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Mpox(formerly monkeypox):pathogenesis,prevention,and treatment

Signal Transduction and Targeted Therapy 2024年第1期9卷 234-248页

作者： Junjie Lu Hui Xing Chunhua Wang Mengjun Tang Changcheng Wu Fan Ye Lijuan Yin Yang Yang Wenjie Tan Liang Shen Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and ScienceHubei ProvinceXiangyang 441021China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China College of Biotechnology Tianjin University of Science&TechnologyTianjin 300457China Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for infectious diseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China

In 2022,a global outbreak of Mpox(formerly monkeypox)occurred in various countries across Europe and America and rapidly spread to more than 100 countries and *** World Health Organization declared the outbreak to be a public health emergency of international concern due to the rapid spread of the Mpox ***,nations intensified their efforts to explore treatment strategies aimed at combating the infection and its ***,the available therapeutic options for Mpox virus infection remain *** far,only a few numbers of antiviral compounds have been approved by regulatory *** the high mutability of the Mpox virus,certain mutant strains have shown resistance to existing pharmaceutical *** highlights the urgent need to develop novel antiviral drugs that can combat both drug resistance and the potential threat of ***,there is a lack of comprehensive literature on the pathophysiology and treatment of *** address this issue,we conducted a review covering the physiological and pathological processes of Mpox infection,summarizing the latest progress of anti-Mpox *** analysis encompasses approved drugs currently employed in clinical settings,as well as newly identified small-molecule compounds and antibody drugs displaying potential antiviral efficacy against ***,we have gained valuable insights from the process of Mpox drug development,including strategies for repurposing drugs,the discovery of drug targets driven by artificial intelligence,and preclinical drug *** purpose of this review is to provide readers with a comprehensive overview of the current knowledge on Mpox.

关键词： prevention treatment intensified

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Research on longitudinal control technology in the transition section of tilt-rotor aircraft based on linear active disturbance rejection control 2

Research on longitudinal control technology in the transitio...

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2023 2nd International Conference on Aerospace and control Engineering, ICoACE 2023

作者： Xu, Shaofeng Chang, Shaoping Shi, Pengfei Wang, Lin AVIC Xi'An Flight Automatic Control Research Institute Xi'an710065 China National Key Laboratory of Science and Technology on Aircraft Control Xi'an710065 China

To solve the problem of strong coupling and control redundancy in the transition section of the tilt-rotor, this paper presents a longitudinal control method based on linear active disturbance rejection control (LADRC), verified by simulation. Firstly, the nonlinear dynamics model of tilt-rotor aircraft based on the mechanism method is established, and the model's accuracy is verified by comparing the trim result with the generic tilt-rotor aircraft simulation (GTRS) model verified by flight test in XV-15. Then, the control and redundant rudder surface assignment strategies for tilt-rotor aircraft are proposed. Then, the vertical and vertical control law of tilt-rotor aircraft is designed, the linear expansion state observer (LESO) model is analyzed and derived, and the linear active disturbance rejection controller suitable for attitude loop control of tilt-rotor is designed. The altitude and velocity loops are controlled. Finally, the proposed linear active disturbance rejection control (LADRC) controller is verified by simulation, and the whole process of tilting transition is simulated. The results show that the proposed control strategy and the controller designed in this paper have strong anti-disturbance ability, fast response speed, and high control precision and can be used in the transition section of tilt-rotor aircraft. The vertical direction shall be well controlled. © Published under licence by IOP Publishing Ltd.

关键词： controllers

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Correcting on-chip distortion of control pulses with silicon spin qubits

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Chinese Physics B 2025年第1期34卷 265-271页

作者： Ming Ni Rong-Long Ma Zhen-Zhen Kong Ning Chu Wei-Zhu Liao Sheng-Kai Zhu Chu Wang Gang Luo Di Liu Gang Cao Gui-Lei Wang Hai-Ou Li Guo-Ping Guo CAS Key Laboratory of Quantum Information University of Science and Technology of China(USTC)Hefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Integrated Circuit Advanced Process Research and Development Center Institute of MicroelectronicsChinese Academy of Sciences(CAS)Beijing 100029China Hefei National Laboratory Hefei 230088China Beijing Superstring Academy of Memory Technology Beijing 100176China Origin Quantum Computing Company Limited Hefei 230026China

