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Impact factors of Blastocystis hominis infection in persons living with human immunodeficiency virus:a large-scale,multi-center observational study from China

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Infectious Diseases of Poverty 2023年第5期12卷 95-96页

作者： Shun-Xian Zhang Ji-Chun Wang Zhong-Wei Li Jin-Xin Zheng Wen-Ting Zhou Guo-Bing Yang Ying-Fang Yu Xiu-Ping Wu Shan Lv Qin Liu Mu-Xin Chen Yan Lu Zhi-Hui Dou Da-Wei Zhang Wen-Wen Lv Lei Wang Zhen-Hui Lu Ming Yang Pei-Yong Zheng Yue-Lai Chen Li-Guang Tian Xiao-Nong Zhou Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai China Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research On Tropical Diseases National Institute of Parasitic Diseases Shanghai China School of Global Health Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of Medicine Shanghai China Department of Science and Technology Chinese Center for Disease Control and Prevention Beijing China Gansu Province People’s Hospital Gansu Provincial Hospital Lanzhou China National Health Commission (NHC) Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Gansu Provincial Center for Disease Control and Prevention Lanzhou China National Center for AIDS/STD Control and Prevention China Center for Disease Control and Prevention Beijing China The People’s Liberation Army 302 Hospital Beijing China Clinical Research Institute Shanghai Jiao Tong University School of Medicine Shanghai China

Background Blastocystis hominis(Bh)is zoonotic parasitic pathogen with a high prevalent globally,causing opportunistic infections and diarrhea *** immunodeficiency virus(HIV)infection disrupts the immune system by depleting CD4^(+)T lymphocyte(CD4^(+)T)cell counts,thereby increasing Bh infection risk among persons living with HIV(PLWH).However,the precise association between Bh infection risk and HIV-related biological markers and treatment processes remains poorly ***,the purpose of the study was to explore the association between Bh infection risk and CD4^(+)T cell counts,HIV viral load(VL),and duration of interruption in antiviral therapy among *** A large-scale multi-center cross-sectional study was conducted in China from June 2020 to December *** genetic presence of Bh in fecal samples was detected by real-time fluorescence quantitative polymerase chain reaction,the CD4^(+)T cell counts in venous blood was measured using flowcytometry,and the HIV VL in serum was quantified using fluorescence-based *** cubic spline(RCS)was applied to assess the non-linear association between Bh infection risk and CD4^(+)T cell counts,HIV VL,and duration of interruption in highly active antiretroviral therapy(HARRT).Results A total of 1245 PLWH were enrolled in the study,the average age of PLWH was 43 years[interquartile range(IQR):33,52],with 452(36.3%)being female,50.4%(n=628)had no immunosuppression(CD4^(+)T cell counts>500 cells/μl),and 78.1%(n=972)achieved full virological suppression(HIV VL<50 copies/ml).Approximately 10.5%(n=131)of PLWH had *** prevalence of Bh was found to be 4.9%[95%confidence interval(CI):3.8-6.4%]among *** nonlinear associations were observed between the Bh infection risk and CD4^(+)T cell counts(Pfor nonlinearity<0.001,L-shaped),HIV VL(Pfor nonlinearity<0.001,inverted U-shaped),and duration of interruption in HARRT(Pfor nonlinearity<0.001,inverted U-shaped).Conclusions

关键词： Blastocystis hominis Human immunodeficiency virus Viral load Non-linear association Restricted cubic spline Propensity score China

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Spatial Analysis of People Living with HIV/aids Transmitted Through Commercial Heterosexual Contact or Non-Marital Non-Commercial Heterosexual Contact—China,2018

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China CDC weekly 2021年第15期3卷 316-319页

作者： Zhilong Dong Xiaohong Pan Chang Cai Qianqian Qin George F.Gao Fan Lyu National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouZhejiangChina National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina.

Summary What is already known about this topic?Significant changes in human immunodeficiency virus(HIV)transmission modes have occurred in China,and the proportion of heterosexual transmission increased in recent *** is added by this report?The proportions of diverse transmission routes and subgroups of heterosexual transmission were analyzed by provincial-level administrative divisions(PLADs).

