检索结果-内蒙古大学图书馆

arXiv 2021年

作者： Zhang, Chunyi Tang, Fujie Chen, Mohan Zhang, Linfeng Qiu, Diana Y. Perdew, John P. Klein, Michael L. Wu, Xifan Department of Physics Temple University PhiladelphiaPA19122 United States HEDPS Center for Applied Physics and Technology College of Engineering Peking University Beijing100871 China Program in Applied and Computational Mathematics Princeton University PrincetonNJ08544 United States Department of Mechanical Engineering and Materials Science Yale University New HavenCT06520 United States Department of Chemistry Temple University PhiladelphiaPA19122 United States Institute for Computational Molecular Science Temple University PhiladelphiaPA19122 United States

Within the framework of Kohn-Sham density functional theory (DFT), the ability to provide good predictions of water properties by employing a strongly constrained and appropriately normed (SCAN) functional has been extensively demonstrated in recent years. Here, we further advance the modeling of water by building a more accurate model on the fourth rung of Jacob’s ladder with the hybrid functional, SCAN0. In particular, we carry out both classical and Feynman path-integral molecular dynamics calculations of water with the SCAN0 functional and the isobaric-isothermal ensemble. In order to generate the equilibrated structure of water, a deep neural network potential is trained from the atomic potential energy surface based on ab initio data obtained from SCAN0 DFT calculations. For the electronic properties of water, a separate deep neural network potential is trained using the Deep Wannier method based on the maximally localized Wannier functions of the equilibrated trajectory at the SCAN0 level. The structural, dynamic, and electric properties of water were analyzed. The hydrogen-bond structures, density, infrared spectra, diffusion coefficients, and dielectric constants of water, in the electronic ground state, are computed using a large simulation box and long simulation time. For the properties involving electronic excitations, we apply the GW approximation within many-body perturbation theory to calculate the quasiparticle density of states and bandgap of water. Compared to the SCAN functional, mixing exact exchange mitigates the self-interaction error in the meta-generalized-gradient approximation and further softens liquid water towards the experimental direction. For most of the water properties, the SCAN0 functional shows a systematic improvement over the SCAN functional. © 2021, CC BY.

关键词： Deep neural networks

来源：评论

学校读者我要写书评

暂无评论

Mixed-linker MOF-303 membranes for pervaporation

引用

Journal of Membrane science Letters 2023年第2期3卷

作者： Fang-Hsuan Hu Li-Tang Chi Guan-Bo Syu Tsyr-Yan Yu Ming-Pei Lin Jiun-Jen Chen Wen-Yueh Yu Dun-Yen Kang Department of Chemical Engineering National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei 10617 Taiwan Institute of Atomic and Molecular Sciences Academia Sinica No. 1 Sec. 4 Roosevelt Road Taipei 10617 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei 10617 Taiwan Green Energy and Environment Research Laboratories Industrial Technology Research Institute No. 195 Sec. 4 Chung Hsing Road Hsinchu 31040 Taiwan

Metal-organic frameworks (MOFs) hold great promise as porous materials for pervaporation applications. However, the exploration of MOF membranes in this field is still in its early stages. One of the main challenges is the relatively low mass flux and stability of pure MOF membranes compared to other materials used in pervaporation. In this study, we propose a novel approach to enhance the separation performance of MOF membranes for water and ethanol separation. Our strategy involves incorporating the 2,5-thiophenedicarboxylic acid (TDC) linker into the MOF-303 structure, partially replacing the 3,5-pyrazoledicarboxylic acid (PDC) linker. The goal is to increase the aperture size of the microporous channels in the pristine MOF-303 membrane, thereby improving the mass flux. X-ray diffraction characterization, combined with Rietveld refinement, confirmed that the partial substitution of PDC with TDC resulted in an increased pore-limiting diameter (PLD) of MOF-303. For instance, the pristine MOF-303 exhibited a PLD of 5.78 Å, while MOF-303(70/30) with 70% TDC replacement displayed a PLD of 6.02 Å. To fabricate the mixed-linker MOF-303 membranes, we utilized a seeded growth method, which yielded membranes with dense layers, as confirmed by scanning electron microscopy and air permeation characterization. The prepared membranes were subjected to pervaporation tests to evaluate their performance in separating 90 wt.% ethanol at 60 °C. The pristine MOF-303 membrane exhibited notable separation capabilities, with an average flux of 0.071 kg·m −2 ·hr −1 and a water/ethanol separation factor of 5371. Surpassing the unmodified MOF-303, the mixed-linker MOF-303(50/50) membrane demonstrated improved mass flux and water/ethanol separation factor. Specifically, the MOF-303(50/50) membrane displayed an average flux of 0.092 kg·m −2 ·hr −1 and a water/ethanol separation factor of 8500. Importantly, the unmodified MOF-303 membrane exhibited instability during prolonged pervaporation

