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SID Symposium, Seminar, and Exhibition 2019, Display Week 2019

作者： Jiang, Yingfei Zhou, Xiaochen Qin, Guangkui Xu, Xiaoguang Lee, Seunghee Yang, Deng-Ke Chemical Physics Interdisciplinary Program Liquid Crystal Institute Kent State University KentOH44242 United States BOE Technology Group Co. No. 9 Dize RD BDA Beijing100171 China Department of Polymer Nano-Science and Technology Chonbuk National University Jeonbuk Jeonju561-756 Korea Republic of

ISBN: (纸本)9781510896161

When a LCD display static images, power consumption can be reduced by employing a low driving frequency. However, when the driving frequency is decreased, there is a problem that the brightness of the display may change with time, a phenomenon known as flickering. One factor responsible for the flickering issue is flexoelectric effect. We show that flickering in ADvanced Super Dimension Switch (ADS) LCD can be significantly reduced by doping a liquid crystal dimer and using polymer stabilization. We demonstrated that 2 Hz driving frequency can be used to display static images. © 2019 SID.

关键词： Liquid crystal displays

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Saturable intercalation doping enables scalable and selective graphene gas sensors on plastic

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Chemical Engineering Journal 2025年 515卷

作者： Kwon, Bitnuri Lee, Jung Hun Jo, Sae Byeok Hwang, Jinhyun Lee, Donggeun Cha, Jonghyun Lim, Soomook Suk, Ji Won Lee, Wi Hyoung Department of Organic and Nano System Engineering Konkuk University Seoul05029 Cuba Department of Materials Science and Engineering and the Materials Research Center Northwestern University 2220 Campus Drive EvanstonIL60208-3108 United States School of Chemical Engineering Sungkyunkwan University Suwon16419 Cuba Sungkyunkwan University Suwon16419 Cuba Advanced Materials Program Department of Materials Science and Engineering Konkuk University Seoul05029 Cuba School of Mechanical Engineering Sungkyunkwan University Suwon16419 Cuba Department of Smart-Fab. Technology Sungkyunkwan University Suwon16419 Cuba Department of Materials Science and Engineering Konkuk University Seoul05029 Cuba

Developing highly sensitive and selective gas sensors for nitrogen dioxide (NO2) detection remains crucial for environmental monitoring and public health protection. Graphene-based chemiresistive sensors show promise due to their exceptional electronic properties and high surface area, which enhance gas adsorption. However, they face persistent challenges in selectivity, stability, and sensitivity characteristics. This study presents a facile one-step molecular intercalation doping approach that can effectively overcome these limitations. By intercalating carefully selected dopant molecules between graphene and flexible substrates during the wet-transfer process, we achieve uniform doping distribution while maintaining intrinsic carrier mobility. The resulting sensors demonstrate remarkable NO2 detection capabilities with a limit of detection of 1 ppb at room temperature. Importantly, the intercalated devices exhibit exceptional stability over extended periods of time and show minimal cross-sensitivity to common interfering gases. Moreover, the sensors retain their sensing characteristics under mechanical deformation, including fully transparent gas sensors with a dogbone structure, thereby enabling seamless integration into wearable monitoring systems. Our scalable fabrication process and comprehensive understanding of the intercalation doping mechanism provide a practical pathway for the development of reliable, flexible gas sensors capable of addressing real-world environmental and healthcare challenges. © 2025 Elsevier B.V.

关键词： pH sensors

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Protein and lipid expansion microscopy with trypsin and tyramide signal amplification for 3D imaging

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Scientific reports 2023年第1期13卷 21922页

作者： Ueh-Ting Tim Wang Xuejiao Tian Yae-Huei Liou Sue-Ping Lee Hsiao-Tang Hu Chieh-Han Lu Po-Ting Lin Ya-Jen Cheng Peilin Chen Bi-Chang Chen Affiliated Senior High School of National Taiwan Normal University Taipei 106348 Taiwan. Research Center for Applied Sciences Academia Sinica Taipei 11529 Taiwan. Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Tsing Hua University Taipei 11529 Taiwan. Department of Engineering and System Science National Tsing Hua University Hsinchu 300 Taiwan. Institute of Molecular Biology Academia Sinica Taipei 11529 Taiwan. Institute and Undergraduate Program of Electro-Optical Engineering National Taiwan Normal University Taipei 116 Taiwan. Neuroscience Program NPAS Academia Sinica Taipei 11529 Taiwan ROC. Research Center for Applied Sciences Academia Sinica Taipei 11529 Taiwan. chenb10@gate.sinica.edu.tw.

