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Integrated analysis of lncRNAs expression profiling in systemic lupus erythematosus

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Rheumatology & Autoimmunity 2024年第2期4卷 119-121页

作者： Fen Zhang Guifang Zhao Yujie Bu Xing Cen Rong Zhao Fengwu Chen Shengxiao Zhang Junwei Chen Department of Rheumatology The Second Hospital of Shanxi Medical UniversityTaiyuanShanxiChina State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong UniversityXi'anShaanxiChina

To the Editor,Systemic lupus erythematosus(SLE)is a chronic autoimmune disease with serious harm to human health and various clinical manifestations,which is characterized by over-activity of lymphocytes,production of autoantibodies,and effects on multiple organs.1 So far,the pathogenesis of SLE remains unclear;it is believed that genetic,environmental,infectious,and other factors participate in the pathogenesis of *** the gradual in-depth study of transcriptomics,genetic factors may be the root cause of SLE,2 and epigenetics plays an important role in genetic factors of SLE.3 Epigenetics means heritable changes in gene expression without shifting the DNA *** principal mechanisms of epigenetic regulation include histone modification,DNA methylation,and regulation of noncoding *** the past,studies of transcriptomics mainly focused on protein-coding ***,protein-coding genes that encode exons account for 1.5%of the genome,and genes without protein-coding capability account for more than 80%of the human genome.4 Therefore,studies of transcriptomics began to pay attention to long noncoding RNAs(lncRNAs),which play key roles in transcription control,posttranscriptional processing,protein metabolism,immune cell differentiation,and immune responses.5 However,knowledge of related lncRNAs in SLE remains limited.

关键词： lupus erythematosus organs

Novel Solid-State Hydrolysis Kinetics of Nabh4 for Stable and High-Capacity On-Line Hydrogen Production

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SSRN 2024年

作者： Chen, Jiawei Wu, Zhen Zheng, Jie Shi, Yu Xie, Lei Yang, Fusheng Wang, Yuqi Zhang, Zaoxiao School of Chemical Engineering Northwest University Xi’an710069 China School of Chemical Engineering and Technology Xi’an Jiaotong University Xi’an710049 China College of Chemistry and Molecular Engineering Peking University Beijing100871 China Sunan Institute for Molecular Engineering Peking University Jiangsu 215500 China State Key Laboratory of Multiphase Flow for Power Engineering Xi’an Jiaotong University Xi’an710049 China

Solid-state hydrolysis of NaBH4 could achieve high-capacity on-line hydrogen production. However, the stability of hydrogen production in the solid-state hydrolysis process has been questioned. In this paper, a novel kinetics is proposed for the solid-state hydrolysis behavior. The acceleration factor β is introduced into the traditional shrinking core model to reveal the relationship between "dissolution" and "catalytic hydrolysis" in the solid-state hydrolysis process. The comparison results show a good agreement between the model and experiment in the temperature range of 303.15-348.15 K. Meanwhile, the kinetics conclusions and product characterization indicated that the "excessive dissolution" of NaBH4 and the "dehydration of by-products" are two important factors contributing to the uncontrolled reaction. Based on the parametric analysis and experimental verification, the optimum temperature for solid-state hydrolysis is approximately 323.15 K. Besides, the adjustment of the water intake strategy to intermittent intake reduced water consumption by 36.6%. As a result, the hydrogen release capacity could be increased to as high as 5.49 wt.% (close to the U.S. Department of Energy 2025 gravimetric hydrogen storage capacity of 5.5 wt.%), even though the weight of water is taken into account as reactant. © 2024, The Authors. All rights reserved.