In semiconductor quantum dot systems,pulse distortion is a significant source of coherent errors,which impedes qubit characterization and ***,we demonstrate two calibration methods using a two-qubit system as the detector to correct distortion and calibrate the transfer function of the control *** methods are straightforward to implement,robust against noise,and applicable to a wide range of qubit *** two methods differ in correction accuracy and *** first,coarse predistortion(CPD)method,partially mitigates *** second,all predistortion(APD)method,measures the transfer function and significantly enhances exchange oscillation *** methods use exchange oscillation homogeneity as the metric and are suitable for any qubit driven by a diabatic *** believe these methods will enhance qubit characterization accuracy and operation quality in future applications.

关键词： quantum computation quantum dot pulse distortion

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Analysis of Transceiver RF Impairments on Artificial Noise Suppression in Frequency-Hopping Systems

IEEE Transactions on Sustainable Computing

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IEEE Transactions on Sustainable Computing 2024年第3期10卷 475-490页

作者： Song, Changqing Zhao, Hongzhi Yu, Yong Li, Zhuo Shao, Shihai University of Electronic Science and Technology of China National Key Laboratory of Wireless Communications Chengdu611731 China Laboratory of Electromagnetic Space Cognition and Intelligent Control Beijing100089 China Yangzhou Marine Electronic Instrument Institute Yangzhou225101 China

The artificial noise shielded frequency-hopping (ANFH) architecture can secure wireless communications against interference and eavesdropping. However, the AN suppression performance is highly sensitive to the radio frequency (RF) impairments, and the transceiver in-phase and quadrature (IQ) imbalances and phase noise in FH systems are more severe for the wide FH bandwidth. In this study, the AN-FH transceivers under RF impairments are mathematically modeled. Subsequently, distortions for transceiver phase noise are represented by the common phase error, distortions for transceiver IQ imbalances are represented by the mirror image component, and closed-form expressions for their respective power are derived and compared with the thermal noise power. Finally, the AN suppression capability is evaluated via the AN suppression ratio (ANSR), defined as the ratio of the AN-plus-noise power before and after suppression. It is found that when only phase noise exists, shortening the channel compensation cycle can enhance ANSR and reduce ANSR degradation;when the distortions' power is smaller than the thermal noise power, it is also recommended to enhance the transmitting power and the power ratio of AN to information signals. When only IQ imbalances exist, increasing the power ratio of AN to information signals is suggested;when the distortions' power is smaller than the thermal noise power, enhancing the transmitting power is also suggested © 2016 IEEE.

关键词： Phase noise

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An Optimization Method for the Swing of a Quadrotor Flight Suspension System 25

An Optimization Method for the Swing of a Quadrotor Flight S...

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25th IEEE China Conference on System Simulation technology and its Application, CCSSTA 2024

作者： Yang, Sen Zang, Xinlian Tong, Jigang Xie, Tian Jin, Xin Tianjin University of Technology The School of Electrical Engineering and Automation Tianjin China AVIC Xi'an Flight Automatic Control Research Institute National key laboratory of science and technology on aircraft control Xi'an China

ISBN: (纸本)9798350366600

The aim of this study is to explore optimization control methods for suspension systems during the flight of quadcopters. The traditional control method of suspension system has some problems such as oscillation and instability, so an optimization scheme based on Gaussian pseudo-general algorithm is proposed in this paper. Through numerical simulation and actual flight test, the effectiveness of the optimization algorithm in improving system stability and reducing oscillation amplitude is verified. At the same time, this study conducted a comparative analysis of the suspension system of the quadrotor vehicle and the free fall body, and the optimization algorithm is found to be feasible and can well improve the control accuracy and stability of the system, and provide strong support for the safety of the quadrotor vehicle in various application scenarios. © 2024 IEEE.

