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Mechanism of iron on the intestinal epithelium development in suckling piglets

Science China(Life Sciences) 2023年第9期66卷 2070-2085页

作者： Lanmei Yin Yitong Zhang Jun Li Jing Zhou Qiye Wang Jing Huang Jianzhong Li Huansheng Yang Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China Key Laboratory of Agro-ecological Processes in Subtropical Region Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin 300308China State Key Laboratory of Food Safety Technology for Meat Products Yinxiang GroupFujian Aonong BiologicaI Science and Technology Group Co.Ltd.Key Laboratory of Swine Nutrition and Feed Science of Fujian ProvinceZhangzhou 363000China

This study aimed to investigate the mechanism of iron on intestinal epithelium development of suckling piglets. Compared with newborn piglets, 7-day-old and 21-day-old piglets showed changes in the morphology of the jejunum, increased proliferation,differentiated epithelial cells, and expanded enteroids. Intestinal epithelium maturation markers and iron metabolism genes were significantly changed. These results suggest that lactation is a critical stage in intestinal epithelial development, accompanied by changes in iron metabolism. In addition, deferoxamine(DFO) treatment inhibited the activity of intestinal organoids at passage 4(P4) of 0-day-old piglets, but no significant difference was observed in epithelial maturation markers at passage 1(P1) and P4,and only argininosuccinate synthetase 1(Ass1) and β-galactosidase(Gleb) were up-regulated at passage 7(P7). These results in vitro show that iron deficiency may not directly affect intestinal epithelium development through intestinal stem cells(ISCs). The iron supplementation significantly down-regulated the m RNA expression of interleukin-22 receptor subunit alpha-2(IL-22RA2)in the jejunum of piglets. Furthermore, the m RNA expression of IL-22 in 7-day-old piglets was significantly higher than that in0-day-old piglets. Adult epithelial markers were significantly up-regulated in organoids treated with recombinant murine cytokine IL-22. Thus, IL-22 may play a key role in iron-affecting intestinal epithelium development.

关键词： iron suckling piglets intestinal epithelium development interleukin-22

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Tracking performance limitations of MIMO discrete-time networked control systems with multiple constraints

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Science China(Information Sciences) 2023年第8期66卷 267-268页

作者： Xiaowei JIANG Bin ZHANG Xiangyong CHEN Huaicheng YAN School of Automation China University of Geosciences Key Laboratory of Industrial Internet of Things & Networked Control Ministry of Education Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education School of Automation and Electrical Engineering Linyi University Key Laboratory of Smart Manufacturing in Energy Chemical Process of the Ministry of Education

Dear editor,Networked control systems(NCSs) have attracted widespread attention in some fields because they offer the advantages of reduced cabling, greater resource sharing,and ease of installation and maintenance [1]. However, in an unreliable network environment, network constraints can significantly limit the performance of NCSs.

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Model predictive control of grid-connected PV power generation system considering optimal MPPT control of PV modules

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Protection and control of Modern Power Systems 2021年第1期6卷 407-418页

作者： Yingying Zhao Aimin An Yifan Xu Qianqian Wang Minmin Wang College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhou730050GansuChina Key Laboratory of Gansu Advanced Control for Industrial Processes Lanzhou730050GansuChina National Demonstration Center for Experimental Electrical and Control Engineering Education Lanzhou University of TechnologyLanzhou730050GansuChina

Because of system constraints caused by the external environment and grid faults,the conventional maximum power point tracking(MPPT)and inverter control methods of a PV power generation system cannot achieve optimal power *** can also lead to misjudgments and poor dynamic *** address these issues,this paper proposes a new MPPT method of PV modules based on model predictive control(MPC)and a finite control set model predictive current control(FCS-MPCC)of an *** the identification model of PV arrays,the module-based MPC controller is designed,and maximum output power is achieved by coordinating the optimal combination of spectral wavelength and module *** FCS-MPCC algorithm is then designed to predict the inverter current under different voltage vectors,the optimal voltage vector is selected according to the optimal value function,and the corresponding optimal switching state is applied to power semiconductor devices of the *** MPPT performance of the MPC controller and the responses of the inverter under different constraints are verified,and the steady-state and dynamic control effects of the inverter using FCS-MPCC are compared with the traditional feedforward decoupling PI control in Matlab/*** results show that MPC has better tracking performance under constraints,and the system has faster and more accurate dynamic response and flexibility than conventional PI control.

