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160P Characteristics and outcomes of young breast cancer patients harboring BRCA pathogenic variants according to histologic subtype

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ESMO Open 2024年 9卷 103182-103182页

作者： E. Agostinetto M. Bruzzone A-S. Hamy-Petit H.J. Kim C.K. Chiodi R. Bernstein Molho S. Linn K. Pogoda E. Carrasco F. Derouane J. Bajpai N. Lopetegui Lia A.H. Partridge K-A. Phillips A. Toss C. Rousset-Jablonski F. Giugliano E. de Azambuja E. Blondeaux M. Lambertini ATPT Institute Jules Bordet Bruxelles Belgium U.O. Clinical Epidemiology IRCCS Ospedale Policlinico San Martino Genoa Italy Department of Medical Oncology Institut Curie Paris France Division of Breast Surgery Department of Surgery Asan Medical Center - University of Ulsan Seoul Republic of Korea Cancer Survivorship Program - Molecular Predicitors and New Targets in Oncology Institut Gustave Roussy - Inserm UMR 981 Villejuif France Oncology Department Chaim Sheba Medical Center Ramat Gan Israel Department of Molecular Pathology NKI-AVL - Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital Amsterdam Netherlands Department of Breast Cancer and Reconstructive Surgery Maria Sklodowska-Curie National Research Institute of Oncology Warsaw Poland Hereditary Cancer Genetics Unit Medical Oncology Department Vall d’Hebron University Hospital Barcelona Spain Department of General Medical Oncology and Multidisciplinary Breast Center Leuven Cancer Institute University Hospitals Leuven Leuven Belgium Medical Oncology Department Tata Memorial Hospital - Tata Memorial Centre Mumbai India Hematology/Medical Oncology Taussig Cancer Center-Cleveland Clinic Cleveland OH USA Medical Oncology Dana-Farber Cancer Institute Boston MA USA Medical Oncology Department Peter MacCallum Cancer Center Melbourne VIC Australia Department of Oncology and Haematology Azienda Ospedaliero - Universitaria Policlinico di Modena Modena Italy Surgery Centre Léon Bérard Lyon France Early Drug Development IEO - Istituto Europeo di Oncologia Milan Italy Epidemiology Unit IRCCS Ospedale Policlinico San Martino Genoa Italy Department of Medical Oncology IRCCS AOU San Martino - IST-Istituto Nazionale per la Ricerca sul Cancro Genoa Italy

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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction (vol 53, pg 65, 2021)

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NATURE GENETICS 2021年第3期53卷 413-413页

作者： Conti, David V. Darst, Burcu F. Moss, Lilit C. Saunders, Edward J. Sheng, Xin Chou, Alisha Schumacher, Fredrick R. Al Olama, Ali Amin Benlloch, Sara Dadaev, Tokhir Brook, Mark N. Sahimi, Ali Hoffmann, Thomas J. Takahashi, Atushi Matsuda, Koichi Momozawa, Yukihide Fujita, Masashi Muir, Kenneth Lophatananon, Artitaya Wan, Peggy Le Marchand, Loic Wilkens, Lynne R. Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Nordestgaard, Borge G. Nielsen, Sune F. Weischer, Maren Bojesen, Stig E. Roder, Martin Andreas Iversen, Peter Batra, Jyotsna Chambers, Suzanne Moya, Leire Horvath, Lisa Clements, Judith A. Tilley, Wayne Risbridger, Gail P. Gronberg, Henrik Aly, Markus Szulkin, Robert Eklund, Martin Nordstrom, Tobias Pashayan, Nora Dunning, Alison M. Ghoussaini, Maya Travis, Ruth C. Key, Tim J. Riboli, Elio Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Albanes, Demetrius Weinstein, Stephanie J. Mucci, Lorelei A. Giovannucci, Edward Lindstrom, Sara Kraft, Peter Hunter, David J. Penney, Kathryn L. Turman, Constance Tangen, Catherine M. Goodman, Phyllis J. Thompson, Ian M., Jr. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Parent, Marie-Elise Stanford, Janet L. Ostrander, Elaine A. Geybels, Milan S. Koutros, Stella Freeman, Laura E. Beane Stampfer, Meir Wolk, Alicja Hakansson, Niclas Andriole, Gerald L. Hoover, Robert N. Machiela, Mitchell J. Sorensen, Karina Dalsgaard Borre, Michael Blot, William J. Zheng, Wei Yeboah, Edward D. Mensah, James E. Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Wu, Yudong Zhao, Shan-Chao Sun, Zan Thibodeau, Stephen N. McDonnell, Shannon K. Schaid, Daniel J. West, Catharine M. L. Burnet, Neil Barnett, Gill Maier, Christiane Schnoeller, Thomas Luedeke, Manuel Kibel, Adam S. Drake, Bettina F. Cussenot, Olivier Cancel-Tassin, Gerald Center for Genetic Epidemiology Department of Preventive Medicine Keck School of Medicine University of Southern California/Norris Comprehensive Cancer Center Los Angeles CA USA The Institute of Cancer Research London UK Royal Marsden NHS Foundation Trust London UK Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland OH USA Seidman Cancer Center University Hospitals Cleveland OH USA Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge Strangeways Research Laboratory Cambridge UK Stroke Research Group Department of Clinical Neurosciences University of Cambridge Cambridge UK Fundación Pública Galega Medicina Xenómica Santiago De Compostela Spain Instituto de Investigación Sanitaria de Santiago de Compostela Santiago De Compostela Spain Centro de Investigación en Red de Enfermedades Raras (CIBERER) Madrid Spain Department of Epidemiology and Biostatistics University of California San Francisco CA USA Institute for Human Genetics University of California San Francisco CA USA Department of Urology University of California San Francisco San Francisco CA USA Laboratory for Statistical Analysis RIKEN Center for Integrative Medical Sciences Yokohama Japan Department of Genomic Medicine National Cerebral and Cardiovascular Center Research Institute Suita Japan Laboratory of Clinical Genome Sequencing Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan Biobank Tokyo Japan Laboratory for Genotyping Development RIKEN Center of Integrative Medical Sciences Yokohama Japan Laboratory for Cancer Genomics RIKEN Center of Integrative Medical Sciences Yokohama Japan Division of Population Health Health Services Research and Primary Care School of Health Sciences Faculty of Biology Medicine and Health University of Manchester Manchester UK Warwick Medical School University of Warwick C

