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Circulating short-chain and branched short-chain fatty acids and the risk of incident type 2 diabetes: findings from the 4C study

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Life Metabolism 2025年第2期 29-38页

作者： Shuangyuan Wang Hong Lin Xiaojing Jia Yiting Lin Chunyan Hu Mian Li Yu Xu Min Xu Jie Zheng Xinjie Zhao Yanli Li Lulu Chen Tianshu Zeng Ruying Hu Zhen Ye Lixin Shi Qing Su Yuhong Chen Xuefeng Yu Li Yan Tiange Wang Zhiyun Zhao Guijun Qin Qin Wan Gang Chen Meng Dai Di Zhang Bihan Qiu Xiaoyan Zhu Ruixin Liu Xiao Wang Xulei Tang Zhengnan Gao Feixia Shen Xuejiang Gu Zuojie Luo Yingfen Qin Li Chen Xinguo Hou Yanan Huo Qiang Li Guixia Wang Yinfei Zhang Chao Liu Youmin Wang Shengli Wu Tao Yang Huacong Deng Jiajun Zhao Yiming Mu Guowang Xu Shenghan Lai Donghui Li Guang Ning Weiqing Wang Yufang Bi Jieli Lu the 4C Study Group Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People's Republic of China Shanghai National Center for Translational Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics Chinese Academy of Sciences Department of Endocrine and Metabolic Diseases Union Hospital Tongji Medical College Huazhong University of Science and Technology Zhejiang Provincial Center for Disease Control and Prevention Department of Endocrine and Metabolic Diseases Affiliated Hospital of Guiyang Medical College Department of Endocrine and Metabolic Diseases Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Endocrine and Metabolic Diseases Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Endocrine and Metabolic Diseases Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Endocrine and Metabolic Diseases The First Affiliated Hospital of Zhengzhou University Department of Endocrine and Metabolic Diseases The Affiliated Hospital of Southwest Medical University Department of Endocrine and Metabolic Diseases Fujian Provincial Hospital Fujian Medical University Department of Endocrine and Metabolic Diseases The First Hospital of Lanzhou University Department of Endocrine and Metabolic Diseases Dalian Municipal Central Hospital Department of Endocrine and Metabolic Diseases The First Affiliated Hospital of Wenzhou Medical University Department of Endocrine and Metabolic Diseases The First Affiliated Hospital of Guangxi Medical University Department of Endocrine and Metabolic Diseases Qilu Hospital of Shandong Univ

Previous studies suggested that fecal short-chain fatty acids（SCFAs） and branched short-chain fatty acids（BCFAs） are associated with glucose regulation. However, the potential relationship between circulating SCFAs and BCFAs with incident diabetes risk in both men and women remains unidentified in prospective cohort studies. In this study, we examined a panel of nine serum SCFAs and BCFAs in 3414 subjects with incident diabetes, and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort study. In fully adjusted conditional logistic regression models, total SCFAs, total BCFAs, and isovaleric acid were significantly associated with incident type 2 diabetes mellitus（T2DM）(P < 0.05). Interestingly, gender-specific analysis showed that per standard deviation（SD） increment of SCFAs were positively associated with incident T2DM among women, with the odds ratio（95% confidence interval） of 1.16（1.05-1.29） for total SCFAs and 1.18（1.07-1.31） for propionate, respectively(P < 0.05, false discovery rate（FDR） < 0.05). No significant associations were observed in men. A significant interaction was detected between men and women for propionate(Pinteraction< 0.001, FDR < 0.01). After further adjustment of insulin measurements, the associations of serum propionate with diabetes remained significant（P < 0.05, FDR < 0.05）. Meanwhile, the associations of total BCFAs and isovaleric acid with diabetes were partially mediated by triglycerides, insulin resistance, and β-cell function in mediation analysis. These findings, for the first time in a large prospective cohort, provide evidence for an association between circulating SCFAs and BCFAs with T2DM risk, and support the potential role of circulating propionate with gender disparities in the early pathogenesis of diabetes.