关键词： Grid-connected PV power generation system Model predictive control Maximum power point tracking Inverter Optimal value function

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Damage detection of cylindrical structural steels based on finite element analysis 5

Damage detection of cylindrical structural steels based on f...

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5th International Conference on Informatics Engineering and Information Science, ICIEIS 2022

作者： Huang, Ling Xu, Zi Jian Yuan Wei, X. Wang, Gang College of Electrical and Information Engineering Lanzhou University of Technology Lanzhou730050 China Key Laboratory of Gansu Advanced Control for Industrial Processes Lanzhou University of Technology Lanzhou730050 China National Demonstration Center for Experimental Electrical and Control Engineering Education Lanzhou University of Technology Lanzhou730050 China

ISBN: (纸本)9781510660090

In this paper, the ultrasonic transmission process and damage detection in rod structure are experimentally studied. In the finite element simulation, according to the nonlinear interaction between the different Lamb wave excitation signals and the fixed size crack on the rod, the signal mechanism is analyzed and how to locate the damage signal is explained. The fatigue crack evolution of rod assembly is further tested by experimental method. It is consistent with the simulation results. It is found that the ultrasonic guided wave signal with excitation is very sensitive to cracks. Finite element analysis and excitation signals can be used as potential methods for quantitative evaluation of cracks in metal parts. The results of this study provide a basis for modeling and simulation using finite element in the field of nondestructive evaluation and structural health monitoring © 2022 SPIE.

关键词： Finite element method

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Hybrid algorithm of invasive weeds and particle swarm optimization

Hybrid algorithm of invasive weeds and particle swarm optimi...

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IEEE International Conference on Cloud Computing and Intelligence Systems (CCIS)

作者： Xianjun Du Zhuohang Li College of Electrical Engineering and Information Engineering Lanzhou Univ. of Tech Lanzhou China Key Laboratory of Gansu Advanced Control for Industrial Process Lanzhou Univ. of Tech Lanzhou China

Aiming at the disadvantages of low optimization accuracy and easy to fall into local optimum of particle swarm optimization algorithm, a hybrid algorithm combining the invasive weed algorithm and particle swarm optimization algorithm is proposed. The main structure of the hybrid algorithm is PSO, and IWO makes the algorithm avoid falling into local optimum. The simulation test is carried out with 11 benchmark test functions, and through comparison with the other two improved PSO algorithms, it is concluded that the hybrid algorithm in this paper is not easy to fall into local optimization and has high optimization accuracy.

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Batch process quality prediction based on TFCMixer modeling

SSRN

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SSRN 2025年

作者： Zhao, Xiaoqiang Liu, Yongyong Hui, Yonyong Liu, Kai Yao, Qinglei College of Electrical and Information Engineering Lanzhou University of Technology Lanzhou730050 China Gansu Key Laboratory Advanced Control for Industrial Processes Lanzhou University of Technology Lanzhou730050 China National Experimental Teaching Center of Electrical and Control Engineering Lanzhou University of Technology Lanzhou730050 China

Deep learning models are now widely used for the prediction of quality variables in batch processes. However, the dynamics and nonlinearities of batch processes, and long training time of deep learning models are unfavorable for quality prediction. To address these issues, an batch process quality prediction method based on the Temporal Feature Convolutional Mixer (TFCMixer) model is proposed. First, the maximum information coefficient (MIC) method is utilized to filter out the process variables that are more relevant to the quality variables to reduce the model training time. Second, a temporal feature convolution processor is designed to extract key information from the time series. On the one hand, the pro cessor processes the data in time dimension through convolution operation to learn the dynamic changes of the data in time, and utilizes double convolution operation to process the feature dimension in the data, so that the model can learn the interaction information between the features, which helps to deeply understand the complex relationship between the features and improve the prediction accuracy of the model;on the other hand, it incorporates a residual scale block to regulate the model's training time. Scale is incorporated to regulate the effect of residual signals in the final output, so as to adjust the performance of the model according to different tasks and data characteristics, and the Hard Swish activation function with continuous differentiability is introduced to stabilize the training of the model. Then, the temporal projection is combined with a temporal feature convolution processor to perform the conversion between time steps. Finally, experiments are conducted using data from the penicillin fermentation process and semiconductor wafer etching process. The results demonstrate the accuracy and effectiveness of the proposed model, which requires fewer iterations for training to achieve excellent prediction results. © 2025, The Authors. All ri

关键词： Batch data processing

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Effects of particle size and oil-immersed concentration on the dust layer minimum ignition temperature and combustion characteristics of oil-immersed coal

