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Temporal and Spatial Trends in HIV Positivity Rate for VCT Clinics—China,2015–2022

China CDC weekly 2024年第1期6卷 6-11页

作者： Yi Liu Rong Su Dongmin Li Shaorong Wang Mengjie Han National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Human immunodeficiency virus(HIV)voluntary counseling and testing(VCT)clinics play a critical role in identifying and diagnosing HIV *** study aimed to describe the trend of HIV positivity rate(HPR)among Chinese VCT clinics between 2015 and ***:This study utilized data from the China Information System for Disease control and prevention to analyze the trend in the HPR for VCT clinics from 2015 to *** HPR was calculated by dividing the number of newly-reported HIV cases by the number of HIV tests,multiplied by 100%.To identify temporal and spatial trends in the HPR,we employed joinpoint regression analysis and the Getis-Ord hotspot ***:From 2015 to 2022,VCT clinics in China performed a total of 22,075,386 HIV tests,leading to the identification of 260,353 HIV cases,resulting in a HPR of 1.18%.The HPR consistently declined over the study period,with an average annual percent change(AAPC)of−7.5%(95%confidence interval:−12.6%,−2.2%,P<0.05).The number of HPR hotspots also decreased from 41 in 2015 to 23 in *** HPR hotspots were primarily located in Yunnan,Sichuan,Guangdong,and Guangxi provincial-level administrative divisions(PLADs).Among the 31 PLADs,16 showed a significant decrease in HPR during the study period(AAPC<0,PAAPC<0.05).Conclusions:VCT clinics in China have played a significant role in identifying HIV *** declining HPR observed in these clinics may indicates the progress has been made in some degree in mitigating HIV among high-risk ***,it is crucial to further improving the utilization of VCT clinics for HIV testing.

关键词： VCT dividing Spatial

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Characteristics of the HIV/aids Epidemic among People Aged≥50 Years in China during 2018–2021

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Biomedical and Environmental Sciences 2024年第4期37卷 399-405页

作者： HOU Yu Shan JIN Yi Chen CAI Chang TANG Hou Lin QIN Qian Qian LYU Fan National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study aimed to determine the current epidemiological status of PLWHA aged≥50 years in China from 2018 to *** also aimed to recommend targeted interventions for the prevention and treatment of HIV/aids in elderly *** Data on newly reported cases of PLWHA,aged≥50 years in China from 2018 to 2021,were collected using the *** tests and spatial analyses were also *** Between 2018 and 2021,237,724 HIV/aids cases were reported among patients aged≥50 years in *** main transmission route was heterosexual transmission(91.24%).Commercial heterosexual transmission(CHC)was the primary mode of transmission among males,while non-marital non-CHC([NMNCHC];60.59%)was the prevalent route in *** proportion of patients with CHC decreased over time(Z=67.716,P<0.01),while that of patients with NMNCHC increased(Z=153.05,P<0.01).The sex ratio varied among the different modes of infection,and it peaked at 17.65 for *** spatial analysis indicated spatial clustering,and the high-high clustering areas were mainly distributed in the southwestern and central-southern *** In China,PLWHA,aged≥50 years,were predominantly infected through heterosexual *** primary modes of infection were CHC and *** were variations in the sex ratio among different age groups,infected through various sexual ***/aids cases exhibited spatial *** on these results,the expansion of HIV testing,treatment,and integrated behavioral interventions in high-risk populations is recommended to enhance disease detection in key regions.

关键词： HIV/aids Aged≥50 years China

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Psychoactive Substance Use and the Impact on the aids Epidemic Among the MSM Population:a Meta-Analysis—Worldwide,2014-2023

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China CDC weekly 2024年第42期6卷 1086-1092,I0001-I0006页

作者： Donghang Luo Jie Xu Wei Luo National Center for AIDS/STD Control&Prevention Chinese Center for Diseases Control and PreventionBeijingChina

What is already known about this topic?There is a correlation between psychoactive substance use and heightened human immunodeficiency virus(HIV)susceptibility in men who have sex with men(MSM)populations,although the precise impact on transmission risk remains *** is added by this report?In MSM populations,rush poppers and amphetamines are widely used,with rates of 10.91%and 9.97%.In China,rush poppers usage is notably higher at 47.26%.For other regions and coutries,amphetamines(12.86%),rush poppers(3.62%),and GHB(3.34%)are most ***,17%of MSM use psychoactive substances,with higher HIV risk from amphetamines[Odds ratio(OR)3.06]compared to rush poppers(OR 1.51)and general substances(OR 1.76).What are the implications for public health practice?This study supports the idea that targeting specific regions and types of psychoactive substances for reduction among MSM populations can help decrease HIV transmission as well as promote prevention strategies.

