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Exploration of an Efficient Simultaneous Molecular Detection Method of HIV,HCV,and Syphilis from a Single Dried Blood Spot

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Biomedical and Environmental Sciences 2021年第4期34卷 257-264页

作者： MA Jie Qiong XU Qing Qing HE Lin HE Xiao Xia CHEN Kai WANG Yue Hua XING Wen Ge JIANG Yan National HIV Reference Laboratory National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective The aim of the present study was to evaluate the performance of the simultaneous detection of HIV-1 RNA,HIV-1 DNA,and HCV RNA using one dried blood spot(DBS)as an alternative sample to *** A total of 571 paired DBS/plasma samples were collected from men who have sex with men(MSM)and injection drug users(IDUs),and serological and molecular assays were *** plasma results as the reference standard,the performance of DBS tests for HIV-1 RNA,HIV-1 DNA,and HCV RNA was ***’s correlation coefficients and Bland-Altman analysis were performed to assess the correlation and concordance between DBS and *** Among paired plasma/DBS samples with detectable HIV-1 RNA and HCV RNA,five samples(5/32)were not detectable in DBS,while measurable HIV-1 RNA levels were present in plasma(1.44 to3.99 log10 copies/m L).There were two samples(2/94)with undetectable HCV RNA in DBS,while measurable HCV RNA levels were present in plasma(-5 to 5.99 log10 copies/m L).The correlation between HIV-1 RNA light chain variable region(VL)values obtained from plasma and DBS showed that r=0.683(P<0.01),n=27 and r=0.612(P<0.01),n=89 in HCV ***-Altman analysis revealed that in HIV-1 RNA,the mean(±SD)difference between HIV-1 RNA in plasma and DBS was 1.00±1.01 log10 copies/m L,and all samples were within±1.96 SD(-0.97 to 2.97 log10 copies/m L)for *** mean difference(±SD)in HCV RNA was 0.15±1.08 log10 copies/m L,and 94.38%(84/89)were within±1.96 SD(-1.96 to 2.67 log10 copies/m L).Overall,HIV-1 RNA and HCV RNA levels obtained from a DBS were lower than those obtained from ***-1 DNA in a DBS showed concordant results with HIV-1 RNA in ***-1 DNA RT-PCR using a DBS showed acceptable *** The performance of the simultaneous detection of HIV-1 RNA,HIV-1 DNA,and HCV RNA using one DBS was ***,as an alternative sample to plasma,may be a viable option for the simultaneous detection of HIV-1 RNA,HIV-1 DNA,and HCV R

关键词： Dried blood spot(DBS) Correlation Bland-Altman HIV-1 RNA HIV-1 DNA HCV RNA

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Trends in Mortality and Prevalence of Reported HIV/aids Cases——China,2002-2021

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China CDC weekly 2023年第42期5卷 943-947页

作者： Zhihui Dou Yanan Luo Yan Zhao Xiaoying Zheng Mengjie Han National Center for AIDS/STD Control and Prevention China Center for Disease Control and PreventionBeijingChina Department of Global Health School of Public HealthPeking UniversityBeijingChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina

Summary What is already known about this topic?Annually,only the incidence and mortality for Acquired Immune Deficiency Syndrome(aids)patients are officially *** is added by this report?For the first time,information detailing the reported rate,mortality rate,and prevalence rate trends of HIV,aids,and HIV/aids in China’s entire population over the past two decades has been *** are the implications for public health practice?Our research overcomes the longstanding limitation of HIV/aids analysis as the sole ***,it incorporates a comprehensive examination of the overall population,utilizing indicators and analytic methods from chronic disease analyses.

关键词： mortality HIV/aids Immune

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Application of the back-calculation method for estimating new HIV infections in Dehong Dai and Jingpo Autonomous Prefecture, Yunnan Province, 2010-2023

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Chinese Journal of Epidemiology 2025年第4期46卷 669-675页

作者： Xiao, Minyang Yang, Yuecheng Jia, Manhong Tang, Houlin Shi, Yuhua Fu, Liru Zhang, Zuyang Tang, Renhai Wang, Xiaowen Chen, Fangfang Yunnan Provincial Center for Disease Control and Prevention Kunming 650500 China Dehong Prefecture Center for Disease Control and Prevention Mangshi 678400 China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

