检索结果-内蒙古大学图书馆

RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts

Cellular & molecular Immunology 2023年第1期20卷 94-109页

作者： Seyeon Bae Kibyeong Kim Keunsoo Kang Haemin Kim Minjoon Lee Brian Oh Kaichi Kaneko Sungkook Ma Jae Hoon Choi Hojoong Kwak Eun Young Lee Sung Ho Park Kyung-Hyun Park-Min Arthritis and Tissue Degeneration Program David Z.Rosensweig Genomics Research CenterHospital for Special SurgeryNew YorkNY10021USA Department of Medicine Weill Cornell Medical CollegeNew YorkNY10065USA Department of Biological Science Ulsan National Institute of Science&Technology(UNIST)Ulsan44919Republic of Korea Department of Life Science College of Natural SciencesResearch Institute for Natural SciencesHanyang UniversitySeoulKorea Department of Microbiology Dankook UniversityCheonan3116Republic of Korea Department of Molecular Biology and Genetics Cornell UniversityIthacaUSA Division of Rheumatology Department of Internal MedicineSeoul National University College of MedicineSeoulKorea BCMB Allied Program Weill Cornell Graduate School of Medical SciencesNew YorkNY10021USA

Monocyte/macrophage lineage cells are highly plastic and can differentiate into various cells under different environmental stimuli. Bone-resorbing osteoclasts are derived from the monocyte/macrophage lineage in response to receptor activator of NF-κB ligand (RANKL). However, the epigenetic signature contributing to the fate commitment of monocyte/macrophage lineage differentiation into human osteoclasts is largely unknown. In this study, we identified RANKL-responsive human osteoclast-specific superenhancers (SEs) and SE-associated enhancer RNAs (SE-eRNAs) by integrating data obtained from ChIP-seq, ATAC-seq, nuclear RNA-seq and PRO-seq analyses. RANKL induced the formation of 200 SEs, which are large clusters of enhancers, while suppressing 148 SEs in macrophages. RANKL-responsive SEs were strongly correlated with genes in the osteoclastogenic program and were selectively increased in human osteoclasts but marginally presented in osteoblasts, CD4+ T cells, and CD34+ cells. In addition to the major transcription factors identified in osteoclasts, we found that BATF binding motifs were highly enriched in RANKL-responsive SEs. The depletion of BATF1/3 inhibited RANKL-induced osteoclast differentiation. Furthermore, we found increased chromatin accessibility in SE regions, where RNA polymerase II was significantly recruited to induce the extragenic transcription of SE-eRNAs, in human osteoclasts. Knocking down SE-eRNAs in the vicinity of the NFATc1 gene diminished the expression of NFATc1, a major regulator of osteoclasts, and osteoclast differentiation. Inhibiting BET proteins suppressed the formation of some RANKL-responsive SEs and NFATc1-associated SEs, and the expression of SE-eRNA:NFATc1. Moreover, SE-eRNA:NFATc1 was highly expressed in the synovial macrophages of rheumatoid arthritis patients exhibiting high-osteoclastogenic potential. Our genome-wide analysis revealed RANKL-inducible SEs and SE-eRNAs as osteoclast-specific signatures, which may contribute to t

关键词： Osteoclasts super-enhancers enhancer RNAs Rheumatoid arthritis

来源：评论

学校读者我要写书评

暂无评论

Effect of Carpolobia lutea leaf extract on erectile dysfunction induced by Paroxetine in rats

引用

Phytomedicine Plus 2024年第3期4卷 100609-100609页

作者： Elekofehinti, Olusola Olusola Akintoye, Oluwapelumi Nifesimi Akinjiyan, Moses Orimoloye Oluwamodupe, Cecilia Ojo, Funmilola Mabel Molehin, Olorunfemi Raphael Oluwatuyi, Adedotun Olayemi Ayodeji, Folasade Oluwatobiloba Alonge, Sunday Ayodele Adanlawo, Isaac Gbadura Bioinformatics and Molecular Biology Unit Department of Biochemistry Federal University of Technology Akure Teady Bioscience Research Laboratory Phytomedicine Molecular Biology & Bioinformatics lab Department of Chemical Science (Biochemistry program) Olusegun Agagu University of Science and Technology Department of Biological Sciences (Botany Programme) Olusegun Agagu University of Science and Technology Department of Biochemistry Faculty of Science Ekiti State University