关键词： Metal-organic framework MOF MOF membrane Pervaporation Mixed-linker MOF

来源：评论

学校读者我要写书评

暂无评论

Ser235 phosphorylation of hepatitis C virus NS5A is required for NS5A dimerization and drug resistance

引用

Life sciences 2024年 337卷 122338页

作者： Lee, Wei-Ping Tsai, Keng-Chang Liao, Shi-Xian Huang, Yi-Hsiang Hou, Ming-Chih Lan, Keng-Hsin Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan Institute of Biochemistry and Molecular Biology School of Life Sciences National Yang Ming Chiao Tung University Taipei Taiwan National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei Taiwan The Ph.D. Program for Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan School of Medicine College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Institute of Clinical Medicine School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Institute of Pharmacology College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan

Hepatitis C virus (HCV) infection is recognized as a major causative agent of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HCV non-structural protein 5A (NS5A) is a dimeric phosphoprotein with a hyperphosphorylated form to act as a switch that regulates HCV replication and assembly. NS5A inhibitors have been utilized as the scaffold for combination therapy of direct-acting antiviral agents (DAA). However, the mode of action of NS5A inhibitors is still unclear due to the lack of mechanistic detail regarding NS5A phosphorylation and dimerization in the HCV life cycle. It has been demonstrated that phosphorylation of NS5A at Ser235 is essential for RNA replication of the JFH1 strain. In this report, we found that NS5A phosphomimetic Ser235 substitution (Ser-to-Asp mutation) formed a dimer that was resistant to disruption by NS5A inhibitors as was the NS5A resistance-associated substitution Y93H. Phosphorylation of NS5A at Ser235 residue was required for the interaction of two NS5A-WT molecules in JFH1-based cell culture system but not absolutely required for dimerization of the NS5A-Y93H mutant. Interestingly, HCV nonstructural proteins from the subgenomic replicon NS3-5A was required for NS5A-WT dimerization but not required for NS5A-Y93H dimerization. Our data suggest that spontaneous Ser235 phosphorylation of NS5A and ensuing dimerization account for resistance of the JFH1/NS5A-Y93H mutant to NS5A inhibitors. © 2023 Elsevier Inc.

关键词： Drug resistance Hepatitis C virus NS5A dimerization Ser235 phosphorylation

来源：评论

学校读者我要写书评

暂无评论

Evaluating the antiviral efficacy and specificity of chlorogenic acid and related herbal extracts against SARS-CoV-2 variants via spike protein binding intervention

引用

Journal of Traditional and Complementary Medicine 2024年

作者： Hsieh, Wen-Yu Yu, Chu-Nien Chen, Chang-Chang Chiou, Chun-Tang Green, Brian D. Lee, Oscar K. Wu, Chia-Chune Doan, Ly Hien Huang, Chi-Ying F. Huang, Cheng Liu, Chien-Ju Chen, Yu-Hsin Cheng, Jing-Jy Pan, Heng-Chih Liu, Hui-Kang Biomedical Industry Ph.D. Program National Yang Ming Chiao Tung University Taipei 11221 Taiwan Institute of Clinical Medicine National Yang Ming Chiao Tung University Taipei 11221 Taiwan Division of Chinese Materia Medica Development National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei 11221 Taiwan Institute for Global Food Security School of Biological Sciences Queen's University Belfast Belfast BT7 1NN United Kingdom Department of Orthopedics China Medical University Hospital Taichung Taiwan Institute of Biopharmaceutical Sciences College of Pharmaceutical Sciences National Yang Ming Chiao Tung University Taipei 11221 Taiwan Institute of Biotechnology Vietnam Academy of Science and Technology Hanoi Viet Nam Program in Molecular Medicine College of Life Sciences National Yang Ming Chiao Tung University Taipei 11221 Taiwan Taiwan National Graduate Program in Molecular Medicine Academia Sinica National Yang Ming Chiao Tung University Taipei 11221 Taiwan Institute of Clinical Medicine College of Medicine National Yang Ming Chiao Tung Taipei 11221 Taiwan Department of Biotechnology and Laboratory Science in Medicine School of Biomedical Science and Engineering National Yang Ming Chiao Tung Taipei 11221 Taiwan Department of Biochemistry School of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Earth and Life Sciences University of Taipei Taipei 11036 Taiwan Tea and Beverage Research Station Ministry of Agriculture Yangmei Township Taoyuan County 326011 Taiwan Taichung District Agricultural Research and Extension Station Ministry of Agriculture Chang-Hwa County 515008 Taiwan Division of Basic Chinese Medicine National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei 11221 Taiwan Department of Nephrology Chang Gung Memorial Hospital Keelung City 204201 Taiwan Ph.D. Program in the Clinical Drug Development of Herbal Medicine Taipei Medical University Taipei

