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Cell Biomaterials 2025年

作者： Anthony O. Omole Hannah S. Newton Edward Cedrone Kimia Nematpour Shaojun Xie Yongmei Zhao Bao Tran Marina A. Dobrovolskaia Nicole F. Steinmetz Aiiso Yufeng Li Family Department of Chemical and Nano Engineering University of California San Diego La Jolla San Diego CA 92093 USA Shu and K.C. Chien and Peter Farrell Collaboratory University of California San Diego La Jolla San Diego CA 92093 USA Center for Nano-ImmunoEngineering University of California San Diego La Jolla San Diego CA 92093 USA Moores Cancer Center University of California San Diego La Jolla San Diego CA 92093 USA Nanotechnology Characterization Lab Cancer Research Technology Program Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute Frederick MD 21702 USA Sequencing Facility Bioinformatics Group Biomedical Informatics and Data Science Directorate Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute Frederick MD 21702 USA CCR Sequencing Facility Cancer Research Technology Program Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute Frederick MD 21702 USA Department of Bioengineering University of California San Diego La Jolla San Diego CA 92093 USA Department of Radiology University of California San Diego La Jolla San Diego CA USA Institute for Materials Discovery and Design University of California San Diego La Jolla San Diego CA 92093 USA Center for Engineering in Cancer Institute of Engineering Medicine University of California San Diego La Jolla San Diego CA 92093 USA

Cowpea mosaic virus (CPMV) is a plant virus with potent anti-tumor efficacy. Intratumoral CPMV, but not cowpea chlorotic mottle virus (CCMV), reprograms the tumor microenvironment priming durable, systemic anti-tumor immunity. Here, we performed a side-by-side mechanism of action comparison between CPMV and CCMV. Through immune-multiplexing and trafficking studies we observed that CPMV and CCMV are taken up by innate immune cells at similar rates but are processed differently. While CCMV induces proinflammatory interleukins 22, 23, and 27, CPMV is a strong inducer of type I, II, and III interferons, which contribute to the activation and enhancement of immune cell function. We observed that CPMV RNAs activate Toll-like receptor (TLR) 7 upon delivery—and not CCMV RNAs; CPMV RNAs persist longer within cells compared with CCMV. Taken together, this work identifies determinants for CPMV’s unique mechanism for intratumoral immunotherapy. It also broadens our understanding of the utility of plant viruses for biomedical applications.

关键词： plant viruses intratumoral immunotherapy cowpea mosaic virus cowpea chlorotic mottle virus cancer nanotechnology

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Correction: Solventless thermal crosslinked polymer protective layer for high stable lithium metal batteries

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Sustainable Energy & Fuels 2020年第2期4卷 952-952页

作者： Hyunjin Kim Youn Sang Kim Jeeyoung Yoo Program in Nano Science and Technology Graduate School of Convergence Science and Technology Seoul National University Seoul 151-744 Republic of Korea Advanced Institutes of Convergence Technology 864-1 Iui-dong Yeongtong-gu Suwon-si Gyeonggi-do 443-270 Republic of Korea School of Energy Engineering Kyungpook National University Daegu 41566 Republic of Korea

Correction for ‘Solventless thermal crosslinked polymer protective layer for high stable lithium metal batteries’ by Hyunjin Kim et al., Sustainable Energy Fuels, 2020, DOI: 10.1039/c9se01046g.

Correction for ‘Solventless thermal crosslinked polymer protective layer for high stable lithium metal batteries’ by Hyunjin Kim et al., Sustainable Energy Fuels, 2020, DOI: 10.1039/c9se01046g.

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Effects of Flexoelectricity and Ion on the Flicker of Fringe Field Switching Liquid Crystal Display

Effects of Flexoelectricity and Ion on the Flicker of Fringe...