关键词： HIV/aids Spatial immunodeficiency

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Global Transmission of Human Immunodeficiency Virus 1 Subtype C and Its Impact on the Circulation of B/C Recombination Strains in China

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Infectious Microbes & Diseases 2022年第4期4卷 157-160页

作者： Zhanmou Liu Yanling Liang Yi Feng Kang Li Yiming Shao Guangxi Key Laboratory of AIDS Prevention and Treatment and Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease School of Public HealthGuangxi Medical UniversityNanningChina Division of Research on Virology and Immunology National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

This study aimed to reconstruct the origin and worldwide epidemic history of human immunodeficiency virus(HIV)1 subtype C and comprehend how HIV-1 subtype C was introduced into and spread throughout China in the formof B/C recombinant *** sequences ofHIV-1 subtype C and some other subtypes deposited before December 31,2020 were downloaded from the Los Alamos HIV Database and the Chinese national center for aids/std control and prevention *** available sequences were screened for quality,and Bayesian analysis was used to build the maximum clade credibility evolutionary tree to analyze and judge the origin and spread of HIV-1 subtype ***-1 subtype C originated in central Africa around 1952,then spread to southern Africa around 1969 and to eastern Africa around ***-1 subtype C fromsouthern Africa was introduced into India in ***-1 subtype C of eastern Africa was introduced into Brazil in *** HIV-1 subtype C was exported to China in three migration events during the period from 1986 to *** two predominant recombinants in China(CRF07_BC and CRF08_BC)emerged in 1988 and 1990,*** B/C recombinants,namely,CRF64_BC,CRF61_BC and CRF62_BC,originated in 1993,2002 and 2000,*** study has reconstructed the global origin and evolutionary history of HIV-1 subtype *** addition,our study demonstrated that the Chinese HIV-1 subtype C originated from three related Indian lineages around the mid to late 1980s and,since then,has formed some B/C recombinants with subtype B that caused a widespread epidemic in China.

关键词： HIV-1 subtype C origin B/C recombination strains China global

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Recommend Guideline on prevention of Mother-to-Child Transmission of HIV in China in 2020

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Infectious Diseases & Immunity 2023年第2期3卷 52-59页

作者： Shuiling Qu Qian Wang Xiaoyan Wang Yaping Qiao Jun Yao Zhen Li Xi Jin Zhixin Li Ailing Wang Chinese Center for Disease Control and Prevention Beijing 102206China National Center for Women and Children's Health Chinese Center for Disease Control and PreventionBeijing 100081China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

In China, a pilot project for the prevention of mother-to-child transmission (PMTCT) of the HIV was initiated in 2001. For the PMTCT of HIV, the Chinese government has released versions of the guidelines since 2004. In 2014, the World Health Organization released guidance on global processes and criteria for the validation of elimination of mother-to-child transmission of HIV and syphilis. To promote the elimination of mother-to-child transmission of HIV, syphilis, and hepatitis B virus in China, the Chinese government updated the Guideline for PMTCT of HIV, Syphilis, and Hepatitis B in 2020 (briefly as Guideline-2020). The Guideline-2020 comprises 5 parts: goals, interventions, support measures, duties and cooperation of departments, and definition indicators for PMTCT of HIV and corresponding calculation formulas. Compared with the previous versions, the key points updated in the Guideline-2020 are that the goals are set again, and health education and promotion, the procedure of HIV testing for pregnant women, and the antiretroviral therapy regimen for HIV-positive pregnant women and antiretroviral) prophylaxis regimen for infants are all updated. The antiretroviral prophylaxis regimen as zidovudine-lamivudine-nevirapine/lopinavir/ritonavir twice per day for 6 weeks is recommended for infants at high exposure risk to HIV, whereas the third antiretroviral therapy regimen as tenofovir-lamivudine-lopinavir/ritonavir is recommended for HIV-positive pregnant women, and indicators for PMTCT of HIV and corresponding calculation formulas are defined.

关键词： HIV PMTCT Guideline Updated China

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Association between the triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular diseases in people living with human immunodeficiency virus:Evidence from a retrospectively cohort study 2005-2022

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Chinese Medical Journal 2024年第22期137卷 2712-2719页

