检索结果-内蒙古大学图书馆

arXiv 2021年

作者： Li, Jiaxin Li, Ying Cao, Pei-Chao Zheng, Xu Peng, Yu-Gui Li, Baowen Zhu, Xue-Feng Alù, Andrea Qiu, Cheng-Wei Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore School of Mechatronics Engineering Harbin Institute of Technology Harbin150001 China Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentation College of Information Science and Electronic Engineering Zhejiang University Hangzhou310027 China ZJU-Hangzhou Global Science and Technology Innovation Center Key Lab. of Advanced Micro Nano Electronic Devices & Smart Systems of Zhejiang Zhejiang University Hangzhou310027 China International Joint Innovation Center ZJU-UIUC Institute Electromagnetics Academy at Zhejiang University Zhejiang University Haining314400 China School of Physics and Innovation Institute Huazhong University of Science and Technology Wuhan430074 China Department of Physics University of Colorado BoulderCO80309 United States Department of Electrical Engineering City University of New York New YorkNY10031 United States Department of Mechanical Engineering University of Colorado BoulderCO80309 United States

The reciprocity principle governs the symmetry in transmission of electromagnetic and acoustic waves, as well as the diffusion of heat between two points in space, with important consequences for thermal management and energy harvesting. There has been significant recent interest in materials with time-modulated properties, which have been shown to efficiently break reciprocity for light, sound, and even charge diffusion. Quite surprisingly, here we show that, from a practical point of view, time modulation cannot generally be used to break reciprocity for thermal diffusion. We establish a theoretical framework to accurately describe the behavior of diffusive processes under time modulation, and prove that thermal reciprocity in dynamic materials is generally preserved by the continuity equation, unless some external bias or special material is considered. We then experimentally demonstrate reciprocal heat transfer in a time-modulated device. Our findings correct previous misconceptions regarding reciprocity breaking for thermal diffusion, revealing the generality of symmetry constraints in heat transfer, and clarifying its differences from other transport processes in what concerns the principles of reciprocity and microscopic reversibility. © 2021, CC BY.

关键词： Energy harvesting

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The application of an extracellular vesicle-based biosensor in early diagnosis and prediction of chemoresponsiveness in ovarian cancer

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Cancer Letters 2024年 581卷 216533-216533页

作者： Tsang, Benjamin K. Asare-Werehene, Meshach Hunter, Rob Gerber, Emma Reunov, Arkadiy Brine, Isaiah Chang, Chia-Yu Chang, Chia-Ching Shieh, Dar-Bin Burger, Dylan Anis, Hanan Departments of Obstetrics & Gynecology and Cellular & Molecular Medicine Centre for Infection Immunity and Inflammation Interdisciplinary School of Health Sciences University of Ottawa Ottawa ON K1N 6N5 Canada Chronic Disease Program Ottawa Hospital Research Institute The Ottawa Hospital Ottawa ON K1Y 4E9 Canada Department of Biology St. Francis Xavier University 2320 Notre Dame Avenue Antigonish NS B2G 2W5 Canada School of Electrical Engineering and Computer Science Ottawa-Carleton Institute for Biomedical Engineering University of Ottawa Ottawa ON K1N 6N5 Canada Department of Biological Science and Department of Electrophysics Technology Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) National Yang Ming Chiao Tung University Hsinchu 30068 Taiwan Institute of Basic Medical Science Institute of Oral Medicine and Department of Stomatology Advanced Optoelectronic Technology Center and Center for Micro/Nano Science and Technology National Cheng Kung University Hospital National Cheng Kung University Tainan 704 Taiwan Institute of Physics Academia Sinica Taipei 10529 Taiwan

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Development and validation of a novel combinational index of liquid biopsy biomarker for longitudinal lung cancer patient management

The journal of liquid biopsy

引用

The journal of liquid biopsy 2024年 6卷 100167页

作者： Min-Yi Liao Yun-Jie Hao Ching-Shan Luo Ching-Mei Chen Po-Hao Feng Hsin-Yu Yang Da-Jeng Yao Kang-Yun Lee Fan-Gang Tseng Department of Power Mechanical Engineering National Tsing Hua University Hsinchu 30013 Taiwan. Department of Engineering and System Science National Tsing Hua University Hsinchu 30013 Taiwan. International Ph.D. Program in Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan. TMU Research Center of Thoracic Medicine Taipei Medical University Taipei 11031 Taiwan. Division of Pulmonary Medicine Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Nano Science and Technology Program National Tsing Hua University Hsinchu 30013 Taiwan. Institute of Nano Engineering and Micro Systems (NEMS) National Tsing Hua University Hsinchu 30013 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu 30013 Taiwan.

