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International Conference on computer Supported Cooperative Work in Design

作者： Kecheng Tang Jian-Tao Zhou Xu Guo College of Computer Science Inner Mongolia University Hohhot China National & Local Joint Engineering Research Center of Intelligent Information Processing Technology for Mongolian Hohhot China Engineering Research Center of Ecological Big Data Ministry of Education Hohhot China Inner Mongolia Engineering Laboratory for Cloud Computing and Service Software Hohhot China Inner Mongolia Key Laboratory of Social Computing and Data Processing Hohhot China Inner Mongolia Key Laboratory of Discipline Inspection and Supervision Big Data Hohhot China Inner Mongolia Engineering Laboratory for Big Data Analysis Technology Hohhot China

ISBN: (数字)9798350349184

ISBN: (纸本)9798350349191

Fuzzing is increasingly being utilized as a method to test the reliability of Deep Learning (DL) systems. In order to detect more errors in DL systems, exploring the internal logic of more DNNs has become the main objective of fuzzing. Despite advancements in the seed selection aspect of fuzzing, considerable opportunities still exist for improving testing efficiency. Current research has issues with the repeated consideration of neurons in the model that will be covered in the future by other seeds, leading to redundant seeds and lower testing efficiency. Additionally, there is a lack of a method to measure the potential of seeds to increase coverage, making it difficult to select the most worthy seeds for mutation in each iteration. We propose an uncovered neurons information based (UNIB) fuzzing method for DNN. UNIB uses clustering methods to organize the seed queue based on initial seed data, aiming to enhance the coverage rate improved in each iteration. It also integrates coverage information from the testing phase to identify the seeds with the greatest potential. The experimental results show that UNIB achieved a higher NC than the second-best method by 1.1% and 3% in LetNet-4 and LetNet-5, respectively. UNIB consistently required the fewest number of iterations to reach the same NC as other methods. For both LetNet-4 and LetNet-5, the adversarial test case sets generated by UNIB exhibited the highest diversity.

关键词： Deep learning Federated learning Current measurement Neurons Neural networks Fuzzing Software

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Accurate Leukocyte Detection Based on Deformable-DETR and Multi-Level Feature Fusion for Aiding Diagnosis of Blood Diseases

arXiv

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arXiv 2024年

作者： Chen, Yifei Zhang, Chenyan Chen, Ben Huang, Yiyu Sun, Yifei Wang, Changmiao Fu, Xianjun Dai, Yuxing Qin, Feiwei Peng, Yong Gao, Yu HDU-ITMO Joint Institute Hangzhou Dianzi University Hangzhou310018 China Medical Big Data Lab Shenzhen Research Institute of Big Data Shenzhen518172 China School of Artificial Intelligence Zhejiang College of Security Technology Wenzhou325016 China National-local Joint Engineering Research Center for Digitalized Electrical Design Technology Wenzhou University Wenzhou325035 China School of Computer Science and Technology Hangzhou Dianzi University Hangzhou310018 China Department of Hematology Zhejiang Hospital Hangzhou310018 China

In standard hospital blood tests, the traditional process requires doctors to manually isolate leukocytes from microscopic images of patients’ blood using microscopes. These isolated leukocytes are then categorized via automatic leukocyte classifiers to determine the proportion and volume of different types of leukocytes present in the blood samples, aiding disease diagnosis. This methodology is not only time-consuming and labor-intensive, but it also has a high propensity for errors due to factors such as image quality and environmental conditions, which could potentially lead to incorrect subsequent classifications and misdiagnosis. Contemporary leukocyte detection methods exhibit limitations in dealing with images with fewer leukocyte features and the disparity in scale among different leukocytes, leading to unsatisfactory results in most instances. To address these issues, this paper proposes an innovative method of leukocyte detection: the Multi-level Feature Fusion and Deformable Self-attention DETR (MFDS-DETR). To tackle the issue of leukocyte scale disparity, we designed the High-level Screening-feature Fusion Pyramid (HS-FPN), enabling multi-level fusion. This model uses high-level features as weights to filter low-level feature information via a channel attention module and then merges the screened information with the high-level features, thus enhancing the model’s feature expression capability. Further, we address the issue of leukocyte feature scarcity by incorporating a multi-scale deformable self-attention module in the encoder and using the self-attention and cross-deformable attention mechanisms in the decoder, which aids in the extraction of the global features of the leukocyte feature maps. The effectiveness, superiority, and generalizability of the proposed MFDS-DETR method are confirmed through comparisons with other cutting-edge leukocyte detection models using the private WBCDD, public LISC and BCCD datasets. Our source code and private WBCCD