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus infect the respiratory tract through surface proteins, causing similar symptoms. Since the onset of the COVID-19 pandemic, both viruses have posed significant ongoing global health threats. Like the influenza virus, SARS-CoV-2 evolves into variants that can reduce vaccine efficacy. Thus, herbal medicines are being explored as supplementary options to enhance protection against these infections. This study aimed to investigate the therapeutic potential of chlorogenic acid (3-CQA) and related extracts from green coffee beans and Echinacea purpurea against SARS-CoV-2 variants and H1N1 infection. The methods employed included an ELISA-based trimeric spike protein binding assay, viral infection assays, plaque assays, and molecular docking studies. Results showed that 3-CQA blocked spike protein/angiotensin converting enzyme 2 (ACE2) binding for most SARS-CoV-2 variants of concern, except the Delta variant. Extracts from Green coffee bean and E. purpurea effectively blocked all variants tested. Additionally, antibodies blocked spike protein binding up to Omicron BA.2. molecular docking suggested that 3-CQA binding to Omicron BA.1, BA.2, and BA.4, though not to the Delta spike protein, may lead to steric hindrance, preventing receptor-binding domain interactions with ACE2. Finally, both 3-CQA and E. purpurea extract showed preventive effects against H1N1 viral infection, though with lower potency compared to SARS-CoV-2. In conclusion, 3-CQA has potential as a phytoconstituent marker for herbs with bioactive properties against SARS-CoV-2 and H1N1 viral infections. © 2024 Center for Food and Biomolecules, National Taiwan University

关键词： Chlorogenic acid COVID-19 Echinacea purpurea Green coffee bean H1N1 influenza virus SARS-CoV-2 variants Spike protein

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing

引用

Nature communications 2023年第1期14卷 158页

作者： Kerry Blair Muhammad Tehseen Vlad-Stefan Raducanu Taha Shahid Claudia Lancey Fahad Rashid Ramon Crehuet Samir M Hamdan Alfredo De Biasio Leicester Institute of Structural & Chemical Biology and Department of Molecular & Cell Biology University of Leicester Lancaster Rd Leicester LE1 7HB UK. Bioscience Program Division of Biological and Environmental Sciences and Engineering King Abdullah University of Science and Technology Thuwal 23955 Saudi Arabia. CSIC-Institute for Advanced Chemistry of Catalonia (IQAC) C/ Jordi Girona 18-26 08034 Barcelona Spain. Bioscience Program Division of Biological and Environmental Sciences and Engineering King Abdullah University of Science and Technology Thuwal 23955 Saudi Arabia. samir.hamdan@kaust.edu.sa. Leicester Institute of Structural & Chemical Biology and Department of Molecular & Cell Biology University of Leicester Lancaster Rd Leicester LE1 7HB UK. alfredo.debiasio@kaust.edu.sa. Bioscience Program Division of Biological and Environmental Sciences and Engineering King Abdullah University of Science and Technology Thuwal 23955 Saudi Arabia. alfredo.debiasio@kaust.edu.sa.

来源：评论

学校读者我要写书评

暂无评论

Effects of biocholine powder supplementation in ewe lambs: Growth, rumen fermentation, antioxidant status, and metabolism

引用

Biotechnology Reports 2021年 29卷 e00580页

作者： Leal, Karoline W. Alba, Davi F. Cunha, Marily G. Marcon, Hiam Oliveira, Fernanda C. Wagner, Roger Silva, Anielen D. Lopes, Thalison F. de Jesus, Loren S.B. Schetinger, Maria Rosa C. Zotti, Claiton A. Kessler, Julcemar D. Vedovatto, Marcelo Silva, Aleksandro S. Da Postgraduate Program in AnimalScience State University of Santa Catarina (UDESC) Chapecó SC Brazil Department of Food Science Technology Federal University Santa Maria (UFSM) Santa Maria RS Brazil Department of Biochemistry and Molecular Biology UFSM Santa Maria RS Brazil University of the West of Santa Catarina Xanxerê SC Brazil Department of Animal Science UDESC Chapecó SC Brazil State University of Mato Grosso Do Sul Aquidauana MS Brazil