作者： Liqin Sun Yinsong Luo Xinyun Jia Hui Wang Fang Zhao Lukun Zhang Bin Ju Haiyan Wang Duo Shan Yun He Hongzhou Lu Jiaye Liu Department of Infectious Diseases National Clinical Research Center for Infectious DiseasesShenzhen Third People’s HospitalShenzhenGuangdong 518010China School of Public Health Shenzhen University Medical SchoolShenzhenGuangdong 518060China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Introduction:The triglyceride to high-density lipoprotein cholesterol(TG/HDL-C)ratio,a novel biomarker for metabolic syndrome(MetS),has been validated in the general population as being significantly correlated with cardiovascular disease(CVD)***,its capabilities to predict CVD in people living with human immunodeficiency virus(HIV;PLWH)remain ***:We conducted a retrospective cohort study of 16,081 PLWH who initiated antiretroviral therapy(ART)at the Third People’s Hospital of Shenzhen(China)from 2005 to *** baseline TG/HDL-C ratio was calculated as TG(mmol/L)divided by HDL-C(mmol/L).We employed a multivariate Cox proportional hazards model to assess the association between the TG/HDL-C ratio and CVD occurrence,using Kaplan-Meier curves and log-rank tests to compare survival *** increase in prediction risk upon the addition of the biomarker to the conventional risk model was examined through the assessment of changes in net reclassification improvement(NRI)and integrated discrimination improvement(IDI).Nonlinear relationships were investigated using a restricted cubic spline plot,complemented by a two-piecewise Cox proportional hazards model to analyze threshold ***:At the median follow-up of 70 months,213 PLWH developed ***-Meier curves demonstrated a significant association between the increased risk of CVD and a higher TG/HDL-C ratio(log-rank P<0.001).The multivariate-adjusted Cox proportional hazards regression model indicated that the CVD hazard ratios(HR)(95%confidence intervals[95%CIs])for Q2,Q3,and Q4 versus Q1 of the TG/HDL-C ratio were 2.07(1.24,3.45),2.17(1.32,3.57),and 2.20(1.35,3.58),respectively(P<0.05).The consideration of the TG/HDL-C ratio in the model,which included all significant factors for CVD incidence,improved the predictive risk,as indicated by the reclassification metrics(NRI 16.43%,95%CI 3.35%-29.52%,P=0.014).The restriction cubic spline plot demonstrated an upward trend betw

关键词： Triglycerides Cholesterol,HDL Human immunodeficiency virus HIV Cardiovascular disease Incidence

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Relationship Between Drug Resistance and Death in HIV-Infected Patients Receiving Antiretroviral Therapy—7 PLADs,China,2010−2019

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China CDC weekly 2021年第14期3卷 291-297页

作者： Tianhao Zhang Lingjie Liao Yiming Shao Yi Feng Yuhua Ruan Hui Xing State Key Laboratory of Infectious Disease Prevention and Control(SKLID) National Center for AIDS/STD Control and Prevention(NCAIDS)Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina

Summary What is already known about this topic?With increasing coverage of antiretroviral therapy(ART)for HIV-infected patients,more and more attention has been paid to the impact of HIV drug resistance on death in those patients in *** is added by this report?Among HIV-infected patients receiving ART,the risk of death is higher in patients with HIV drug resistance[adjusted odds ratio(AOR)=4.25.

关键词： death patients Infect

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From a Deadly Disease to a Manageable Chronic Disease,HIV/aids Remains a Challenge for Mankind

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Infectious Microbes & Diseases 2023年第2期5卷 41-43页

作者： Shimiao Shao Yiming Shao State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina.

Acquired immune deficiency syndrome(aids)is caused by human immunodeficiency virus(HIV),which was found by French scientists 40 years ago,12 years after aids was firstly reported by US scientists.2 TheHIV/aids pandemic has spread to every country of theworldwith over 84 million infections and more than 40 million deaths since the start of the epidemic.3 According to Joint United Nations Programme on HIV/aids(UNaids),there are 38.4 million people living with HIV/aids(PLWHA)in 2021.4 In order to realize the Ending aids Plan by 2030,the UNaids made the intermediate target of less than 500,000 new HIV infections and 500,000 aids-related deaths in 2020.5 In the 2021 United Nations(UN)75th General Assembly,the General Secretary reported that the 2020 target of Ending aids Plan was not reached,6 with 1.7 million HIV infections and 690,000 aids-related deaths in 2019.7 In order to bring the Ending aids Plan back on track,UNaids setup a higher goal of“95-95-95,”meaning the percentage for all PLWHA who know their HIV status.

关键词： acquired immune deficiency syndrome human immunodeficiency virus combination antiretroviral therapy molecular transmission network

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Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/aids Individuals—China,2015 and 2018

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China CDC weekly 2021年第53期3卷 1133-1138页

作者： Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing State Key Laboratory of Infectious Disease Prevention and Control(SKLID) National Center for AIDS/STD Control and Prevention(NCAIDS)Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina.

Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more *** study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and ***:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this *** RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)*** Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral ***:The prevalence of TDR was not significantly increased over *** prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,***:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance.

关键词： drugs Stanford HIV/aids

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Estimating Costs of the HIV Comprehensive Intervention Using the Spectrum Model--China,2015-2019

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China CDC weekly 2022年第25期4卷 554-559,I0002页

作者： Youran Zhang Lili Wang Zhen Jiang Hongjing Yan Xiaoxia Liu Jing Gu Guoyong Wang Xiaosong Cheng Qiyan Leng Qisui Long Zimian Liang Jing Wang Liang Liang Yanchao Qiu Lin Chen Hang Hong School of Health Service Management Anhui Medical UniversityHefei CityAnhui ProvinceChina Division of Prevention and intervention National Center for AIDS and STD Control and PreventionChinese Center for Disease Control and PreventionBeijing MunicipalityChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityGuangxi Zhuang Autonomous RegionChina Zhenjiang Center for Disease Control and Prevention Zhenjiang CityJiangsu ProvinceChina Wuxi Center for Disease Control and Prevention Wuxi CityJiangsu ProvinceChina Shandong Provincial Center for Disease Control and Prevention Jinan CityJiangsu ProvinceChina Yantai Center for Disease Control and Prevention Yantai CityShandong ProvinceChina Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Foshan Center for Disease Control and Prevention Foshan CityGuangdong ProvinceChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Shijiazhuang Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou CityZhejiang ProvinceChina Ningbo Center for Disease Control and Prevention Ningbo CityZhejiang ProvinceChina

Introduction:In order to facilitate human immunodeficiency virus(HIV)treatment and prevention,the resource needs for HIV national strategic planning in developing regions were estimated based on Spectrum,the universal HIV costeffectiveness analysis ***:Based on the theoretical framework of Spectrum,the study developed a cost measurement tool for HIV,and calculated the cost of HIV prevention and control in 6 sampled cities in China during 2015–2019 using the Spectrum ***:From 2015 to 2019,the average annual costs for HIV prevention and control for Shijiazhuang,Yantai,Ningbo,Zhenjiang,Foshan,and Wuxi cities were 46.78,47.55,137.49,24.73,74.37,and 58.30 million Chinese yuan(CNY),*** per capita costs were 4.37,6.73,17.33,7.77,17.56,and 8.91 CNY,*** terms of the cost structure,the ratio of preventive intervention funds to therapeutic intervention funds(antiviral treatment)varied in sampled ***:Developing comprehensive and systematic HIV fund calculation methods can provide a research basis for rational resource allocation in the field of HIV.

关键词： prevention Ningbo rational

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Supervised Analysis of Hepatitis C Virus RNA-Positive Case Reporting in County-Level Hospitals--China,2013−2018

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China CDC weekly 2020年第31期2卷 587-590页

作者： Faxin Hei Guowei Ding Shaodong Ye Hailiang Yu Lin Pang Zhongfu Liu National Center for STD/AIDS Prevention and Control Chinese Center for Disease Control and PreventionBeijingChina

What is already known on this topic?To understand the status of the diagnosis and reporting of hepatitis C and standardize the reporting of hepatitis C cases in county-level hospitals,we conducted the first supervised analysis of hepatitis C cases in county-level hospitals in China from 2013 to 2018,covering all provincial-level administrative divisions(PLADs)except *** is added by this report?Through 6 years of supervision,we have obtained key data such as the nucleic acid detection rate and positive rate of hepatitis C virus(HCV)antibody positive cases in our county-level hospitals,the report rate and accuracy of HCV RNA positive cases,and standardized and improved the hepatitis C case reporting in countylevel hospitals to improve data quality and provide data support for the judgment and estimation of hepatitis C in *** are the implications for public health practice?By strengthening the management and supervision of hepatitis C case reporting,the reporting rate and accuracy of HCV RNA positive cases in county-level hospitals in China had been greatly *** combining the number of HCV antibody tests and the number of viral nucleic acid tests in medical institutions around the country,it was possible to effectively assess the current status of hepatitis C in China and to provide a scientific basis for the development of hepatitis C prevention and treatment measures.

关键词： prevention diagnosis strengthening

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