Objective New HIV infections serve as a crucial indicator for assessing the dynamic changes in the HIV epidemic. This study aims to estimate the number of new HIV infections in Dehong Dai and Jingpo Autonomous Prefecture of Yunnan Province (Dehong), using a back-calculation method that integrates diagnosis delay approaches and Bayesian theory. Additionally, it compares the differences between these two estimation methods. Methods Data were obtained from the Chinese Information System for Disease control and prevention. Based on CD4⁺ T lymphocytes (CD4) counts depletion model, the first CD4 count prior to antiretroviral therapy of HIV-infected individuals diagnosed in Dehong from 2010 to 2023 was utilized to retroactively determine the infection date of HIV-infected individuals and ascertain the annual number of new HIV infections who had been diagnosed. Subsequently, the diagnosis delay distribution method and Bayesian theory were leveraged to assess the diagnosis probability of newly infected individuals, thereby projecting the number of new HIV infections in the region over the specified period. Results During 2010-2023, a total of 5 693 individuals aged 15 and above, excluding mother-to-child transmission, were diagnosed with HIV in Dehong. After excluding 364 cases due to missing CD4 count results or abnormal first CD4 counts (≥2 000 cells/μl), 5 329 HIV-infected individuals were included in the final analysis. Through CD4 counts back-calculation from 2010 to 2023, the annual number of new infections diagnosed was 479, 427, 337, 305, 256, 219, 194, 193, 131, 166, 120, 71, 42 and 47. When using the diagnosis delay distribution method and life table analysis, the cumulative diagnosis probability rose from 0.301 within one year to 0.913 within 14 years, leading to a reduction in the number of estimated new infections from 577 in 2010 to 168 in 2023, with a total estimate of 4 412 (95%CI:4 350-4 480). Alternatively, based on Bayesian theory, the diagnosis

关键词： Back-calculation method CD4+ T lymphocyte HIV New infections

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Immune recall enhances cross-reactive antibody longevity after a large wave of SARS-CoV-2 breakthrough infection

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Signal Transduction and Targeted Therapy 2024年第9期9卷 3563-3565页

作者： Dan Li Qingfei Chu Kang Li Lanjuan Li Yiming Shao State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Dear Editor,Although coronavirus disease 2019(COVID-19)is no longer deemed a“Public Health Emergency of International Concern”,the global transmission dynamics of SARS-CoV-2 have shifted due to vaccination,emergency of virus variants,and pre-existing coronavirus immunity.1–3 It remains unclear how cross-reactive and pre-existing humoral immunity might impact the effectiveness of vaccines and antibodies against new viral mutations.4,5 This study seeks to elucidate the cross-reactivity of coronavirus antibodies induced by previously unencountered Omicron BA.5/BF.7 variants in the breakthrough infection(BTI)population.

关键词： immunity infection breakthrough

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China CDC weekly 2022年第47期4卷 1043-1050页

作者： Hui Liu Qiyu Zhu Lei Zhang Yujing Liu Peng Xu Maohe Yu Jixiang Fan Xiaohong Pan Xi Chen Huifang Xu Qinying He Mengjie Han National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing MunicipalityChina Chinese Association of STD and AIDS Prevention and Control Beijing MunicipalityChina Beijing Chaoyang Kangzhong Health and Education Center Beijing MunicipalityChina Tianjin Center for Disease Control and Prevention Tianjin MunicipalityChina Jilin Provincial Center for Disease Control and Prevention Changchun CityJilin ProvinceChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Hunan Provincial Center for Disease Control and Prevention Changsha CityHunan ProvinceChina Guangdong Provincial Association of STD and AIDS Prevention and Control Guangzhou CityGuangdong ProvinceChina Chengdu Center for Disease Control and Prevention Chengdu CitySichuan ProvinceChina.

Summary What is already known about this topic?The number of newly diagnosed human immunodeficiency virus(HIV)cases among Chinese youth 15–24 years of age shows an upward trend between 2010 and *** is added by this report?This survey is on a larger scale as compared to previous *** shows inadequate HIV knowledge—especially on HIV treatment,self-testing,and postexposure prophylaxis—among college students.A significant gap exists between knowledge and behavior as indicated by the low condom use rate despite a high knowledge level.

关键词： knowledge Attitude testing

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Spatial Analysis of HIV/aids Cases Among Out-of-School Youth Aged 15-24 Years-China,2010-2020

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China CDC weekly 2021年第48期3卷 1015-1017页

作者： Shaorong Wang Junjie Wang Peng Xu Wanting Lyu Mengjie Han National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?There are 4,000 new HIV infections every day worldwide,and 31%of which are in adolescents aged 15–24 years ***,previous study is not aware of the distribution of out-of-... 详细信息

关键词： HIV/aids Spatial Cases

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DNA vaccine prime and replicating vaccinia vaccine boost induce robust humoral and cellular immune responses against MERS-CoV in mice

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Virologica Sinica 2024年第3期39卷 490-500页

作者： Xiuli Shen Shuhui Wang Yanling Hao Yuyu Fu Li Ren Dan Li Wenqi Tang Jing Li Ran Chen Meiling Zhu Shuo Wang Ying Liu Yiming Shao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Changping Laboratory Yard 28Science Park RoadChangping DistrictBeijing 102206China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