Background: Erectile dysfunction (ERDF) has been implicated as an adverse effect of Paroxetine. Sildenafil (Viagra) is a conventional currently used in the management of this ailment but with side effects. Carpolobia lutea (CL) is a medicinal plant, traditionally explored and established for its aphrodisiac potential. Aim of the Study: The study aims to investigate the effect of Carpolobia lutea Extract (CLE) on ERDF rats induced by paroxetine at the molecular level and its phytocompounds’ interaction with proteins linked to the erection pathway. Methods: Forty-eight adult male Wistar rats were randomly grouped into six experimental groups: normal control, (20 mg/kg PI- ERDF + 1 ml distilled water) and treated groups (10 mg/kg Sildenafil, 50 mg/kg of CLE, 100 mg/kg of CLE and 200 mg/kg of CLE. Rats were administered paroxetine for five days before their sexual behaviour was examined through mounting frequency and latency when introduced to female rats. Antioxidant assays (DPPH, FRAB and TBARS) were performed over the 21-day experiment, and molecular investigations (in vivo and in silico) on ERDF-linked genes were conducted. Results: CLE has good in vitro antioxidant content. Paroxetine upregulated the expressions of phosphodiesterase-5, arginase, acetylcholinesterase, AMP deaminase and interleukin-6 relative to control. However, CLE downregulated these proteins and upregulated Nrf2, Androgen receptor, and Luteinizing hormone compared to PI- ERDF. CLE-phytocompounds like quercetin favourably interacted with phosphodiesterase-5 and nitric oxide synthase. Conclusion: The findings suggest that Carpolobia lutea leaf's phytocompounds show potential as a therapeutic agent in ERDF management. © 2024 The Author(s)

关键词： Carpolobia lutea Erectile dysfunction Gene expression Medicinal plants

来源：评论

学校读者我要写书评

暂无评论

PET-derived bis(2-hydroxyethyl) terephthalate as a new linker source for solvent-free and hydrothermal synthesis of BDC-based MOFs

引用

Materials Today Nano 2024年 25卷

作者： Krisbiantoro, Philip Anggo Kuo, Tzu-Jung Chang, Yu-Chia Liao, Weisheng Sun, Jih-Peng Yang, Chun-Yen Kamiya, Yuichi Shieh, Fa-Kuen Chen, Chia-Chin Wu, Kevin C.-W Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei11529 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Faculty of Environmental Earth Science Hokkaido University Nishi 5 Kita 10 Kita-ku Sapporo060-0810 Japan Department of Chemistry National Central University Taoyuan32001 Taiwan Center of Atomic Initiative for New Materials National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taoyuan Taiwan

To date, the high cost of organic linkers and the energy-consuming synthesis processes remain two of the main challenges for the commercialization of metal-organic frameworks (MOFs). Herein, we demonstrate that polyethylene terephthalate (PET)-derived bis(2-hydroxyethyl) terephthalate (BHET) is a new linker source that enables the facile solvent-free and hydrothermal synthesis of BDC-based MOFs. Using BHET as a linker source, UiO-66(Zr) was rapidly synthesized via a solvent-free "grind and bake" technique, while Ca-BDC and Ba-BDC were easily obtained by using hydrothermal synthesis. We found that the hydrolysis of BHET to terephthalate anion (BDC2−) over proton produced from the hydrolysis/clustering of Zr precursor and hydroxyl anion produced from the dissolution of M(OH)2 (M = Ca or Ba) was the key to the crystal growth of solvent-free synthesized UiO-66(Zr) and hydrothermally synthesized M-BDC (M = Ca or Ba), respectively. While the as-synthesized UiO-66(Zr) was highly active for the esterification of lactic acid (LA) with ethanol (EtOH), Ca-BDC and Ba-BDC exhibited remarkable electrochemical performance for lithium storage. Our strategy provides a major step towards realizing the idea of a more facile, green, and low-cost synthesis of PET-derived MOFs compared to prior arts applicable for catalysis and energy applications. © 2024

关键词： Lithium-ion batteries

来源：评论

学校读者我要写书评

暂无评论

Investigation of oxygen-related defect engineering in nonstoichiometric vanadium oxides for electrochromic zinc-ion batteries with superior electrochromic-electrochemical performance

引用

Chemical Engineering Journal 2025年 515卷

作者： Kim, Yonghan kim, Ilgyu Lee, Hye Kang Na, Hyunmin Jung, Ji-Won Yun, Tae Gwang Department of of Molecular Science and Technology Ajou University Gyeonggi Suwon16499 Korea Republic of Department of Materials Science and Engineering Konkuk University Seoul05029 Korea Republic of Advanced Materials Program Department of Materials Science and Engineering Konkuk University Seoul05029 Korea Republic of

