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Novel Genetic Risk Variants Associated with Oral Tongue Squamous Cell Carcinoma

Head and Neck Pathology 2025年第1期19卷 45-45页

作者： Nikkilä, Rayan Mäkitie, Antti Joensuu, Heikki Markkanen, Saara Elenius, Klaus Monni, Outi Palotie, Aarno Saarentaus, Elmo Salo, Tuula Bizaki-Vallaskangas, Argyro Department of Otorhinolaryngology - Head and Neck Surgery University of Helsinki and HUS Helsinki University Hospital Helsinki Finland Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer and Research Helsinki Finland Research Program in Systems Oncology Faculty of Medicine University of Helsinki Helsinki Finland Department of Oncology HUS Helsinki University Hospital and University of Helsinki Helsinki Finland Department of Otolaryngology Faculty of Medicine and Health Technology Tampere University Tampere Finland The Wellbeing Services County of Pirkanmaa Tampere Finland Institute of Biomedicine and MediCity Research Laboratory University of Turku Turku Finland Turku Bioscience Centre University of Turku and Åbo Akademi University Turku Finland Department of Oncology Turku University Hospital Turku Finland iCAN Digital Precision Cancer Medicine Flagship University of Helsinki Helsinki Finland Applied Tumor Genomics Research Program Faculty of Medicine University of Helsinki Helsinki Finland Institute for Molecular Medicine Finland and the Helsinki Institute of Life Science University of Helsinki Helsinki Finland The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics The Broad Institute of MIT and Harvard Cambridge MA United States Analytic and Translational Genetics Unit Department of Medicine Department of Neurology and Department of Psychiatry Massachusetts General Hospital Boston MA United States Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland Translational Immunology Research Program Faculty of Medicine University of Helsinki Helsinki Finland Department of Pathology HUS Helsinki University Hospital Helsinki Finland Research Unit of Population Health Faculty of Medicine University of Oulu Oulu Finland Medical Research Center Oulu University Hospital Oulu Finland

Purpose: Limited data from genome-wide association studies (GWAS) focusing on oral tongue squamous cell carcinoma (OTSCC) are available. The present study was conducted to explore genetic associations for OTSCC. Methods: A GWAS on 376 cases of OTSCC was conducted using the FinnGen Data Freeze-12 dataset. The case-cohort included 205 males and 171 females. Cases with malignancies involving the base of the tongue or lingual tonsil were excluded from the case-cohort. Individuals with no recorded history of malignancy were used as controls (n = 407,067). A Phenome-wide association study (PheWAS) was performed for the lead variants to assess their co-associations with other cancers. Results: GWAS analysis identified three genome-wide significant loci associated with OTSCC (p < 5 × 10–8), located at 5p15.33 (rs27067 near gene LINC01511), 10q24 (rs1007771191 near RPS3AP36), and 20p12.3 (rs1438070080 near PLCB1), respectively. PheWAS showed associations of rs27067 mainly with prostate cancer (OR = 1.06, p = 5.41 × 10^–7), and seborrheic keratosis (OR = 1.11, p = 1.51 × 10^–11). A co-directional effect with melanoma was also observed (OR = 0.93, p = 6.24 × 10^–5). Conclusion: The GWAS detected two novel genetic associations with OTSCC. Further research is needed to identify the genes at these loci that contribute to the molecular pathogenesis of OTSCC. © The Author(s) 2025.

关键词： FinnGen Genetic variant Genome-wide association Single nucleotide polymorphism Tongue cancer

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Ultrahigh-quality graphene resonators by liquid-based strain-engineering

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Nanoscale Horizons 2023年第1期9卷 156-161页

作者： Chen, Ding-Rui Hu, I-Fan Chin, Hao-Ting Yao, Yu-Chi Raman, Radha Hofmann, Mario Liang, Chi-Te Hsieh, Ya-Ping Institute of Atomic and Molecular Sciences Academia Sinica Taipei10617 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei10617 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei10617 Taiwan Department of Physics National Taiwan University Taipei10617 Taiwan Department of Physics National Central University Taoyuan320 Taiwan

Two-dimensional (2D) material-based nanoelectromechanical (NEM) resonators are expected to be enabling components in hybrid qubits that couple mechanical and electromagnetic degrees of freedom. However, challenges in their sensitivity and coherence time have to be overcome to realize such mechanohybrid quantum systems. We here demonstrate the potential of strain engineering to realize 2D material-based resonators with unprecedented performance. A liquid-based tension process was shown to enhance the resonance frequency and quality factor of graphene resonators six-fold. Spectroscopic and microscopic characterization reveals a surface-energy enhanced wall interaction as the origin of this effect. The response of our tensioned resonators is not limited by external loss factors and exhibits near-ideal internal losses, yielding superior resonance frequencies and quality factors to all previously reported 2D material devices. Our approach represents a powerful method of enhancing 2D NEM resonators for future quantum systems. © 2024 The Royal Society of Chemistry