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84–5.29) for men of European ancestry to 3.74 (95% CI, 3.36–4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14–2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71–0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.

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Expression of Interleukin-15 and Its Receptor on the Surface of Stimulated Human Umbilical Vein Endothelial Cells

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2009年第5期29卷 527-534页

作者：刘秀平左玉梅张维娜杨德光熊长云张小舟 College of Life Science and Technology Huazhong University of Science and Technology Hubei Vocational and Technical College Department of Cardiology Southwest Hospital Third Military Medical University Institute of Organ Transplantation Key Laboratory of Organ TransplantationMinistry of Education/Ministry of HealthTongji HospitalTongji Medical CollegeHuazhong University of Science and Technology College of Agriculture Northeast Agricultural University Molecular Targets Development Program National Cancer Institute-Frederick National Institutes of Health Frederick Xianggan Medical College Hospital Huazhong University of Science and Technology

Summary： Human interleukin-15 （hIL-15） is an important cytokine to activate endothelial cells and can be regulated by many other cytokines. The aim of this study is to examine the ability of interferon-γ （IFN-γ）, and tumor necrosis factor-or （TNF-α to induce the production of human interleukin-15 （hIL-15） and IL-15 receptor （IL-15Rα by human umbilical vein endothelial cells （HUVECs）. The data are summarized as follows： 1. Northern blot revealed that IL-15 mRNA was up-regulated by IFN-γ and TNF-α 2. Intracellular IL-15 protein was visualized by fluorescence microscopy, whereas the expression of IL-15 on the surface of HUVECs was detected by fluorescence activated cell sorting （FACS）, and no detectable IL-15 in the medium was verified by ELISA. 3. IL-15Rα was detected on the surface of HUVECs by FACS after IFN-α and TNF-α stimulation, whereas Western blotting revealed that the elevated expression on surface IL-15Rα was not due to the increased protein expression. The conclusion demonstrated from our results is that IFN-α and TNF-α play an important role in regulating the expression of IL-15 and IL-15Rα on the surface of HUVECs.

关键词： endothelial cells interleukin- 15 interleukin- 15 receptor cytokines

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Enantioselective Synthesis of (+)‐Chamaecypanone C: A Novel Microtubule Inhibitor†

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Angewandte Chemie 2009年第8期121卷

作者： Suwei Dong Ernest Hamel Ruoli Bai David G. Covell John A. Beutler John A. Porco Department of Chemistry Center for Chemical Methodology and Library Development (CMLD‐BU) Boston University 590 Commonwealth Avenue Boston MA 02215 (USA) Fax: (+1) 617‐358‐2847 Toxicology and Pharmacology Branch National Cancer Institute at Frederick MD (USA) Screening Technologies Branch Developmental Therapeutics Program Division of Cancer Treatment and Diagnosis National Cancer Institute at Frederick MD (USA) Molecular Targets Development Program National Cancer Institute at Frederick MD (USA)

Zurück und hin im Tandem : Die Totalsynthese von (+)‐Chamaecypanon C gelang mithilfe einer Retro‐Diels‐Alder/Diels‐Alder‐Tandemreaktion (siehe Schema). Erste biologische Untersuchungen zeigen, dass (+)‐Cham... 详细信息

关键词： Cycloadditionen Cyclopentadienon Mikrotubuli‐Inhibitor Naturstoffe Totalsynthesen

