检索结果-内蒙古大学图书馆

Xenoestrogen effects on the gut microbiome

Current Opinion in Endocrine and Metabolic Research 2021年 19卷 41-45页

作者： Rosenfeld, Cheryl S. Christopher S Bond Life Sciences Center University of Missouri Columbia 65211 MO United States Biomedical Sciences University of Missouri Columbia 65211 MO United States MU Institute for Data Science and Informatics (MU IDSI) University of Missouri Columbia 65211 MO United States Thompson Center for Autism and Neurobehavioral Disorders University of Missouri Columbia 65211 MO United States Genetics Area Program University of Missouri Columbia 65211 MO United States

Endocrine disrupting chemicals (EDCs) that act as xenoestrogens are natural and synthetic chemicals widely present in food products, industrial products, and the environment. Such compounds can activate or inhibit normal hormonal pathways by binding to steroid and non-steroid receptors. It is becomingly apparent that resident bacteria in the gut and elsewhere in the body can dramatically influence host responses. As such, increasing number of studies have examined how EDCs affect the gut microbiome in a range of animal species. This review article will examine what is known about how various xenoestrogens, including bisphenol A (BPA), phthalates, and phytoestrogens, affect the gut microbiome in vertebrate species, any known secondary host effects, such as through alteration of gut metabolites, and future directions in the field. © 2021 Elsevier Ltd

关键词： Bisphenol A Genistein Phytoestrogens Rodent models Xenoestrogens

来源：评论

学校读者我要写书评

暂无评论

Developmental exposure of California mice to endocrine disrupting chemicals and potential effects on the microbiome-gut-brain axis at adulthood (vol 10, 10902, 2020)

引用

SCIENTIFIC REPORTS 2020年第1期10卷 1-17页

作者： Kaur, Sarabjit Sarma, Saurav J. Marshall, Brittney L. Liu, Yang Kinkade, Jessica A. Bellamy, Madison M. Mao, Jiude Helferich, William G. Schenk, A. Katrin Bivens, Nathan J. Lei, Zhentian Sumner, Lloyd W. Bowden, John A. Koelmel, Jeremy P. Joshi, Trupti Rosenfeld, Cheryl S. Christopher S Bond Life Sciences Center University of Missouri Columbia USA Biomedical Sciences University of Missouri Columbia USA MU Metabolomics Center University of Missouri Columbia USA MU Institute of Data Science and Informatics University of Missouri Columbia USA Food Science and Human Nutrition University of Illinois Urbana USA Physics Randolph College Lynchburg USA DNA Core Facility University of Missouri Columbia USA Department of Biochemistry University of Missouri Columbia USA Department of Physiological Sciences College of Veterinary Medicine University of Florida Gainesville USA Center for Environmental and Human Toxicology College of Veterinary Medicine University of Florida Gainesville USA Environmental Health Sciences Yale University New Haven USA Department of Health Management and Informatics School of Medicine University of Missouri Columbia USA Thompson Center for Autism and Neurobehavioral Disorders University of Missouri Columbia USA Genetics Area Program University of Missouri Columbia USA

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

关键词：

来源：评论

学校读者我要写书评

暂无评论

SNPViz v2.0: A web-based tool for enhanced haplotype analysis using large scale resequencing datasets and discovery of phenotypes causative gene using allelic variations

SNPViz v2.0: A web-based tool for enhanced haplotype analysi...

引用

IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Shuai Zeng Mária Škrabišová Zhen Lyu Yen On Chan Kristin Bilyeu Trupti Joshi University of Missouri-Columbia Columbia USA Faculty of Science Palacký University in Olomouc Olomouc Czech Republic MU Institute for Data Science and Informatics University of Missouri-Columbia Columbia USA USDA/ARS Plant Genetics Research Unit University of Missouri-Columbia Columbia USA