关键词： Resonators

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Laser-Induced Graphene-Based microfluidic electrochemical biosensor for clinical analysis

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Microchemical Journal 2025年 213卷

作者： Karintrithip, Wimala Boobphahom, Siraprapa Puthongkham, Pumidech Sakdaphetsiri, Kittiya Rodthongkum, Nadnudda International Graduate Program of Nanoscience & Technology Chulalongkorn University Phayathai Road Patumwan Bangkok 10330 Thailand Research Center for Neuroscience Institute of Molecular Biosciences Mahidol University Nakhon Pathom 73170 Thailand Department of Chemistry Faculty of Science Chulalongkorn University Phayathai Road Pathumwan Bangkok 10330 Thailand Metallurgy and Materials Science Research Institute Chulalongkorn University Phayathai Road Pathumwan Bangkok 10330 Thailand Center of Excellence in Responsive Wearable Materials Metallurgy and Materials Science Research Institute Chulalongkorn University Soi Chula 12 Phayathai Road Pathumwan Bangkok 10330 Thailand

Laser-induced graphene (LIG) has emerged as a versatile electrode material for electrochemical devices due to its flexibility in fabrication and modification capabilities. The large accessible surface area derived from the three-dimensional (3D) porous structure of LIG electrodes with their fast electron transfer kinetics facilitates their applications in electrochemical sensors, especially for point-of-care (POC) diagnosis. The combination of LIG electrode and microfluidic system offers great potential in terms of cost-effectiveness, fabrication precision, and rapid analysis, making it a promising alternative to conventional screen-printed electrodes. Furthermore, the microfluidic technology significantly improves analytical accuracy by enabling high-throughput screening, precise fluid control at the micro-scale, and reliable analytical assessment. Herein, the recent advancements in the integration of laser-induced graphene (LIG) into microfluidic platforms for electrochemical biosensors, with a focus on fabrication techniques and electrochemical performance metrics, including sensitivity, selectivity, and reproducibility are presented. Fabrication and electrochemical techniques are also discussed systematically. Finally, the integration of LIG with microfluidic system for clinical applications and the future direction of these innovative biosensing devices are described. © 2025 Elsevier B.V.

关键词： Electrochemical biosensor Laser-induced graphene (LIG) Microfluidic point-of-care (POC)

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Investigation of oxygen-related defect engineering in nonstoichiometric vanadium oxides for electrochromic zinc-ion batteries with superior electrochromic-electrochemical performance

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Chemical Engineering Journal 2025年 515卷

作者： Yonghan Kim Ilgyu kim Hye Kang Lee Hyunmin Na Ji-Won Jung Tae Gwang Yun Department of of Molecular Science and Technology Ajou University Suwon Gyeonggi 16499 Republic of Korea Department of Materials Science and Engineering Konkuk University Seoul 05029 Republic of Korea Advanced Materials Program Department of Materials Science and Engineering Konkuk University Seoul 05029 Republic of Korea

Electrochromic-energy storage systems (e-ESS), which visualize the electrochemical charge–discharge process, are experiencing a rapid increase in demand for advanced applications. Electrochromic aqueous zinc-ion batteries (e-AZiBs) systems have emerged as a promising alternative due to their environmental friendliness, enhanced stability, and high volumetric energy density. In this study, we developed a non-stoichiometric vanadium oxide cathode that optimizes both electrochemical and electrochromic performance by controlling the oxygen defect concentration. By optimizing the annealing temperature, we effectively controlled the concentration of oxygen defects, which enhanced Zn 2+ diffusion kinetics within the layered structure of V 2 O 5 and promoted more reversible energy storage reactions. In particular, Ec -VO 350 sample, with the most favorable level of oxygen defects, exhibited a specific capacity of 383 mAh/g, representing a 160 % improvement in electrochemical performance compared to pristine V 2 O 5 . Additionally, the structural modifications induced by oxygen defects significantly improved electrochemical stability, achieving 98.27 % capacity retention after 500 cycles at 2 A/g, demonstrating excellent reversibility. Meanwhile, although the defect states generated by oxygen vacancies can affect the electronic structure and negatively influence electrochromic properties such as coloration efficiency and ΔT, Ec -VO 350 sample successfully achieved a coloration efficiency of 46.8 cm 2 /C and a ΔT of 65 %, owing to its enhanced Zn 2+ diffusion kinetics despite a reduced optical bandgap. The methodology for developing the non-stoichiometric vanadium oxide cathode presented in this study offers an innovative strategy to enhance the potential for electrochromic energy storage systems (e-ESS) in advanced applications.