The objective of this study was to evaluate the effects of biocholine powder (BP) added to the concentrate of ewe lambs on growth, rumen fermentation, antioxidant status, and metabolism. Forty-eight Lacaune lambs were divided 3 treatments: T0, T4, and T8, representing 0, 4, and 8 g of BP per animal/day added to the concentrate, respectively. The T4 and T8 lambs had greater average daily gain from d 0–75 (0.22, 0.25, and 0.26 kg/d for T0, T4 and T8, respectively). T4 and T8 lambs had higher methylene blue test results (indicating microbiological activity), and the higher effects were detected for T8 lambs. The BP in lamb's diet increased the ruminal concentration of propionate (T4 and T8). The T8 lambs had greater serum activity of superoxide dismutase and glutathione transferase, and lower reactive oxygen species levels. We conclude that BP is a biotechnological additive with high nutritional potential. © 2020 The Authors

关键词： Choline Nutrition Nutritional biotechnology Sheep Supplements

来源：评论

学校读者我要写书评

暂无评论

Frailty in chronic myeloid leukemia: evidence from 2016–2018 Nationwide Inpatient Sample of the US

引用

BMC Geriatrics 2023年第1期23卷 334-334页

作者： Huan-Tze, Lin Yun-Ru, Liu Kuan-Der, Lee Huey-En, Tzeng Department of Internal Medicine Division of Hematology and Oncology Taipei Medical University Hospital Taipei Taiwan Joint Biobank Office of Human Research Taipei Medical University Taipei Taiwan Department of Medical Research Taichung Veterans General Hospital 1650 Boulevard Sect. 4 Taichung City 40705 Taiwan Department of Medicine Division of Hematology/Medical Oncology Taichung Veterans General Hospital Taichung City Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery and Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan

Background: Frailty is a marker of poor prognosis in older adults with hematologic malignancies and contributes to the severe vulnerability of the aging population to adverse health outcomes. This study aimed to determine the association between frailty and outcomes in hospitalized patients with chronic myeloid leukemia (CML). Methods: The International Classification of Diseases (ICD-10) identified data on hospitalized patients 20 years or older admitted with CML between 2016 and 2018 in the US National Inpatient Sample (NIS) database. The cohort was further divided into groups of patients with or without frailty. Logistic regression analysis was performed to determine associations between study variables and clinical outcomes. A stratified analysis of the association between frailty and in-hospital mortality by age group was also performed. Results: A total of 13,849 hospitalized patients with CML were included, 49.6% of whom had frailty. The mean age of the patients was 65.1 years, and 7,619 (56.2%) of them were male. Frailty was associated with nearly 4 times the risk of in-hospital mortality, 3 times the risk of unfavorable discharge, 3 times the risk of prolonged LOS, and significantly more in total hospital costs. In addition, frailty was associated with a significantly increased risk of in-hospital mortality in all age subgroups (< 40 years, 40–59 years, and > 60 years) compared with no frailty. Conclusions: Frailty strongly predicts poor clinical outcomes in US patients with CML. © 2023, The Author(s).

关键词： Chronic myeloid leukemia (CML) Frailty In-hospital outcome Nationwide Inpatient Sample (NIS)

来源：评论

学校读者我要写书评

暂无评论

Tissue clearing and its applications in neuroscience (vol 21, pg 61, 2020)

引用

NATURE REVIEWS NEUROscience 2020年第5期21卷 298-298页

作者： Ueda, Hiroki R. Ertuerk, Ali Chung, Kwanghun Gradinaru, Viviana Chedotal, Alain Tomancak, Pavel Keller, Philipp J. Department of Systems Pharmacology University of Tokyo Tokyo Japan Laboratory for Synthetic Biology RIKEN BDR Suita Japan Institute for Stroke and Dementia Research Klinikum der Universität München Ludwig-Maximilian University of Munich Munich Germany Institute of Tissue Engineering and Regenerative Medicine Helmholtz Zentrum München Neuherberg Germany Munich Cluster for Systems Neurology (SyNergy) Munich Germany Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge MA USA Picower Institute for Learning and Memory Massachusetts Institute of Technology Cambridge MA USA Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA USA Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA USA Eli & Edythe Broad Institute of MIT and Harvard Cambridge MA USA Center for NanoMedicine Institute for Basic Science Seoul Republic of Korea Graduate Program of Nano Biomedical Engineering Yonsei-IBS Institute Yonsei University Seoul Republic of Korea Division of Biology and Biological Engineering California Institute of Technology Pasadena CA USA Institut de la Vision Sorbonne Université INSERM CNRS Paris France Max Planck Institute of Molecular Cell Biology and Genetics Dresden Germany IT4Innovations Technical University of Ostrava Ostrava Czech Republic Janelia Research Campus Howard Hughes Medical Institute Ashburn VA USA