ISBN: (数字)9781728162157

ISBN: (纸本)9781728162164

Single nucleotide polymorphisms (SNPs) and insertions/deletions (Indels) are widely spread across all chromosomes of the genome and act as biological markers, which aid in identification of genes associated with traits or phenotypes. With the advances in next-generation sequencing (NGS) technology, large amounts of SNPs and Indels data have become available, making it difficult to effectively perform analysis across multiple samples and intuitively integrate, compare and/or visualize them simultaneously. Genome-wide association studies (GWAS) is a widely used method to find genetic variations associated with a trait, but it lacks an efficient way to investigate genomic variant functions. To tackle these issues, we have developed SNPViz v2.0, a web-based tool to visualize large-scale haplotype blocks with detailed SNPs and Indels grouped by their chromosomal coordinates, along with their overlapping gene models, phenotype to genotype accuracies, Gene Ontology (GO) annotations, protein families (Pfam) annotations, genomic variant annotations, and their functional effects. Moreover, SNPViz v2.0 integrates several large scale soybean SNPs and Indels datasets including G. Soja, GWAS, NAM41, USB-15x, USB-40x, MSMC and Zhou302, available from multiple studies. SNPViz v2.0 is deployed for all organisms and available in both SoyKB and KBCommons frameworks. For soybean data only, the SNPViz 2.0 is publicly available at http://***/SNPViz2/. For other organisms such as Arabidopsis thaliana, mus musculus and Zea mays, SNPViz 2.0 is publicly available in their respective knowledge bases at https://***.

关键词： Tools data visualization Bioinformatics Genomics databases Annotations Organisms

来源：评论

学校读者我要写书评

暂无评论

Adapting Segment Anything Model (SAM) through Prompt-based Learning for Enhanced Protein Identification in Cryo-EM Micrographs

Adapting Segment Anything Model (SAM) through Prompt-based L...

引用

Medical Artificial Intelligence (MedAI), IEEE International Conference on

作者： Fei He Zhiyuan Yang Mingyue Gao Biplab Poudel Newgin Sam Ebin Sam Dhas Rajan Gyawali Ashwin Dhakal Jianlin Cheng Dong Xu Department of Electrical Engineering and Computer Science NextGen Precision Health Bond Life Sciences Center University of Missouri Columbia USA Bond Life Sciences Center University of Missouri Columbia USA MU Institute for Data Science and Informatics University of Missouri Columbia USA Department of Electrical Engineering and Computer Science NextGen Precision Health University of Missouri Columbia USA

ISBN: (数字)9798350377613

ISBN: (纸本)9798350377620

Cryo-electron microscopy (cryo-EM) remains pivotal in structural biology, yet the task of protein particle picking, integral for 3D protein structure construction, is laden with manual inefficiencies. While recent AI tools such as Topaz and crYOLO are advancing the field, they do not fully address the challenges of cryo-EM images, including low contrast, complex shapes, and heterogeneous conformations. This study explored prompt-based learning to adapt the state-of-the-art image segmentation foundation model Segment Anything Model (SAM) for cryo-EM. This focus was driven by the desire to optimize model performance with a small number of labeled data without altering pre-trained parameters, aiming for a balance between adaptability and foundational knowledge retention. Through trials with three prompt-based learning strategies, namely head prompt, prefix prompt, and encoder prompt, we observed enhanced performance and reduced computational requirements compared to the fine-tuning approach. This work not only highlights the potential of prompting SAM in protein identification from cryo-EM micrographs but also suggests its broader promise in biomedical image segmentation and object detection.

关键词： Proteins Training Protein engineering Image segmentation Adaptation models Computational modeling Object detection Object recognition Photomicrography Biomedical imaging

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Developmental exposure of California mice to endocrine disrupting chemicals and potential effects on the microbiome-gut-brain axis at adulthood

引用

Scientific reports 2020年第1期10卷 12524页

作者： Sarabjit Kaur Saurav J Sarma Brittney L Marshall Yang Liu Jessica A Kinkade Madison M Bellamy Jiude Mao William G Helferich A Katrin Schenk Nathan J Bivens Zhentian Lei Lloyd W Sumner John A Bowden Jeremy P Koelmel Trupti Joshi Cheryl S Rosenfeld Christopher S Bond Life Sciences Center University of Missouri Columbia MO 65211 USA. Biomedical Sciences University of Missouri Columbia MO 65211 USA. MU Metabolomics Center University of Missouri Columbia MO 65211 USA. MU Institute of Data Science and Informatics University of Missouri Columbia MO 65211 USA. Food Science and Human Nutrition University of Illinois Urbana IL 61801 USA. Physics Randolph College Lynchburg VA 24503 USA. DNA Core Facility University of Missouri Columbia MO 65211 USA. Department of Biochemistry University of Missouri Columbia MO 65211 USA. Department of Physiological Sciences College of Veterinary Medicine University of Florida Gainesville FL 32610 USA. Center for Environmental and Human Toxicology College of Veterinary Medicine University of Florida Gainesville FL 32610 USA. Environmental Health Sciences Yale University New Haven CT 06510 USA. Department of Health Management and Informatics School of Medicine University of Missouri Columbia MO 65211 USA. Christopher S Bond Life Sciences Center University of Missouri Columbia MO 65211 USA. rosenfeldc@missouri.edu. Biomedical Sciences University of Missouri Columbia MO 65211 USA. rosenfeldc@missouri.edu. MU Institute of Data Science and Informatics University of Missouri Columbia MO 65211 USA. rosenfeldc@missouri.edu. Thompson Center for Autism and Neurobehavioral Disorders University of Missouri Columbia MO 65211 USA. rosenfeldc@missouri.edu. Genetics Area Program University of Missouri Columbia MO 65211 USA. rosenfeldc@missouri.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