关键词： Hydrolysis

Enhanced Low-Temperature Behavior of Selective Catalytic Reduction of Nox by Co on Fe-Based Catalyst with Looping Oxygen Vacancy

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SSRN 2022年

作者： Pan, Yuqing Li, Na Li, Ke Ran, Shiyuan Wu, Chenyang Zhou, Qulan Liu, Jiyuan Li, Shuzhou State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University Xi’an710049 China School of Materials Science and Engineering Nanyang Technological University Singapore639798 Singapore Singapore138634 Singapore

The industrial applications of de-NOx require the high activity window of the catalysts to be shifted from high to low temperatures for energy saving. Selective catalytic reduction (SCR) of NOx by CO, as an alternative to NH3-SCR, is a promising de-NOx technology that facilitates the synergistic removal of pollutants. Herein, we report a new Fe2O3/amorphous SiO2 catalyst with high low-temperature activity for CO-SCR. A combination of experiments and density functional theory (DFT) calculations obtains direct evidence that an optimal content of oxygen vacancy enhances the low-temperature NO conversion ratio and N2 selectivity of Fe2O3-based catalyst to over 80% and maintain 100% CO conversion by promoting NN coupling via ONNO/N2O and NCO/NNCO2 intermediates. Compared with conventional defect engineering, such as doping other metals or artificially generating oxygen defects, the α-Fe2O3 (110) facet automatically enables an oxygen vacancy generation-filling cycle in the CO-SCR reaction, following Mars-van Krevelen (MvK) mechanism. This work advances a fundamental understanding of CO-SCR reaction mechanism over Fe2O3-based catalysts and provides insights for future studies to improve heterogeneous metal oxide catalysts. © 2022, The Authors. All rights reserved.

关键词： Oxygen vacancies

Quantitative Evaluation of Clinical Efficacy of Laser Thermotherapy for Port-Wine Stains Through Reflectance Spectra Measurements and an Inverse Radiation Algorithm

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Zhongguo Jiguang/Chinese Journal of Lasers 2025年第9期52卷

作者： Li, Dong Li, Xiaoyang Zhang, Pengfei Chen, Bin Ying, Zhaoxia State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong University Shaanxi Xi’an710049 China Shaanxi Provincial Institute for Skin Disease and STD Control Shaanxi Xi’an710003 China

Objective Port-wine stains (PWS) are congenital vascular malformations caused by the abnormal dilation of capillaries and venules in the skin. Affecting 0.3%‒0.5% of newborns, PWS typically manifest as pinkish patches on the face and neck that darken and thicken over time, significantly impacting patients’physical and mental well-being. Pulsed dye laser (PDL) therapy, based on selective photothermolysis, is the gold standard for PWS treatment. By targeting hemoglobin in abnormal blood vessels with specific wavelengths, PDL induces thermal damage to the vasculature while sparing surrounding tissues. However, due to variability in skin types, lesion depths, and laser parameters, clinical outcomes often depend on subjective evaluations and physician experience. These limitations underscore the urgent need for objective, quantitative, and noninvasive methods to assess skin structure and monitor treatment efficacy. This study integrates reflectance spectroscopy with an inverse Monte Carlo radiation method to quantify changes in key skin parameters before and after laser treatment. By measuring and reconstructing parameters such as epidermal thickness, melanin volume fraction, blood volume fraction, and blood oxygen saturation, this study establishes a robust framework for evaluating treatment outcomes and optimizing laser parameters. Additionally, it investigates differences in treatment responses between pediatric and adult patients, providing critical insights for personalized therapeutic strategies. Methods Eleven patients with PWS underwent pulsed dye laser (PDL) therapy at a wavelength of 595 nm, with an energy density of 8 J/cm2 and a fixed spot diameter of 7 mm. Reflectance spectra of the skin were measured before and after treatment using an HR400 CG-UV-NIR spectrometer (Fig. 1). To enhance efficacy, a double-irradiation strategy was employed, in which the second laser exposure followed the first after five minutes. For spectral analysis, an inverse Monte Carlo r

关键词： Hemoglobin oxygen saturation

Visualization Experiments and Piston Effect of Heat Transfer on Supercritical Carbon Dioxide in a Mini Vertical Upward flow