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SID Symposium, Seminar, and Exhibition 2018, Display Week 2018

作者： Jiang, Yingfei Zhou, Xiaochen Qin, Guangkui Xu, Xiaoguang Lee, Seunghee Yang, Deng-Ke Chemical Physics Interdisciplinary Program Liquid Crystal Institute Kent State University KentOH44242 United States BOE Technology Group Co No. 9 Dize RD BDA Beijing100171 China Department of Polymer Nano-Science and Technology Chonbuk National University Jeonbuk Jeonju561-756 Korea Republic of

ISBN: (纸本)9781510867659

Although LCDs are the leading technology for flat panel displays, their energy efficiency is low. One way to improve the energy efficiency is to decrease the driving frequency when static images are displayed. As the driving frequency is decreased, the transmittance of the display may vary with time, known as flickering. We carried out both experimental and simulation studies to investigate the origins that cause the flickering problem. Our results show that flexoelectric effect caused by non-uniform liquid crystal director configurations and ions in the liquid crystal are the main factors responsible for the flickering. We quantitatively analyzed the flickering caused by the two factors. © 2018 SID.

关键词： Ions

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Publisher Correction: Atomistic insights into highly active reconstructed edges of monolayer 2H-WSe2 photocatalyst

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Nature communications 2022年第1期13卷 1755页

作者： Mohammad Qorbani Amr Sabbah Ying-Ren Lai Septia Kholimatussadiah Shaham Quadir Chih-Yang Huang Indrajit Shown Yi-Fan Huang Michitoshi Hayashi Kuei-Hsien Chen Li-Chyong Chen Center for Condensed Matter Sciences National Taiwan University Taipei 10617 Taiwan. Center of Atomic Initiative for New Materials National Taiwan University Taipei 10617 Taiwan. Institute of Atomic and Molecular Sciences Academia Sinica Taipei 10617 Taiwan. On leave from Tabbin Institute for Metallurgical Studies Tabbin Helwan 109 Cairo 11421 Egypt. Department of Physics National Taiwan University Taipei 10617 Taiwan. Nano Science and Technology Taiwan International Graduate Program Academia Sinica Taipei 11529 Taiwan. Institute of Physics Academia Sinica Taipei 11529 Taiwan. Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 11529 Taiwan. Department of Physics National Central University Taoyuan City 32001 Taiwan. International Graduate Program of Molecular Science and Technology National Taiwan University Taipei 10617 Taiwan. Department of Chemistry Hindustan Institute of Technology and Science Chennai 603103 India. Center for Condensed Matter Sciences National Taiwan University Taipei 10617 Taiwan. chenkh@pub.iams.sinica.edu.tw. Institute of Atomic and Molecular Sciences Academia Sinica Taipei 10617 Taiwan. chenkh@pub.iams.sinica.edu.tw. Center for Condensed Matter Sciences National Taiwan University Taipei 10617 Taiwan. chenlc@ntu.edu.tw. Center of Atomic Initiative for New Materials National Taiwan University Taipei 10617 Taiwan. chenlc@ntu.edu.tw. Department of Physics National Taiwan University Taipei 10617 Taiwan. chenlc@ntu.edu.tw.

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Curved copper nanowires-based robust flexible transparent electrodes via all-solution approach

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nano Research 2017年第9期10卷 3077-3091页

作者： Zhenxing Yin Seung Keun Song Sanghun Cho Duck-Jae You Jeeyoung Yoo Suk Tai Chang Youn Sang Kim Program in Nano Science and Technology Graduate School of Convergence Science and Technology Seoul National University Seoul 08826 Republic of Korea School of Chemical Engineering and Materials Science Chung-Ang University Seou106974 Republic of Korea Advanced Institutes of Convergence Technology 145 Gwanggyo-ro Yeongtong-gu Suwon-si Gyeonggi-do 16229 Republic of Korea

