoplexy (CP) and templated insertions (TI) which result in aberrant transcriptional patterns. Abnormal expression of genes on chr1 lead to the adverse clinical outcome and studies focussed on 1p12, 1p32.3 and 1q12-21 identified potential causal genes including TENT5C, CDKN2C, CKS1B, PDZK1, BCL9, ANP32E, ILF2, ADAR, MDM2 and MCL1 but none fully explain the clinical behavior. To address this deficiency and to relate chromatin structure to gene deregulation we present a multiomic bioinformatic analysis of SV, CNA, mutation and expression changes in relation to the chromatin structure of *** We analysed data derived from 1,154 CoMMpass trial patients. We analyzed 972 NDMM patients with whole exome for mutations, and 752 whole genomes for copy number, translocations, complex rearrangements such as CP, CT and TI as previously described. Using GISTIC 2.0, we identified hotspots of CNA. This information was then analyzed in conjunction to the RNA-seq data derived from 643 patients to determine the aberrant transcriptional landscape of chr1. Using HiC data derived from U266 MM cell line, we associated these changes with TAD structures, A/B compartments, and histone marks along chr1, to gene expression changes, and recurrent SV. Using the cell line dependency map for CRISPR knockdown of the gene set on chr1 derived from 20 MM cell lines we related cell viability to chr1 copy number *** •We identified 7 hotspots of deletion, 9 of gain, 3 of CT and 2 of templated-insertion across chr1. We mapped these regions to epigenetic plots and show that gained regions are hypomethylated compared to the rest of chr1 (Wilcoxon, p=0.0002). Overall

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In-situ observation of hydrogen nanobubbles formation on graphene surface by AFM-SECM

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Electrochimica Acta 2024年 493卷

作者： Kholimatussadiah, Septia Hsu, Chia-Ling Ke, Shang-Wei Chou, Tsu-Chin Wu, Yung-Fu Yakimova, Rositsa Kumatani, Akichika Chen, Kuei-Hsien Chen, Li-Chyong Du, He-Yun Department of Physics National Taiwan University Taipei 10617 Taiwan Nano Science and Technology Taiwan International Graduate Program Academia Sinica Taipei 10617 Taiwan Center for Condensed Matter Sciences National Taiwan University Taipei 10617 Taiwan Center of Atomic Initiative for New Materials National Taiwan University Taipei 10617 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Institute of Atomic and Molecular Sciences Academia Sinica Taipei 10617 Taiwan Institute of Analytical and Environmental Sciences National Tsing Hua University Hsinchu 300044 Taiwan Department of Physics Chemistry and Biology Linköping University SE-581 83 Linköping Sweden Institute of Engineering Innovation School of Engineering The University of Tokyo Tokyo 113-8656 Japan Saitama 332-0012 Japan Tohoku University Sendai980-8577 Japan Battery Research Center of Green Energy Ming Chi University of Technology New Taipei City24301 Taiwan Biochemical Technology R&D Center Ming Chi University of Technology New Taipei City24301 Taiwan Center for Sustainability and Energy Technologies Chang Gung University Taoyuan City33302 Taiwan

Gas bubble evolution is an important phenomenon in many electrochemical processes and it is highly sensitive to the surface properties. Here we visualize the gas bubble dynamics on the surface of different graphene substrates during hydrogen evolution reaction (HER) using atomic force microscopy combined with scanning electrochemical microscopy. The low overpotential and low surface hydrophobicity of few-layer graphene formed on C-phase SiC causes the uniform distribution of hydrogen nanobubbles, which easily depart from the surface during the reaction. Conversely, the high overpotential and more hydrophobic surface of HOPG induces hydrogen bubbles to linger on the surface for an extended duration, leading to its accumulation and the subsequent formation of microbubbles. This in-situ nanoscale electrochemical mapping of hydrogen bubble dynamics provides new insight into electrocatalytic HER that occurs on non-metal electrodes. © 2024 Elsevier Ltd

关键词： Graphene

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Direct Z-Scheme Heterostructure of In-Situ Planted Zno Nanorods on G-C3n4 Thin Sheets Sprayed on Tio2 Layer: A Strategy for Ternary-Photoanode Engineering Towards Enhanced Photoelectrochemical Water Splitting