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Mobile population dynamics and malaria vulnerability:a modelling study in the China-Myanmar border region of Yunnan Province,China

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Infectious Diseases of Poverty 2018年第1期7卷 355-365页

作者： Tian-Mu Chen Shao-Sen Zhang Jun Feng Zhi-Gui Xia Chun-Hai Luo Xu-Can Zeng Xiang-Rui Guo Zu-Rui Lin Hong-Ning Zhou Shui-Sen Zhou Department of Malaria National Institute of Parasitic DiseasesChinese Center for Disease Control and Prevention207 Rui Jin Er RoadShanghai 200025People’s Republic of China WHO Collaborating Centre for Tropical Diseases 207 Rui Jin Er RoadShanghai 200025People’s Republic of China National Center for International Research on Tropical Diseases Ministry of Science and Technology207 Rui Jin Er RoadShanghai 200025People’s Republic of China Key Laboratory of Parasite and Vector Biology Ministry of Health207 Rui Jin Er RoadShanghai 200025People’s Republic of China Yunnan Institute of Parasitic Diseases PuerPeople’s Republic of China Yingjiang County Center for Disease Control and Prevention DehongPeople’s Republic of China

Background:The China-Myanmar border region presents a great challenge in malaria elimination in China,and it is essential to understand the relationship between malaria vulnerability and population mobility in this ***:A community-based,cross-sectional survey was performed in five villages of Yingjiang county during September ***-prick blood samples were obtained to identify asymptomatic infections,and imported cases were identified in each village(between January 2013 and September 2016).A stochastic simulation model(SSM)was used to test the relationship between population mobility and malaria vulnerability,according to the mechanisms of malaria ***:Thirty-two imported cases were identified in the five villages,with a 4-year average of 1 case/year(range:0-5 cases/year).No parasites were detected in the 353 blood samples from *** median density of malaria vulnerability was 0.012(range:0.000-0.033).The average proportion of mobile members of the study population was 32.56%(range:28.38-71.95%).Most mobile individuals lived indoors at night with mosquito *** SSM model fit the investigated data(χ2=0.487,P=0.485).The average probability of infection in the members of the population that moved to Myanmar was 0.011(range:0.0048-0.1585).The values for simulated vulnerability increased with greater population mobility in each ***:A high proportion of population mobility was associated with greater malaria vulnerability in the China-Myanmar border *** population-specific measures should be used to decrease the risk of malaria re-establishment in China.

关键词： Malaria Importation Vulnerability Mobile population Individual-based model

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Author Correction: Traps and transport resistance are the next frontiers for stable non-fullerene acceptor solar cells

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Nature communications 2022年第1期13卷 4475页

作者： Christopher Wöpke Clemens Göhler Maria Saladina Xiaoyan Du Li Nian Christopher Greve Chenhui Zhu Kaila M Yallum Yvonne J Hofstetter David Becker-Koch Ning Li Thomas Heumüller Ilya Milekhin Dietrich R T Zahn Christoph J Brabec Natalie Banerji Yana Vaynzof Eva M Herzig Roderick C I MacKenzie Carsten Deibel Institut für Physik Technische Universität Chemnitz 09126 Chemnitz Germany. Institute of Materials for Electronics and Energy Technology (i-MEET) Friedrich-Alexander-Universität Erlangen-Nürnberg 91054 Erlangen Germany. Helmholtz Institute Erlangen-Nürnberg for Renewable Energy (HI ERN) Immerwahrstrasse 2 91058 Erlangen Germany. Guangdong Provincial Key Laboratory of Optical Information Materials and Technology Institute of Electronic Paper Displays South China Academy of Advanced Optoelectronics South China Normal University Guangzhou 510006 P. R. China. Physikalisches Institut Dynamik und Strukturbildung - Herzig Group Universität Bayreuth Universitätsstr. 30 95447 Bayreuth Germany. Advanced Light Source Lawrence Berkeley National Laboratory Berkeley CA 94720 USA. Department of Chemistry and Biochemistry University of Bern 3012 Bern Switzerland. Integrated Center for Applied Photophysics and Photonic Materials Technische Universität Dresden 01062 Dresden Germany. Center for Advancing Electronics Dresden Technische Universität Dresden 01062 Dresden Germany. State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and Devices School of Materials Science and Engineering South China University of Technology 381 Wushan Road 510640 Guangzhou China. Department of Engineering Durham University Lower Mount Joy South Road Durham DH1 3LE UK. Institut für Physik Technische Universität Chemnitz 09126 Chemnitz Germany. deibel@physik.tu-chemnitz.de.