关键词：

来源：评论

学校读者我要写书评

暂无评论

MiRNA Changes in the Mouse Placenta Due to Bisphenol a Exposure

引用

Epigenomics 2021年第24期13卷 1909-1919页

作者： Jiude Mao Jessica A Kinkade Nathan J Bivens Cheryl S Rosenfeld 1 Christopher S Bond Life Sciences Center University of Missouri Columbia MO65211 USA2 Biomedical Sciences University of Missouri Columbia MO65211 USA 2 Biomedical Sciences University of Missouri Columbia MO65211 USA 3 Genomics Technology Core Facility University of Missouri Columbia MO65211 USA 2 Biomedical Sciences University of Missouri Columbia MO65211 USA4 MU Institute for Data Science & Informatics University of Missouri Columbia MO65211 USA5 Thompson Center for Autism & Neurobehavioral Disorders University of Missouri Columbia MO65211 USA6 Genetics Area Program University of Missouri Columbia MO65211 USA

Aim:To determine small RNA expression changes in mouse placenta induced by bisphenol A (BPA) ***:Exposing female mice to BPA two weeks prior to conception through gestational day 12.5; whereupon fetal placentas were collected, frozen in liquid nitrogen and stored at -80°C. Small RNAs were isolated and used for small ***:43 small RNAs were differentially expressed. Target mRNAs were closely aligned to those expressed by thymus and brain, and pathway enrichment analyses indicated that such target mRNAs regulate neurogenesis and associated neurodevelopment ***:BPA induces several small RNAs in mouse placenta that might provide biomarkers for BPA exposure. Further, the placenta might affect fetal brain development through the secretion of miRNAs.

关键词： EDC endocrine disrupting chemicals miRNA phenolic compounds RNA-sequencing trophoblast

来源：评论

学校读者我要写书评

暂无评论

Impact of bisphenol-A and synthetic estradiol on brain, behavior, gonads and sex hormones in a sexually labile coral reef fish

引用

Hormones and Behavior 2021年第0期136卷 105043-105043页

作者： Gonzalez, Jose A. Histed, Abigail R. Nowak, Ewelina Lange, Dominica Craig, Sarah E. Parker, Coltan G. Kaur, Achint Bhuvanagiri, Supriya Kroll, Kevin J. Martyniuk, Christopher J. Denslow, Nancy D. Rosenfeld, Cheryl S. Rhodes, Justin S. The Beckman Institute for Advanced Science and Technology University of Illinois d0e N. Mathews Ave Urbana 61801 IL United States The Neuroscience Program University of Illinois 405 N. Mathews Ave Urbana 61801 IL United States Department of Physiological Sciences and Center for Environmental and Human Toxicology College of Veterinary Medicine University of Florida Gainesville 32610 FL United States Department of Biomedical Sciences Bond Life Sciences Center Thompson Center for Autism and Neurobehavioral Disorders MU Institute for Data Science and Informatics and Genetics Area Program University of Missouri Columbia 65211 MO United States Department of Psychology University of Illinois 405 N. Mathews Ave Urbana 61801 IL United States

