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The recombinant EHV-1 vector producing CDV hemagglutinin as potential vaccine against canine distemper

MICROBIAL PATHOGENESIS 2017年第0期111卷 388-394页

作者： Pan, Zihao Liu, Jin Ma, Jiale Jin, Qiuli Yao, Huochun Osterrieder, Nikolaus Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China Nanjing Chi Yuan Biol Technol Co Ltd Nanjing Jiangsu Peoples R China Free Univ Berlin FB Vet Med Inst Virol D-14163 Berlin Germany

Canine distemper virus (CDV), is a pantropic agent of morbillivirus that causes fetal disease in dogs. Base on a broad host rang of CDV, the continued vaccines inoculation is unavoidable to pose gene recombination risk in vaccine virus and wild virus. The current study presents the construction of novel vectors, using equine herpesvirus type 1 (EHV-1) expressing the canine distemper virus (CDV). The recent field strain hemagglutinin protein and nucleoprotein were used for the construction of the viral vector vaccines. Based on the Bacterial artificial chromosome (BAC) genomes of EHV-1 RacH strain, the recombinant EHV-1 vaccine virus encoding CDV hemagglutinin protein (EHV-H) or CDV nucleoprotein (EHV-N) was constructed separately. The constructed BACs were rescued after 72 h post infection, and the expression of H or N in the recombinant viruses was confirmed by western-blotting. Furthermore, high levels of neutralizing antibodies were induced persistently following vaccination in the groups EHVH&EHV-N and EHV-H, but the EHV-N group. The groups of vaccinated EHV-H and EHV-H&EHV-N pups were monitored for clinical signs, whereas the vaccinated EHV-N group developed moderate symptoms. The present study demonstrated that EHV-1 based recombinant virus carrying CDV H could be a promising vaccine candidate against canine distemper. (C) 2017 Published by Elsevier ltd.

关键词： CDV EHV-1 Viral vector vaccine Hemagglutinin Nucleoprotein

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Fabrication and characterization of low-cost and green vacuum insulation panels with fumed silica/rice husk ash hybrid core material

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MATERIALS & DESIGN 2016年 107卷 440-449页

作者： Li, Cheng-Dong Saeed, Muhammad-Umar Pan, Ning Chen, Zhao-Feng Xu, Teng-Zhou Nanjing Univ Aeronaut & Astronaut Coll Materials Sci & Technol Int Lab Insulat & Energy Efficiency Materials Nanjing 210016 Jiangsu Peoples R China Nanjing Univ Aeronaut & Astronaut Jiangsu Collaborat Innovat Ctr forAdvanced Inorga Nanjing 210016 Jiangsu Peoples R China Univ Calif Davis NEAT Biol Syst Engn Davis CA 95616 USA Suzhou VIP New Mat Co Ltd Hong Da Fang Yuan Grp Suzhou 215400 Peoples R China

Novel fiber/powder hybrid core materials (HCMs) containing various combination ratios of fumed silica (FS), rice husk ash (RHA), carbon black, titanium dioxide and polyester chopped strand were prepared by dry powder mixing method. The HCMs and their corresponding vacuum insulation panel (VIP) samples were thoroughly characterized to get insight information about their microstructures, structural stability and thermal conductivities. The results revealed that the HCMs possessed a hierarchical meso-/macro-structure with a high porosity of 80.5-87.9% and a fine pore size of 150.9-2103 nm. Both compression and rebound ratios of the VIPs initially increased (up to -59%) with the increasing RHA content and thereafter decreased till 39% and 31% respectively. The initial total thermal conductivities of the VIPs were -5.5 mW/(m K), which increased with the increasing RHA content as well. The proposed VIPs possessed not only a low total thermal conductivity (at 100-100,000 Pa) in between that of glassfiber-VIPs and opacified FS-VIPs but also a much longer service life than glassfiber-VIPs. The addition of 36 wt.% RHA resulted in a 32% reduction in the cost of HCMs, while still maintaining its super insulation capability. The optimum RHA content that led to a low-cost and highly thermal efficient VIP was 26-36 wt.%. (C) 2016 Elsevier ltd. All rights reserved.