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2型糖尿病患者的体力活动、久坐行为与心血管疾病患病风险的关系——MIDiab研究（英文）

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Engineering 2023年第1期 26-35页

作者：武亚飞秦贵军王桂侠刘礼斌陈兵管庆波袁中尚侯旭高聆徐潮张海清张栩李秋宋勇峰景斐马世瞻邵珊珊赵萌郭庆玲童南伟赵红燕谢晓敏刘超单忠艳成志锋余学峰陈述林杨涛王颜刚李冬梅闫朝丽郭立新姬秋和王文绢赵家军 Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases Shandong Provincial Hospital Affiliated to Shandong First Medical University Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases Shandong First Medical University Department of Endocrine and Metabolic Diseases The First Affiliated Hospital of Zhengzhou University Department of Endocrinology and Metabolism First Hospital of Jilin University Department of Endocrinology and Metabolism Fujian Medical University Union Hospital Endocrinology Department The Southwest Hospital of AMU Department of Biostatistics School of Public Health Shandong University Department of Endocrinology and Metabolism West China Hospital of Sichuan University Department of Endocrine and Metabolic Diseases Ruijin Hospital Shanghai Jiao Tong University School of Medicine Department of Endocrinology The First People's Hospital of Yinchuan Department of Endocrinology Nanjing Integrated Traditional Chinese and Western Medicine Hospital (the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine) Department of Endocrinology and Metabolism & Institute of Endocrinology the First Hospital of China Medical University Department of Endocrinology the Fourth Affiliated Hospital of Harbin Medical University Division of Endocrinology Department of Internal Medicine Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology Department of Endocrinology Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College Department of Endocrinology the First Affiliated Hospital of Nanjing Medical University Department of Endocrinology and Metabolic Diseases the Affiliated Hospital of Qingdao University Division of Endocrinology Department of Internal Medicine Inner Mongolia Autonomous Region People's Hospital Department of Endocrinology the Affiliated Hospital of Inner Mongolia Medic

本文的研究目的是探讨中国2型糖尿病（type 2 diabetes mellitus, T2DM）患者的中等至剧烈强度身体活动（Moderate-to-vigorous-intensity physical activity, MVPA）时间和久坐（sedentary,SED）时间与心血管疾病（cardiovascular disease, CVD）风险及多种因素[即血压（blood pressure, BP）、体重指数（body mass index, BMI）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol, LDL-C）和糖化血红蛋白A1（glycated hemoglobin A1c, HbA1c）]控制状况的关系。本研究为一项基于9152名T2DM人群的横断面研究，数据来自于“Multifactorial Intervention on Type 2 Diabetes Study”，简称MIDiab研究。根据患者自我报告的MVPA时间和SED时间，将身体活动水平分为：低(<150 min·week–1)、中(150～450 min·week–1)、高(≥450min·week–1)三组；久坐行为水平也分为：低(<4 h·d–1)、中(4～8 h·d–1)、高(≥8 h·d–1)三组。本研究的主要结局指标是CVD，将有自我报告CVD疾病史的患者定义为有CVD风险。采用混合效应逻辑回归模型估计与MVPA时间和SED时间相关的CVD风险和多因素控制状态的优势比（odds ratio, OR）及95%置信区间（confidence interval, CI），对中国地理区域特征进行调整。本研究人群年龄的平均±标准差为（60.87±8.44）岁，其中44.5%为女性，25.1%的患者自我报告有CVD疾病史。校正潜在的混杂因素后，发现高水平的MVPA时间与CVD风险之间存在负相关关系，且独立于SED时间，然而在中等水平MVPA时间组没有观察到这种关联。与低水平身体活动组的参与者相比，高水平身体活动组的人更容易达到BMI的目标水平。进一步评估二者对CVD风险的联合作用，与参照组(即SED时间<4 h·d–1和MVPA时间≥450 min·week–1)相比，低水平身体活动组(MVPA时间<150 min·week–1)的CVD患病风险显著升高。其中，与SED时间<4 h·d–1相关的OR值为1.270（95%CI为1.040～1.553），与SED时间≥8 h·d–1相关的OR值为1.499（95%CI为1.149～1.955）。在T2DM患者中，长时间的久坐行为(即≥8 h·d–1的SED时间)与CVD风险增加有关；高水平的身体活动(即MVPA时间≥450 min·week–1)与CVD患病风险降低有关，且独立于SED时间。

