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Synergistic Glutathione Depletion and STING Activation to Potentiate Dendritic Cell Maturation and Cancer Vaccine Efficacy

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Angewandte Chemie 2024年第10期136卷

作者： Dr. Jianping Liu Dr. Ye Zhang Bowei Yang Dr. Yingbo Jia Prof. Rui-Tian Liu Dr. Lingwen Ding Prof. Zheyu Shen Prof. Xiaoyuan Chen Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore School of Biomedical Engineering Southern Medical of University Guangzhou Guangdong 510515 P. R. China CAS Key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou Jiangsu 215123 P. R. China State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 P. R. China Department of Pathology Yong Loo Lin School of Medicine National University of Singapore Singapore 119074 Singapore Clinical Imaging Research Center Center for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive Proteos Singapore 138673 Singapore

Dendritic cell (DC) maturation and antigen presentation are key factors for successful vaccine-based cancer immunotherapy. This study developed manganese-based layered double hydroxide (Mn-LDH) nanoparticles as a self-adjuvanted vaccine carrier that not only promoted DC maturation through synergistically depleting endogenous glutathione (GSH) and activating STING signaling pathway, but also facilitated the delivery of model antigen ovalbumin (OVA) into lymph nodes and subsequent antigen presentation in DCs. Significant therapeutic-prophylactic efficacy of the OVA-loaded Mn-LDH (OVA/Mn-LDH) nanovaccine was determined by the tumor growth inhibition in the mice bearing B16-OVA tumor. Our results showed that the OVA/Mn-LDH nanoparticles could be a potent delivery system for cancer vaccine development without the need of adjuvant. Therefore, the combination of GSH exhaustion and STING pathway activation might be an advisable approach for promoting DC maturation and antigen presentation, finally improving cancer vaccine efficacy.

关键词： Antigen Delivery DC Maturation GSH Depletion ROS Upregulation STING Activation

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Perovskite Photovoltaic Cells: Synergistic Effect of Excited State Property and Aggregation Characteristic of Organic Semiconductor on Efficient Hole-Transportation in Perovskite Device (Adv. Funct. Mater. 5/2021)

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Advanced Functional Materials 2021年第5期31卷

作者： Bonghyun Jo Hansol Park Eswaran Kamaraj Sewook Lee Bumho Jung Sivaraman Somasundaram Gyeong G. Jeon Kyu-Tae Lee Namdoo Kim Jong H. Kim Bong-Gi Kim Tae Kyu Ahn Sanghyuk Park Hui Joon Park Department of Organic and Nano Engineering Hanyang University Seoul 04763 Korea Department of Energy Science Sungkyunkwan University Suwon 16419 Korea Human-Tech Convergence Program Hanyang University Seoul 04763 Korea Department of Chemistry Kongju National University Kongju 32588 Korea Department of Molecular Science and Technology Ajou University Suwon 16499 Korea Department of Physics Inha University Incheon 22212 Korea Department of Organic and Nano System Engineering Konkuk University Seoul 05029 Korea

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The application of an extracellular vesicle-based biosensor in early diagnosis and prediction of chemoresponsiveness in ovarian cancer

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Cancer Letters 2024年 581卷 216533-216533页

作者： Tsang, Benjamin K. Asare-Werehene, Meshach Hunter, Rob Gerber, Emma Reunov, Arkadiy Brine, Isaiah Chang, Chia-Yu Chang, Chia-Ching Shieh, Dar-Bin Burger, Dylan Anis, Hanan Departments of Obstetrics & Gynecology and Cellular & Molecular Medicine Centre for Infection Immunity and Inflammation Interdisciplinary School of Health Sciences University of Ottawa Ottawa ON K1N 6N5 Canada Chronic Disease Program Ottawa Hospital Research Institute The Ottawa Hospital Ottawa ON K1Y 4E9 Canada Department of Biology St. Francis Xavier University 2320 Notre Dame Avenue Antigonish NS B2G 2W5 Canada School of Electrical Engineering and Computer Science Ottawa-Carleton Institute for Biomedical Engineering University of Ottawa Ottawa ON K1N 6N5 Canada Department of Biological Science and Department of Electrophysics Technology Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) National Yang Ming Chiao Tung University Hsinchu 30068 Taiwan Institute of Basic Medical Science Institute of Oral Medicine and Department of Stomatology Advanced Optoelectronic Technology Center and Center for Micro/Nano Science and Technology National Cheng Kung University Hospital National Cheng Kung University Tainan 704 Taiwan Institute of Physics Academia Sinica Taipei 10529 Taiwan