关键词： Vacuum insulation panel Hybrid core material Pore structure compression behavior Thermal conductivity Low cost

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Thermo-physical properties of polyester fiber reinforced fumed silica/hollow glass microsphere composite core and resulted vacuum insulation panel

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ENERGY AND BUILDINGS 2016年第Aug.期125卷 298-309页

作者： Li, Chengdong Li, Binbin Pan, Ning Chen, Zhaofeng Saeed, Muhammad Umar Xu, Tengzhou Yang, Yong Nanjing Univ Aeronaut & Astronaut Int Lab Insulat & Energy Efficiency Mat Coll Mat Sci & Technol Nanjing 210016 Jiangsu Peoples R China Nanjing Univ Aeronaut & Astronaut Jiangsu Collaborat Innovat Ctr Adv Inorgan Funct Nanjing 210016 Jiangsu Peoples R China Univ Calif Davis Nanomat Environm Agr & Technol NEAT Biol Syst Eng Davis CA 95616 USA Suzhou VIP New Mat Co Ltd Hong Da Fang Yuan Grp Suzho 215400 Peoples R China

In recent years, various fiber/powder hybrid core materials (HCMs) are increasingly used as VIP core. In this paper, novel HCMs from mixtures of fumed silica (FS), hollow glass microsphere (HGM), polyester chopped strand fibers, titanium dioxide and carbon black powders were successfully fabricated by the dry powder mixing method. The effect of various HGM fractions on the thermo-physical properties of the HCMs and resulted VIPs was investigated. The HCMs possessed an excellent porous structure with a high porosity of 80-90% and a fine average pore size of 19.0-181.1 nm while the corresponding VIPs had a low density of 170-298 kg/m(3). HGM additions led to a shift in the average pore diameter of HCMs toward a finer value and more concentrated distribution but posed an increase on specific surface area of the HCMs. Both the compression and rebound ratio of the VIPs were greatly reduced by adding HGMs in FS matrix. Total thermal conductivity versus air pressure (from 0.1 Pa to 1.013 x 10(5) Pa) curves of the HCMs with various HGM contents and the contributions of gaseous, solid, and radiative thermal conductivity on total thermal conductivity of the HCMs were conducted, respectively. The results showed that the total thermal conductivity of VIPs increased with the HGM addition but could maintain at a low value of less than 7.2 mW/(m K) when HGM content was less than 26 wt.%. HCMs with 6 wt.% HGM were recommended for VIPs in refrigeration while that with 26 wt.% HGM were recommended for VIPs in building sectors. (C) 2016 Elsevier B.V. All rights reserved.

关键词： Vacuum insulation panel Hybrid core material Fumed silica Hollow glass microsphere Thermo-physical properties Pore size distribution compressive behavior Thermal conductivity Building insulation Refrigeration insulation

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Electrochemically activated PMS and PDS: Radical oxidation versus nonradical oxidation

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CHEMICAL ENGINEERING JOURNAL 2020年 391卷 123560-123560页

作者： Song, Haoran Yan, Linxia Wang, Yuwei Jiang, Jin Ma, Jun Li, Changping Wang, Gang Gu, Jia Liu, Peng Dongguan Univ Technol Res Ctr Ecoenvironm Engn Sch Environm & Civil Engn Dongguan 523808 Guangdong Peoples R China Shenzhen Li Yuan Water Design & Consultat Co Ltd Shenzhen 518031 Guangdong Peoples R China Guangdong Univ Technol Inst Environm & Ecol Engn Guangzhou 510006 Guangdong Peoples R China Harbin Inst Technol Sch Environm State Key Lab Urban Water Resource & Environm Harbin 150090 Heilongjiang Peoples R China Nanjing Univ Sci & Technol Sch Environm & Biol Engn Nanjing 210094 Jiangsu Peoples R China