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SSRN 2022年

作者： Lyu, Haicai Wang, Han Bi, Qincheng Niu, Fenglei School of Nuclear Science and Engineering North China Electric Power University Beijing102206 China State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong University No.28 Xianning West Road Xi’an710049 China

The characteristics of supercritical heat transfer and flow patterns visualization were investigated experimentally. System parameters are pressure of 7.4 ~ 8.44 MPa, the mass flux of 600 ~ 1600 kg·m -2 ·s -1 and heat flux up to 319 kW·m -2 . The basic experimental data of heat transfer coefficient and frictional pressure drop were obtained. Local heat transfer coefficient was calculated with respect to the mass flux, heat flux and pressure. The scenario of in-tube supercritical carbon dioxide was presented by a high-resolution camera. Experimental results show that the heat transfer peak happens when the wall temperature is above the pseudo-critical temperature, and in-tube fluid is lower than the pseudo-critical temperature. Exciting phenomenon of critical opalescence is observed under the pressure of 7.4 MPa and a temperature of 31.68 ˚C. Rapid alternation of sky blue and milky white was captured in an extremely short period time, which may be related to Rayleigh scattering due to drastic density fluctuation. Piston effect of strongly uneven aggregation was formed due to the variation of thermal physical property, which can be used to exposit the mechanism of supercritical heat transfer peak near the pseudo-critical temperature. Ration of density and volumetric coefficient of expansion can be represented for the piston effect to produce the modified Jackson’s correlation, which owns the average error of -0.69% and root-mean-square error of 10.35%. © 2022, The Authors. All rights reserved.

关键词： Visualization

Predicting self-diffusion coefficients of light gases in supercritical carbon dioxide: A molecular dynamics method

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The Journal of Supercritical Fluids 2025年 225卷

作者： Tongjia Zhang Bowei Zhang Jie Zhang Xiaoran Rong Hui Jin State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong University Xi’an Shaanxi 710049 PR China

The methanation of CO 2 and supercritical CO 2 (scCO 2 ) fracturing represent effective approaches for CO 2 utilization and greenhouse effect mitigation. In these process, light gases like H 2 , O 2 , CO, CH 4 are commonly involved. However, limited studies have focused on the diffusion behavior of these gases in scCO 2 under high-pressure conditions, as well as a shortage of self-diffusion coefficient data and prediction equations specifically designed for scCO 2 solvents. To address this gap, molecular dynamics (MD) simulations were employed to compute the self-diffusion coefficients of several light gases in scCO 2 across a wide temperature range (313 K–713 K) and at high pressures (75.994 bar, 101.325 bar and 126.656 bar) under infinitely dilute conditions. The effects of temperature, density, viscosity, molecular mass, and solute–solvent interaction energy on the self-diffusion behavior were systematically analyzed. Two empirical equations (a Speedy–Angell-type power-law equation and a newly developed equation incorporating temperature, density, and viscosity) were refitted based on simulation data. The overall relative errors are 4.52 % and 4.44 %, respectively, indicating an improved accuracy compared to conventional experimental and MD-based empirical equations.

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Numerical investigation of natural convection characteristics of a heat pipe-cooled passive residual heat removal system for molten salt reactors

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Nuclear Science and Techniques 2020年第7期31卷 25-33页

作者： Cheng-Long Wang Hao Qin Da-Lin Zhang Wen-Xi Tian Guang-Hui Su Sui-Zheng Qiu Department of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049China Shaanxi Key Laboratory of Advanced Nuclear Energy and Technology Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China

The limited availability of studies on the natural convection heat transfer characteristics of fluoride salt has hindered progress in the design of passive residual heat removal systems(PRHRS)for molten salt *** paper presents results from a numerical investigation of natural convection heat transfer characteristics of fluoride salt and heat pipes in the drain tank of a *** results are compared with experimental data,demonstrating the accuracy of the calculation *** distribution of fluoride salt and heat transfer characteristics are obtained and *** radial temperature of liquid fluoride salt in the drain tank shows a uniform distribution,while temperatures increase with increase in axial height from the bottom to the top of the drain *** addition,natural convection intensity increases with increase in height of the heat pipes in the *** between heat pipes has no obvious effect on the natural convection heat transfer *** study will contribute to the design of passive heat removal systems for advanced nuclear reactors.