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Controlling the selection stringency of phage display using a microfluidic device (vol 9, pg 1033, 2009)

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LAB ON A CHIP 2009年第24期9卷 3604-3604页

作者： Liu, Yanli Adams, Jonathan D. Turner, Kelisha Cochran, Frank V. Gambhir, Sanjiv Sam Soh, H. Tom Neuroscience Research Institute Department of Materials Department of Physics School of Science and Technology Molecular Imaging Program at Stanford Department of Mechanical Engineering

We report the utilization of microfluidic technology to phage selection and demonstrate that accurate control of washing stringency in our microfluidic magnetic separator (MMS) directly impacts the diversity of isolated peptide sequences. Reproducible generation of magnetic and fluidic forces allows controlled washing conditions that enable rapid convergence of selected peptide sequences. These findings may provide a foundation for the development of automated microsystems for rapid in vitrodirected evolution of affinity reagents. [ABSTRACT FROM AUTHOR]

关键词： Magnetic separators accuracy control Affinity Reagent Phage display Peptides directed evolution Magnetic force Microfluidics Microfluidic Devices Washing

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Role of atrial natriuretic peptide and oxytocin in gastric emptying delay induced by right atrial stretch in rats

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American Journal of Physiology - Regulatory Integrative and Comparative Physiology 2025年第3期328卷 R396-R407页

作者： Palheta, Raimundo C. da Silva, Moisés T.B. Georgii, Ana Débora N.P. Silva, Camila M.S. Siqueira, Rômmulo C.L. Reis, Wagner L. Ruginsk, Silvia G. Elias, Lucila L.K. Antunes-Rodrigues, José Santos, Armênio A. Laboratory of Veterinary Pharmacology Department of Veterinary Medicine Federal University of Vale do São Francisco Petrolina Brazil Laboratory of Physiology MedinUP/RISE-Health Department of Immuno-Physiology and Pharmacology School of Medicine and Biomedical Sciences University of Porto Porto Portugal School of Chemistry Federal University of Rio de Janeiro Rio de Janeiro Brazil Program in Cellular and Molecular Medicine Boston Children’s Hospital Harvard Medical School Boston MA United States Federal Institute of Education Science and Technology of Ceará Limoeiro do Norte Brazil Department of Physiological Sciences Center for Biological Sciences Federal University of Santa Catarina Florianópolis Brazil Department of Physiological Sciences Biomedical Sciences Institute Federal University of Alfenas Alfenas Brazil Department of Physiology Ribeirão Preto Medical School University of São Paulo Ribeirão Preto Brazil Department of Physiology and Pharmacology School of Medicine Federal University of Ceará Fortaleza Brazil

Fluid volume and osmolality balance are maintained by complex neuroendocrine and liquid-salt intake behavior, cardiovascular and renal mechanisms, and gastrointestinal adjustments. Mechanical stretching of the right atrium [atrial stretch (AS)] enhances central venous pressure and heart rate while decreasing gastric emptying (GE) of liquid in rats. We evaluated the effect of AS on GE and plasma levels of atrial natriuretic peptide (ANP), oxytocin (OT), and corticosterone (CORT) to determine whether ANP contributes to the OT-mediated GE delay of liquids due to AS in awake rats. Initially, we performed thoracotomy followed by right appendectomy (AX) or sham thoracotomy. One week later, rats were randomly subjected to pretreatment with NaCl 0.15 M (control), atosiban (AT, OT-antagonist), anantin (ANT, ANP-antagonist), or dexamethasone (DEX). Afterward, 50 lL of AS was administered for 5 min or not (sham). Then, the rats were fed a test meal, and GE of liquids or solids was performed. The other animals were pretreated with NaCl 0.15 M, atosiban, anantin, or dexamethasone, followed by OT treatment for GE assessment. Compared with the sham group, 50 lL of AS decreased the GE of the liquid and solid test meals. This phenomenon was prevented by AT, ANT, DEX, and surgical procedures with AX. AS also increased plasma levels of ANP, OT, and CORT. In turn, oxytocin treatment decreased GE and increased plasma ANP, OT, and CORT levels, while AT, ANT, and DEX prevented OT-induced GE delay. Hence, AS delayed GE of liquid in rats, a phenomenon that involves oxytocinergic pathways and ANP activities. Copyright © 2025 The Authors.