Curved Cu nanowire (CCN)-based high-performance flexible transparent conductive electrodes (FTCEs) were fabricated via a fully solution-processed approach, involving synthesis, coating, patterning, welding, and transfer. Each step involved an innovative technique for completing the all-solution processes. The high-quality and well-dispersed CCNs were synthesized using a multi-polyol method through the synergistic effect of specific polyol reduction. To precisely control the optoelectrical properties of the FTCEs, the CCNs were uniformly coated on a polyimide (PI) substrate via a simple meniscus-dragging deposition method by tuning several coating parameters. We also employed a polyurethane (PU)-stamped patterning method to effectively produce 20 μm patterns on CCN thin films. The CCN thin films exhibited high electrical performance, which is attributed to the deeply percolated CCN network formed via a solvent-dipped welding method. Finally, the CCN thin films on the PI substrate were partially embedded and transferred to the PU matrix to reduce their surface roughness. Through consecutive processes involving the proposed methods, a highly percolated CCN thin film on the PU matrix exhibited high optoelectrical performance (R s = 53.48 Ω/□ at T = 85.71%), excellent mechanical properties (R/R 0 < 1.10 after the 10th repetition of tape peeling or 1,000 bending cycles), and a low root-mean-square surface roughness (R rms = 14.36 nm).

关键词： curved Cu nanowires all-solution processes 20 μm patterns high performance transparent electrode

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Recent advances in molecularly imprinted polymers toward biomedical healthcare devices

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Biosensors & bioelectronics 2025年 287卷 117637页

作者： Youngjun Seo Yonghwan Kim Jaeheung Kim Hyo Gi Jung Jae Won Jang Hyunji Kim Kyo Seon Hwang Dongtak Lee Sang Won Lee Jeong Hoon Lee Dae Sung Yoon School of Biomedical Engineering Korea University Seoul 02841 Republic of Korea Interdisciplinary Program in Precision Public Health Korea University Seoul 02841 Republic of Korea. Department of Clinical Pharmacology and Therapeutics College of Medicine Kyung Hee University Seoul 02447 Republic of Korea. Department of Bioengineering & Nano-bioengineering Research Center for Bio Materials and Process Development Incheon National University Incheon 22012 Republic of Korea Division of Bioengineering Incheon National University Incheon 22012 Republic of Korea. Terasaki Institute for Biomedical Innovation Los Angeles CA 90064 USA. Electronic address: skylsw5@korea.ac.kr. KU-KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea Department of Integrative Energy Engineering College of Engineering Korea University Seoul 02841 Republic of Korea. Electronic address: hellojhlee@korea.ac.kr. Interdisciplinary Program in Precision Public Health Korea University Seoul 02841 Republic of Korea Astrion Inc Seoul 02841 Republic of Korea. Electronic address: dsyoon@korea.ac.kr.

Following the increase in the global aging population, the importance of monitoring various disease-related biomarkers at an early stage has increased to ensure the health of the elderly. In an aging society, point-of-care (POC) systems are needed to care for elderly people who have physical and mental disorders. In light of the increasing prominence of POC systems, there is a growing effort to address the limitations associated with conventional receptors in wearable devices by substituting them with molecularly imprinted polymer (MIP). MIPs are well-known synthetic receptors engineered with specific binding cavities based on the "lock and key" principle. They could be synthesized in various configurations depending on specific types of monomers and templates. Compared to conventional receptors such as antibodies and aptamers, MIPs exhibit outstanding advantages, including good stability, cost-effectiveness, ease of synthesis, reusability, and broad applicability. These advantages have led to their extensive application in biomedical healthcare devices. This review summarizes a comparative analysis of sensors utilized for the detection of disease-specific biomarkers through diverse MIP applications and methodologies. Furthermore, we evaluated recent advancements in the miniaturization of MIPs and their integration with wearable biomedical devices for comprehensive healthcare monitoring applications. Finally, we delineated the existing limitations that need to be surmounted for the effective implementation of MIP-based biomedical devices and outlined future objectives for the enhancement of wearable and wireless biomedical healthcare monitoring devices.