In this study, a comparison between electrochemically activated peroxomonosulfate (PMS) and peroxydisulfate (PDS) using carbon anodes was conducted for the first time. PMS activation was achieved using graphite (GR) and multi-walled carbon nanotube (MWCNT) anodes, which significantly promoted the degradation of organic pollutants sulfamethoxazole (SMX). The radical probing and scavenging experiments demonstrated that SO4 center dot- was the dominant reactive species (64.93% relative contribution ratio). By contrast, nonradical oxidation accounted for 95.79% relative contribution ratio to organic pollutants degradation in electrochemically activated PDS process under the identical conditions. The structure difference between PDS (-O4S-SO4-) and PMS (HO-SO4-) led to their various reactivities. The electrochemically activated PMS molecule (PMS*, acting as nonradical oxidation) had higher reactivity and lower stability than electrochemically activated PDS molecule (PDS*, acting as nonradical oxidation), thus to quickly decomposed to SO4 center dot-. Interestingly, electrochemically activated PMS (radical oxidation system) exhibited stronger resistance towards water background components than PDS (nonradical oxidation system), being suitable to treat the complicated water and wastewater containing various ions and organic compounds.

关键词： Peroxomonosulfate Peroxydisulfate Sulfate radical Nonradical oxidation Carbon anodes

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Towards artificial photosynthesis: Sustainable hydrogen utilization for photocatalytic reduction of co2 to high-value renewable fuels

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CHEMICAL ENGINEERING JOURNAL 2020年 402卷 126184-126184页

作者： Nguyen Van-Huy Nguyen Ba-Son Jin, Zhong Shokouhimehr, Mohammadreza Jang, Ho Won Hu, Chechia Singh, Pardeep Raizada, Pankaj Peng, Wanxi Lam, Su Shiung Xia, Changlei Nguyen, chinh chien Kim, Soo Young Le Quyet Van Ton Duc Thang Univ Dept Management Sci & Technol Dev Ho Chi Minh City Vietnam Ton Duc Thang Univ Fac Sci Appl Ho Chi Minh City Vietnam Lac Hong Univ Key Lab Adv Mat Energy & Environm Applicat Bien Hoa Vietnam Nanjing Univ Sch Chem & Chem Engn Jiangsu Key Lab Adv Organ Mat Key Lab Mesoscop Chem MOE Nanjing 210023 Jiangsu Peoples R China Seoul Natl Univ Res Inst Adv Mat Dept Mat Sci & Engn Seoul 08826 South Korea Chung Yuan Christian Univ R&D Ctr Membrane Technol & Res Ctr Circular Econ Dept Chem Engn Taoyuan 32023 Taiwan Shoolini Univ Fac Basic Sci Sch Chem Solan 173212 Himachal Prades India Henan Agr Univ Henan Prov Engn Res Ctr Biomass Value Added Prod Sch Forestry Zhengzhou 450002 Peoples R China Univ Malaysia Terengganu Pyrolysis Technol Res Grp Inst Trop Aquaculture & Fisheries Akuatrop Kuala Terengganu 21030 Terengganu Malaysia Univ Malaysia Terengganu Inst Trop Biodivers & Sustainable Dev BioD Tropik Kuala Terengganu 21030 Terengganu Malaysia Nanjing Forestry Univ Coll Mat Sci & Engn Coinnovat Ctr Efficient Proc & Utilizat Forestry Nanjing 210037 Jiangsu Peoples R China Anhui Juke Graphene Technol Co Ltd Bozhou 233600 Peoples R China Duy Tan Univ Inst Res & Dev Da Nang 550000 Vietnam Duy Tan Univ Fac Environm & Chem Engn Da Nang 550000 Vietnam Korea Univ Dept Mat Sci & Engn 145 Anam Ro Seoul 02841 South Korea