SSRN

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SSRN 2023年

作者： Hung, Chen-Hsiung Aboubakr, Ahmed Esmail A. Hussien, Mahmoud Kamal Sabbah, Amr Hassan, Ahmed E. Elsayed, Mohamed Hammad Wen, Zhenhai Chen, Kuei-Hsien Sustainable Chemical Science and Technology Taiwan International Graduate Program Taiwan Department of Applied Chemistry National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Institute of Chemistry Academia Sinica 128 Sec 2 Academia Rd. Nankang Taipei11529 Taiwan Department of Chemistry Faculty of Science Assiut University Assiut71516 Egypt Institute of Atomic and Molecular Sciences Academia Sinica Taipei10617 Taiwan Center for Condensed Matter Sciences National Taiwan University Taipei10617 Taiwan CAS Key Laboratory of Design and Assembly of Functional Nanostructures And Fujian Provincial Key Laboratory of Materials and Techniques Toward Hydrogen Energy Fujian Institute of Research on The Structure of Matter Chinese Academy of Sciences Fujian Fuzhou350002 China University of Chinese Academy of Sciences Beijing100049 China Department of Chemistry Faculty of Science Al-Azhar University Nasr City Cairo11884 Egypt

A novel approach to enhance the separation and transfer of charge carriers of photoanode for photoelectrochemical water splitting has developed. We improved the procedures for in-situ implantation of ZnO on g-C3N4, resulting in strong chemical adhesion between the interface of ZnO and g-C3N4. Our airbrushing procedure for fabricating the g-C3N4/ZnO composite on TiO2 also enhanced the charge collection efficiency, enabling us to construct a high performance photoanode. The Z-scheme type charge migration route was verified by EPR spectroscopy through trapping the radicals generated by charges and holes. PEC-WS measurements showed that TiO2/g-C3N4/ZnO heterostructure improved the produced photocurrent by about 160-, 40-, 20-, 8-, 2-, and 2-fold, relative to pristine g-C3N4, pristine ZnO nanorods, ZnO/g-C3N4 composite, pristine TiO2, TiO2/ZnO, and TiO2/g-C3N4, respectively, versus reversible hydrogen electrode (RHE) at 1.23 V. © 2023, The Authors. All rights reserved.

关键词： Zinc oxide

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Mercaptopurine-loaded sandwiched tri-layered composed of electrospun polycaprolactone/poly (Methyl methacrylate) nanofibrous scaffolds as anticancer carrier with antimicrobial and antibiotic features: Sandwich configuration nanofibers, release study and in vitro bioevaluation tests

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International Journal of Nanomedicine 2021年 16卷 6937-6955页

作者： Salim, Samar A. Kamoun, Elbadawy A. Evans, Stephen El-Moslamy, Shahira H. El-Fakharany, Esmail M. Elmazar, Mohamed M. Abdel-Aziz, A.F. Abou-Saleh, R.H. Salaheldin, Taher A. Nanotechnology Research Center (NTRC) The British University in Egypt (BUE) Cairo 11837 Egypt Biochemistry Group Chemistry Dep. Faculty of Science Mansoura University Mansoura Egypt Polymeric Materials Research Dep Advanced Technology and New Materials Research Institute (ATNMRI) City of Scientific Research and Technological Applications (SRTA-City) Alexandria 21934 Egypt Molecular and Nanoscale Physics Group School of Physics and Astronomy University of Leeds Leeds LS2 9JT United Kingdom Bioprocess Development Dep GEBRI City of Scientific Research and Technological Applications (SRTA-City) Alexandria 21934 Egypt Protein Research Dep. GEBRI City of Scientific Research and Technological Applications (SRTA-City) Alexandria 21934 Egypt Faculty of Pharmacy The British University in Egypt (BUE) Cairo 11837 Egypt Biophysics Group Dep. of Physics Faculty of Science Mansoura University Mansoura Egypt Nanoscience and Technology Program Faculty of Advanced Basic Science Galala University Suez Egypt Pharmaceutical Research Institute Albany College of Pharmacy and Health Sciences Albany 12144 NY United States