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我国流行的非洲猪瘟病毒颗粒精细三维结构解析

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中国预防兽医学报 2019年第11期41卷 1188-1188页

作者： Wang Nan Zhao Dongming CAS Key Laboratory of Infection and Immunity National Laboratory of Macromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China. University of Chinese Academy of Sciences Beijing 100049 China. State Key Laboratory of Veterinary Biotechnology and National High Containment Laboratory for Animal Diseases Control and Prevention Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150069 China. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech University Shanghai 201210 China. Laboratory of Structural Biology School of Medicine Tsinghua University Beijing 100084 China. State Key Laboratory of Medicinal Chemical Biology Nankai University Tianjin 300353 China.

非洲猪瘟(African Swine Fever,ASF)是猪的一种烈性传染性病毒病,死亡率接近100%,被世界动物卫生组织(OIE)列为需要通报的动物疫病,我国列为一类动物疫病。ASF于1921年在肯尼亚首次发现,至今已有近百年的历史。该疫病从非洲传播至欧洲... 详细信息

非洲猪瘟(African Swine Fever,ASF)是猪的一种烈性传染性病毒病,死亡率接近100%,被世界动物卫生组织(OIE)列为需要通报的动物疫病,我国列为一类动物疫病。ASF于1921年在肯尼亚首次发现,至今已有近百年的历史。该疫病从非洲传播至欧洲、南美洲、亚洲等多个国家。近一年来,非洲猪瘟病毒传播速度明显加快,呈现愈演愈烈趋势,据国际动物健康组织通报数据显示,2019年1月至2019年9月期间,曾爆发或者正在爆发非洲猪瘟疫情的国家有23个,包含12个欧洲国家、9个亚洲国家和2个非洲国家,其中亚洲几个国家的疫情尤为严重。

关键词：非洲猪瘟世界动物卫生组织一类动物疫病动物健康 OIE 传播速度三维结构数据显示

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Composite Learning for Trajectory Tracking control of Robot Manipulators with Output Constraints

Composite Learning for Trajectory Tracking Control of Robot ...

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International Conference on Information science and technology (ICIST)

作者： Dianye Huang Chenguang Yang Yongping Pan Shilu Dai Zhaojie Ju Key Laboratory of Autonomous Systems and Networked Control College of Automation Science and Engineering South China University of Technology Guangzhou China Department of Biomedical Engineering National University of Singapore Singapore Singapore School of Computing University of Portsmouth Portsmouth UK

In this paper, a trajectory tracking scheme for robot manipulators with unknown dynamics is investigated, with the consideration of output constraints as well as small bounded external disturbances. Firstly, a modified backstepping control scheme is employed to control the robot manipulators where in the first step of the design a tan-type barrier Lyapunov candidate is chosen in order to tackle the constraint problem. Secondly, the philosophy of dynamic surface control is incorporated to implement the calculation of prediction errors, which can also reduce “explosion of complexity” of the backstepping scheme. In addition, composite learning is introduced for a better estimation of unknown parameters, and for canceling out the uncertainties of the robot manipulators. Stability analysis shows that the proposed control scheme guarantees a small bounded tracking error with parameter convergence in the absence of the stringent persistent excitation condition. Finally, a simulation is conducted and the results demonstrate the superiority of the proposed controller in the aspects of tracking capability and parameter estimation.