Electrochromic-energy storage systems (e-ESS), which visualize the electrochemical charge–discharge process, are experiencing a rapid increase in demand for advanced applications. Electrochromic aqueous zinc-ion batteries (e-AZiBs) systems have emerged as a promising alternative due to their environmental friendliness, enhanced stability, and high volumetric energy density. In this study, we developed a non-stoichiometric vanadium oxide cathode that optimizes both electrochemical and electrochromic performance by controlling the oxygen defect concentration. By optimizing the annealing temperature, we effectively controlled the concentration of oxygen defects, which enhanced Zn2+ diffusion kinetics within the layered structure of V2O5 and promoted more reversible energy storage reactions. In particular, Ec-VO 350 sample, with the most favorable level of oxygen defects, exhibited a specific capacity of 383 mAh/g, representing a 160 % improvement in electrochemical performance compared to pristine V2O5. Additionally, the structural modifications induced by oxygen defects significantly improved electrochemical stability, achieving 98.27 % capacity retention after 500 cycles at 2 A/g, demonstrating excellent reversibility. Meanwhile, although the defect states generated by oxygen vacancies can affect the electronic structure and negatively influence electrochromic properties such as coloration efficiency and ΔT, Ec-VO 350 sample successfully achieved a coloration efficiency of 46.8 cm2/C and a ΔT of 65 %, owing to its enhanced Zn2+ diffusion kinetics despite a reduced optical bandgap. The methodology for developing the non-stoichiometric vanadium oxide cathode presented in this study offers an innovative strategy to enhance the potential for electrochromic energy storage systems (e-ESS) in advanced applications. © 2025

关键词： Virtual storage

来源：评论

学校读者我要写书评

暂无评论

Using 4D-STEM to Map 3D Morphologies of 2D Materials

引用

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 262-263页

作者： Mireles, Adan Shi, Chuqiao Park, Jeongwon Shin, Bongki Sung, Suk Hyun Ophus, Colin Hovden, Robert Kang, Kibum Han, Yimo Applied Physics Graduate Program Smalley-Curl Institute Rice University Houston TX United States Department of Materials Science and NanoEngineering Rice University Houston TX United States Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon South Korea Department of Materials Science and Engineering University of Michigan Ann Arbor MI United States National Center for Electron Microscopy Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA United States

来源：评论

学校读者我要写书评

暂无评论

The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders

引用

Neural Regeneration Research 2022年第6期17卷 1165-1171页

作者： Rafhanah Banu Bte Abdul Razar Yinghua Qu Saravanan Gunaseelan John Jia En Chua Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore LSI Neurobiology Programme National University of SingaporeSingaporeSingapore Institute for Health Innovation and Technology National University of SingaporeSingaporeSingapore Healthy Longevity Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore

The human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function *** circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain *** converging evidence indicates that alterations in neural circuits arising from abnormalities during early neuronal development or neurodegeneration contribute significantly to the etiology of neurological *** this notion,efforts to identify genetic causes of these disorders have uncovered an over-representation of genes encoding proteins involved in the processes of neuronal differentiation,maturation,synaptogenesis and synaptic *** and elongation protein zeta-1,a Kinesin-1 adapter,has emerged as a key central player involved in many of these *** and elongation protein zeta-1-dependent transport of synaptic cargoes and mitochondria is essential for neuronal development and synapse ***,it acts downstream of guidance cue pathways to regulate axo-dendritic ***,perturbing its function causes abnormalities in neuronal development and synapse formation both in the brain as well as the peripheral nervous *** and deletions of the fasciculation and elongation protein zeta-1 gene are linked to neurodevelopmental ***,altered phosphorylation of the protein contributes to neurodegenerative ***,these findings strongly implicate the importance of fasciculation and elongation protein zeta-1 in the establishment of neuronal circuits and its maintenance.

关键词： fasciculation and elongation protein zeta-1 neurological disorder neuronal development neuronal differentiation neuronal networks synapse formation synaptic function

来源：评论

学校读者我要写书评

暂无评论

Atomic excitation trapping in dissimilar chirally coupled atomic arrays

引用

Physical Review Research 2024年第1期6卷 013320-013320页

作者： I Gusti Ngurah Yudi Handayana Chun-Chi Wu Sumit Goswami Ying-Cheng Chen H. H. Jen Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica 115201 Taiwan Republic of China Department of Physics National Central University Taoyuan City 320317 Taiwan Republic of China Institute of Atomic and Molecular Sciences Academia Sinica Taipei 10617 Taiwan Republic of China Physics Division National Center for Theoretical Sciences Taipei 10617 Taiwan Republic of China