Expansion microscopy, whereby the relative positions of biomolecules are physically increased via hydrogel expansion, can be used to reveal ultrafine structures of cells under a conventional microscope. Despite its utility for achieving super-resolution imaging, expansion microscopy suffers a major drawback, namely reduced fluorescence signals caused by excessive proteolysis and swelling effects. This caveat results in a lower photon budget and disfavors fluorescence imaging over a large field of view that can cover an entire expanded cell, especially in 3D. In addition, the complex procedures and specialized reagents of expansion microscopy hinder its popularization. Here, we modify expansion microscopy by deploying trypsin digestion to reduce protein loss and tyramide signal amplification to enhance fluorescence signal for point-scanning-based imaging. We name our new methodology TT-ExM to indicate dual trypsin and tyramide treatments. TT-ExM may be applied for both antibody and lipid staining. TT-ExM displayed enhanced protein retention for endoplasmic reticulum and mitochondrial markers in COS-7 cell cultures. Importantly, TT-ExM-based lipid staining clearly revealed the complex 3D membrane structures in entire expanded cells. Through combined lipid and DNA staining, our TT-ExM methodology highlighted mitochondria by revealing their DNA and membrane structures in cytoplasm, as well as the lipid-rich structures formed via phase separation in nuclei at interphase. We also observed lipid-rich chromosome matrices in the mitotic cells. These high-quality 3D images demonstrate the practicality of TT-ExM. Thus, readily available reagents can be deployed in TT-ExM to significantly enhance fluorescence signals and generate high-quality and ultrafine-resolution images under confocal microscopy.

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Revised model for cell cycle regulation by iron: differential roles between transferrin and ferritin

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Redox Biology 2025年 85卷

作者： Ryo Yanagiya Hiroko Kato Akinori Ninomiya Masaya Ueno Akane Kanamori Yuji Miyatake Masahiro Oka Keisuke Ishii Tadashi Matsuura So Nakagawa Atsushi Hirao Makoto Onizuka Ai Kotani Department of Regulation of Infectious Cancers Research Institute for Microbial Diseases The University of Osaka Suita Japan Department of Hematology and Oncology Tokai University School of Medicine Isehara Japan Department of Drug Discovery and Biomedical Sciences Faculty of Medicine Saga University Saga Japan Core Instrumentation Facility Immunology Frontier Research Center The University of Osaka Suita Japan Central Instrumentation Laboratory Research Institute for Microbial Diseases The University of Osaka Suita Japan Division of Molecular Genetics Cancer and Stem Cell Research Program Cancer Research Institute Kanazawa University Kakuma-machi Kanazawa Japan WPI Nano Life Science Institute (WPI-Nano LSI) Kanazawa University Kakuma-machi Kanazawa Japan Perseus Proteomics Inc. Tokyo Japan Department of Molecular Life Science Tokai University School of Medicine Isehara Japan Division of Omics Sciences Institute of Medical Sciences Tokai University Isehara Japan Division of Interdisciplinary Merging of Health Research Micro/Nano Technology Center Tokai University Hiratsuka Japan

Iron is essential for neoplasms including natural killer (NK) cell lymphoma, and mainly supplemented by transferrin and stored by ferritin. Although accumulating studies had demonstrated that iron chelation arrests cell cycle progression at G1 phase, our previous studies showed the induction of DNA double strand break at S phase cell cycle without G1 arrest by selective inhibition of cellular transferrin uptake, indicating that the existence of some undiscovered differences in the roles of the two major iron sources for cell cycle regulation. In this study, we identified a novel cell cycle regulation of transferrin binding iron in NK cell lymphoma. Blocking transferrin uptake induced S phase arrest owing to the dysfunction of nascent DNA synthesis. Moreover, canonical G1 arrest was observed with mitochondrial dysfunction followed by downregulation of mTORC1 and dephosphorylation of Rb only when intracellular iron storage was deprived by iron chelation. These results suggested that iron is critically involved in at least two steps of the cell cycle: the S phase and G1/S transition. Especially, considering the toxicity of mitochondrial dysfunction to normal cells and cell cycle dependent manner of S phase-specific DNA damage due to selective inhibition of transferrin uptake, transferrin receptor blockers are thought to be more suitable than iron chelators as antineoplastic agents. Overall, the current canonical model of cell cycle regulation by iron requires revision.