Endocrine disrupting chemicals, such as bisphenol A (BPA) and ethinylestradiol (EE2), are detected in the marine environment from plastic waste and wastewater effluent. However, their impact on reproduction in sexually labile coral reef fish is unknown. The objective of this study was to determine impacts of environmentally relevant concentrations of BPA and EE2 on behavior, brain gene expression, gonadal histology, sex hormone profile, and plasma vitellogenin (Vtg) levels in the anemonefish, Amphiprion ocellaris. A. ocellaris display post-maturational sex change from male to female in nature. Sexually immature, male fish were paired together and fed twice daily with normal food (control), food containing BPA (100 μg/kg), or EE2 (0.02 μg/kg) (n = 9 pairs/group). Aggression toward an intruder male was measured at 1, 3, and 6 months. Blood was collected at 3 and 6 months to measure estradiol (E2), 11-ketotestosterone (11-KT), and Vtg. At the end of the study, fish were euthanized to assess gonad morphology and to measure expression of known sexually dimorphic genes in the brain. Relative to control, BPA decreased aggression, altered brain transcript levels, increased non-vitellogenic and vitellogenic eggs in the gonad, reduced 11-KT, and increased plasma Vtg. In two BPA-treated pairs, both individuals had vitellogenic eggs, which does not naturally occur. EE2 reduced 11-KT in subordinate individuals and altered expression of one transcript in the brain toward the female profile. Results suggest BPA, and to a lesser extent EE2, pollution in coral reef ecosystems could interfere with normal reproductive physiology and behavior of the iconic sexually labile anemonefish. © 2021 Elsevier Inc.

关键词： 11-Ketotestosterone Aggression Bisphenol A EDC Endocrine disruptor Estradiol Ethinylestradiol Feminization Gonad Plastic Pollution Protandrous sex change Reproduction Vitellogenic Xenoestrogen

来源：评论

学校读者我要写书评

暂无评论

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

引用

Nature Genetics 2025年 1-13页

作者： Strom, Nora I. Gerring, Zachary F. Galimberti, Marco Yu, Dongmei Halvorsen, Matthew W. Abdellaoui, Abdel Rodriguez-Fontenla, Cristina Sealock, Julia M. Bigdeli, Tim Coleman, Jonathan R. Mahjani, Behrang Thorp, Jackson G. Bey, Katharina Burton, Christie L. Luykx, Jurjen J. Zai, Gwyneth Alemany, Silvia Andre, Christine Askland, Kathleen D. Bäckman, Julia Banaj, Nerisa Barlassina, Cristina Nissen, Judith Becker Bienvenu, O. Joseph Black, Donald Bloch, Michael H. Børte, Sigrid Bosch, Rosa Breen, Michael Brennan, Brian P. Brentani, Helena Buxbaum, Joseph D. Bybjerg-Grauholm, Jonas Byrne, Enda M. Cabana-Dominguez, Judit Camarena, Beatriz Camarena, Adrian Cappi, Carolina Carracedo, Angel Casas, Miguel Cavallini, Maria Cristina Ciullo, Valentina Cook, Edwin H. Crosby, Jesse Cullen, Bernadette A. De Schipper, Elles J. Delorme, Richard Djurovic, Srdjan Elias, Jason A. Estivill, Xavier Falkenstein, Martha J. Fundin, Bengt T. Garner, Lauryn Gironda, Christina Goes, Fernando S. Grados, Marco A. Grove, Jakob Guo, Wei Haavik, Jan Hagen, Kristen Harrington, Kelly Havdahl, Alexandra Höffler, Kira D. Hounie, Ana G. Hucks, Donald Hultman, Christina Janecka, Magdalena Jenike, Eric Karlsson, Elinor K. Kelley, Kara Klawohn, Julia Krasnow, Janice E. Krebs, Kristi Lange, Christoph Lanzagorta, Nuria Levey, Daniel Lindblad-Toh, Kerstin Macciardi, Fabio Maher, Brion Mathes, Brittany McArthur, Evonne McGregor, Nathaniel McLaughlin, Nicole C. Meier, Sandra Miguel, Euripedes C. mulhern, Maureen Nestadt, Paul S. Nurmi, Erika L. O’Connell, Kevin S. Osiecki, Lisa Ousdal, Olga Therese Palviainen, Teemu Pedersen, Nancy L. Piras, Federica Potluri, Sriramya Rabionet, Raquel Ramirez, Alfredo Rauch, Scott Reichenberg, Abraham Riddle, Mark A. Ripke, Stephan Rosário, Maria C. Sampaio, Aline S. Schiele, Miriam A. Skogholt, Anne Heidi Sloofman, Laura G. Smit, Jan Artigas, María Soler Thomas, Laurent F. Tifft, Eric Vallada, Homero van Kirk, Nathanial Veenstra-VanderWeele, Jeremy Vulink, Nienke N. Walker, Christopher P. Wang, Ying Wendland, Jens R. Winsvold Department of Psychology Humboldt-Universität zu Berlin Berlin Germany Department of Psychiatric Phenomics and Genomics (IPPG) Ludwig-Maximilians University Munich Munich Germany Centre for Psychiatry Research Department of Clinical Neuroscience Karolinska Institutet and Stockholm Health Services Region Stockholm Stockholm Sweden Department of Biomedicine Aarhus University Aarhus Denmark University Hospital of Psychiatry and Psychotherapy University of Bern Bern Switzerland Department of Mental Health and Neuroscience Translational Neurogenomics QIMR Berghofer Medical Research Institute Brisbane QLD Australia Department of Population Health and Immunity Healthy Development and Ageing Walter and Eliza Hall Institute of Medical Research Melbourne VIC Australia Department of Psychiatry Human Genetics Yale University New Haven CT United States VA Connecticut Healthcare System West Haven CT United States Department of Center for Genomic Medicine Psychiatric and Neurodevelopmental Genetics Unit Massachusetts General Hospital Boston MA United States Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge MA United States Department of Genetics University of North Carolina at Chapel Hill Chapel Hill NC United States Department of Psychiatry Amsterdam University Medical Centers University of Amsterdam Amsterdam Netherlands Center for Research in Molecular Medicine and Chronic Diseases (CiMUS) Genomics and Bioinformatics University of Santiago de Compostela Santiago de Compostela Spain Grupo de Medicina Xenómica Genetics Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS) Santiago de Compostela Spain Vanderbilt Genetics Institute Vanderbilt University Nashville TN United States Department of Psychiatry and Behavioral Sciences SUNY Downstate Health Sciences University Brooklyn NY United States VA NY Harbor Healthcare System Brooklyn NY United States Social Genetic and Developmental Psychiatry Centre Insti