关键词： atrial distension gastric emptying gastrointestinal motility neuroendocrine balance

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Nitrogen Pretreatment of Growth Substrates for Vacancy-Saturated MoS2

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ACS Applied Materials and Interfaces 2023年第36期15卷 42746-42752页

作者： Yao, Yu-Chi Wu, Bo-Yi Chin, Hao-Ting Yen, Zhi-Long Ting, Chu-Chi Hofmann, Mario Hsieh, Ya-Ping Institute of Atomic and Molecular Sciences Academia Sinica Taipei10617 Taiwan Department of Physics National Taiwan University Taipei10617 Taiwan Graduate Institute of Opto-Mechatronics Department of Mechanical Engineering National Chung Cheng University Chia-Yi62102 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei10617 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei10617 Taiwan

Two-dimensional transition-metal dichalcogenides (2D TMDCs) are considered promising materials for optoelectronics due to their unique optical and electric properties. However, their potential has been limited by the occurrence of atomic vacancies during synthesis. While post-treatment processes have demonstrated the passivation of such vacancies, they increase process complexity and affect the TMDC’s quality. We here introduce the concept of pretreatment as a facile and powerful route to solve the problem of vacancies in MoS2. Low-temperature nitridation of the sapphire substrate prior to growth provides a nondestructive method to MoS2 modification without introducing new processing steps or increasing the thermal budget. Spectroscopic characterization and atomic-resolution microscopy reveal the incorporation of nitrogen from the sapphire surface layer into chalcogen vacancies. The resulting MoS2 with nitrogen-saturated defects shows a decrease in midgap states and more intrinsic doping as confirmed by ab initio calculations and optoelectronic measurements. The demonstrated pretreatment method opens up new routes toward future, high-performance 2D electronics, as evidenced by a 3-fold reduction in contact resistance and a 10-fold improved performance of 2D photodetectors. © 2023 American Chemical Society

关键词： Molybdenum compounds

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Enhancing the Electrochemical Activity of 2D Materials Edges through Oriented Electric Fields

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ACS Nano 2024年第30期18卷 19828-19835页

作者： Wang, Hao Chen, Ding-Rui Lin, You-Chen Lin, Po-Han Chang, Jui-Teng Muthu, Jeyavelan Hofmann, Mario Hsieh, Ya-Ping Institute of Atomic and Molecular Sciences Academia Sinica Taipei10617 Taiwan Department of Physics National Taiwan University Taipei10617 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei10617 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei10617 Taiwan Department of Low Dimensional Systems J. Heyrovský Institute of Physical Chemistry Prague18200 Czech Republic

The edges of 2D materials have emerged as promising electrochemical catalyst systems, yet their performance still lags behind that of noble metals. Here, we demonstrate the potential of oriented electric fields (OEFs) to enhance the electrochemical activity of 2D materials edges. By atomically engineering the edge of a fluorographene/graphene/MoS2 heterojunction nanoribbon, strong and localized OEFs were realized as confirmed by simulations and spatially resolved spectroscopy. The observed fringing OEF results in an enhancement of the heterogeneous charge transfer rate between the edge and the electrolyte by 2 orders of magnitude according to impedance spectroscopy. Ab initio calculations indicate a field-induced decrease in the reactant adsorption energy as the origin of this improvement. We apply the OEF-enhanced edge reactivity to hydrogen evolution reactions (HER) and observe a significantly enhanced electrochemical performance, as evidenced by a 30% decrease in Tafel slope and a 3-fold enhanced turnover frequency. Our findings demonstrate the potential of OEFs for tailoring the catalytic properties of 2D material edges toward future complex reactions. © 2024 The Authors. Published by American Chemical Society.

关键词： Electric fields

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A label-free electrochemical biosensor for detection of miRNA-34a breast cancer marker using disposable gold nanoparticles modified screen-printed reduced graphene oxide-molybdenum disulfide composited electrodes

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Microchemical Journal 2025年 213卷

作者： Primpray, Vitsarut Pasakon, Patiya Kamsong, Wichayaporn Wisitsoraat, Anurat Laiwattanapaisal, Wanida Karuwan, Chanpen Graduate Program in Clinical Biochemistry and Molecular Medicine Department of Clinical Chemistry Faculty of Allied Health Sciences Chulalongkorn University Bangkok 10330 Thailand National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA) Pathum Thani 12120 Thailand Department of Clinical Chemistry Faculty of Allied Health Sciences Chulalongkorn University Bangkok 10330 Thailand Center of Excellence for Biosensors and Bioengineering (CEBB) Chulalongkorn University Bangkok 10330 Thailand

