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Recent advance in synthesis and application of heteroatom zeolites

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Chinese Chemical Letters 2021年第1期32卷 328-338页

作者： Tingting Pang Xuanyu Yang Chenyi Yuan Ahmed A.Elzatahry Abdulaziz Alghamdi Xing He Xiaowei Cheng Yonghui Deng School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China Materials Science and Technology Program College of Arts and SciencesQatar UniversityP.O.Box 2713DohaQatar Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China

Incorporation of heteroatoms into the framewo rk of zeolites has become a significant strategy to improve their performance in catalysis and adsorption,because the obtained heteroatom zeolites exhibit quite different properties from the conventional aluminosilicate zeolites in aspects of surface acidity,pore structures,particle size and so *** this review,the progress on the heteroatom zeolites including their synthesis and application is ***,the recent advance on the design and synthesis of different heteroatom zeolites is *** emphasis is placed on the introduction and comparison of three typical methods,including the direct synthesis,post synthesis and improved direct synthesis,for the traditional heteroatom zeolites(such as TS-1,Sn-MFI,Sn-β) and newly-reported heteroatom zeolites(such as W-MFI,Mo-MFI).According to their intrinsic characteristics,the application of heteroatom zeolites in diverse fields,such as production of fine chemicals,air pollution control and biomass conversion is then ***,the challenges and perspective on the future development of heteroatom zeolites in low-cost preparation and practical application are proposed.

关键词： Heteroatom zeolite Incorporation Tetrahedral coordination Research status Synthesis Application Prospective

Air-liquid microfluidics-integrated surface-enhanced Raman spectroscopy for selective molecular adsorption and detection to achieve bacterial discrimination

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Biosensors and Bioelectronics 2025年 285卷 117576页

作者： Ku, Chi-Yao Chiang, Yu-Wei Hsu, Huai-Yuan Cheng, Ho-Wen Chen, Ko-Lun Han, Yin-Yi Wang, Juen-Kai Wang, Yuh-Lin Huang, Nien-Tsu Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Institute of Atomic and Molecular Sciences Academia Sinica Taipei Taiwan Molecular Science and Technology Taiwan International Graduate Program Academia Sinica Taipei Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei Taiwan Department of Anesthesiology National Taiwan University Hospital Taipei100229 Taiwan Department of Trauma National Taiwan University Hospital Taipei100229 Taiwan Center for Condensed Matter Sciences National Taiwan University Taipei Taiwan Center for Atomic Initiative for New Materials National Taiwan University Taipei Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan

Bacterial discrimination is crucial for accurate microbiological diagnosis and timely antibiotic treatment. Surface-enhanced Raman spectroscopy (SERS) is an ideal technique due to its non-invasive, label-free molecular sensing capabilities. By analyzing bacterial supernatants, containing various purine derivatives, SERS can differentiate bacterial species based on their unique spectral distributions. However, the same bacterial species with different antibiotic resistance may secrete similar purine derivatives, differing only slightly in composition. Furthermore, each purine derivative may have a different molecular affinity to the SERS substrate, making it difficult to distinguish the exact molecular ratio. To improve SERS-based bacterial discrimination, we propose an air-liquid microfluidics-integrated SERS system (ALM-SERS) that selectively adsorbs and detects bacterial secretions. By taking features of precise microdroplet manipulation and contact area from microfluidics and features of selective molecular adsorption and fingerprints characterization from the SERS technique, we successfully perform a "sequential molecular adsorption" strategy to address the signal interference of complicated molecular mixtures in existing SERS methods. As a proof of concept, we first evaluate the molecular affinity of purine derivatives and then demonstrate the competitive analyte adsorption using adenine/cytosine and hypoxanthine/uracil sample mixtures. Finally, we tested six bacterial supernatants, including two Gram types and four strains with identical taxonomy but differing antibiotic resistance. Another six clinically isolated bacterial samples with different antibiotic resistance were also applied. Our results showed that a successful bacterial discrimination between similar species was not possible using a single SERS spectrum. In summary, the ALM-SERS system offers a powerful approach for bacterial discrimination, even when spectral differences are subtle. Beyond microb