Obsessive–compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3 and CTNND1 and multiple genes in the major histocompatibility complex (MHC) region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and the cortex, along with D₁ and D₂ type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 65 of 112 additional phenotypes, including all the psychiatric disorders we examined. In particular, OCD shared genetic risk with anxiety, depression, anorexia nervosa and Tourette syndrome and was negatively associated with inflammatory bowel diseases, educational attainment and body mass index. © The Author(s) 2025.

关键词：

来源：评论

学校读者我要写书评

暂无评论

穿山甲可能不是新型冠状病毒的中间宿主

引用

中国预防兽医学报 2020年第12期42卷 1311-1311页

作者： LIU PING JIANG JING-ZHE WANXIU-FENG Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and Utilization Guangdong Institute of Applied Biological Resources Guangdong Academy of Science Guangzhou Guangdong Province China. Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization Ministry of Agriculture South China Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Guangzhou Guangdong Province China. Department of Molecular Microbiology and Immunology School of Medicine University of Missouri Columbia Missouri United States of America. Department of Electrical Engineering & Computer Science College of Engineering University of Missouri Columbia Missouri United States of America. MU Center for Research on Influenza Systems Biology (CRISB) University of Missouri Columbia Missouri United States of America. Bond Life Sciences Center University of Missouri Columbia Missouri United States of America. MU Institute for Data Science and Informatics University of Missouri Columbia Missouri United States of America. Guangdong Provincial Key Laboratory of Silviculture Protection and Utilization Guangdong Academy of Forestry Guangzhou Guangdong Province China. Institute of Animal Health Guangdong Academy of Agricultural Sciences Guangzhou Guangdong Province China. Guangdong Provincial Wildlife Rescue Center Guangzhou Guangdong Province China.

当前,新型冠状病毒肺炎(COVID-19)疫情仍在全球范围内肆虐,新冠肺炎的防控工作依然是重中之重。研究表明新型冠状病毒与中菊头蝠携带的Bat-CoV-RaTG13冠状病毒全基因组核苷酸一致性高达96%,推测该病毒可能起源于蝙蝠,再由中间野生动物... 详细信息

当前,新型冠状病毒肺炎(COVID-19)疫情仍在全球范围内肆虐,新冠肺炎的防控工作依然是重中之重。研究表明新型冠状病毒与中菊头蝠携带的Bat-CoV-RaTG13冠状病毒全基因组核苷酸一致性高达96%,推测该病毒可能起源于蝙蝠,再由中间野生动物宿主进一步传播,但目前中间宿主仍然未知。