Background: 6-Mercaptopurine (6-MP) is a potential anti-cancer agent which its therapeutic and limitation applicability due to its high toxicity. Objective: Herein, 6-MP was loaded into tri-layered sandwich nanofibrous scaffold (the top layer composed of poly methyl methacrylate/polycaprolactone (PMMA/PCL), the middle layer was PCL/PMMA/6-MP, and the bottom layer was PCL/PMMA to improve its bioactivity, adjusting the release-sustainability and reduce its toxicity. Methods: Electrospun trilayered nanofibers composed of PCL/PMMA were utilized as nanomats for controlling sustained drug release. Four groups of sandwich scaffold configurations were investigated with alteration of (PMMA: PCL) composition. Results: The sandwich scaffold composed of 2%PCL/4%PMMA/1%6-MP showed the best miscibility, good homogeneity and produced the smoothest nanofibers and low crystallinity. All fabricated 6-MP-loaded-PCL/PMMA scaffolds exhibited antimicrobial properties on the bacterial and fungal organisms, where the cytotoxicity evaluation proved the safety of scaffolds on normal cells, even at high concentration. Scaffolds provided a sustained-drug release profile that was strongly dependent on (PCL: PMMA). As (PCL: PMMA) decreased, the sustained 6-MP release from PCL/PMMA scaffolds increased. Results established that ~18% and 20% of 6-MP were released after 23h from (4%PCL/4%PMMA/1%6-MP) and (2%PCL/4%PMMA/1%6-MP), respectively, where this release was maintained for more than 20 days. The anti-cancer activity of all fabricated scaffolds was also investigated using different cancerous cell lines (e.g., Caco-2, MDA, and HepG-2) results showed that 6-MP-loaded-nanofibrous mats have an anti-cancer effect, with a high selective index for breast cancer. We observed that viability of a cancer cell was dropped to about 10%, using nanofibers containing 2% PCL/4%PMMA/1%6-MP. Conclusion: Overall, the PCL: PMMA ratio and sandwich configuration imparts a tight control on long-term release profile and

关键词： 6-Mercaptopurine 6-MP Anticancer PCL/PMMA Polycaprolactone/poly methyl methacrylate Sandwich scaffold Sustained drug release

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Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis

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Materials Today Bio 2023年 23卷 100876页

作者： Jheng, Pei-Ru Chiang, Chia-Che Kang, Jiunn-Horng Fan, Yu-Jui Wu, Kevin C.-W. Chen, Yan-Ting Liang, Jia-Wei Bolouki, Nima Lee, Jyh-Wei Hsieh, Jang-Hsing Chuang, Er-Yuan Graduate Institute of Nanomedicine and Medical Engineering Graduate Institute of Biomedical Materials and Tissue Engineering Institute of Biomedical Optomechatronics International Ph.D. Program in Biomedical Engineering School of Biomedical Engineering College of Biomedical Engineering Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Physical Medicine and Rehabilitation Taipei Medical University Hospital Taipei Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institute Keyan Road Zhunan Miaoli City350 Taiwan Department of Chemical Engineering National Taiwan University No.1 Sec. 4 Roosevelt Rd Taipei10617 Taiwan Department of Plasma Physics and Technology Faculty of Science Masaryk University Brno Czech Republic Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City Taiwan Department of Materials Engineering Ming Chi University of Technology New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan

A new approach to treating vascular blockages has been developed to overcome the limitations of current thrombolytic therapies. This approach involves biosafety and multimodal plasma-derived theranostic platelet vesicle incorporating iron oxide constructed nano-propellers platformed technology that possesses fluorescent and magnetic features and manifold thrombus targeting modes. The platform is capable of being guided and visualized remotely to specifically target thrombi, and it can be activated using near-infrared phototherapy along with an actuated magnet for magnetotherapy. In a murine model of thrombus lesion, this proposed multimodal approach showed an approximately 80 % reduction in thrombus residues. Moreover, the new strategy not only improves thrombolysis but also boosts the rate of lysis, making it a promising candidate for time-sensitive thrombolytic therapy. © 2023 The Authors

关键词： Infrared devices

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Association of lipid composition and unsaturated fatty acids of VLDL with atrial remodeling in metabolic syndrome

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Scientific Reports 2023年第1期13卷 1-14页