Objectives:Many cancer biomarkers such as the circulating tumor cells/microemboli (CTCs/CTM) have been reported significant associations with clinical outcomes. However, different biomarkers have different sensitivities and specificities for cancer types and cohort patients, and synergistic effects between certain biomarkers have also been observed, leading to the inaccurate, fluctuating, and even controversial results when multiple biomarkers are analyzed together. In this paper, a novel combinational index, P-score, was developed for monitoring and predicting the disease condition of lung cancer patients during follow-up visits. Materials and methods:There were totally 13 return patients with 54 blood samples involved in this study to examine the number of CTC and CTM. Information from one group of 7 patients including 27 blood samples with published clinical data was employed to develop while those from another group of 4 patients containing 14 blood samples with unpublished clinical data were used to validate the P score in prediction. Enumerations were based on immunofluorescent staining images. Distributions of CTC/CTM and their frequencies in stratified patients were carefully examined and analyzed the ROC curve and AUC value to develop the P score and P score-based prediction model. Results and conclusion:We found that the predictive power of P-score was not only comparable to the traditional cancer marker, in comparison with individual CTC/CTM, more false positives could be corrected by using P-score, thereby to improve the accuracy of analysis. From our preliminary validation tests, the prognosis and disease progression monitored longitudinally by P-score were further confirmed by clinical outcome data from physicians and its sensitivity was even better than those from individual biomarkers. We believe that this novel combinational indicator could be a promising tool to interpret clinical outcomes more accurately from multiple factors, particularly useful

关键词： Circulating tumor cells/microemboli Combinational index Disease monitoring and prognosis Drug screening Lung cancer

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Negative refraction of ultra-squeezed in-plane hyperbolic designer polaritons

arXiv

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arXiv 2020年

作者： Chen, Qiaolu Yang, Yihao Zhang, Li Chen, Jialin Lin, Xiao Li, Rujiang Wang, Zuojia Zhang, Baile Chen, Hongsheng Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentation College of Information Science and Electronic Engineering Zhejiang University Hangzhou310027 China ZJU-Hangzhou Global Science and Technology Innovation Center Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang Zhejiang University Hangzhou310027 China Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore Singapore Centre for Disruptive Photonic Technologies Photonics Institute Nanyang Technological University Singapore Singapore

The in-plane negative refraction of high-momentum (i.e., high-k) photonic modes could enable many applications such as imaging and hyperlensing in a planar platform at deep-subwavelength scales. However, its practical implementation in experiments remains elusive so far. Here we propose a class of hyperbolic metasurfaces, which is characterized by an anisotropic magnetic sheet conductivity and can support the in-plane ultrahigh-k magnetic designer polaritons. Based on such metasurfaces, we report the first experimental observation of the all-angle negative refraction of designer polaritons at extremely deep-subwavelength scales. Moreover, we directly visualize the designer polaritons with hyperbolic dispersions. Importantly, for these hyperbolic polaritons, we find that their squeezing factor is ultra-large and, to be specific, it can be up to 129 in the experiments, a record-breaking value exceeding those in naturally hyperbolic materials. The present scheme for the achievement of negative refraction is also applicable to other natural materials and may enable intriguing applications in nanophotonics. Besides, the proposed metasurfaces are readily tailorable in space and frequency, which could serve as a versatile platform to explore the extremely high confinement and unusual propagation of hyperbolic polaritons. Copyright © 2020, The Authors. All rights reserved.