关键词： Raman spectroscopy

Atomic excitation trapping in dissimilar chirally-coupled atomic arrays

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arXiv 2023年

作者： Handayana, I Gusti Ngurah Yudi Wu, Chun-Chi Goswami, Sumit Chen, Ying-Cheng Jen, H.H. Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taiwan Department of Physics National Central University Taoyuan City320317 Taiwan Institute of Atomic and Molecular Sciences Academia Sinica Taipei10617 Taiwan Physics Division National Center for Theoretical Sciences Taipei10617 Taiwan

Atomic array coupled to a one-dimensional nanophotonic waveguide allows photon-mediated dipole-dipole interactions and nonreciprocal decay channels, which hosts many intriguing quantum phenomena owing to its distinctive and emergent quantum correlations. In this atom-waveguide quantum system, we theoretically investigate the atomic excitation dynamics and its transport property, specifically at an interface of dissimilar atomic arrays with different interparticle distances. We find that the atomic excitation dynamics hugely depends on the interparticle distances of dissimilar arrays and the directionality of nonreciprocal couplings. By tuning these parameters, a dominant excitation reflection can be achieved at the interface of the arrays in the single excitation case. We further study two effects on the transport property-of external drive and of single excitation delocalization over multiple atoms, where we manifest a rich interplay between multi-site excitation and the relative phase in determining the transport properties. Finally, we present an intriguing trapping effect of atomic excitation by designing multiple zones of dissimilar arrays. Similar to the single excitations, multiple excitations are reflected from the array interfaces and trapped as well, although complete trapping of many excitations together is relatively challenging at long time due to a faster combined decay rate. Our results can provide insights to nonequilibrium quantum dynamics in dissimilar arrays and shed light on confining and controlling quantum registers useful for quantum information processing. Copyright © 2023, The Authors. All rights reserved.

关键词： Transport properties

Three-level Λ-type microwave memory via parametric-modulation-induced transparency in a superconducting quantum circuit

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Physical Review Research 2023年第3期5卷 033192-033192页

作者： Kai-I Chu Wen-Te Liao Yung-Fu Chen Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 11529 Taiwan Department of Physics National Central University Taoyuan City 32001 Taiwan Physics Division National Center for Theoretical Sciences Taipei 10617 Taiwan Center for Quantum Technology Hsinchu 30013 Taiwan Quantum Technology Center National Central University Taoyuan City 32001 Taiwan

We investigate theoretically a type of microwave memory that is composed of a single transmon qubit and a coupling resonator. The synergy of the parametric modulation of the qubit resonance frequency and a microwave directly driving the qubit transition can constitute effective three-level Λ-type electromagnetically induced transparency. We demonstrate that the dynamical control of such a parametric modulation allows for the possibility of microwave storage and retrieval using a single qubit. Our results pave the way towards the practical implementation of quantum information in superconducting circuits.

关键词： Electromagnetically induced transparency Quantum memories Quantum optics with artificial atoms Superconducting quantum optics Superconducting qubits

A photonic engine fueled by quantum-correlated atoms

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arXiv 2023年

作者： Feyisa, Chimdessa Gashu Jen, Hsiang Hua Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taiwan Department of Physics National Central University Taoyuan City320317 Taiwan Institute of Atomic and Molecular Sciences Academia Sinica Taipei10617 Taiwan Physics Division National Center for Theoretical Sciences Taipei10617 Taiwan

Entangled states are an important resource for quantum information processing and for the fundamental understanding of quantum physics. An intriguing open question would be whether entanglement can improve the performance of quantum heat engines in particular. One of the promising platforms to address this question is to use entangled atoms as a non-thermal bath for cavity photons, where the cavity mirror serves as a piston of the engine. Here we theoretically investigate a photonic quantum engine operating under an effective reservoir consisting of quantum-correlated pairs of atoms. We find that maximally entangled Bell states alone do not help extract useful work from the reservoir unless some extra populations in the excited states or ground states are taken into account. Furthermore, high efficiency and work output are shown for the non-maximally entangled superradiant state, while negligible for the subradiant state due to lack of emitted photons inside the cavity. Our results provide insights in the role of quantum-correlated atoms in a photonic engine and present new opportunities in designing a better quantum heat engine. Copyright © 2023, The Authors. All rights reserved.