converting solar energy into fuel via photo-assisted water splitting to generate H-2 or drive co2 photoreduction is an attractive scientific and technological goal to address the increasing global demand for energy and to reduce the impact of energy production on climate change. Solar-driven hydrogenation of co2 into value-added chemical products is one of the most promising strategies for reducing co2 and is anticipated to be a sustainable energy source shortly. In this study, we focus on the utilization of different sustainable H-2 sources for the photoreduction of co2 to value-added organic products. Various photocatalysts, photoreactor configurations, and reaction parameters for the photoreduction of co(2 )are discussed. For future research endeavors, a general approach for the photoreduction of co2 to mimic natural photosynthesis, in which the H-2 source is provided directly during the photocatalytic water splitting, is proposed and verified to generate value-added organic products successfully.

关键词： Artificial synthesis Photocatalysts Nanomaterials Hydrogenation co2 photoreduction Photoreactors

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Investigation into the treatment and resource recovery of rifamycin mycelial dreg with thermal alkaline pretreatment-anaerobic digestion

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JOURNAL OF CLEANER PRODUCTION 2023年 427卷

作者： Zhang, Quan Gong, Xuejiao Zhang, Yu Wang, Xueting Pan, Xiaowen Zhou, Yanfeng Xu, Xijun Zhang, Qi Ji, Xiao-Ming Wang, Weijun Xing, Defeng Ren, Nanqi Lee, Duu-Jong Chen, Chuan Harbin Inst Technol Sch Environm State Key Lab Urban Water Resource & Environm Harbin 150090 Heilongjiang Peoples R China City Univ Hong Kong Dept Mech Engn Tat Chee Ave Hong Kong Peoples R China Nanjing Agr Univ Coll Resources & Environm Sci Nanjing 210095 Peoples R China Yuan Ze Univ Dept Chem Engn & Mat Sci Chungli 32003 Taiwan Power China Huadong Engn Corp Ltd Hangzhou 311122 Zhejiang Peoples R China Changhai Biol Co Zhejiang Med Co Ltd Shaoxing 312366 Zhejiang Peoples R China Heilongjiang Agr Engn Vocat Coll Harbin 150070 Heilongjiang Peoples R China

Rifamycin, a highly potent drug for the treatment of tuberculosis should raise environmental concerns due to its massive production of mycelial dreg (RMD). The RMD treatment by anaerobic digestion (AD) is a highly promising endeavor, but has still far from explicit. Herein, the thermal alkaline pretreatment (TAP)-AD process with RMD as substrate was performed. The optimal temperature, pH, and reaction time for TAP were 140 degrees C, 12, and 3 h, respectively. The optimal RMD concentration (1%) and inoculation ratio (2:1, sludge: RMD, mass ratio) were subsequently determined, leading to an increase of 86.4% in cumulative methane production. correspondingly, a functional core taxa including fermentative bacteria and methanogens was enriched. Molecular ecological network (pMEN) revealed an ecological niche-based functional redundancy, which facilitated the efficiency and stability of the AD system. Notably, representative draft genome recovered from raw RMD possessed the potential fermentation capability, and the phosphotransferase component for carbohydrate transport may not be affected by rifamycin-B according to the results of molecular docking. Taking these factors, an innovative insight into the natural suitability of RMD as native fermentation inoculum was carefully presented. This study clarifies the feasibility of TAP-AD in the treatment of RMD. Moreover, it contributes to a deeper understanding of the ecological properties and microbial mechanisms in AD systems.

关键词： Anaerobic digestion Thermal alkaline pretreatment Rifamycin mycelial dreg core functional taxa Genome-centric metabolic potential

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UPLC-Q TOF-MS-Based metabolomics and anti-myocardial ischemia activity of Dioscoreae Nipponicae Rhizoma from different geographical origins

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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 2023年 234卷 115551页