关键词： Iron Transferrin Cell cycle S phase arrest Nascent DNA synthesis Mitochondria ANKL aggressive natural killer cell leukemia DEG differentially expressed gene DEP differentially expressed protein DFO deferoxamine EdU 5-ethynyl-2′-deoxyuridine FC fold change GEO gene expression omnibus GSEA gene set enrichment analysis LC-MS/MS liquid chromatography-tandem mass spectrometry LIP labile iron pool NK natural killer PDX patient-derived xenograft mouse RIPA radio-immunoprecipitation assay ROS reactive oxygen species scRNA-seq single-cell RNA-sequencing MQ mitoquinone T003 PPMX-T003 TfR1 transferrin receptor 1 TfR1-Ab TfR1 inhibitory antibody

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Scintillation properties of cerium-doped Tl 2 LaCl 5 Crystal: Investigating the effects of size and cerium concentration

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Radiation Physics and Chemistry 2025年 237卷

作者： Lam Tan Truc Nguyen Thanh Luan Arshad Khan Gul Rooh D.W. Jeong J. Kaewkhao H.J. Kim S. Kothan Department of Physics Kyungpook National University Daegu 41566 Republic of Korea Center for High Energy Physics Kyungpook National University Daegu 41566 Republic of Korea Department of Physics Faculty of Arts and Sciences Najran University Najran Saudi Arabia Advanced Materials and Nano Research Center (AMNRC) Najran University P.O. Box: 1988 Najran 11001 Saudi Arabia Department of Physics Abdul Wali Khan University Mardan 23200 Pakistan Physics Program Faculty of Science and Technology Nakhon Pathom Rajabhat University Nakhon Pathom 73000 Thailand Center of Excellence in Glass Technology and Materials Science (CEGM) Nakhon Pathom Rajabhat University Nakhon Pathom 73000 Thailand Center of Radiation Research and Medical Imaging Department of Radiologic Technology Faculty of Associated Medical Sciences Chiang Mai University Chiang Mai 50200 Thailand

The cerium-doped Tl 2 LaCl 5 (TLC: Ce 3+ ) scintillator has emerged as a highly promising material for radiation detection applications such as positron emission tomography (PET), owing to its high effective atomic number (Z eff ) density and excellent scintillation properties. In this study, we grew a large-sized TLC crystal with a diameter of approximately 1 inch; however, the resulting crystal exhibited some cracks. Comprehensive characterization reveals stable light outputs and energy resolutions across different crystal sizes with only a negligible variation observed in large size crystals. In addition, faster decay and rise times are observed with higher cerium concentrations, achieving a significant decay time reduction to 31 ns with 20 % Ce doping, comparable with commercial scintillators such as LaBr 3 : Ce 3+ . These findings underscore the potential of TLC: Ce 3+ as a scalable and high-performance scintillator, suitable for advanced time-of-flight PET applications, despite the challenge posed by its hygroscopic nature for large-scale manufacturing.

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Author Correction: Predicting the efficiency of prime editing guide RNAs in human cells

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Nature biotechnology 2024年第3期42卷 529页

作者： Hui Kwon Kim Goosang Yu Jinman Park Seonwoo Min Sungtae Lee Sungroh Yoon Hyongbum Henry Kim Department of Pharmacology Yonsei University College of Medicine Seoul Republic of Korea. Brain Korea 21 Plus Project for Medical Sciences Yonsei University College of Medicine Seoul Republic of Korea. Center for Nanomedicine Institute for Basic Science (IBS) Seoul Republic of Korea. Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University Seoul Republic of Korea. Electrical and Computer Engineering Seoul National University Seoul Republic of Korea. Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea. Graduate School of Data Science Seoul National University Seoul Republic of Korea. Department of Pharmacology Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Brain Korea 21 Plus Project for Medical Sciences Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Center for Nanomedicine Institute for Basic Science (IBS) Seoul Republic of Korea. hkim1@yuhs.ac. Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University Seoul Republic of Korea. hkim1@yuhs.ac. Severance Biomedical Science Institute Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Graduate Program of NanoScience and Technology Yonsei University Seoul Republic of Korea. hkim1@yuhs.ac.