关键词： Biomarker Healthcare monitoring Molecularly imprinted polymer Point-of-care Wearable biomedical devices

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Carbon sequestration in mangrove ecosystems: Sources, transportation pathways, influencing factors, and its role in the carbon budget

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Earth-science Reviews 2025年 269卷

作者： Shafiqa Ali Gobinda Dey Nguyen Hoang Kim Nuong Abdur Rahman Liang-Chi Wang Uttara Sukul Koyeli Das Raju Kumar Sharma Shan-Li Wang Chien Yen Chen Department of Earth and Environmental Sciences National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Doctoral Program in Science Technology Environment and Mathematics National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Department of Agricultural Chemistry National Taiwan University Taipei 106319 Taiwan Environment and Disaster Monitoring Center National Chung Cheng University Chiayi 621 Taiwan Department of Biomedical Sciences Graduate Institute of Molecular Biology National Chung Cheng University 168 University Road Ming-Shung Chiayi County 62102 Taiwan Department of Chemistry and Biochemistry National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan Center for Nano Bio-Detection Center for Innovative Research on Aging Society AIM-HI National Chung Cheng University 168 University Road Min-Hsiung Chiayi County 62102 Taiwan You-Cheng Engineering & Technology Co. Ltd 168 University Road Min-Hsiung Chiayi County 62102 Taiwan

Global efforts to mitigate climate change emphasize the critical need to reduce atmospheric CO₂ levels and enhance carbon sinks. Mangrove ecosystems, renowned for their substantial carbon sequestration capacity, play a vital role in sequestering significant amounts of carbon. This review explores carbon fluxes in mangrove ecosystems, emphasizing autochthonous and allochthonous carbon sequestration mechanisms. Specifically, it discusses the pathways through which carbon is absorbed and stored, including biological productivity, sediment accumulation, and carbonate precipitation. Furthermore, the role of microbial communities and root systems in carbon stabilization, nutrient cycling, and methane oxidation is also examined, highlighting their significance in enhancing sequestration efficiency. Moreover, this study evaluates the factors influencing carbon sequestration efficiency in mangroves and the methods used for its quantification. Finally, this review assesses the contribution of mangroves to the global carbon budget, emphasizing their strategic role in offsetting atmospheric CO 2 and enhancing coastal ecosystem resilience. However, significant research gaps remain in understanding the mechanism of carbon transformation, the interaction between diverse carbon sources, sediment dynamics, and long-term stability of buried organic matter across varying mangrove settings.

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Temperature-dependence of hypersound dynamics in SrRuO3/SrTiO3 heterostructures

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Physical Review B 2018年第6期98卷 064308-064308页

作者： Chi-Yuan Yang (楊濟源) Kung-Hsuan Lin (林宮玄) Department of Physics National Taiwan University Taipei 10617 Taiwan Nano-Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 11529 Taiwan Institute of Physics Academia Sinica Taipei 11529 Taiwan

We studied GHz hypersound in heterostructures of SrRuO3 (SRO) and SrTiO3 (STO) by using femtosecond pulses with fluence as low as several tens of μJ/cm2. We found that the efficiency of generating hypersound in SRO, through thermal expansion, is linear up to optical fluence of a few mJ/cm2. We further investigated the propagation of acoustic pulses in the STO substrate. The acoustic properties of STO dramatically changed around the temperature of structural transition (105 K) because the generated hypersound was coupled to the softening mode. Nevertheless, our experimental results revealed that the quadratic frequency dependence of acoustic attenuation in STO, predicted by the mode-coupling theory, breaks down at tens of GHz. Finally, the refractive index of STO was experimentally obtained between 365 and 400 nm, for which there was disagreement in previous results.