作者： Yang, Xiao-fang Miao, Yu Yang, Da-wei Kong, Ren yuan, Bo Quan, Jian-ye Bu, Wei China Acad Chinese Med Sci Expt Res Ctr Beijing Peoples R China Lunan Pharmaceut Grp Co Ltd State Key Lab Gener Manufacture Technol Tradit Chi Linyi Shandong Peoples R China Liaocheng Peoples Hosp Zhong Yuan Acad Biol Med Liaocheng Peoples R China Jiangsu Univ Technol Inst Bioinformat & Med Engn Changzhou Peoples R China Jiangsu Normal Univ Sch Life Sci Xuzhou Peoples R China Jiangsu Normal Univ Inst Sci & Technol Xuzhou Peoples R China

The dried rhizome of Dioscorea nipponica Makino ("Chuanshanlong" in chinese) is a medicinal herb with multiple major producing areas. The main objective of this study was the comparative profiling of Dioscoreae Nipponicae Rhizoma (DNR) from various geographical origins. A hypoxia/reoxygenation-induced H9c2 cell injury model was established, and the antimyocardial ischemia activity of DNR samples from different origins was detected using the cell counting kit-8 (CCK-8) method. The result showed that the antimyocardial ischemia potential of DNR samples from the Heilongjiang province was higher than that of the other studied samples. Subsequently, a plant metabolomics technique utilizing ultra-high performance liquid chromatography coupled with quadrupole timeof-flight mass spectrometry (UPLC-Q TOF-MS) was used to determine the differences in DNR samples from various geographical origins. Forty compounds, including steroidal saponins, free fatty acids, and organic acids, were tentatively identified based on UPLC-Q TOF-MS fragmentation pathways and via comparison with available reference standards. Partial least squares discriminant analysis was performed to estimate the differences in DNR samples from different origins. Five compounds were significantly up-regulated and correlated with antimyocardial ischemia in DNR samples from Heilongjiang province. Molecular docking was used to discern the interactions of key markers with the active sites of the target protein. The findings signified that UPLC-Q TOF-MS metabolomics coupled with molecular docking is a powerful tool to rapidly identify the quality control characteristics of DNR samples and their products. The research provides a direction for the rational utilization of DNR.

关键词： Dioscorea Nipponica Rhizoma UPLC-Q TOF-MS Metabolomics Myocardial ischemia Molecular docking

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Measuring routine childhood vaccination coverage in 204 countries and territories, 1980-2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1

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LANCET 2021年第10299期398卷 503-521页