关键词： Object detection

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A Wavelet-CNN-LSTM Model for Tailings Pond Risk Prediction

arXiv

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arXiv 2020年

作者： Yang, Jun Li, Qing Sun, Yixuan Wang, Wei Li, Linchao Wang, Xuwei Jia, Shengyao Tong, Renyuan National and Local Joint Engineering research center for Disaster Monitoring Technologies and Instruments China Jiliang University Hangzhou310051 China Zhejiang Provincial Key Laboratory of Intelligent Manufacturing Quality Big Data Traceability Analysis and Application China Jiliang University Hangzhou310051 China Zhejiang PeckerAI Technology. Ltd Hangzhou310018 China College of Computer Science and Technology Zhejiang University Hangzhou310027 China

Tailings ponds are places for storing industrial waste. The saturation line is the key factor of quantifying the safety of tailings pond. Existing saturation line time-series prediction methods are mainly based on statistical models or shallow machine learning models. Although these models aim to capture the time dependence of the sequence data, the channel and temporal are even unavailable in principle. In this paper, we presents a two-stage forecasting method, which embeds the channel and temporal attention into a hybrid CNN-LSTM model to predict the saturation line. In the first stage, the discrete wavelet transform (DWT) is applied to capture the refined sequence information. In the second stage, the CNN-LSTM model is utilized to learn the basic spatial and temporal features in the time series. Furthermore, the channel and temporal attention model are embedded into CNN-LSTM model to enhance the feature extracting ability in channel and temporal dimension. Consequently, our proposed model is shown to outperform classic models on five real-world datasets. Copyright © 2020, The Authors. All rights reserved.

关键词： Forecasting

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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

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NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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The repertoire of mutational signatures in human cancer (vol 578, pg 94, 2020)

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NATURE 2023年第7948期614卷 E41-E41页

作者： Alexandrov, Ludmil B. Kim, Jaegil Haradhvala, Nicholas J. Huang, Mi Ni Ng, Alvin Wei Tian Wu, Yang Boot, Arnoud Covington, Kyle R. Gordenin, Dmitry A. Bergstrom, Erik N. Islam, S. M. Ashiqul Lopez-bigas, Nuria Klimczak, Leszek J. McPherson, John R. Morganella, Sandro Sabarinathan, Radhakrishnan Wheeler, David A. Mustonen, Ville Getz, Gad Rozen, Steven G. Stratton, Michael R. Department of Cellular and Molecular Medicine Department of Bioengineering Moores Cancer Center University of California San Diego CA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Cellular and Molecular Medicine and Department of Bioengineering University of California San Diego La Jolla CA USA UC San Diego Moores Cancer Center San Diego CA USA University of California San Diego San Diego CA USA Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Massachusetts General Hospital Boston MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama Japan Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada Programme in Cancer & Stem Cell Biology Duke-NUS Medical School Singapore Singapore Centre for Computational Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Centre for Computational Biology Duke-NUS Medical School Singapore Singapore SingHealth Duke-NUS Institute of Precision Medicine National Heart Centre Singapore Singapore Singapore Cancer Science Institute of Singapore National University of Singapore Singapore Singapore Institute of Molecular and Cell Biology Singapore Singapore Laboratory of Cancer Epigenome Division of Medical Science National Cancer Centre Singapore Singapore Singapore Duke-NUS Medical School Singapore Singapore Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Genome Integrity and Structural Biology Laboratory National Ins

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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

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NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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