关键词： Flight testing

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Four ribbons of double-layer graphene suspending masses for NEMS applications

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Microsystems & Nanoengineering 2024年第5期10卷 277-286页

作者： Xuge Fan Chang He Jie Ding Sayedeh Shirin Afyouni Akbari Wendong Zhang Advanced Research Institute of Multidisciplinary Sciences Bejing Institute of Technology100081 BeijingChina School of Integrated Circuits and Electronics Bejing Institute of Technology100081 BeijingChina Center for Interdisciplinary Science of Optical Quantum and NEMS Integration Beijing 100081China Advanced NEMS Group Ecole Polytechnique Federale de Lausanne(EPFL)1015 LausanneSwitzerland State Key Laboratory of Dynamic Measurement Technology North University of ChinaTaiyuan 030051China National Key Laboratory for Electronic Measurement Technology School of Instrument and ElectronicsNorth University of ChinaTaiyuan 030051China

Graphene ribbons with a suspended proof mass for nanomechanical systems have been rarely ***,we report three types of nanomechanical devices consisting of graphene ribbons(two ribbons,four ribbons-cross and four ribbons-parallel)with suspended Si proof masses and studied their mechanical *** resonance frequencies and built-in stresses of three types of devices ranged from tens of kHz to hundreds of kHz,and from 82.61 MPa to 545.73 MPa,respectively,both of which decrease with the increase of the size of proof *** devices with four graphene ribbons featured higher resonance frequencies and spring constants,but lower built-in stresses than two ribbon devices under otherwise identical *** Young's modulus and fracture strain of double-layer graphene were measured to be 0.34 TPa and 1.13%respectively,by using the experimental data and finite element analysis(FEA)*** studies would lay the foundation for understanding of mechanical properties of graphene ribbons with a suspended proof mass and their potential applications in nanoelectromechanical systems.

关键词： proof layer double

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A Enhanced Feature Extraction for 3D Object Detection 25

A Enhanced Feature Extraction for 3D Object Detection

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25th IEEE China Conference on System Simulation technology and its Application, CCSSTA 2024

作者： Meng, Qingao Tong, Jigang Yang, Sen Xie, Tian Jin, Xin Tianjin University of Technology The School of Electrical Engineering and Automation Tianjin China Avic Xi'an Flight Automatic Control Research Institute National Key Laboratory of Science and Technology on Aircraft Control Xi'an China

ISBN: (纸本)9798350366600

3D object detection is crucial for autopilot and augmented reality applications. However, accurate feature extraction is the key to achieve high-precision detection, but traditional methods face the challenges of information loss and computational inefficiency. To address this, we propose an enhanced feature extraction method. We first divide the 3D space into voxel grids of varying scales. Then, using 3D sparse convolution, we extract features which are compressed along the Z axis to form BEV (Bird's Eye View) feature images. An efficient multi-scale attention mechanism is then employed to enhance these BEV features. The refined feature map is subsequently located and classified through a CT-stacking module and RPN (Region Proposal Network). Voxel features from the proposal and 3D backbone are passed through a voxel RoI pool to directly extract RoI features from the 3D features for further refinement. Finally, a cascaded attention network refines the proposal and strengthens confidence prediction. Experiments on test set validate our method effectiveness, showing improved accuracy over traditional voxel methods. Overall, this enhanced feature extraction technique offers a promising solution for 3D target detection, particularly in scenarios demanding high real-time performance and precision. © 2024 IEEE.

关键词： Feature extraction

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Diminishing ether-oxygen content of electrolytes enables temperature-immune lithium metal batteries

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science China Chemistry 2023年第9期66卷 2700-2710页

作者： Tao Liu Jingnan Feng Zhe Shi Huajun Li Weina Zhao Minglei Mao Xiangzhen Zhu Yong-Sheng Hu Hong Li Xuejie Huang Liquan Chen Liumin Suo Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Department of Nuclear Science and Engineering and Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control Guangdong Key Laboratory of Environmental Catalysis and Health Risk ControlSchool of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China

The reversibility of lithium(Li) metal anodes is highly susceptible to temperature,owing to the aggravated side reactions at high temperatures and serious Li dendrite growth at low *** it is extremely challenging to simultaneously realize the high Li reversibility in both low and high temperature ***,an oxygen-free solvent(n-hexane,HEX) assisted with the hexyl methyl ether and 1 mol L^(-1)lithium bis(fluorosulfonyl)imide is proposed to constitute an electrolyte for temperatureimmune lithium metal *** demonstrates that the HEX not only greatly suppresses the solvent reduction even at high temperatures but also weaken the Li~+-solvent interaction for the facile Li-ion desolvation,leading to high Li Coulombic efficiencies(99.59% at 25℃,99.30%at 60℃ and 98.75% at -30℃) and the dendrite-free Li plating from -30℃ to 60℃.Benefitting from the low density and temperature-immune properties of our electrolyte,the sulfurized polyacrylonitrile(3.8mAh cm^(-2))||Li(60 μm) pouch-cells deliver 278 Wh kg^(-1)energy density and maintain the stable performance over 50 cycles,and retain 248 and 320 Wh kg^(-1) energy density at -30℃ and 60℃,*** work provides a new perspective on the electrolyte design for wide-temperature Li metal batteries.