作者： Galles, Natalie C. Liu, Patrick Y. Updike, Rachel L. Fullman, Nancy Nguyen, Jason Rolfe, Sam Sbarra, Alyssa N. Schipp, Megan F. Marks, Ashley Abady, Gdiom Gebreheat Abbas, Kaja M. Abbasi, Sumra Wajid Abbastabar, Hedayat Abd-Allah, Foad Abdoli, Amir Abolhassani, Hassan Abosetugn, Akine Eshete Adabi, Maryam Adamu, Abdu A. Adetokunboh, Olatunji O. Adnani, Qorinah Estiningtyas Sakilah Advani, Shailesh M. Afzal, Saira Aghamir, Seyed Mohammad Kazem Ahinkorah, Bright Opoku Ahmad, Sohail Ahmad, Tauseef Ahmadi, Sepideh Ahmed, Haroon Ahmed, Muktar Beshir Rashid, Tarik Ahmed Salih, Yusra Ahmed Akalu, Yonas Aklilu, Addis Akunna, chisom Joyqueenet Al Hamad, Hanadi Alahdab, Fares Albano, Luciana Alemayehu, Yosef Alene, Kefyalew Addis Al-Eyadhy, Ayman Alhassan, Robert Kaba Ali, Liaqat Aljunid, Syed Mohamed Almustanyir, Sami Altirkawi, Khalid A. Alvis-Guzman, Nelson Amu, Hubert Andrei, Catalina Liliana Andrei, Tudorel Ansar, Adnan Ansari-Moghaddam, Alireza Antonazzo, Ippazio cosimo Antony, Benny Arabloo, Jalal Arab-Zozani, Morteza Artanti, Kurnia Dwi Arulappan, Judie Awan, Asma Tahir Awoke, Mamaru Ayenew Ayza, Muluken Altaye Azarian, Ghasem Azzam, Ahmed Y. Darshan, B. B. Babar, Zaheer-Ud-Din Balakrishnan, Senthilkumar Banach, Maciej Bante, Simachew Animen Barnighausen, Till Winfried Barqawi, Hiba Jawdat Barrow, Amadou Bassat, Quique Bayarmagnai, Narantuya Ramirez, Diana Fernanda Bejarano Bekuma, Tariku Tesfaye Belay, Habtamu Gebrehana Belgaumi, Uzma Iqbal Bhagavathula, Akshaya Srikanth Bhandari, Dinesh Bhardwaj, Nikha Bhardwaj, Pankaj Bhaskar, Sonu Bhattacharyya, Krittika Bibi, Sadia Bijani, Ali Biondi, Antonio Boloor, Archith Braithwaite, Dejana Buonsenso, Danilo Butt, Zahid A. Camargos, Paulo Carreras, Giulia Carvalho, Felix Castaneda-Orjuela, Carlos A. Chakinala, Raja Chandra Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Chowdhury, Fazle Rabbi Christopher, Devasahayam J. Chu, Dinh-Toi Chung, Sheng-chia cortesi, Paolo Angelo costa, Vera Marisa couto, Rosa A. S. Dadras, Omid Dagnew, Amare Be Univ Washington Inst Hlth Metr & Evaluat Seattle WA 98195 USA Univ Washington Sch Med Dept Hlth Metr Sci Seattle WA USA Univ Washington Dept Anesthesiol & Pain Med Seattle WA 98195 USA Univ Washington Dept Global Hlth Seattle WA 98195 USA Univ Calif Los Angeles David Geffen Sch Med Los Angeles CA 90095 USA Adigrat Univ Dept Nursing Adigrat Ethiopia London Sch Hyg & Trop Med Dept Infect Dis Epidemiol London England Natl Univ Med Sci NUMS Dept Biol Sci Rawalpindi Pakistan Natl Univ Med Sci NUMS Multidisciplinary Dept Rawalpindi Pakistan Univ Tehran Med Sci Adv Diagnost & Intervent Radiol Res Ctr Tehran Iran Univ Tehran Med Sci Res Ctr Immunodeficiencies Tehran Iran Univ Tehran Med Sci Urol Res Ctr Tehran Iran Univ Tehran Med Sci Multiple Sclerosis Res Ctr Tehran Iran Univ Tehran Med Sci Dept Epidemiol & Biostat Tehran Iran Univ Tehran Med Sci Pediat Chron Kidney Dis Res Ctr Tehran Iran Univ Tehran Med Sci Dept Med Immunol Tehran Iran Univ Tehran Med Sci Sina Trauma & Surg Res Ctr Tehran Iran Univ Tehran Med Sci Noncommunicable Dis Res Ctr Tehran Iran Univ Tehran Med Sci Endocrinol & Metab Res Ctr Tehran Iran Univ Tehran Med Sci Digest Dis Res Inst Tehran Iran Cairo Univ Dept Neurol Cairo Egypt Cairo Univ Dept Endem Med & Hepatogastroenterol Cairo Egypt Jahrom Univ Med Sci Dept Parasitol & Mycol Jahrom Iran Karolinska Univ Hosp Dept Lab Med Huddinge Sweden Debre Berhan Univ Dept Publ Hlth Debre Berhan Ethiopia Debre Berhan Univ Dept Nursing Debre Berhan Ethiopia Hamadan Univ Med Sci Dept Environm Hlth Engn Hamadan Hamadan Iran Stellenbosch Univ Dept Global Hlth Cape Town South Africa South African Med Res Council Cochrane South Africa Cape Town South Africa South African Med Res Council Cape Town South Africa Stellenbosch Univ Ctr Excellence Epidemiol Modelling & Anal Stellenbosch South Africa Karya Husada Inst Hlth Sci Dept Midwifery Kediri Indonesia Auckland Univ Technol Dept Midwifery Auckland New Zealand Terasaki