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Journal of Thermal Analysis and Calorimetry 2024年第18期149卷 10297-10309页

作者： Luo, Zhenmin Yang, Yong Ding, Xuhan Luo, Chuanxu Zhang, Fan Zhang, Man Shu, Chi-Min School of Safety Science and Engineering Xi’an University of Science and Technology 58 Yanta Mid. Rd. Shaanxi Xi’an710054 China Shaanxi Key Laboratory of Prevention and Control of Coal Fire 58 Yanta Mid. Rd. Shaanxi Xi’an710054 China Shaanxi Engineering Research Centre for Industrial Process Safety and Emergency Rescue 58 Yanta Mid. Rd. Shaanxi Xi’an710054 China Department of Safety Health and Environmental Engineering National Yunlin University of Science and Technology 123 University Rd. Sec. 3 Yunlin Douliou64002 Taiwan

This paper studied the minimum ignition temperature of the dust layer (MITL) of oil-immersed coal and the heat effect and apparent activation energy (Ea) of raw coal and oil-immersed coal. Based upon the results, the addition of crude oil to coal could reduce the MITL, ameliorate the ignition sensitivity, and increase the heat effect of coal dust. The average Ea of oil-immersed coal was lower than that of raw coal. When there was a 10.8 mass% oil-immersed concentration of oil-immersed coal with the most acceptable particle size (≤ 75 μm), the MITL was 24.24% lower than that of raw coal. Furthermore, the exothermic value of oil-immersed coal was 26.67% higher than that of raw coal. Besides, the average Ea of oil-immersed coal was 26.8% lower than that of raw coal. The research herein is expected to improve people’s understanding of the thermal hazard characteristics of oil-immersed coal dust, reduce the risk of coal dust fires and explosions, and ensure production safety. Graphical Abstract: (Figure presented.) © Akadémiai Kiadó, Budapest, Hungary 2024.

关键词： Coal

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Event-Triggered SMC for Networked Markov Jumping Systems With Channel Fading and Applications: Genetic Algorithm

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IEEE Transactions on Cybernetics 2023年第10期53卷 6503-6515页

作者： Qi, Wenhai Zhang, Ning Zong, Guangdeng Su, Shun-Feng Yan, Huaicheng Yeh, Ruey-Huei Qufu Normal University School of Engineering Rizhao276826 China Chengdu University School of Information Science and Engineering Chengdu610106 China Tiangong University School of Control Science and Engineering Tianjin300387 China National Taiwan University of Science and Technology Department of Electrical Engineering Taipei106 Taiwan East China University of Science and Technology Key Laboratory of Smart Manufacturing in Energy Chemical Process of Ministry of Education Shanghai200237 China National Taiwan University of Science and Technology Department of Industrial Management Taipei106 Taiwan

The event-triggered sliding-mode control (SMC) for discrete-time networked Markov jumping systems (MJSs) with channel fading is investigated by means of a genetic algorithm. In order to reduce resource consumption in the transmission process, an event-triggered protocol is adopted for networked MJSs. A key feature is that the signal transmission is inevitably affected by fading phenomenon due to delay, random noise, and amplitude attenuation in a networked environment. With the aid of a common sliding surface, an event-triggered SMC law is designed by adjusting the system network mode. Under the framework of stochastic Lyapunov stability, sufficient conditions are constructed to ensure the mean-square stability of the closed-loop networked MJSs, and the sliding region is reached around the specified sliding surface. Moreover, based on the iteration optimizing accessibility of objective function, an effective SMC approach under genetic algorithm is proposed to minimize the convergence region around the sliding surface. Finally, the effectiveness of the proposed method is proved by the F-404 aircraft model. © 2013 IEEE.

关键词： Markov processes

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Engineered Bacillus subtilis alleviates intestinal oxidative injury through Nrf2-Keap1 pathway in enterotoxigenic Escherichia coli(ETEC) K88-infected piglet

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第6期24卷 496-509页

作者： Chaoyue WEN Hong ZHANG Qiuping GUO Yehui DUAN Sisi CHEN Mengmeng HAN Fengna LI Mingliang JIN Yizhen WANG Institute of Feed Science Key Laboratory of Animal Feed and Nutrition of Zhejiang ProvinceKey Laboratory of Molecular Animal NutritionMinistry of EducationKey Laboratory of Animal Nutrition and Feed Science in Eastern ChinaMinistry of AgricultureCollege of Animal SciencesZhejiang UniversityHangzhou 310058China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China College of Advanced Agricultural Science University of Chinese Academy of SciencesBejing 100039China