关键词： Multiferroics Multilayer thin films Perovskites Brillouin scattering & spectroscopy Femtosecond laser irradiation Femtosecond laser spectroscopy Ultrafast pump-probe spectroscopy

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Anomalous Z2 antiferromagnetic topological phase in pressurized SmB6

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Physical Review B 2018年第19期97卷 195145-195145页

作者： Kai-Wei Chang Peng-Jen Chen Department of Physics National Taiwan University Taipei 10617 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 11529 Taiwan and National Taiwan University Taipei 10617 Taiwan Institute of Physics Academia Sinica Taipei 11529 Taiwan

Antiferromagnetic materials, whose time-reversal symmetry is broken, can be classified into the Z2 topology if they respect some specific symmetry. Since the theoretical proposal, however, no materials have been found to host such Z2 antiferromagnetic topological (Z2−AFT) phase to date. Here we demonstrate that the topological Kondo insulator SmB6 can be a Z2−AFT system when pressurized to undergo an antiferromagnetic phase transition. In addition to proposing the possible candidate for a Z2−AFT material, in this work we also illustrate the anomalous topological surface states of the Z2−AFT phase which have not been discussed before. Originating from the interplay between the topological properties and the antiferromagnetic surface magnetization, the topological surface states of the Z2−AFT phase behave differently as compared with those of a topological insulator. Besides, the Z2−AFT insulators are also found promising in the generation of tunable spin currents, which is an important application in spintronics.

关键词： Antiferromagnetism First-principles calculations Topological phases of matter

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(Invited) SnS2 Thin Film and Powder for Artificial Photosynthesis

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ECS Meeting Abstracts 2020年第39期MA2020-01卷

作者： Kuei-Hsien Chen Indrajit Shown Tadesse Billo Reta Yu-Kai Wu Li-Chyong Chen Academia Sinica Center for Condensed Matter Sciences Natl Taiwan Univ Inst.of Atomic and Molecular Sci Academia Sinica Taipei Taiwan Nano Science and Technology Program Academia Sinica Institute of Atomic and Molecular Sciences Academia SinicaTaiwan National Taiwan University

Solar photoreduction of CO2 to produce value added hydrocarbons is highly desirable to tackle environmental and energy issues. [1-2] Despite the great improvement in the efficiency and cost of solar cells, the efficiency in artificial photosynthesis is much lower than the >15% of solar cells. Recent progress in 2D chalcogenides with tunable bandgap and layer numbers offers great opportunity for the investigation in this field. In this work, thin film and powder SnS2 have been synthesized for the study. Hydrothermal synthesis of carbon-containing SnS2 exhibits a highly active photocatalytic conversion of CO2 to selective hydrocarbons under visible-light irradiation. Overall, the carbon doping in the SnS2 nanostructure plays a key role and significantly enhance the visible light photocatalytic activity with a photochemical quantum efficiency above 0.7%. [3-4] Meanwhile, Thin film SnS2 has been grown for the mechanism study. By carbon-ion implantation of the thin film, we observed enhanced CO2 reduction under solar illumination. Other FTIR, Raman, NMR, BET, SECM, and synchrotron based facilities including APXPS and XAS have been used to investigate this issue. 1. Shown, H.C. Hsu, Y.C. Chang, C.H. Lin, P.K. Roy, A. Ganguly, C.H. Wang, J.K. Chang, C.I. Wu, L.C. Chen, K.H. Chen, nano Letters 14, 6097-6103 (2014). 2. Billo, F.Y. Fu, P. Raghunath, I. Shown, W.F. Chen, H.T. Lien, T.H. Shen, J.F. Lee, M. C. Lin, J.S. Hwang, C.H. Lee, L.C. Chen, and K.H. Chen, Small 14, 1702928 (2018). 3. Shown, S. Samireddi, Y.C. Chang, R. Putikam, P.H. Chang, A. Sabbah, F.Y. Fu, W.F. Chen, C.I. Wu, T.Y. Yu, P.W. Chung, M.C. Lin, L.C. Chen, and K.H. Chen, Nature Comm. 9, 169 (2018). 4. Y. Fu, I. Shown, C.H. Li, P. Raghunath, T.Y. Lin, T. Billo, H.L. Wu, C.I. Wu, P.W. Chung, M.C. Lin, L.C. Chen, and K.H. Chen, ACS Appl. Mater. & Interface 11, 28 (2019).

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