Breast cancer is a perilous disease, causing a high mortality rate and posing a major public health challenge worldwide. Traditional clinical diagnosis of breast cancer typically relies on tissue biopsy, which is invasive, time-consuming, costly and skill dependent. In contrast, liquid biopsy is minimally invasive by utilizing body fluid samples to detect biomarkers, such as microRNAs (miRNAs). This study explores a novel electrochemical biosensor based on a disposable screen-printed electrode comprising reduced graphene oxide (rGO) and molybdenum disulfide (MoS₂) for detecting miRNA-34a, a key biomarker of breast cancer. The sensor utilizes the advantageous properties of two-dimensional nanomaterials, including high surface area and conductivity, to enhance sensitivity and performance. Additionally, the presence of sulfur in the composite is beneficial for anchoring metal nanoparticles. Consequently, the screen-printed reduced graphene oxide and molybdenum disulfide composite electrodes (SPrGO-MoS₂Es) are effective for functionalization with gold nanoparticles (AuNPs), which further improve conductivity and enable specific probe immobilization through covalent binding. The biosensor detects miRNA-34a by measuring the current response of ferrocyanide as a redox probe using differential pulse voltammetry. The developed SPrGO/MoS₂E biosensor has a detection range of 0.1 nM to 1000 nM and a detection limit of 66 pM with excellent specificity. Moreover, the biosensor demonstrated high accuracy, precision, and stability for detecting miRNA-34a in serum samples with low, medium, and high concentrations. Therefore, it can be an easy-to-use, cost-effective tool with potential applications in point-of-care testing for breast cancer. © 2025

关键词： Electrochemical biosensor miRNA-34a Molybdenum disulfide Reduced graphene oxide Screen-printed electrode

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Feasibility of Inferring Spatial Transcriptomics from Single-Cell Histological Patterns for Studying Colon Cancer Tumor Heterogeneity

Feasibility of Inferring Spatial Transcriptomics from Single...

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18th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2025

作者： Fatemi, Michael Y. Lu, Yunrui Azher, Zarif L. Sharma, Cyril Feng, Eric Diallo, Alos B. Srinivasan, Gokul Rosner, Grace M. Pointer, Kelli B. Christensen, Brock C. Salas, Lucas A. Tsongalis, Gregory J. Palisoul, Scott M. Perreard, Laurent Kolling, Fred W. Vaickus, Louis J. Levy, Joshua J. University of Virginia CharlottesvilleVA United States Emerging Diagnostic and Investigative Technologies Department of Pathology and Laboratory Medicine Dartmouth Health LebanonNH United States Department of Computer Science Purdue University West LafayetteIN United States Thomas Jefferson High School for Science and Technology AlexandriaVA United States Department of Epidemiology Dartmouth College Geisel School of Medicine HanoverNH United States Program in Quantitative Biomedical Sciences Dartmouth College Geisel School of Medicine HanoverNH United States Department of Medicine Section of Radiology Oncology Dartmouth Health LebanonNH United States Department of Molecular and Cell Biology Dartmouth College Geisel School of Medicine HanoverNH United States Genomics Shared Resource Dartmouth Cancer Center LebanonNH United States Department of Dermatology Dartmouth Health LebanonNH United States Department of Pathology and Laboratory Medicine Cedars Sinai Medical Center Los AngelesCA United States Department of Computational Biomedicine Cedars Sinai Medical Center Los AngelesCA United States Division of Biology and Biological Engineering California Institute of Technology PasadenaCA United States

Spatial transcriptomics (ST) enables studying spatial organization of gene expression within tissues, offering insights into the molecular diversity of tumors. Recent methods have demonstrated the capability to disaggregate this information at subspot resolution by leveraging both expression and histological patterns. Elucidating such information from histology alone presents a significant challenge, but if solved can enable spatial molecular analysis at cellular resolution even where ST data is not available, reducing study costs. This study explores integrating single-cell histological and transcriptomic data to infer spatial mRNA expression patterns in colorectal cancer whole slide images. A cell-graph neural network algorithm was developed to align histological information extracted from detected cells with single cell RNA, facilitating the analysis of cellular groupings and gene relationships. We demonstrate that single-cell transcriptional heterogeneity within a spot could be predicted from histological markers extracted from cells detected within it. Our model exhibited proficiency in delineating overarching gene expression patterns across whole-slide images. This approach compared favorably to traditional computer vision methods which did not incorporate single cell expression during the model training. This innovative approach augments the resolution of spatial molecular assays utilizing histology as sole input through co-mapping of histological and transcriptomic datasets at the single-cell level. © 2025 by SCITEPRESS– science and technology Publications, Lda.

关键词： Tumors

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