Background Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabilities. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020, Release 1, we did a systematic analysis of global, regional, and national vaccine coverage trends using a statistical framework, by vaccine and over time. Methods For this analysis we collated 55 326 country-specific, cohort-specific, year-specific, vaccine-specific, and dosespecific observations of routine childhood vaccination coverage between 1980 and 2019. Using spatiotemporal Gaussian process regression, we produced location-specific and year-specific estimates of 11 routine childhood vaccine coverage indicators for 204 countries and territories from 1980 to 2019, adjusting for biases in countryreported data and reflecting reported stockouts and supply disruptions. We analysed global and regional trends in coverage and numbers of zero-dose children (defined as those who never received a diphtheria-tetanus-pertussis [DTP] vaccine dose), progress towards GVAP targets, and the relationship between vaccine coverage and sociodemographic development. Findings By 2019, global coverage of third-dose DTP (DTP3;81.6% [95% uncertainty interval 80.4-82 .7]) more than doubled from levels estimated in 1980 (39.9% [37.5-42.1]), as did global coverage of the first-dose measles-containing vaccine (MCV1;from 38.5% [35.4-41.3] in 1980 to 83.6% [82.3-84.8] in 2019). Third- dose polio vaccine (Pol3) coverage also increased, from 42.6% (41.4-44.1) in 1980 to 79.8% (78.4-81.1) in 2019, and global coverage of newer vaccines increased rapidly between 2000 and 2019. The global number of zero-dose children fell by nearly 75% between 1980 and 2019, from

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Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

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NATURE MEDICINE 2020年第5期26卷 750-759页