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Overcoming the surface paradox: Buried perovskite quantum dots in wide-bandgap perovskite thin films

arXiv

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arXiv 2025年

作者： Zhang, Hao Pasha, Altaf Metcalf, Isaac Zhou, Jianlin Staunstrup, Mathias Zhu, Yunxuan Liao, Shusen Ssennyimba, Ken Chen, Jia-Shiang Reddy, Surya Prakash Thébaud, Simon Hou, Jin Shuai, Xinting Mandani, Faiz Sidhik, Siraj Jones, Matthew R. Ma, Xuedan Balakrishna, R. Geetha Susarla, Sandhya Ginger, David S. Katan, Claudine Kanatzidis, Mercouri G. Bawendi, Moungi G. Natelson, Douglas Tamarat, Philippe Lounis, Brahim Even, Jacky Mohite, Aditya D. Department of Chemical and Biomolecular Engineering Rice University HoustonTX77005 United States Applied Physics Program Smalley‐Curl Institute Rice University HoustonTX77005 United States Centre for Nano and Material Sciences Jain University Jain Global Campus Kanakapura Karnataka Bangalore562112 India Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States Université de Bordeaux LP2N Talence France Institut d’Optique CNRS LP2N Talence France Department of Physics and Astronomy Rice University HoustonTX77005 United States Center for Nanoscale Materials Argonne National Laboratory LemontIL60439 United States School for Engineering of Matter Transport and Energy Arizona State University TempeAZ85281 United States UMR 6082 CNRS INSA de Rennes Rennes35708 France Department of Chemistry Rice University HoustonTX77005 United States Department of Chemistry University of Washington Box 351700 SeattleWA98195-1700 United States UMR 6226 Rennes35000 France Department of Chemistry Northwestern University EvanstonIL United States Department of Chemistry Massachusetts Institute of Technology 77 Massachusetts Avenue CambridgeMA02139 United States Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States

Colloidal perovskite quantum dots (PQDs) are an exciting platform for on-demand quantum, and classical optoelectronic and photonic devices. However, their potential success is limited by the extreme sensitivity and low stability arising from their weak intrinsic lattice bond energy and complex surface chemistry. Here we report a novel platform of buried perovskite quantum dots (b-PQDs) in a three-dimensional perovskite thin-film, fabricated using one-step, flash annealing, which overcomes surface related instabilities in colloidal perovskite dots. The b-PQDs demonstrate ultrabright and stable single-dot emission, with resolution-limited linewidths below 130 μeV, photon-antibunching (g2(0)=0.1), no blinking, suppressed spectral diffusion, and high photon count rates of 104/s, consistent with unity quantum yield. The ultrasharp linewidth resolves exciton fine-structures (dark and triplet excitons) and their dynamics under a magnetic field. Additionally, b-PQDs can be electrically driven to emit single photons with 1 meV linewidth and photon-antibunching (g2(0)=0.4). These results pave the way for on-chip, low-cost single-photon sources for next generation quantum optical communication and sensing. © 2025, CC BY.