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Modulation of Interleukin-15-induced Suppression of Human Neutrophil Apoptosis by TNFα

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第4期27卷 354-357页

作者：刘秀平熊长云李春红杨德光 College of Life Science and Technology Huazhong Universty of Science and Technology Molecular Targets Development Program National Cancer Institute-Frederick National Institutes of Health Frederick Affiliated Tumor Hospital Harbin Medical University College of Agriculture Northeast Agricultural University

Human interleukin-15 （IL-15） is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic agent. The modulatory effect of TNFα was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFa was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect by TNFα might be associated with a reduction of the expression of the anti-apoptotic Bcl-XI protein detected by Western blotting. It is concluded that TNFα can be used to modulate IL- 15-induced suppression of neutrophil apoptosis within certain time course.

关键词： neutrophil interleukin-15 TNFα apoptosis Bcl-XI

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Influenza a (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor

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Antiviral Chemistry and Chemotherapy 2007年第6期18卷 317-327页

作者： Smee, Donald F. Wandersee, Miles K. Checketts, Melissa B. Saucedo, Carrie Boyd, Michael R. Mishin, Vasiliy P. Gubareva, Larisa V. Institute for Antiviral Research Utah State University Logan UT United States Molecular Targets Development Program Center for Cancer Research NCI-Frederick Frederick MD United States Cancer Research Institute College of Medicine University of South Alabama Mobile AL United States University of Virginia Health Science Center Charlottesville VA United States Department of Infectious Diseases St. Jude Children's Research Hospital Memphis TN United States Virus Surveillance and Diagnosis Branch Influenza Division Centers for Disease Control and Prevention Atlanta GA United States

Influenza A/New Caledonia/20/99 (H1N1) virus was studied for development of resistance to cyanovirin-N (CVN). CVN neutralizes virus infectivity by binding to specific high-mannose oligosaccharides on the viral haemagglutinin 1 (HA1) subunit. During virus adaptation to mice in the absence of CVN treatment the virus became resistant to CVN (CVN-MR virus), as did virus passaged in cell culture in the presence of CVN (CVN-R virus). The CVN-R virus possessed a single amino acid change at position 94a (Asn94aAsp) of HA1 that eliminated this glycosylation site. The CVN-MR virus at mouse passage 7 was a mixture of clones, consisting of a single mutation (Asp225Gly) and double mutations (Asn63Ser+Asp225Gly or Asn94a+Asp225Gly), eliminating glycosylation sites. CVN did not bind well to the CVN-R and CVN-MR viruses. Propagating these viruses in cells treated with 1 mM deoxymannojirimycin (dMJ, mannosidase inhibitor) increased sensitivity to CVN, suggesting that glycans attached at other sites on HA1 that typically are not high-mannosidic became so due to dMJ treatment. Further evaluation showed that the Asp225Gly mutant virus was sensitive to the inhibitor and did not kill mice or induce weight loss. The CVN-R virus was also avirulent to mice. The double-mutant CVN-MR viruses were resistant to CVN and caused deaths and severe weight loss in mice. CVN-R virus subjected to mouse adaptation acquired the 225 mutation and a lethal phenotype. Thus, the 225 mutation in the HA receptor-binding site in combination with a loss of glycan at Asn (63 or 94a) are important for mouse adaptation in this virus. The mutations reported here causing resistance to CVN are consistent with its known mode of action. ©2008 International Medical Press.

关键词： Collectins Haemagglutinin Mutations Neutralization Oligomannose

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BOOK REVIEW

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Journal of Herbs, Spices & Medicinal Plants 2003年第1期10卷 99-100页

作者： John A. Beutler[a] [a] Assay Development Screening & Dereplication Group Molecular Targets Drug Discovery Program Frederick MD

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Herbal Medicine: Chaos in the Marketplace By Rowena K. Richter. Haworth Herbal Press, Binghamton, NY. 2003. xvii + 220 pp. 21.3 cm × 15.5 cm. $19.95. ISBN 0-7890-1620-6 (paper).

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Journal of Natural Products 2003年第1期67卷 124页

作者： John A. Beutler Molecular Targets Development Program National Cancer Institute Frederick Maryland 21702

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Encoded Fiber‐Optic Microsphere Arrays for Probing Protein–Carbohydrate Interactions†

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Angewandte Chemie 2003年第43期115卷

作者： Eddie W. Adams Jörn Ueberfeld Daniel M. Ratner Barry R. O'Keefe David R. Walt Peter H. Seeberger Department of Chemistry Massachusetts Institute of Technology Cambridge MA 02139 USA Fax: (+1) 617‐253‐2979 The Max Tishler Laboratory for Organic Chemistry Department of Chemistry Tufts University Medford MA 02155 USA Molecular Targets Development Program NCI Center for Cancer Research National Cancer Institute NCI‐Frederick Frederick MD 21702 USA

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