作者： Kinyoki, Damaris K. Ross, Jennifer M. Lazzar-Atwood, Alice Munro, Sandra B. Schaeffer, Lauren E. Bhattacharjee, Natalia V. collison, Michael L. cork, Michael A. cormier, Natalie Weaver, Nicole Davis Deshpande, Aniruddha Dharmaratne, Samath Dhamminda Earl, Lucas Henry, Nathaniel J. Hollerich, Gillian Johnson, Kimberly B. Kassebaum, Nicholas J. Krohn, Kris J. Letourneau, Ian D. Marczak, Laurie B. Mayala, Benjamin K. Mokdad, Ali H. Mosser, Jonathan F. Murray, Christopher J. L. Naghavi, Mohsen Osgood-Zimmerman, Aaron E. Pickering, Brandon V. Pigott, David M. Ray, Sarah E. Sbarra, Alyssa N. Schipp, Megan F. VanderHeide, John Wang, Haidong Wiens, Kirsten E. Afshin, Ashkan Hay, Simon I. Sartorius, Benn Khalil, Ibrahim A. Abbasalizad-Farhangi, Mahdieh M. Hasankhani, Milad Abbasi, Masoumeh Farzam, Hossein Moradi, Masoud Rezaeian, Shahab Abbastabar, Hedayat Abdelalim, Ahmed El-Jaafary, Shaimaa I. Shehata, Hatem Samir Abdoli, Amir Abdollahi, Mohammad Abdollahpour, Ibrahim Abdulkader, Rizwan Suliankatchi Abebe, Nebiyu Dereje Deribe, Kebede Abebo, Teshome Abuka Abegaz, Kedir Hussein Abolhassani, Hassan Rezaei, Nima Abreu, Lucas Guimaraes Abrigo, Michael R. M. Abushouk, Abdelrahman I. Accrombessi, Manfred Mario Kokou Acharya, Dilaram Adabi, Maryam Adebiyi, Akindele Olupelumi Ilesanmi, Olayinka Stephen Adedeji, Isaac Akinkunmi Adekanmbi, Victor Adeoye, Abiodun Moshood Adetokunboh, Olatunji O. Mahasha, Phetole Walter Ndwandwe, Duduzile Edith Nnaji, Chukwudi A. Sambala, Evanson Zondani Adham, Davoud Aduroja, Posi Emmanuel Dipeolu, Isaac Oluwafemi Ibitoye, Segun Emmanuel John-Akinola, Yetunde O. Oluwasanu, Mojisola Morenike Advani, Shailesh M. Afarideh, Mohsen Esteghamati, Alireza Ghajar, Alireza Heidari, Behnam Sayyah, Mehdi Aghaali, Mohammad Agrawal, Anurag Ahmad, Tauseef Ahmadi, Keivan Ahmadi, Sepideh Ahmed, Muktar Beshir Gebrehiwot, Tsegaye Tewelde Gesesew, Hailay Abrha Ahmed, Rushdia Das Gupta, Rajat Ajumobi, Olufemi Akal, Chalachew Genet Demeke, Feleke Mekonnen Melese, Addisu Akalu, Temesgen Yihunie Baraki, Adhanom Gebreegzi Univ Washington Inst Hlth Metr & Evaluat Seattle WA 98195 USA Univ Washington Sch Med Dept Hlth Metr Sci Seattle WA USA Univ Washington Dept Global Hlth Seattle WA 98195 USA Univ Washington Dept Med Seattle WA USA Tabriz Univ Med Sci Sch Nutr & Food Sci Tabriz Iran Kermanshah Univ Med Sci Kermanshah Iran Univ Tehran Med Sci Adv Diagnost & Intervent Radiol Res Ctr Tehran Iran Cairo Univ Dept Neurol Cairo Egypt Jahrom Univ Med Sci Dept Parasitol & Mycol Jahrom Iran Univ Tehran Med Sci TIPS Toxicol & Dis Grp Tehran Iran Isfahan Univ Med Sci Neurosci Res Ctr Esfahan Iran Minist Hlth Dept Publ Hlth Riyadh Saudi Arabia Addis Ababa Univ Sch Publ Hlth Addis Ababa Ethiopia Wachemo Univ Publ Hlth Hosanna Ethiopia Hawassa Univ Coll Med & Hlth Sci Hawassa Ethiopia Madda Walabu Univ Biostat & Hlth Informat Bale Robe Ethiopia Addis Ababa Univ Radiotherapy Ctr Addis Ababa Ethiopia Karolinska Univ Hosp LABMED Huddinge Sweden Univ Tehran Med Sci Res Ctr Immunodeficiencies Tehran Iran Univ Fed Minas Gerais Dept Pediat Dent Belo Horizonte MG Brazil Philippine Inst Dev Studies Res Dept Quezon City Philippines Ain Shams Univ Cardiovasc Med Abbasiya Egypt IRCB Cotonou Benin Dongguk Univ Dept Prevent Med Gyeongju South Korea Kathmandu Univ Dept Community Med Devdaha Nepal Hamadan Univ Med Sci Hamadan Iran Univ Ibadan Dept Community Med Ibadan Nigeria Univ Coll Hosp Dept Community Med Ibadan Nigeria Olabisi Onabanjo Univ Dept Sociol Ago Iwoye Nigeria Cardiff Univ Sch Med Cardiff S Glam Wales Univ Ibadan Coll Med Ibadan Nigeria Elyon Heart Rehabil Ctr Community Cardiovasc Res Unit Ibadan Nigeria Stellenbosch Univ Dept Global Hlth Stellenbosch South Africa South African Med Res Council Cochrane South Africa Cape Town South Africa Ardabil Univ Med Sci Sch Hlth Ardebil Iran Univ Ibadan Dept Hlth Promot & Educ Ibadan Nigeria NIH Social Behav Res Branch Bldg 10 Bethesda MD 20892 USA Georgetown Univ Canc Prevent & Control Washingt

A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1-70.8) million) to 6.4% (58.3 (47.6-70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8-38.5) million) in 2000 to 6.0% (55.5 (44.8-67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern china, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic.

关键词： Malnutrition Obesity Risk factors Signs and symptoms

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