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Mechanistic Insights into Enhanced Reactivation of Organophosphate-Inhibited Enzymes by Methyl-Substituted 2-Pralidoxime Analogs

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The journal of physical chemistry. B 2025年第23期129卷 2025 May 27页

作者： Phiphob Naweephattana Nalinee Kongkaew Panida Surawatanawong Nawee Kungwan Yin Fang Peter Wolschann Phornphimon Maitarad Kowit Hengphasatporn Yasuteru Shigeta Thanyada Rungrotmongkol Alisa S Vangnai Center of Excellence in Biocatalyst and Sustainable Biotechnology Department of Biochemistry Faculty of Science Chulalongkorn University Bangkok 10330 Thailand. Program in Bioinformatics and Computational Biology Graduate School Chulalongkorn University Bangkok 10330 Thailand. Department of Chemistry and Center of Excellence for Innovation in Chemistry Faculty of Science Mahidol University Bangkok 10400 Thailand. Department of Chemistry Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand. Research Center for Translational Medicine Shanghai East Hospital Affiliated to Tongji University Shanghai 200120 China. Institute of Theoretical Chemistry University of Vienna Vienna 1010 Austria. Research Center of Nano Science and Technology Department of chemistry College of Science Shanghai University Shanghai 200444 China. Center for Computational Sciences University of Tsukuba 1-1-1 Tennodai Ibaraki Tsukuba 305-8577 Japan.

Organophosphate (OP) compounds, such as paraoxon (POX), inhibit enzymes critical for neurotransmission, causing severe neurotoxic effects. Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM is commonly employed to reverse this inhibition, but its reactivation efficiency is limited. This study computationally explores the reactivation mechanisms of 2-PAM and its methyl-substituted analogs, 4-methyl-2-PAM (4-Met-2-PAM), and 4,6-dimethyl-2-PAM (4,6-Dimet-2-PAM). The reactivation process involves several key steps, such as hydrogen transfer and nucleophilic substitution (). Introducing methyl groups at positions 4 and 6 increases the negative charge on the oxime oxygen, improving nucleophilicity and reactivity. Both 4-Met-2-PAM and 4,6-Dimet-2-PAM show better reactivity than 2-PAM, with 4,6-Dimet-2-PAM demonstrating the greatest improvement. This enhanced reactivity shifts the rate-determining step from nucleophilic substitution to the initial hydrogen transfer. These findings offer valuable insights for designing more effective oxime-based antidotes for organophosphate poisoning.

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Density functional study on the oxygen evolution reaction mechanism of transition metal doped bimetallic NiCu phosphate surface

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Computational and Theoretical Chemistry 2025年 1250卷

作者： Hamdi Ikhwan Dzaki Ahmad Syaifullah Muhammad Arkan Nuruzzahran Nadhratun Naiim Mobarak Sasfan Arman Wella Fadjar Fathurrahman Ni Luh Wulan Septiani Adhitya Gandaryus Saputro Graduate Program of Engineering Physics Faculty of Industrial Technology Institut Teknologi Bandung Bandung West Java 40132 Indonesia PT. PLN (Persero) Indonesia Department of Chemical Sciences Faculty of Science and Technology Universiti Kebangsaan Malaysia 43600 UKM Bangi Selangor Darul Ehsan Malaysia Research Center for Quantum Physics National Research and Innovation Agency (BRIN) South Tangerang 15314 Indonesia Collaboration Research Center for Advanced Energy Materials BRIN - Institut Teknologi Bandung Bandung 40132 Indonesia Quantum and Nano Technology Research Group Bandung Institute of Technology Bandung 40132 Indonesia Research Centre for Nanoscience and Nanotechnology Institut Teknologi Bandung Bandung West Java 40132 Indonesia Research Center for Electronics National Research and Innovation Agency KST Samaun Samadikun Bandung 40135 Indonesia

We have explored the oxygen evolution reaction (OER) activity of both undoped nickel copper phosphate (NiCuPO) and transition metal-doped NiCuPO-M (M = Mn, Fe, Co) surfaces using periodic density functional theory (DFT)-based calculations. Our findings highlight that while the undoped NiCuPO surface exhibits a high overpotential of 0.98 V, the introduction of transition metal doping remarkably enhances the OER performance, reducing the overpotential to as low as 0.41 V in the Mn-doped case, outperforming the widely used IrO 2 catalyst. This enhancement is primarily due to a favorable shift in the d -band center, which increases O* adsorption strength and decreases the OER overpotential. Among the doped systems, Mn and Fe doping demonstrate the most substantial reductions in overpotential, underscoring their potential as efficient catalysts for OER applications.