关键词： prevention precise Impact

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Survival of People Living with HIV/aids from Pre-ART Era to Treat-all Era—China,1985–2022

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China CDC weekly 2024年第48期6卷 1264-1270页

作者： Shi Wang Houlin Tang Decai Zhao Chang Cai Yichen Jin QianQian Qin Fangfang Chen Liping Fei Hehe Zhao Zhongnian Yang Fan Lyu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:A comprehensive analysis of nationwide survival trends for people living with human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/aids,PLWHA)from the initial reported case to present has not been *** study evaluated the survival outcomes of PLWHA reported in China from 1985 to ***:We analyzed data from PLWHA recorded in the national HIV/aids Comprehensive Response Information Management System from 1985 to *** rates were calculated using Kaplan-Meier curves,and factors associated with survival time were analyzed using Cox proportional hazard ***:Progressive relaxation of antiretroviral therapy initiation criteria led to significant improvements in survival rates across different diagnostic periods in *** 1-year and 5-year cumulative survival rates increased from 85.2%and 66.1%in the 1985–2003 cohort to 91.1%and 81.4%in the 2016–2022 *** proportional hazard analysis revealed elevated mortality risks among males,individuals aged≥65 years,those with injection drug use or other transmission routes,hospital-tested patients,and those with lower CD4 counts at diagnosis or without ***:Antiretroviral therapy has effectively reduced mortality risk among PLWHA in *** efforts should focus on expanding HIV testing to reduce the proportion of late diagnoses with lower CD4 counts and providing targeted,differentiated services for older populations to further decrease mortality risk among PLWHA.

关键词： Survival HIV/aids mortality

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Evolution of HIV Epidemic and Emerging Challenges—China,1989–2023

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China CDC weekly 2024年第48期6卷 1251-1256页

作者： Chang Cai Houlin Tang Dongmin Li Qianqian Qin Fangfang Chen Yichen Jin Fan Lyu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:This study aimed to provide a comprehensive analysis of the human immunodeficiency virus(HIV)epidemiological landscape in China through a historical review and current ***:Data were extracted from China’s HIV/aids Comprehensive Response Information Management System(CRIMS).Transmission patterns across different phases were visualized using stacked area *** correlations between transmission routes were analyzed using scatter plots and Pearson correlation *** extent and trends of HIV spread among the general population were evaluated using Venn diagrams and Cochran-Armitage ***:The HIV epidemic in China evolved through four distinct phases:injecting drug user(IDU)dominated(1989–1994),former plasma donor(FPD)outbreak(1995–2005),sexual transmission dominance(2006–2014),and general population spread(2015–present).A strong correlation was observed between provinces reporting high numbers of IDU cases and those with elevated heterosexual transmission(r=0.88,P<0.001).Between 2015 and 2023,393,926 cases were identified among the general population through non-marital and non-commercial heterosexual contact(NMNCHC).The proportion of general population cases among heterosexual transmissions increased significantly from 46.2%to 55.7%(Z=42.7,P<0.001).Conclusion:The significant spread of HIV into the general population necessitates the development of targeted prevention strategies for both high-risk and general populations to address emerging epidemiological challenges.

关键词： prevention elevated IDU

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Willingness to Pay for Antiretroviral Drugs Covered by Medical Insurance among People Living with HIV in 18 Chinese Cities

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Biomedical and Environmental Sciences 2024年第11期37卷 1283-1293页

作者： Jingkun Hu Houlin Tang Wenting Kang Shuyu Wang Jie Xu Decai Zhao Yang Hao Xinlun Wang Fan Lyu Guang Zhang Peng Xu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Chinese Association of STD&AIDS Prevention and Control Beijing 100050China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention Beijing 102206China