关键词： Atoms

Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1258-1270页

作者： Ziwen Zheng Guo Li Chong Cui Fang Wang Xiaohan Wang Zhijiao Xu Huiping Guo Yuxin Chen Honghai Tang Daqi Wang Mingqian Huang Zheng-Yi Chen Xingxu Huang Huawei Li Geng-Lin Li Xiaoxiang Hu Yilai Shu ENT Institute and Department of Otorhinolaryngology Eye&ENT HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China NHC Key Laboratory of Hearing Medicine(Fudan University) Shanghai 200032China State Key Laboratory of Agrobiotechnology China Agricultural UniversityBeijing 100193China College of Biological Sciences China Agricultural UniversityBeijing 100193China School of Life Science and Technology Southeast UniversityNanjing 210096China Department of Otolaryngology-Head and Neck Surgery Graduate Program in Speech and Hearing Bioscience and Technology and Program in NeuroscienceHarvard Medical SchoolBostonMA 02115USA Eaton-Peabody Laboratory Massachusetts Eye and Ear InfirmaryBostonMA 02114USA School of Life Science and Technology ShanghaiTech UniversityShanghai 200031China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Institutes of Brain Science and the Collaborative Innovation Center for Brain Science Fudan UniversityShanghai 200031China

CRISPR/RfxCas13d(CasRx)editing system can specifically and precisely cleave single-strand RNAs,which is a promising treatment for various disorders by downregulation of related gene ***,we tested this RNA-editing approach on Beethoven(Bth)mice,an animal model for human DFNA36 due to a point mutation in *** first screened 30 sgRNAs in cell cultures and found that CasRx with sgRNA3 reduced the Tmc1^(Bth)transcript by 90.8%,and the Tmc1 wild type transcript(Tmc1^(+))by 44.3%.We then injected a newly developed AAV vector(***)based CasRx into the inner ears of neonatal Bth mice,and we found that Tmc1^(Bth)was reduced by 70.2%in 2 weeks with few off-target effects in the whole ***,we found improved hair cell survival,rescued hair bundle degeneration,and reduced mechanoelectrical transduction ***,the hearing performance,measured in both ABR and DPOAE thresholds,was improved significantly in all ages over 8 ***,therefore,have validated the CRISPR/CasRx-based RNA editing strategy in treating autosomal-dominant hearing loss,paving way for its further application in many other hereditary diseases in hearing and beyond.

关键词： CRISPR/Cas editing hearing

Robustness of tripartite entangled states in passive PT-symmetric qubits

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arXiv 2024年

作者： Feyisa, C.G. Liu, Cheng-Yu Hasan, Muhammad S. You, J.S. Ku, Huan-Yu Jen, H.H. Institute of Atomic and Molecular Sciences Academia Sinica Taipei10617 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taiwan Department of Physics National Central University Taoyuan320317 Taiwan Department of Physics National Taiwan Normal University Taipei11677 Taiwan Physics Division National Center for Theoretical Sciences Taipei10617 Taiwan

Non-Hermitian quantum systems have attracted significant interest in recent years due to the presence of unique spectral singularities known as exceptional points (EPs), where eigenvalues and eigenvectors coalesce. The drastic changes in these systems around their EPs have led to unique entanglement dynamics, which remained elusive until quite recently. In this work, we theoretically investigate the robustness of tripartite entanglement induced by EPs of the passive PT-symmetric non-Hermitian superconducting qubits, both in stand-alone configurations and hybrid setups with Hermitian qubits. In particular, we consider the qubits with both all-to-all and nearest-neighbour couplings under uniform and non-uniform coupling strengths. Our results reveal that non-Hermitian qubits with all-to-all coupling generate GHZ states, while those with nearest-neighbour interactions produce W states. These entangled states are resilient to non-uniform couplings and off-resonant driving fields. Moreover, the hybrid configurations combining Hermitian and non-Hermitian qubits suggest the importance of EPs for generating and maintaining genuine tripartite entanglement in our system. Additionally, driving the PT-symmetric qubits with a strong Rabi frequency can help sustain tripartite entanglement over time by countering losses, while strong inter-qubit coupling can benefit these entangled states in the low dissipation regime. These findings suggest that exploiting non-Hermitian systems and their associated EPs can create robust entangled states which are useful for both fundamental studies and quantum technologies. Copyright © 2024, The Authors. All rights reserved.