关键词： Photons

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Biologically-induced synthetic manganese carbonate precipitate (BISMCP) for potential applications in heavy metal removal

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Heliyon 2023年第5期9卷

作者： Dewi, Anggraeni Kumala Sharma, Raju Kumar Das, Koyeli Sukul, Uttara Lin, Pin-Yun Huang, Yi-Hsun Lu, Chung Ming Lu, Cheng-Kang Chen, Tsung-Hsien Chen, Chien-Yen Department of Physics National Chung Cheng University University Road Minhsiung Chiayi County 62102 Taiwan Doctoral Program in Science Technology Environment and Mathematics Department of Earth and Environmental Sciences National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Chemistry and Biochemistry National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Biomedical Sciences Graduate Institute of Molecular Biology National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Chemical Engineering National Chung Cheng University University Road Minhsiung Chiayi County 62102 Taiwan Department of Chest Division Internal Medicine Ditmanson Medical Foundation Chiayi Christian Hospital 600566 Taiwan Department of Internal Medicine Ditmanson Medical Foundation Chiayi Christian Hospital 600566 Taiwan Center for Nano Bio-Detection Center for Innovative Research on Aging Society AIM-HI National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan

Heavy metal pollution of water is a burning issue of today's world. Among several strategies involved for heavy metal remediation purpose, biomineralization has shown great potential. Of late, research has been focused on developing effective mineral adsorbents with reduced time and cost consumption. In this present paper, the Biologically-Induced Synthetic Manganese Carbonate Precipitate (BISMCP) was produced based on the biologically-induced mineralization method, employing Sporosarcina pasteurii in aqueous solutions containing urea and MnCl₂. The prepared adsorbent was characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), SEM-energy dispersive X-ray spectroscopy (SEM-EDX), X-ray diffraction (XRD) and BET surface area analyzer. EDX analysis showed the elements in the crystal BISMCP were Mn, C, and O. XRD result of BISMCP determined the crystal structure, which is close to rhodochrosite (MnCO₃). Spectral peaks of FTIR at 1641.79 cm⁻¹ confirmed the appearance of C[dbnd]O binding, with strong stretching of CO₃²⁻ in Amide I. From the six kinds of BISMCP produced, sample MCP-6 has the higher specific surface area by BET analysis at 109.01 m²/g, with pore size at 8.76 nm and higher pore volume at 0.178 cm³/g. These specifications will be suitable as an adsorbent for heavy metal removal by adsorption process. This study presents a preliminary analysis of the possibility of BISMCP for heavy metals adsorption using ICP multi-element standard solution XIII (As, Cr, Cd, Cu, Ni, and Zn). BISMCP formed from 0.1 MnCl₂ and 30 ml of bacteria volume (MCP-6) produced a better adsorbent material than others concentrations, with the adsorption efficiency of total As at 98.9%, Cr at 97.0%, Cu at 94.7%, Cd at 88.3%, Zn at 48.6%, and Ni at 29.5%. Future work could be examined its efficiency adsorbing individual heavy metals. © 2023

关键词： Adsorbent material Biologically induced mineralization Biomineralization Heavy metal removal Manganese carbonate (MnCO3) Sporosarcina pasteurii

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Cover Feature: Sodium Ion-Conducting Electrolytes Based on Chloroaluminate Ionic Liquids and δ-NaCl (ChemSusChem 20/2024)

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ChemSusChem 2024年第20期17卷

作者： Sumit Kumar Rajesh Raghupathy Prof. Keti Vezzù Dr. Mounesha N. Garaga Dr. Xiaoping Zhu Prof. Steve Greenbaum Prof. Vito Di Noto Prof. Michele Vittadello Department of Chemistry and Environmental Science Medgar Evers College of the City University of New York (CUNY) 1638 Bedford Avenue Brooklyn NY 11225 USA Bioorganic Research Laboratory Department of Chemistry University of Delhi University Enclave Delhi 110007 India Nano and Bioelectrochemistry Research Laboratory and Carbon Dioxide Research and Green Technology Centre Department of Chemistry School of Advanced Sciences Vellore Institute of Technology Tiruvalam Road Vellore 632014 India Section of Chemistry for the Technology (ChemTech) Department of Industrial Engineering University of Padova Via Marzolo 9 I-35131 Padova PD Italy Department of Physics Hunter College of CUNY 695 Park Avenue New York NY 10021 USA Ph.D. Program in Physics The Graduate Center of CUNY 365 5th Avenue New York New York 10016 USA Centro Studi di Economia e Tecnica dell'Energia Giorgio Levi Cases Via Marzolo 9 I-35131 Padova PD Italy Ph.D. Program in Chemistry The Graduate Center of CUNY 365 5th Avenue New York New York 10016 USA

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Active Gold nanocatalyst Supported Carbon Fiber-Graphene Heterostructures Derived Sensor for Efficient Nitrite Detection

Active Gold Nanocatalyst Supported Carbon Fiber-Graphene Het...