Engineered probiotics can serve as therapeutics based on their ability of produce recombinant immune-stimulating *** this study,we built the recombinant Bacillus subtilis WB800 expressing antimicrobial peptide KR32(WB800-KR32)using genetic engineering methods and investigated its protective effects of nuclear factor-E2-related factor 2(Nrf2)-Kelch-like ECH-associated protein 1(Keap1)pathway activation in intestinal oxidative disturbance induced by enterotoxigenic Escherichia coli(ETEC)K88 in weaned ***-eight weaned piglets were randomly distributed into four treatment groups with seven replicates fed with a basal *** feed of the control group(CON)was infused with normal sterilized saline;meanwhile,the ETEC,ETEC+WB800,and ETEC+WB800-KR32 groups were orally administered normal sterilized saline,5×10^(10)CFU(CFU:colony forming units)WB800,and 5×10^(10)CFU WB800-KR32,respectively,on Days 1-14 and all infused with ETEC K881×10^(10)CFU on Days *** results showed that pretreatment with WB800-KR32 attenuated ETEC-induced intestinal disturbance,improved the mucosal activity of antioxidant enzyme(catalase(CAT),superoxide dismutase(SOD),and glutathione peroxidase(GPx))and decreased the content of malondialdehyde(MDA).More importantly,WB800-KR32 downregulated genes involved in antioxidant defense(GPx and SOD1).Interestingly,WB800-KR32 upregulated the protein expression of Nrf2 and downregulated the protein expression of Keap1 in the ***800-KR32 markedly changed the richness estimators(Ace and Chao)of gut microbiota and increased the abundance of Eubacterium_rectale_ATCC_33656 in the *** results suggested that WB800-KR32 may alleviate ETEC-induced intestinal oxidative injury through the Nrf2-Keap1 pathway,providing a new perspective for WB800-KR32 as potential therapeutics to regulate intestinal oxidative disturbance in ETEC K88 infection.

关键词： Engineered probiotics Intestine Oxidative injury Weaned piglets Nuclear factor-E2-related factor 2(Nrf2)-Kelch-like ECH-associated protein 1(Keap1)pathway

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Simultaneous hydrogen production with photo reforming of lactic acid over MXene derived MoS_(2)/TiO_(2)/Ti_(3)C_(2)nanowires

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Chinese Journal of Catalysis 2025年第4期71卷 234-245页

作者： Seemal Mansoor Zixu Hu Yuxin Zhang Muhammad Tayyab Mazhar Khan Zeeshan Akmal Liang Zhou Juying Lei Muhammad Nasir Jinlong Zhang Key Laboratory for Advanced Materials Shanghai Engineering Research Center for Multi–media Environmental Catalysis and Resource UtilizationJoint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterSchool of Chemistry and Molecular EngineeringEast China University of Science&TechnologyShanghai 200237China National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical ProcessEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090HeilongjiangChina Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Institute of Materials Research Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055GuangdongChina COMSATS Univ Islamabad Interdisciplinary Res Ctr Biomed Mat IRCBMLahore CampusLahore 54000Pakistan

Developing efficient photocatalysts to address collaborative energy and environmental crises still faces significant *** this report,we present a highly efficient MXene–based photocatalyst,which is combined with MoS_(2)nano patches and TiO_(2)/Ti_(3)C_(2)(TTC)nanowires through hydrothermal *** all the composites tested,the optimized photocatalyst gave a remarkable H_(2)and revolving polylactic acid(PLA)into pyruvic acid(PA).Achieving a remarkable H_(2)evolution rate of 637.1 and 243.2μmol g^(−1)h^(−1),in the presence of TEOA and PLA as a sacrificial reagent under UV-vis(λ≥365 nm)light *** improved photocatalytic activity is a result of the combination of dual cocatalyst on the surface of TTC photocatalyst,which create an ideal synergistic effect for the generation of PA and the production of H_(2)*** MoS_(2)TiO_(2)/Ti_(3)C_(2)(MTT)composite can generate more photoexcited charge carriers,leading to the generation of more active radicals,which may enhance the system's photocatalytic *** work aims at demonstrating its future significance and guide the scientific community towards a more efficient approach to commercializing H_(2)through photocatalysis.

关键词： Photo reforming Polylactic acid Hydrogen evolution Lactic acid Pyruvic acid

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