关键词：中间宿主防控工作动物宿主穿山甲冠状病毒全球范围全基因组肺炎

来源：评论

学校读者我要写书评

暂无评论

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

引用

The Lancet 2020年第10258期396卷 1204-1222页

作者： Abbafati, Cristiana Abbas, Kaja M. Abbasi, Mohammad Abbasifard, Mitra Abbasi-Kangevari, Mohsen Abbastabar, Hedayat Abd-Allah, Foad Abdelalim, Ahmed Abdollahi, Mohammad Abdollahpour, Ibrahim Abedi, Aidin Abedi, Parisa Abegaz, Kedir Hussein Abolhassani, Hassan Abosetugn, Akine Eshete Aboyans, Victor Abrams, Elissa M. Abreu, Lucas Guimarães Abrigo, Michael R.M. Abu Haimed, Abdulaziz Khalid Abualhasan, Ahmed Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Abushouk, Abdelrahman I. Acebedo, Alyssa Ackerman, Ilana N. Adabi, Maryam Adair, Tim Adamu, Abdu A. Adebayo, Oladimeji M. Adedeji, Isaac Akinkunmi Adekanmbi, Victor Adelson, Jaimie D. Adeoye, Abiodun Moshood Adetokunboh, Olatunji O. Adham, Davoud Advani, Shailesh M. Afarideh, Mohsen Afshari, Mahdi Afshin, Ashkan Agardh, Emilie E. Agarwal, Gina Agasthi, Pradyumna Agesa, Kareha M. Aghaali, Mohammad Aghamir, Seyed Mohammad Kazem Agrawal, Anurag Ahmad, Tauseef Ahmadi, Alireza Ahmadi, Keivan Ahmadi, Mehdi Ahmadieh, Hamid Ahmadpour, Ehsan Ahmed, muktar Beshir Aji, Budi Akalu, Temesgen Yihunie Akinyemi, Rufus Olusola Akinyemiju, Tomi Akombi, Blessing Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Khurshid Alam, Noore Alam, Samiah Alam, Tahiya Alanezi, Fahad Mashhour Alanzi, Turki M. Albertson, Samuel B. Alcalde-Rabanal, Jacqueline Elizabeth Alema, Niguse Meles Alemu, Biresaw Wassihun Alemu, Yihun mulugeta Alhabib, Khalid F. Alhassan, Robert Kaba Ali, muhammad Ali, Saqib Alicandro, Gianfranco Alijanzadeh, Mehran Alinia, Cyrus Alipour, Vahid Alizade, Hesam Aljunid, Syed Mohamed Alla, François Allebeck, Peter Almadi, Majid Abdulrahman Hamad Almasi, Ali Almasi-Hashiani, Amir Almasri, Nihad A. Al-Mekhlafi, Hesham M. Almulhim, Abdulaziz M. Alonso, Jordi Al-Raddadi, Rajaa M. Altirkawi, Khalid A. Alumran, Arwa Khalid Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Amare, Bekalu Amini, Saeed Amini-Rarani, Mostafa Aminorroaya, Arya Amiri, Fatemeh Amit, Arianna Maever L. Amugsi, Dickson A. Amul, Gianna Gayle Herrera Anbesu, Etsay Woldu Ancuceanu, Robert Anderl Department of Juridical and Economic Studies La Sapienza University Rome Italy Department of Infectious Disease Epidemiology London School of Hygiene and Tropical Medicine London United Kingdom Social Determinants of Health Research Center Tehran Iran Department of Neurology Cairo University Cairo Egypt School of Pharmacy Tehran Iran The Institute of Pharmaceutical Sciences (TIPS) Tehran Iran Neuroscience Research Center Isfahan University of Medical Sciences Isfahan Iran Biostatistics Department Near East University Nicosia Cyprus Biostatistics and Health Informatics Madda Walabu University Bale Robe Ethiopia Research Center for Immunodeficiencies Tehran Iran Karolinska University Hospital Huddinge Sweden Department of Cardiology Dupuytren University Hospital Limoges France University of Limoges Limoges France Department of Pediatric Dentistry Federal University of Minas Gerais Belo Horizonte Brazil Department of Research Philippine Institute for Development Studies Quezon City Philippines Department of Healthcare Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Harvard Medical School Boston MA United States Department of Medicine Ain Shams University Cairo Egypt Hamadan University of Medical Sciences Hamadan Iran School of Medicine Cardiff University Cardiff United Kingdom School of Laboratory Medicine and Science University College Hospital Ibadan Ibadan Nigeria Institute of Cardiovascular Diseases University of Ibadan Ibadan Nigeria Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Cape Town South Africa Department of Global Health Stellenbosch University Cape Town South Africa School of Health Ardabil University of Medical Science Ardabil Iran Social Behavioral Research Branch National Institute of Health Bethesda MD United States Department of Oncology Georgetown University Washington DC DC United States Department of Health Metrics Sciences School of Medicine Seattle WA

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw value

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：