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

关键词： Immunological techniques Light-sheet microscopy Neuroscience

来源：评论

学校读者我要写书评

暂无评论

BPS2025 - A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling

引用

Biophysical Journal 2025年第3期124卷 185a-185a页

作者： Rosalie Lawrence Sophie Shoemaker Aniliese Deal Lan Wang Susan Marqusee Peter Walter Department of Biological Chemistry University of California Los Angeles Los Angeles CA USA Department of Molecular and Cell Biology University of California Berkeley Berkeley CA USA Biophysics Graduate Program University of California Berkeley Berkeley CA USA Hong Kong University of Science and Technology Hong Kong Hong Kong Department of Chemistry University of California Berkeley Berkeley CA USA Howard Hughes Medical Institute University of California San Francisco San Francisco CA USA

来源：评论

学校读者我要写书评

暂无评论

Transdermal nanolipoplex simultaneously inhibits subcutaneous melanoma growth and suppresses systemically metastatic melanoma by activating host immunity

引用

Nanomedicine: Nanotechnology, Biology, and Medicine 2023年 47卷 102628-102628页

作者： Chen, Chia-Hung Weng, Tzu-Han Chuang, Cheng-Hsun Huang, Kai-Yao Huang, Sih-Cheng Chen, Pin-Rong Huang, Hsiao-Hsuan Huang, Ling-Ya Shen, Pei-Chun Chuang, Po-Ya Huang, Hsiao-Yen Wu, Yi-Syuan Chang, Hao-Chiun Weng, Shun-Long Liao, Kuang-Wen Department of Medical Research Hsinchu MacKay Memorial Hospital Hsinchu City30071 Taiwan Dependent of Medical Education MacKay Memorial Hospital Taipei10449 Taiwan Institute of Molecular Medicine and Bioengineering National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Industrial Development Graduate Program of College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Medicine MacKay Medical College New Taipei City25245 Taiwan Department of Obstetrics and Gynecology Hsinchu MacKay Memorial Hospital Hsinchu City30071 Taiwan MacKay Junior College of Medicine Nursing and Management Taipei City11260 Taiwan Drug Development and Value Creation Research Center College of Dental Medicine Kaohsiung Medical University School of Dentistry Graduate Institute of Medicine College of Medicine Center for Cancer Research Kaohsiung Medical University Kaohsiung City80708 Taiwan Center for Intelligent Drug Systems and Smart Bio-devices National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Biotechnology and Bioindustry Sciences National Cheng Kung University Tainan City70101 Taiwan Ph.D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan

Benefit for clinical melanoma treatments, the transdermal neoadjuvant therapy could reduce surgery region and increase immunotherapy efficacy. Using lipoplex (Lipo-PEG-PEI-complex, LPPC) encapsulated doxorubicin (DOX) and carrying CpG oligodeoxynucleotide;the transdermally administered nano-liposomal drug complex (LPPC-DOX-CpG) would have high cytotoxicity and immunostimulatory activity to suppress systemic metastasis of melanoma. LPPC-DOX-CpG dramatically suppressed subcutaneous melanoma growth by inducing tumor cell apoptosis and recruiting immune cells into the tumor area. Animal studies further showed that the colonization and growth of spontaneously metastatic melanoma cells in the liver and lung were suppressed by transdermal LPPC-DOX-CpG. Furthermore, NGS analysis revealed IFN-γ and NF-κB pathways were triggered to recruit and activate the antigen-presenting-cells and effecter cells, which could activate the anti-tumor responses as the major mechanism responsible for the therapeutic effect of LPPC-DOX-CpG. Finally, we have successfully proved transdermal LPPC-DOX-CpG as a promising penetrative carrier to activate systemic anti-tumor immunity against subcutaneous and metastatic tumor. © 2022

关键词： Tumors

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：