Objective Antiretroviral drugs covered by medical insurance have been gradually used by people living with human immunodeficiency virus(PLWH)in recent years in *** study aimed to analyze their willingness to pay(WTP)for antiretroviral *** A mixed-methods study design involving a cross-sectional survey and in-depth interviews was conducted.A cross-sectional survey was performed to collect data on the general characteristics,economic status,antiretroviral therapy(ART)status,and WTP of PLWH in 18 Chinese cities from August 2022 to February *** logistic regression was used to analyze the factors associated with *** of PLWH were interviewed via in-depth interviews,and the data were thematically *** Among the 941 PLWH,271(28.80%)were willing to pay for antiretroviral drugs covered by medical *** basic medical insurance for urban and rural residents,PLWH with the following characteristics were more willing to pay:an educational level of senior high school or technical secondary school,having an undergraduate degree or higher,frequently working away from their hometowns,and homosexual ***-farm workers and recipients of government medical aid were more unwilling to *** basic medical insurance for urban employees,PLWH with the following characteristics were more willing to pay:frequently working away from their hometowns;homosexual transmission;personal annual income≥100,000 CNY;and adverse events of antiretroviral *** main reasons for PLWH’s WTP for antiretroviral drugs covered by medical insurance were that the drugs had fewer adverse events and were easier to *** main reasons for PLWH’s unwillingness to pay were financial difficulties and privacy *** Nearly one-third of PLWH are willing to pay for antiretroviral drugs covered by medical *** the future,PLWH with a high WTP can be guided to use these drugs.

关键词： PLWH Antiretroviral drugs covered by medical insurance Willingness to pay

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Prioritizing the People in HIV prevention:Transforming Data into Effective Policies and Actions

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China CDC weekly 2024年第48期6卷 1249-1250页

作者： Fan Lyu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

In the contemporary landscape of global health challenges,human immunodeficiency virus(HIV)and acquired immunodeficiency syndrome(aids)remain significant public health concerns both domestically and *** UNaids estimates indicate that by the end of 2023,approximately 39.9 million people were living with HIV/aids globally,with 1.3 million new infections and 630,000 deaths(1).While current prevention and treatment strategies have contributed to a steady decline in new infections and mortality rates,we remain considerably distant from achieving the ambitious target of“ending the aids epidemic by 2030”.

关键词： prevention mortality globally

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HIV Infection and Associated Factors Among Out-of-School MSM Aged 16–24 Years—6 Cities and Tianjin Municipality,China,2022–2023

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China CDC weekly 2024年第3期6卷 45-50页

作者： Hui Liu Qiyu Zhu Lei Zhang Yujing Liu Peng Xu Mengjie Han National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Chinese Association of STD and AIDS Prevention and Control BeijingChina Beijing Chaoyang Kangzhong Health and Education Center BeijingChina

What is already known about this topic?Approximately 80%of newly diagnosed human immunodeficiency virus(HIV)cases among individuals aged 15–24 years in China are attributed to out-ofschool *** is added by this report?This study presents findings on HIV prevalence and comprehensive insights into HIV service utilization,risky behaviors,and prevention knowledge among young out-of-school men who have sex with men(MSM)aged 16–24 years in *** population exhibits a disproportionately high burden of HIV,with only 51.6%of HIV cases previously *** are the implications for public health practice?HIV services should be expanded to include these key *** interventions are needed to remove barriers to regular HIV services faced by young key populations.

关键词： prevention remove expanded

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In Memoriam of Professor Hans Wolf

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China CDC weekly 2024年第50期6卷 1345-1346页

作者： Yiming Shao National Center for STD/AIDS Prevention and Control Chinese Center for Disease Control and PreventionBeijingChina

It is with profound sadness that we document this memorial tribute to the honorable Professor Hans Joachim Wolf,an eminent scholar in virology and recipient of the Chinese Government’s Friendship Award,who passed away in *** his distinguished scientific career,*** made seminal contributions to molecular virology,tumor virus research,and HIV/aids studies,while fostering international research and public health collaborations.

关键词： collaboration honor profound

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Changing Mortality and Patterns of Death Causes in HIV Infected Patients—China,2013-2022

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China CDC weekly 2023年第48期5卷 1073-1078页

作者： Yan Zhao Lai Wei Zhihui Dou Decai Zhao Xiumin Gan Yasong Wu Mengjie Han National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The advent of antiretroviral therapy(ART)has markedly decreased mortality rates among patients infected with human immunodeficiency virus(HIV).Globally,there has been a 43%reduction in acquired immunodeficiency syndrome(aids)-related deaths from 2010 to ***,prior research indicates that the initiation of ART at an early stage within China has substantially lowered mortality *** is added by this report?Over the previous decade,following the implementation of China’s universal ART access strategy,the patterns of mortality causes among HIVinfected individuals across the country have undergone significant *** 2022,the all-cause mortality rate among this population was reported at 2.7%,with the non-aids-related mortality rate at 1.8%.However,it is important to consider that the accuracy of death reporting could contribute to potential misclassification of the underlying causes of *** are the implications for public health practice?Efforts to enhance health outcomes should persist in emphasizing the advancement of ART strategies,with a particular focus on mitigating non-aids-related mortality in the future.

关键词： markedly alterations Pattern

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