关键词： Photons

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Recent advances in molecularly imprinted polymers toward biomedical healthcare devices

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Biosensors and Bioelectronics 2025年 287卷 117637页

作者： Seo, Youngjun Kim, Yonghwan Kim, Jaeheung Jung, Hyo Gi Jang, Jae Won Kim, Hyunji Hwang, Kyo Seon Lee, Dongtak Lee, Sang Won Lee, Jeong Hoon Yoon, Dae Sung School of Biomedical Engineering Korea University Seoul02841 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02841 Korea Republic of Department of Clinical Pharmacology and Therapeutics College of Medicine Kyung Hee University Seoul02447 Korea Republic of Department of Bioengineering & Nano-bioengineering Research Center for Bio Materials and Process Development Incheon National University Incheon22012 Korea Republic of Division of Bioengineering Incheon National University Incheon22012 Korea Republic of Terasaki Institute for Biomedical Innovation Los AngelesCA90064 United States KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Department of Integrative Energy Engineering College of Engineering Korea University Seoul02841 Korea Republic of Astrion Inc Seoul02841 Korea Republic of

Following the increase in the global aging population, the importance of monitoring various disease-related biomarkers at an early stage has increased to ensure the health of the elderly. In an aging society, point-of-care (POC) systems are needed to care for elderly people who have physical and mental disorders. In light of the increasing prominence of POC systems, there is a growing effort to address the limitations associated with conventional receptors in wearable devices by substituting them with molecularly imprinted polymer (MIP). MIPs are well-known synthetic receptors engineered with specific binding cavities based on the "lock and key" principle. They could be synthesized in various configurations depending on specific types of monomers and templates. Compared to conventional receptors such as antibodies and aptamers, MIPs exhibit outstanding advantages, including good stability, cost-effectiveness, ease of synthesis, reusability, and broad applicability. These advantages have led to their extensive application in biomedical healthcare devices. This review summarizes a comparative analysis of sensors utilized for the detection of disease-specific biomarkers through diverse MIP applications and methodologies. Furthermore, we evaluated recent advancements in the miniaturization of MIPs and their integration with wearable biomedical devices for comprehensive healthcare monitoring applications. Finally, we delineated the existing limitations that need to be surmounted for the effective implementation of MIP-based biomedical devices and outlined future objectives for the enhancement of wearable and wireless biomedical healthcare monitoring devices. © 2025 Elsevier B.V.

关键词： Diseases

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Topologically Protected Quantum Entanglement Emitters

Research Square

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Research Square 2021年

作者： Wang, Jianwei Dai, Tianxiang Ao, Yutian Bao, Jueming Mao, Jun Chi, Yulin Fu, Zhaorong You, Yilong Chen, Xiaojiong Zhai, Chonghao Tang, Bo Yang, Yan Li, Zhihua Yuan, Luqi Gao, Fei Lin, Xiao Thompson, Mark G. O’Brien, Jeremy L. Li, Yan Hu, Xiaoyong Gong, Qihuang State Key Laboratory for Mesoscopic Physics School of Physics Peking University Beijing100871 China Institute of Microelectronics Chinese Academy of Sciences Beijing100029 China State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and Astronomy Shanghai Jiao Tong University Shanghai200240 China Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentation ZJU-Hangzhou Global Science and Technology Innovation Center College of Information Science and Electronic Engineering Zhejiang University Hangzhou310027 China Quantum Engineering Technology Labs H. H. Wills Physics Laboratory Department of Electrical and Electronic Engineering University of Bristol BristolBS8 1FD United Kingdom Department of Physics The University of Western Australia Perth6009 Australia Frontiers Science Center for Nano-optoelectronics Collaborative Innovation Center of Quantum Matter Peking University Beijing100871 China Collaborative Innovation Center of Extreme Optics Shanxi University Shanxi Taiyuan030006 China Peking University Yangtze Delta Institute of Optoelectronics Jiangsu Nantong226010 China

Entanglement and topology both portray nature at the fundamental level but in different manners. Entangled states of quantum particles are intrinsically sensitive to environment, whereas topological phases of matters represent natural robustness against environmental perturbations. Harnessing topology physics to protect entanglement thus has a great potential for reliable quantum applications. However, generating topologically-protected entanglement remains a significant challenge, which requires operating complex quantum devices in combined extreme conditions. Here we report topologically-protected quantum entanglement emitters, that emit topological Einstein-Podolsky-Rosen entangled state and topological multiphoton entangled state from a monolithically-integrated plug-and-play silicon-photonic chip in ambient conditions. The device emulating a photonic anomalous Floquet insulator allows the generation of up to four-photon topological entangled states at nontrivial edge modes. More importantly, we show that the Einstein-Podolsky-Rosen entanglement emitters can be topologically protected against artificial structure defects, by comparing tomographically measured fidelities of 0.968 ± 0.004 and 0.951 ± 0.01 for the perfect and defected emitters, respectively. Our topologically-protected entanglement emitters may find applications in photonic quantum computation and quantum simulation, and in the study of quantum topological physics. © 2021, CC BY.