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第十届国际（中国）功能材料及其应用学术会议、第六届国际多功能材料与结构学术大会、首届国际新材料前沿发展大会

作者： Kai Chang Huu Tuan Le Duy Thanh Tran Nam Hoon Kim Joong Hee Lee Advanced Materials Institute for BIN Convergence Technology (BK21 Plus Global Program) Department of BIN Convergence Technology Jeonbuk National University Regional Leading Research Center for Nanocarbon-based Energy Materials and Application Technology Jeonbuk National University Center for Carbon Composite Materials Department of Polymer-Nano Science and Technology Jeonbuk National University

The quantitative detection of nitrite level is of quickly growing interest, particularly for the protection of the quality of drinking water resources, treatment of waste water, food process, and control of remediation procedures. Easy and highly selective and sensitive approaches reasonable for rapid and reliable field monitoring are necessary in all mentioned

关键词： Graphene Sensor Active Gold nanocatalyst Supported Carbon Fiber-Graphene Heterostructures Derived Sensor for Efficient Nitrite Detection

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The thickness dependence of quantum oscillations in ferromagnetic Weyl metal SrRuO3

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npj Quantum Materials 2023年第1期8卷 1-10页

作者： Uddipta Kar Akhilesh Kr. Singh Chih-Yu Lin Bipul Das Cheng-Tung Cheng Wei-Li Lee Yu-Te Hsu M. Berben S. Wiedmann Song Yang Chun-Yen Lin Chia-Hung Hsu Wei-Cheng Lee Institute of Physics Academia Sinica Nankang Taipei 11529 Taiwan Nano Science and Technology Taiwan International Graduate Program Academia Sinica and National Taiwan university Taipei Taiwan Department of Physics National Taiwan University Taipei 10617 Taiwan High Field Magnet Laboratory (HFML-EMFL) Radboud University Toernooiveld 7 6525 ED Nijmegen The Netherlands Radboud University Institute for Molecules and Materials Heyendaalseweg 135 6525 AJ Nijmegen The Netherlands Scientific Research Division National Synchrotron Radiation Research Center Hsinchu 30076 Taiwan Department of Physics Applied Physics and Astronomy Binghamton University Binghamton NY 13902 USA

In a thin Weyl semimetal, a thickness dependent Weyl-orbit quantum oscillation was proposed to exist, originating from a nonlocal cyclotron orbit via electron tunnelings between top and bottom Fermi-arc surface states. Here, magneto-transport measurements were carried out on untwinned Weyl metal SrRuO3thin films. In particular, quantum oscillations with a frequencyFs1≈ 30 T were identified, corresponding to a small Fermi pocket with a light effective mass. Its oscillation amplitude appears to be at maximum for thicknesses in a range of 10 to 20 nm, and the phase of oscillation exhibits a systematic change with film thickness. The constructed Landau fan diagram shows an unusual concave downward curvature in the 1/μ0Hn-ncurve, wherenis the Landau level index. From thickness and field-orientation dependence, theFs1oscillation is attributed to be of surface origin. Those findings can be understood within the framework of the Weyl-orbit quantum oscillation effect with non-adiabatic corrections.

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Freshwater microalgae-mediated engineered nanoparticles: Sustainable approach for heavy metals remediation

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Bioresource technology 2025年 132761页

作者： Manish Sutradhar Raju Kumar Sharma Gobinda Dey Uttara Sukul Koyeli Das Md. Taharia Pin-Yun Lin Shafiqa Ali Chin-Wen Wang Chien-Yen Chen Doctoral Program in Science Technology Environment and Mathematics Department of Earth and Environmental Sciences National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Earth and Environmental Sciences National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Chemistry and Biochemistry National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Center for Nano Bio-Detection Center for Innovative Research on Aging Society AIM-HI National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Biomedical Sciences Graduate Institute of Molecular Biology National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan You-Cheng Engineering & Technology Co. Ltd 168 University Road Min-Hsiung Chiayi Country 62102 Taiwan