An atomic array coupled to a one-dimensional nanophotonic waveguide allows photon-mediated dipole-dipole interactions and nonreciprocal decay channels. Such an array possesses many intriguing quantum phenomena due to its distinctive and emergent quantum correlations. In this atom-waveguide quantum system, we theoretically investigate the atomic excitation dynamics and its transport property, specifically at an interface of dissimilar atomic arrays with different interparticle distances. We find that the atomic excitation dynamics is highly dependent on the interparticle distances of dissimilar arrays and the directionality of nonreciprocal couplings. By tuning these parameters, a dominant excitation reflection can be achieved at the interface of the arrays in the single excitation case. We further study two effects on the transport property—of external drive and of single excitation delocalization over multiple atoms—where we manifest a rich interplay between multisite excitation and the relative phase in determining the transport properties. Finally, we present an intriguing trapping effect of atomic excitation by designing multiple zones of dissimilar arrays. Similar to the single excitations, multiple excitations are reflected from the array interfaces and trapped as well, although complete trapping of many excitations together is relatively challenging at long time due to a faster combined decay rate. Our results can provide insights into nonequilibrium quantum dynamics in dissimilar arrays, and they can shed light on confining and controlling quantum registers useful for quantum information processing.

关键词： Dissipative dynamics Nanophotonics Superradiance & subradiance Atomic systems

来源：评论

学校读者我要写书评

暂无评论

Biomass-Based Discrete Furan Oligomers as Materials for Electrochromic Devices

引用

ACS Sustainable Chemistry and Engineering 2024年第1期12卷 459-469页

作者： Atayde, Eduardo C. Fong, Guan-Lun Yeh, Jyun-Yi Matsagar, Babasaheb M. Wang, Yu-Cheng Chen, De-Chian Peng, Chi-How Li, Yi-Pei Yamauchi, Yusuke Ho, Kuo-Chuan Wu, Kevin C.-W. Molecular Science and Technology Program Taiwan International Graduate Program (TIGP-MST) Academia Sinica No. 128 Sec. 2 Academia Road Taipei 11529 Taiwan Department of Chemistry National Tsing Hua University No. 101 Sec. 2 Kuang-Fu Road Hsinchu 30013 Taiwan Department of Chemical Engineering National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei 10617 Taiwan Sustainable Chemical Science and Technology Program Taiwan International Graduate Program (TIGP-SCST) Academia Sinica No. 128 Sec. 2 Academia Road Taipei 11529 Taiwan School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensl Brisbane 4072 QLD Australia Department of Materials Process Engineering Graduate School of Engineering Nagoya University Nagoya 464-8603 Japan Institute of Polymer Science and Engineering National Taiwan University No.1 Sec. 4 Roosevelt Rd. Taipei 10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University No. 135 Yuandong Rd. Taoyuan 320 Taiwan

Electrochromic devices (ECDs) are materials that can undergo reversible changes in transmittance when exposed to different applied potentials. While many conjugated heterocyclic oligomers, such as oligothiophenes, have been developed for this purpose, there is no reported study on the use of discrete oligomeric furans as ECD materials. In this work, we introduce a furan trimer that can be utilized as a discrete electrochromic material, which transitions from light yellow to red and has a very high coloration efficiency of 1940 cm²/C at 507 nm. We propose that the reversible π-stack formation of the oligomer radical cations is behind this phenomenon, as evidenced by both experimental and computational results. The derivability of this oligomer from biomass and its facile synthesis make it an interesting alternative for other existing organic electrochromic materials. © 2023 American Chemical Society

关键词： electrochromism furan oligomer hydroxyalkylation−alkylation reaction solvatochromism π-stacks