关键词： Quantum entanglement

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Observation of topological edge states in thermal diffusion

arXiv

引用

arXiv 2021年

作者： Hu, Hao Han, Song Yang, Yihao Liu, Dongjue Xue, Haoran Liu, Gui-Geng Cheng, Zheyu Wang, Qi Jie Zhang, Shuang Zhang, Baile Luo, Yu School of Electrical and Electronic Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentation College of Information Science and Electronic Engineering Zhejiang University Hangzhou310027 China ZJU-Hangzhou Global Science and Technology Innovation Center Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang Zhejiang University Hangzhou310027 China International Joint Innovation Center ZJU-UIUC Institute Zhejiang University Haining314400 China Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link Singapore637371 Singapore Department of Physics University of Hong Kong Hong Kong Department of Electrical & Electronic Engineering University of Hong Kong China Centre for Disruptive Photonic Technologies Nanyang Technological University Singapore637371 Singapore

The topological band theory predicts that bulk materials with nontrivial topological phases support topological edge states. This phenomenon is universal for various wave systems and has been widely observed for electromagnetic and acoustic waves. Here, we extend the notion of band topology from wave to diffusion dynamics. Unlike the wave systems that are usually Hermitian, the diffusion systems are anti-Hermitian with purely imaginary eigenvalues corresponding to decay rates. Via direct probe of the temperature diffusion, we experimentally retrieve the Hamiltonian of a thermal lattice, and observe the emergence of topological edge decays within the gap of bulk decays. Our results show that such edge states exhibit robust decay rates, which are topologically protected against disorders. This work constitutes a thermal analogue of topological insulators and paves the way to exploring defect-immune heat dissipation. Copyright © 2021, The Authors. All rights reserved.

关键词： Topology

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Polarization-Orthogonal Nondegenerate Plasmonic Higher-Order Topological States

arXiv

引用

arXiv 2021年

作者： Li, Yuanzhen Xu, Su Zhang, Zijian Yang, Yumeng Xie, Xinrong Ye, Wenzheng Liu, Feng Xue, Haoran Jing, Liqiao Wang, Zuojia Chen, Qi-Dai Sun, Hong-Bo Li, Erping Chen, Hongsheng Gao, Fei Interdisciplinary Center for Quantum Information State Key Laboratory of Extreme Photonics and Instrumentation ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang University Hangzhou310027 China International Joint Innovation Center The Electromagnetics Academy Zhejiang University Zhejiang University Haining314400 China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University 2699 Qianjin Street Changchun130012 China Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore637371 Singapore State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision Instrument Tsinghua University Haidian Beijing100084 China Key Lab. of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang Jinhua Institute of Zhejiang University Zhejiang University Jinhua321099 China Shaoxing Institute of Zhejiang University Zhejiang University Shaoxing312000 China

Photonic topological states, providing light-manipulation approaches in robust manners, have attracted intense attention. Connecting photonic topological states with far-field degrees of freedom (DoFs) has given rise to fruitful phenomena. Recently emerged higher-order topological insulators (HOTIs), hosting boundary states two or more dimensions lower than those of bulk, offer new paradigms to localize/transport light topologically in extended dimensionalities. However, photonic HOTIs have not been related to DoFs of radiation fields yet. Here, we report the observation of polarization-orthogonal second-order topological corner states at different frequencies on a designer-plasmonic Kagome metasurface in the far field. Such phenomenon stands on two mechanisms, i.e., projecting the far-field polarizations to the intrinsic parity DoFs of lattice modes and the parity splitting of the plasmonic corner states in spectra. We theoretically and numerically show that the parity splitting originates from the underlying inter-orbital coupling. Both near-field and far-field experiments verify the polarization-orthogonal nondegenerate second-order topological corner states. These results promise applications in robust optical single photon emitters and multiplexed photonic devices. Copyright © 2021, The Authors. All rights reserved.