关键词： passive characteristics pipes

Pore Scale Characterization of Gas–Water flow in Heterogeneous Layered Sandstone

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Energy & Fuels 2023年第24期37卷 19538-19547页

作者： Yongfei Yang Weichen Sun Hai Sun Lei Zhang Junjie Zhong Kai Zhang Jun Yao National Key Laboratory of Deep Oil and Gas China University of Petroleum (East China) Qingdao 266580 P. R. China Research Center of Multiphase Flow in Porous Media School of Petroleum Engineering China University of Petroleum (East China) Qingdao 266580 P. R. China

The existence of beddings and abundant interlayers in sandstone reservoirs severely hinders the exploration and extraction of sandstone gas reservoir resources. In this study, layered heterogeneous sandstone cores were constructed to explore the impact of sandstone layered heterogeneity on gas–water flow, and the gas–water displacement process was imaged by using X-ray tomography. The changes in the fluid distribution were studied with the help of imaging data. After displacement began, under the influence of heterogeneity, fluid entered the dominating channel made up of big pores preferentially, which had a poor displacement effect in the low permeability layer. In the low permeability layer, a large amount of residual gas was stranded downstream in dead-end corners because there were no efficient seepage channels. Using the residual gas’s shape and distribution properties, three categories─network, multiple, and singlet─were divided. The results show that, with the succession, the large-volume connected network residual gas dominant in pore space was dispersed into smaller multiple residual gas; due to poor connection, the initial percentage of the network residual gas in the low permeability layer of the core was lower than the initial percentage of the network residual gas in the high permeability layer, and the extent of the network residual gas’ dispersion was also less than in the core’s high permeability layer; after increasing back pressure, due to the difficulty in retaining multiple residual gas in the core’s high permeability layer, in comparison to the core’s low permeability layer, the core’s high permeability layer had a larger fraction of singlet residual gas. Only multiple and singlet residual gas remained in the pore space. This study offers fundamental knowledge for the investigation of the gas–water flow law in heterogeneous sandstone, which may help to further enhance the gas reservoir recovery in heterogeneous sandstone.

关键词： Cluster chemistry Fluids Layers Permeability Water

Steady-State Multi-Physics Coupling Analysis of Heat Pipe Cooled Reactor Core

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SSRN 2022年

作者： Zhang, Zhipeng Wang, Chenglong Guo, Kailun Tian, Wenxi Qiu, Suizheng Su, Guanghui Department of Nuclear Science and Technology Shaanxi Key Lab. of Advanced Nuclear Energy and Technology Xi’an Jiaotong University Shaanxi Xi’an710049 China State Key Laboratory of Multiphase Flow in Power Engineering China

Due to the advantages of mobility, safety and universality, the heat pipe reactors have great competitiveness in many applications such as strategic defense locations, remote communities, and emergency locations. In addition, most of the heat pipe reactors are designed as solid-state reactors, which avoid the two-phase flow problem caused by the coolant transformation and make it possible to analyze the reactor with multiple physical field coupling. In this work, a typical heat pipe reactor has been carried out a 3-D neutronic-thermal-mechanical analysis, and steady state analysis is performed by OpenMC coupled with COMSOL. Coupling calculation results show that under normal operation, the maximum temperature and thermal expansion of core is 1338.94 K and 2.53 mm. In the steady-state coupling process, the influence of temperature parameters on physical calculation is mainly reflected in k eff and its power level, the maximum temperature drops from 1347.26 K to 1338.94 K, but it has little influence on power distribution. By coupling calculations, the maximum stress of the reactor is reduced by 5.78 MPa. The research results will support the subsequent development of multi-physics coupled transient analysis code for heat pipe reactors. © 2022, The Authors. All rights reserved.

关键词： Heat pipes