作者： Lee, Hsiang-Chun Cheng, Wei-Chung Ma, Wen-Lung Lin, Yu-Hsun Shin, Shyi-Jang Lin, Yi-Hsiung Division of Cardiology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University 100 Tzyou 1st Rd Kaohsiung 807 Taiwan Department of Internal Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Lipid Science and Aging Research Center College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Institute/Center of Medical Science and Technology National Sun Yat-Sen University Kaohsiung Taiwan Graduate Institute of Animal Vaccine Technology National Pingtung University of Science and Technology Pingtung Taiwan PhD Program for Cancer Molecular Biology and Drug Discovery China Medical University and Academia Sinica Taichung Taiwan Research Center for Cancer Biology China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences and Graduate Institution of Cancer Biology School of Medicine China Medical University Taichung Taiwan Department of Medical Research China Medical University Hospital Taichung Taiwan Department of Nursing Asia University Taichung Taiwan Grander Clinic Kaohsiung Taiwan

Subjects with metabolic syndrome (MetS) commonly have atrial remodeling, which indicates a risk for atrial fibrillation. This study determined MetS-related changes in lipid components in very-low-density lipoprotein (VLDL), which has been shown to cause atrial remodeling, the effect of statins on these changes, and the correlation between atrial remodeling and VLDL lipid compositions. Blood samples were collected from 12 non-MetS and 27 sex- and age-matched MetS subjects. Fourteen patients with MetS (MetS-off statin) discontinued statin therapy 14 days before the study, while the remaining 13 remained on it (MetS-on statin). The VLDLs were isolated and processed for mass-based lipid profiling. Lipidomic analyses were performed and associated with atrial remodeling markers measured using standard echocardiography and electrocardiography. Compared with the VLDL components of the non-MetS group, glucosyl/galactosyl ceramide, lyso-phosphatidylcholine, lyso-phosphatidylethanolamine, and triglycerides were enriched in the MetS-off statin group. Statin therapy attenuated all abnormally abundant lipid classes in MetS, except for triglycerides. In addition, lyso-phosphatidylcholine, lyso-phosphatidylethanolamine, and triglycerides were significantly correlated with atrial dilatation, and the latter two were also correlated with the PR interval. Enrichment of double bonds, which indicate unsaturated fatty acids, was also significantly correlated with atrial remodeling and P-wave duration. This study suggests that the pathological lipid payload of MetS-VLDL may contribute to atrial remodeling in patients. © 2023, The Author(s).

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Metal ratio and bimetal nanoarchitectonics of ammonia-based fluoride complex induced nickel hydroxide and manganese oxide composites as active materials of an energy storage device

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Journal of Energy Storage 2024年 80卷

作者： Hsu, Chuan-Chih Yu, You Zher Wu, Chung-Hsien Lee, Pin-Yan Chen, Hung-Ming Husain, Sadang Kongvarhodom, Chutima Hsiao, Yu-Cheng Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Nickel and manganese compounds are widely applied as efficient battery-type active materials for energy storage devices, due to high theoretical capacities and abundant redox states for generating redox reactions to store charges. Morphology plays significant roles on energy storage ability. Structure directing agent (SDA) is widely reported to have ability for modulating configurations of active materials and to achieve excellent surface properties. In this work, it is the first time to use NH4BF4 and NH4HF2 as structure directing agents for synthesizing nickel manganese compounds derived from ZIF67 as active materials of energy storage devices. Bimetallic compounds are composed of nickel hydroxide and manganese oxide, which presents the favorable two-dimensional flower-like structure with high surface area and abundant redox states. The largest specific capacitance (CF) of 1358.2 F/g corresponding to the capacity of 226.4 mAh/g are achieved for the bimetallic compound synthesized using the Ni to Mn precursor ratio of 1 to 1 (NiMn11). The energy storage device assembled using NiMn11 and reduced graphene oxide on Ni foams presents a maximum energy density of 11.45 Wh/kg at the power density of 0.35 kW/kg, and excellent long-term stability with the CF retention of 85.6% and Coulombic efficiency of 87.5% after 10,000 cycles. © 2023

关键词： Fluorine compounds

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Fumigant activity of pyrolysis fractions derived from waste licuri's pericarp (Syagrus coronata - Arecaceae) in the control the red flour beetle Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae)

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Environmental Challenges 2021年 5卷

作者： Mattos, Camila Andrade, Juliana Oliveira, Pamella C.O. Veloso, Marcia C.C. Romeiro, Gilberto A. Folly das Chagas, Evelize Laboratory of Pest and Parasite Studies – Federal Fluminense University – Institute of Biology– Department of Cellular and Molecular Biology – Niterói RJ Brazil Laboratory of Synthesis Chromatography and Environment (SINCROMA) – Federal Fluminense University – Institute of Chemistry – Department of Organic Chemistry – Niterói RJ Brazil Postgraduate Program in Science and Biotechnology – Federal Fluminense University – Niterói RJ Brazil Postgraduate Program in Chemistry – Federal Fluminense University – Niterói RJ Brazil National Institute of Sciences and Technology - Molecular Entomology Brazil