关键词： Polarization

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Demonstration of topological wireless power transfer

arXiv

引用

arXiv 2020年

作者： Zhang Yang, Yihao Jiang, Zhao Chen, Qiaolu Yan, Qinghui Wu, Zhouyi Zhang, Baile Huangfu, Jiangtao Chen, Hongsheng Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentation College of Information Science and Electronic Engineering Zhejiang University Hangzhou310027 China ZJU-Hangzhou Global Science and Technology Innovation Center Key Laboratory of Advanced Micro/Nano Electronic Devices & Smart Systems of Zhejiang Zhejiang University Hangzhou310027 China International Joint Innovation Center ZJU-UIUC Institute Zhejiang University Haining314400 China Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore637371 Singapore Centre for Disruptive Photonic Technologies The Photonics Institute Nanyang Technological University Singapore639798 Singapore Zhejiang University Hangzhou310027 China

Recent advances in non-radiative wireless power transfer (WPT) technique essentially relying on magnetic resonance and near-field coupling have successfully enabled a wide range of applications. However, WPT systems based on double resonators are severely limited to short- or mid-range distance, due to the deteriorating efficiency and power with long transfer distance. WPT systems based on multi-relay resonators can overcome this problem, which, however, suffer from sensitivity to perturbations and fabrication imperfections. Here, we experimentally demonstrate a concept of topological wireless power transfer (TWPT), where energy is transferred efficiently via the near-field coupling between two topological edge states localized at the ends of a one-dimensional radiowave topological insulator. Such a TWPT system can be modelled as a parity-time-symmetric Su-Schrieffer-Heeger (SSH) chain with complex boundary potentials. Besides, the coil configurations are judiciously designed, which significantly suppress the unwanted cross-couplings between nonadjacent coils that could break the chiral symmetry of the SSH chain. By tuning the inter- and intra-cell coupling strengths, we theoretically and experimentally demonstrate high energy transfer efficiency near the exceptional point of the topological edge states, even in the presence of disorder. The combination of topological metamaterials, non-Hermitian physics, and WPT techniques could promise a variety of robust, efficient WPT applications over long distances in electronics, transportation, and industry. © 2020, CC BY.

关键词： Energy transfer

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Photonic topological valley-locked waveguides

arXiv

引用

arXiv 2020年

作者： Chen, Qiaolu Zhang, Li Yan, Qinghui Xi, Rui Chen, Hongsheng Yang, Yihao Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical Instrumentation College of Information Science and Electronic Engineering Zhejiang University Hangzhou310027 China ZJU-Hangzhou Global Science and Technology Innovation Center Key Lab. of Advanced Micro/Nano Electronic Devices and Smart Systems of Zhejiang Zhejiang University Hangzhou310027 China International Joint Innovation Center ZJU-UIUC Institute Zhejiang University Haining314400 China Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link Singapore637371 Singapore Centre for Disruptive Photonic Technologies Photonics Institute Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore

Topological valley kink states have become a significant research frontier with considerable intriguing applications such as robust on-chip communications and topological lasers. Unlike guided modes with adjustable widths in most conventional waveguides, the valley kink states are usually highly confined around the domain walls and thus lack the mode width degree of freedom (DOF), posing a serious limitation to potential device applications. Here, by adding a photonic crystal (PhC) featuring a Dirac point between two valley PhCs with opposite valley-Chern numbers, we design and experimentally demonstrate topological valley-locked waveguides (TVLWs) with tunable mode widths. The photoinc TVLWs could find unique applications, such as high-energy-capacity topological channel intersections, valley-locked energy concentrators, and topological cavities with designable confinement, as verified numerically and experimentally. The TVLWs with width DOF could be beneficial to interface with the exsisting photonic waveguides and devices, and serve as a novel platform for practical use of topological lasing, field enhancement, on-chip communicaitons, and high-capacity energy transport. Copyright © 2020, The Authors. All rights reserved.

关键词： Landforms

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