关键词： wide temperature range oxygen-free solvent dendrite-free Li plating high Coulombic efficiencies lithium metal batteries

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Application of Ag-based materials in high-performance lithium metal anode:A review

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材料科学技术（英文版） 2023年第2期133卷 165-182页

作者： Zhongxiu Liu Sihu Ha Yong Liu Fei Wang Feng Tao Binrui Xu Renhong Yu Guangxin Wang Fengzhang Ren Hongxia Li Provincial and Ministerial Co-Construction of Collaborative Innovation Center for Non-Ferrous Metal New Materials and Advanced Processing Technology Henan Key Laboratory of Non-Ferrous Materials Science & Processing TechnologySchool of Materials Science and EngineeringHenan University of Science and TechnologyLuoyang 471023China Provincial and Ministerial Co-Construction of Collaborative Innovation Center for Non-Ferrous Metal New Materials and Advanced Processing Technology Henan Key Laboratory of Non-Ferrous Materials Science & Processing TechnologySchool of Materials Science and EngineeringHenan University of Science and TechnologyLuoyang 471023China National Joint Engineering Research Center for Abrasion Control and Molding of Metal Materials Henan Key Laboratory of High-Temperature Structural and Functional MaterialsHenan University of Science and TechnologyLuoyang 471003China School of Electrical Engineering Henan University of Science and TechnologyLuoyang 471023China State Key Laboratory of Advanced Refractories Sinosteel Luoyang Institute of Refractories Research Co.Ltd.Luoyang 471039China

Li metal is a promising candidate for battery anodes due to its high theoretical specific capacity(3860 mAh g-1)and low electrochemical potential(-3.04 V).Nevertheless,the challenges for Li metal include uncontrolled dendrites growth,unstable solid electrolyte interface,and infinite volume expansion during Li plating and stripping,which limit the further development of lithium metal anodes(LMAs).Intro-ducing Ag-based materials in LMAs is regarded as one of the most effective solutions to solve the above-mentioned problems,which have received considerable attention because of their superior characteristics,such as high electrical conductivity,outstanding lithiophilicity,and excellent mechanical ***,we review the recent progress on the application of Ag-based materials in ***,the theo-retical mechanism of Ag-based materials and their advantages in LMAs are *** addition,the relationship between their fabrication strategies,micro/nanostructures,and electrochemical performances is systematically ***,the challenges and opportunities for the future research and appli-cation of Ag-based materials in lithium metal batteries are proposed based on the available academic knowledge.

关键词： Ag-based materials Nucleation sites Current collectors Lithium metal anodes Electrochemical performance

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Thermal stability of Pd-Au core-shell nanostructures in an in-situ liquid TEM 4

Thermal stability of Pd-Au core-shell nanostructures in an i...

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2024 4th International Conference on Advanced Materials and Chemical Engineering, AMCE 2024

作者： Meng, Dehuan Liu, Shuai Wang, Weiping Wang, Zixin Hu, Xiaoyan Zhang, Xue Information Science Academy of China Electronics Technology Group Corporation Beijing China National Key Laboratory of Integrated Circuits and Microsystems Beijing100042 China China

The investigation of the thermal stability and evolution of Pd-Au core-shell nanostructures across various temperatures proceeded with in situ heating transmission electron microscopy (TEM) along with spectral analysis techniques. In situ heating transmission electron microscopy (TEM) was utilized to examine the morphology and elemental distribution of core-shell nanostructures composed of Pd0.5-Au0.5 and Pd0.9-Au0.1, which were synthesized via the seed growth technique. Compared with the Pd0.5-Au0.5 core-shell nanostructures, the Pd0.9-Au0.1 core-shell nanostructures have better thermal stability. © Published under licence by IOP Publishing Ltd.

关键词： Shells (structures)

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