The large production of waste and the destination for its disposal is one of the biggest problems faced by the agro-industrial sector. Furthermore, in food production, the control of insect pests during grain storage causes great damage. Scientific research evaluating the effectiveness of pyrolysis products in insects is recent and still little studied. In this work, the aqueous phase (LAF) and bio-oil produced from the residues of licuri have been investigated which insecticidal effect. Licuri shell was subjected to slow pyrolysis carried out in a batch reactor at 400 °C, the LAF and bio-oil were collected from the condenser. The LAF was collected, generating a total of five fractions. The LAF1 was the most toxic fraction to Tribolium castaneum on fumigation assay, reaching 92.5% mortality. Analyses of these fractions by gas chromatography-mass spectrometry (GC–MS) identified a higher content of acetic acid, furan derivates, and other compounds, including oxo-acetic acid, methyl acetate, furfural, 2-methyl furan, 2,5-dimethylfuran, and L-alanine ethylamine. With the result of this study, it may be ^{concluded that LAF is a very promising source of fumigant against an important pest of stored} grains, therefore being a sustainable source to produce a biopesticide. © 2021 The Authors

关键词： Biomass residues Biopesticide Eco-friendly Slow pyrolysis Syagrus coronata Tribolium castaneum

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Diversification of the Carbodicarbene Class by Embedding an Anionic Component in its Scaffold

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Chemistry - A European Journal 2023年第71期29卷 e202302886页

作者： Yu, Cheng-Han Au-Yeung, Ka-Chun Liu, Ruiqin Lee, Chao-Hsien Jiang, Dandan Semagne Aweke, Bamlaku Wu, Chia-Hung Wang, Yu-Jou Wang, Ting-Hsuan Voon Kong, Kien Yap, Glenn P. A. Chen, Wen-Ching Frenking, Gernot Zhao, Lili Ong, Tiow-Gan Institute of chemistry Academia Sinica Taipei115201 Taiwan School of Chemistry and Molecular Engineering State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech University Nanjing China Fachbereich Chemie Philipps-Universität Marburg Hans-Meerwein-Strasse MarburgD-35043 Germany Department of Chemistry and Biochemistry University of Delaware NewarkDE United States Department of Chemistry National Taiwan University Taipei Taiwan Department of Applied Chemistry National Yang Ming Chiao Tung University Hsinchu Taiwan Sustainable Chemical Science and Technology Taiwan International Graduate Program Academia Sinica Taipei Taiwan Corporate R&D Center LCY Chemical Corporation Kaohsiung Taiwan Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung Taiwan

Carbodicarbene (CDC) has become an emerging ligand in many fields due to its strong σ-donating ability. 2- moiety within the framework to leverage the electronic feature of carbon carbone. The elucidation of X-ray crystal structures, ligand competition as well as transmetallation experiments suggest that the anionic moiety has enhanced the overall donor strength of the traditional neutral CDC. Importantly, this anionic scaffold exhibits a facile second coordination toward Au(I), Ag(I) and Pd(II) without any external ligand assistance, whereas previously reported neutral pincer CDC complexes do not possess a two-fold donor capacity. The analysis of the bonding situation via theoretical methods shows that the description of the anionic CDC moieties in terms of dative bonding is preferred over the model of delocalized positive charge, as it accounts for the two-fold donor ability of the divalent carbon atom, preserving a characteristic feature of a carbone. © 2023 Wiley-VCH GmbH.

关键词： Scaffolds

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BIOS-02. RECAPITULATE TUMOR DIVERSION AND SPATIAL PATTERNING IN GLIOBLASTOMA BACKGROUND

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Neuro-Oncology 2023年第SUPPLEMENT_5期25卷 v20-v20页

作者： Lo, Wei-Lun Khoa, Hoang Dang Ta Chuang, Jian-Ying Division of Neurosurgery Shuang-Ho Hospital New Taipei City New Taipei Taiwan (Republic of China) PhD Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei Taipei Taiwan (Republic of China) International Master Program in Medical Neuroscience Taipei Medical University Taipei Taiwan (Republic of China)

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