来源：评论

学校读者我要写书评

暂无评论

Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer

引用

Cell and Bioscience 2023年第1期13卷 1页

作者： Fan, Yu-Ching Fong, Yu-Cin Kuo, Chun-Tse Li, Chia-Wei Chen, Wei-Yu Lin, Jian-Da Bürtin, Florian Linnebacher, Michael Bui, Quoc Thang Lee, Kuan-Der Tsai, Yuan-Chin Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Department of Pathology Wan Fang Hospital Taipei Medical University Taipei Taiwan Department of Pathology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Biochemical Science and Technology College of Life Science National Taiwan University Taipei City 10617 Taiwan Center for Computational and Systems Biology National Taiwan University Taipei City 10617 Taiwan Clinic of General Surgery University Medical Center Rostock Schillingallee 35 Rostock 18057 Germany Clinic of General Surgery Molecular Oncology and Immunotherapy University Medical Center Rostock Schillingallee 69 Rostock 18057 Germany International Ph.D. Program for Cell Therapy and Regeneration Medicine (IPCTRM) School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Post-Baccalaureate Medicine College of Medicine Natioanl Chung Hsing University Taichung Taiwan Cell Therapy and Regenerative Medicine Center and Comprehensive Cancer Center Taichung Veterans General Hospital Taichung Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Background: Pancreatic ductal adenocarcinoma (PDA) is a pernicious disease characterized by an immunosuppressive milieu that is unresponsive to current immunotherapies. Interleukin-1 receptor antagonist (IL-1Ra) is a natural anti-inflammatory cytokine;however, its contribution to cancer pathogenesis and immunosuppression remains elusive. In this research, we investigated the role and mechanism of IL-1Ra in malignant progression of PDA. Results: Through analyzing clinical dataset and examining the pathological tumor tissues and serum samples, we have demonstrated that IL-1Ra expression is elevated in human PDA and positively associated with malignant progression of PDA. To study the biological function of IL-1Ra in tumors, we generated a set of mouse pancreatic cancer cell lines with a knockout (KO) of the Il1rn gene, encoding IL-1Ra, and compared the tumor growth rates in immune-competent and immune-deficient mice. We found that the Il1rn KO cells exhibited greater tumor inhibition in immune-competent mice, highlighting the crucial role of a functional immune system in Il1rn KO-mediated anti-tumor response. Consistently, we found an increase in CD8⁺ T cells and a decrease in CD11b⁺Ly6G⁻ immunosuppressive mononuclear population in the tumor microenvironment of Il1rn KO-derived tumors. To monitor the inhibitory effects of IL-1Ra on immune cells, we utilized a luciferase-based reporter CD4⁺ T cell line and splenocytes, which were derived from transgenic mice expressing ovalbumin-specific T cell receptors in CD8⁺ T cells, and mice immunized with ovalbumin. We showed that IL-1Ra suppressed T cell receptor signaling and inhibited antigen-specific interferon-γ (IFN-γ) secretion and cytolytic activity in splenocytes. Conclusions: Our findings illustrate the immunosuppressive properties of the natural anti-inflammatory cytokine IL-1Ra, and provide a rationale for considering IL-1Ra-targeted therapies in the treatment of

关键词： IFN-γ Immunosuppression interleukin-1 receptor antagonist Pancreatic adenocarcinoma Patient-derived xenograft Tumor microenvironment

来源：评论

学校读者我要写书评

暂无评论

Dynamic changes of fatty acids and (R)-dichlorprop toxicity in Arabidopsis thaliana: correlation, mechanism, and implications

引用

Environmental science and Pollution Research 2024年第43期31卷 55522-55534页

作者： Li, Jun Zhang, Qiushui Chen, Hui Xu, Dongmei Chen, Zunwei Wen, Yuezhong MOE Key Laboratory of Environmental Remediation & amp Ecosystem Health College of Environmental and Resource Sciences Zhejiang University Hangzhou310058 China College of Science and Technology Ningbo University Ningbo315211 China Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province College of Biological and Environmental Engineering Zhejiang Shuren University Hangzhou310015 China Program in Molecular and Integrative Physiological Sciences Department of Environmental Health Harvard University T.H. Chan School of Public Health BostonMA02115 United States

Plant fatty acids (FAs) are critical components of lipids and play an important role in coping with pollution-induced stress. However, the relationship between the fluctuating changes of FAs and the toxic effects of pollutants is not clear. Here, we analyzed and identified 19 FAs, namely 14 medium and long chain fatty acids (MLCFAs) and 5 very long chain fatty acids (VLCFAs). First, a positive correlation between plant biomass and LCFA content was observed. Changes in unsaturation were inversely related to cell membrane permeability, which serves as an indicator of the toxic effects. In particular, the use of herbicides led to a reduction in total FA content, but caused a significant increase in free fatty acids (FFAs), which facilitate oxidative stress. In addition, supplementation with exogenous FAs, particularly linoleic and alpha-linolenic acids, effectively alleviated the toxic inhibition. (R)-dichlorprop causes abnormal FA metabolism that can be reversed by ferrostatin-1, a ferroptosis inhibitor. Under (R)-dichlorprop exposure, the balance of FA unsaturation in plants is disrupted by inhibition of FA desaturase activity, ultimately leading to ferroptosis and disruption of cell membrane integrity. This study aims to enhance the understanding of the ecotoxic effects of herbicides by examining changes in FAs. The findings will provide a scientific basis for controlling environmental risks associated with hazardous substances. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Cell membranes

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：