关键词： Qubits

Accelerating multipartite entanglement generation in non-Hermitian superconducting qubits

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arXiv 2024年

作者： Feyisa, Chimdessa Gashu You, J.S. Ku, Huan-Yu Jen, H.H. Institute of Atomic and Molecular Sciences Academia Sinica Taipei10617 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taiwan Department of Physics National Central University Taoyuan320317 Taiwan Department of Physics National Taiwan Normal University Taipei11677 Taiwan Physics Division National Center for Theoretical Sciences Taipei10617 Taiwan

Open quantum systems are susceptible to losses in information, energy, and particles due to their surrounding environment. One novel strategy to mitigate these losses is to transform them into advantages for quantum technologies through tailored non-Hermitian quantum systems. In this work, we theoretically propose a fast generation of multipartite entanglement in non-Hermitian qubits. Our findings reveal that weakly coupled non-Hermitian qubits can accelerate multiparty entanglement generation by thousands of times compared to Hermitian qubits, in particular when approaching the 2n-th order exceptional points of n qubits in the PT − symmetric regime. Furthermore, we show that Hermitian qubits can generate GHZ states with a high fidelity more than 0.9995 in a timescale comparable to that of non-Hermitian qubits, but at the expense of intense driving and large coupling constant. Our approach is scalable to a large number of qubits, presenting a promising pathway for advancing quantum technologies through the non-Hermiticity and higher-order exceptional points in many-body quantum systems. Copyright © 2024, The Authors. All rights reserved.

关键词： Quantum entanglement

Structure-guided identification and characterization of potent inhibitors targeting PhoP and MtrA to combat mycobacteria

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Computational and Structural Biotechnology Journal 2024年 23卷 1477-1488页

作者： Su, Han-Li Lai, Shu-Jung Tsai, Keng-Chang Fung, Kit-Man Lung, Tse-Lin Hsu, Hsing-Mien Wu, Yi-Chen Liu, Ching-Hui Lai, Hui-Xiang Lin, Jiun-Han Tseng, Tien-Sheng Department of Emergency Medicine Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi City600 Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Research Center for Cancer Biology China Medical University Taichung Taiwan National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei Taiwan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Academia Sinica Taipei11529 Taiwan Institute of Molecular Biology National Chung Hsing University Taichung Taiwan Department of Industrial Technology Ministry of Economic Affairs Taipei Taiwan Food Industry Research and Development Institute Hsinchu City Taiwan

Mycobacteria are causative agents of tuberculosis (TB), which is a global health concern. Drug-resistant TB strains are rapidly emerging, thereby necessitating the urgent development of new drugs. Two-component signal transduction systems (TCSs) are signaling pathways involved in the regulation of various bacterial behaviors and responses to environmental stimuli. Applying specific inhibitors of TCSs can disrupt bacterial signaling, growth, and virulence, and can help combat drug-resistant TB. We conducted a comprehensive pharmacophore-based inhibitor screening and biochemical and biophysical examinations to identify, characterize, and validate potential inhibitors targeting the response regulators PhoP and MtrA of mycobacteria. The constructed pharmacophore model Phar-PR-n4 identified effective inhibitors of formation of the PhoP–DNA complex: ST132 (IC50 = 29 ± 1.6 µM) and ST166 (IC50 = 18 ± 1.3 µM). ST166 (KD = 18.4 ± 4.3 μM) and ST132 (KD = 14.5 ± 0.1 μM) strongly targeted PhoP in a slow-on, slow-off manner. The inhibitory potency and binding affinity of ST166 and ST132 for MtrAC were comparable to those of PhoP. Structural analyses and molecular dynamics simulations revealed that ST166 and ST132 mainly interact with the α8-helix and C-terminal β-hairpin of PhoP, with functionally essential residue hotspots for structure-based inhibitor optimization. Moreover, ST166 has in vitro antibacterial activity against Macrobacterium marinum. Thus, ST166, with its characteristic 1,2,5,6-tetrathiocane and terminal sulphonic groups, has excellent potential as a candidate for the development of novel antimicrobial agents to combat pathogenic mycobacteria. © 2024 The Authors

关键词： Antimicrobial agents