关键词： DFT NiCu phosphate Oxygen evolution reaction Transition metal doping Water electrolysis

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Observing off-resonance motion of nanomechanical resonators as modal superposition

arXiv

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arXiv 2020年

作者： Esmenda, Joshoua Condicion Aguila, Myrron Albert Callera Wang, Jyh-Yang Lee, Teik-Hui Yang, Chi-Yuan Lin, Kung-Hsuan Chang-Liao, Kuei-Shu Katz, Nadav Kafanov, Sergey Pashkin, Yuri Chen, Chii-Dong Department of Engineering and System Science National Tsing Hua University Hsinchu30013 Taiwan Nano-Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei11529 Taiwan Institute of Physics Academia Sinica Taipei11529 Taiwan Department of Physics National Taiwan University Taipei10617 Taiwan Racah Institute of Physics Hebrew University Jerusalem91904 Israel Department of Physics Lancaster University LancasterLA1 4YB United Kingdom

Observation of resonance modes is the most straightforward way of studying mechanical oscillations because these modes have maximum response to stimuli. However, a deeper understanding of mechanical motion could be obtained by also looking at modal responses at frequencies in between resonances. In this paper, we present visualisation of the modal response shapes for a mechanical drum driven off-resonance. Furthermore, we describe these transitions through superposition of resonance modes. Copyright © 2020, The Authors. All rights reserved.

关键词： Modal analysis

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Low-Temperature Synthesis of Weakly Confined Carbyne inside Single-Walled Carbon nanotubes

arXiv

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arXiv 2024年

作者： Zhang, Bo-Wen Qiu, Xi-Yang Ma, Yicheng Hu, Qingmei Fitó-Parera, Aina Kohata, Ikuma Feng, Ya Zheng, Yongjia Zhang, Chiyu Matsuo, Yutaka Wang, YuHuang Chiashi, Shohei Otsuka, Keigo Xiang, Rong Levshov, Dmitry I. Cambré, Sofie Wenseleers, Wim Rotkin, Slava V. Maruyama, Shigeo Department of Mechanical Engineering The University of Tokyo Tokyo113-8656 Japan State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical Engineering Zhejiang University Hangzhou310027 China Theory and Spectroscopy of Molecules and Materials Department of Physics University of Antwerp Antwerp2610 Belgium Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education School of Energy and Power Engineering Dalian University of Technology Liaoning 116024 China Department of Chemistry and Biochemistry Chemical Physics Program Maryland Nano Center University of Maryland College ParkMD20742 United States Department of Chemical Systems Engineering Graduate School of Engineering Nagoya University Nagoya464-8603 Japan Institute of Materials Innovation Institutes for Future Society Nagoya University Nagoya464-8603 Japan Theory and Spectroscopy of Molecules and Materials Department of Chemistry University of Antwerp Antwerp2610 Belgium Nanostructured and Organic Optical and Electronic Materials Department of Physics University of Antwerp Antwerp2610 Belgium Materials Research Institute Department of Engineering Science & Mechanics The Pennsylvania State University University ParkPA16802 United States

Carbyne, a one-dimensional (1D) carbon allotrope with alternating triple and single bonds, has the highest known mechanical strength but is unstable to bending, limiting synthesis to short linear chains. Encapsulation within carbon nanotubes (CNTs) stabilizes carbyne, forming confined carbyne (CC), thus enabling further research concerning attractive 1D physics and materials properties of carbyne. While CC has been synthesized in multi-walled CNTs (MWCNTs) using the arc-discharge method and in double-walled CNTs (DWCNTs) via high-temperature high-vacuum (HTHV) method, synthesis in single-walled CNTs (SWCNTs) has been challenging due to their fragility under such conditions. In this work, we report a low-temperature method to synthesize CC inside SWCNTs (CC@SWCNT). By annealing SWCNTs containing ammonium deoxycholate (ADC) at 400°C, ADC is converted into CC without damaging the SWCNTs. Raman spectroscopy revealed a strong CC phonon (CC-mode) peak at 1860–1870 cm-1, much stronger than the SWCNT G-band peak, confirming a high fraction of CC in the resulting material. The Raman mapping result showed the uniformity of the CC-mode signal across the entire film sample, proving the high efficiency of this method in synthesizing CC in every SWCNT of appropriate size. Notably, the CC-mode peaks of CC@SWCNT (above 1860 cm-1) are higher than those reported in previous CC@CNT samples (mostly -1). This is attributed to larger SWCNT diameters (>0.95 nm) used in this study, compared to the typical 0.6–0.8 nm range. Larger diameters result in reduced confinement, allowing carbyne to closely resemble free-standing carbyne while remaining stabilized. This low-temperature synthesis of long-chain, nearly freestanding carbyne within large-diameter SWCNTs offers new opportunities for exploring 1D physics and the unique properties of carbyne for potential applications. © 2024, CC BY-NC-ND.

关键词： Single-walled carbon nanotubes (SWCN)

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