As of December 2022,2603 laboratory-identified Middle East respiratory syndrome coronavirus(MERS-CoV)infections and 935 associated deaths,with a mortality rate of 36%,had been reported to the World Health Organization(WHO).However,there are still no vaccines for MERS-CoV,which makes the prevention and control of MERS-CoV *** this study,we generated two DNA vaccine candidates by integrating MERS-CoV Spike(S)gene into a replicating Vaccinia Tian Tan(VTT)*** to homologous immunization with either vaccine,mice immunized with DNA vaccine prime and VTT vaccine boost exhibited much stronger and durable humoral and cellular immune *** immunized mice produced robust binding antibodies and broad neutralizing antibodies against the EMC2012,England1 and KNIH strains of ***-Boost immunization also induced strong MERS-S specific T cells responses,with high memory and poly-functional(CD107a-IFN-γ-TNF-α)effector CD8t T *** conclusion,the research demonstrated that DNA-Prime/VTT-Boost strategy could elicit robust and balanced humoral and cellular immune responses against *** study not only provides a promising set of MERS-CoV vaccine candidates,but also proposes a heterologous sequential immunization strategy worthy of further development.

关键词： MERS-CoV VTT vaccine DNA vaccine Humoral and cellular immune responses Prime/boost strategy

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Identifying the Key Nodes of HIV Molecular Transmission Network Among Men Who Have Sex with Men—Guangzhou,Guangdong Province,China,2015–2017

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China CDC weekly 2021年第38期3卷 803-807,I0007,I0008页

作者： Juan Yang Zhigang Han Huifang Xu Hui Xing Peng Xu Weibin Cheng Yuzhou Gu Fan Lyu The National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of HIV/AIDS Control and Prevention Center for Disease Control and PreventionGuangzhouGuangdongChina.

Summary What is already known about this topic?Identifying the most influential spreaders in human immunodeficiency virus(HIV)transmission networks is crucial for developing effective prevention *** is added by this report?This study identified key nodes of the HIV molecular transmission network among men who have sex with men(MSM)by utilizing linkages between sequences to reconstruct the transmission network at the molecular level.

关键词： utilizing prevention network

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Modeling the impact of changing sexual behaviors with opposite-sex partners and STI testing among women and men ages 15-44 on STI diagnosis rates in the United States 2012-2019

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Infectious Disease Modelling 2023年第4期8卷 1169-1176页

作者： Deven T.Hamilton David A.Katz Laura T.Haderxhanaj Casey E.Copen Ian H.Spicknall Matthew Hogben Center for Studies in Demography and Ecology University of WashingtonSeattleWAUSA Department of Global Health University of WashingtonSeattleWAUSA Division of STD Prevention National Center for HIV/AIDSHepatitisSexually Transmitted DiseaseTuberculosis PreventionCenters for Disease Control and PreventionAtlantaGAUSA

Objective:To estimate the potential contributions of reported changes in frequency of penile-vaginal sex(PVS),condom use and STI screening to changes in gonorrhea and chlamydial diagnoses from 2012 to ***:An agent-based model of the heterosexual population in the *** the STI *** was calibrated to 2012 diagnosis rates,testing,condom use,and frequency of *** used behaviors from the 2017-2019 NSFG,and we evaluated changes in diagnosis and incidence rates in ***:Higher testing rates increased gonorrhea and chlamydia diagnosis by 14%and 13%,respectively,but did not reduce *** frequency of PVS reduced the diagnosis rate for gonorrhea and chlamydia 6%and 3%respectively while reducing incidence by 10%and 9%*** condom use had negligible impact on diagnosis and ***:Understanding how changing behavior drives STI incidence is essential to addressing the growing *** in testing and frequency of PVS likely contributed to some,but not all,of the changes in *** research is needed to understand the context within which changing sexual behavior and testing are occurring.

关键词： Gonorrhea Chlamydia Agent-based modeling Simulation

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The Prevalence and Related Effects of HIV Drug-Resistant Strains Against Antiretroviral Therapy in China

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Infectious Microbes & Diseases 2022年第2期4卷 71-74页

作者： Hui Xing Yuhua Ruan Lingjie Liao Yingming Shao State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina

Anti-human immunodeficiency virus(HIV)treatment resistance surveillance has been going on for nearly 18 years in *** this paper,we review the prevalence in China of resistance to reverse transcriptase and protease inhibitors in the HIV-infected population receiving antiretroviral therapy(ART)and the population that stopped ART in recent *** resistance is an important factor affecting the death of patients with acquired immune deficiency syndrome(aids).With the extension of the duration of ART and the expansion of the population receiving ART,especially the widespread promotion of preventive drugs before and after exposure,it is important to obtain insight into the prevalence and types of drug-resistant strains and their impact on the overall aids prevention and treatment effect.

关键词： antiretroviral treatment(ART) drug resistance human immunodeficiency virus(HIV)

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