Recently, convergence of nanotechnology and sustainable approaches has emerged as promising strategy for advanced remediation of heavy metals (HMs) from water. However, engineered nanoparticles (ENPs)-derived from freshwater microalgae gained attention as viable alternative, owing their inherent metal tolerance, rapid-growth rates, and versatile metabolic capabilities. This review predominantly focuses on freshwater microalgae-mediated-ENPs, highlighting intracellular/extracellular pathways induced by biomolecules such as polysaccharides, proteins, lipids, reductases etc., which govern nanoparticle nucleation, stabilization, and functionalization. Subsequently, the review discusses significant types of ENPs including iron, silver, gold, cadmium-sulfide, iron-oxide, nanocomposites, and bio-nano-hybrids nanoparticles, which reported removal efficiency from 21 to 100% of different HMs (lead, cadmium, chromium, copper, zinc, etc.). Despite ENPs exhibit significant potential, their large-scale implementation is constrained by challenges such as scaling-up, nutrient-variability, and high turbidity of wastewater. Future research recommended to focus on optimizing biosynthesis parameters, investigating diverse microalgal-strains, incorporating hybrid nano-materials to enhance their stability, reusability, and scalability for sustainable green-technology.

关键词： Bio-nanotechnology Bioremediation efficiency Environmental nano-materials Green synthesis Heavy metal removal Phytoremediation

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Recent advances in molecularly imprinted polymers toward biomedical healthcare devices

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Biosensors and Bioelectronics 2025年 287卷 117637页

作者： Youngjun Seo Yonghwan Kim Jaeheung Kim Hyo Gi Jung Jae Won Jang Hyunji Kim Kyo Seon Hwang Dongtak Lee Sang Won Lee Jeong Hoon Lee Dae Sung Yoon School of Biomedical Engineering Korea University Seoul 02841 Republic of Korea Interdisciplinary Program in Precision Public Health Korea University Seoul 02841 Republic of Korea Department of Clinical Pharmacology and Therapeutics College of Medicine Kyung Hee University Seoul 02447 Republic of Korea Department of Bioengineering & Nano-bioengineering Research Center for Bio Materials and Process Development Incheon National University Incheon 22012 Republic of Korea Division of Bioengineering Incheon National University Incheon 22012 Republic of Korea Terasaki Institute for Biomedical Innovation Los Angeles CA 90064 USA KU-KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea Department of Integrative Energy Engineering College of Engineering Korea University Seoul 02841 Republic of Korea Astrion Inc Seoul 02841 Republic of Korea

Following the increase in the global aging population, the importance of monitoring various disease-related biomarkers at an early stage has increased to ensure the health of the elderly. In an aging society, point-of-care (POC) systems are needed to care for elderly people who have physical and mental disorders. In light of the increasing prominence of POC systems, there is a growing effort to address the limitations associated with conventional receptors in wearable devices by substituting them with molecularly imprinted polymer (MIP). MIPs are well-known synthetic receptors engineered with specific binding cavities based on the "lock and key" principle. They could be synthesized in various configurations depending on specific types of monomers and templates. Compared to conventional receptors such as antibodies and aptamers, MIPs exhibit outstanding advantages, including good stability, cost-effectiveness, ease of synthesis, reusability, and broad applicability. These advantages have led to their extensive application in biomedical healthcare devices. This review summarizes a comparative analysis of sensors utilized for the detection of disease-specific biomarkers through diverse MIP applications and methodologies. Furthermore, we evaluated recent advancements in the miniaturization of MIPs and their integration with wearable biomedical devices for comprehensive healthcare monitoring applications. Finally, we delineated the existing limitations that need to be surmounted for the effective implementation of MIP-based biomedical devices and outlined future objectives for the enhancement of wearable and wireless biomedical healthcare monitoring devices.

关键词： Biomarker Healthcare monitoring Molecularly imprinted polymer Point-of-care Wearable biomedical devices

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