关键词： Manipulator dynamics Backstepping Uncertainty control systems Convergence

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Noise-based control of opinion dynamics

arXiv

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arXiv 2018年

作者： Su, Wei Chen, Xianzhong Yu, Yongguang Chen, Ge School of Automation and Electrical Engineering University of Science and Technology Beijing Key Laboratory of Knowledge Automation for Industrial Processes Ministry of Education Beijing100083 China School of Science Beijing Jiaotong University Beijing100044 China National Center for Mathematics and Interdisciplinary Sciences Key Laboratory of Systems and Control Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing100190 China

Designing feasible control strategies for opinion dynamics in complex social systems has never been an easy task. It requires a control protocol which 1) is not enforced on all individuals in the society, and 2) does not exclusively rely on specific opinion values shared by the social system. Thanks to the recent studies on noise-induced consensus in opinion dynamics, the noise-based intervention strategy has emerged as the only one meeting both of the above requirements, yet its underlying general theory is still lacking. In this paper, we perform rigorous theoretical analysis and simulations of a noise-based control strategy for opinion formation in which only a fraction of individuals is affected by randomly generated noise. We found that irrespective of the number of noise-driven individuals, including the case of only one single noise-affected individual, the system can attain a quasi-consensus in finite time, and the critical noise strength can be obtained. Our results highlight the efficiency of noise-driven mechanisms for the control of complex social dynamics. Copyright © 2018, The Authors. All rights reserved.

关键词： Dynamics

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Optimal estimation of parameters for scalar field in an expanding spacetime exhibiting Lorentz invariance violation

arXiv

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arXiv 2018年

作者： Liu, Xiaobao Jing, Jiliang Wang, Jieci Tian, Zehua Department of Physics Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of Education Synergetic Innovation Center for Quantum Effects and Applications Hunan Normal University Changsha Hunan410081 China CAS Key Laboratory of Microscale Magnetic Resonance Department of Modern Physics University of Science and Technology of China Hefei230026 China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Hefei230026 China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Hefei230026 China Key Laboratory for Research in Galaxies and Cosmology Chinese Academy of Science 96 JinZhai Road Hefei Anhui230026 China

We address the optimal estimation of quantum parameters, in the framework of local quantum estimation theory, for a massive scalar quantum field in the expanding Robertson-Walker universe exhibiting Lorentz invariance violation (LIV). The information about the history of the expanding spacetime in the presence of LIV can be extracted by taking measurements on the entangled state of particle modes. We find that, in the estimation of cosmological parameters, the ultimate bounds to the precision of the Lorentz-invariant massive scalar field can be improved due to the effects of LIV under some appropriate conditions. We also show that, in the Lorentz-invariant massive scalar field and massless scalar field due to LIV backgrounds, the optimal precision can be achieved by choosing the particles with some suitable LIV, cosmological and field parameters. Moreover, in the estimation of LIV parameter during the spacetime expansion, we prove that the appropriate momentum mode of field particles and larger cosmological parameters can provide us a better precision. Particularly, the optimal precision of the parameters estimation can be obtained by performing projective measurements implemented by the projectors onto the eigenvectors of specific probe states. Copyright © 2018, The Authors. All rights reserved.

关键词： Parameter estimation

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The effects of ZnO doping on microstructure and microwave dielectric properties of Li3Mg2TaO6 ceramics with rock salt structure

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IOP Conference Series: Materials science and Engineering 2019年第1期479卷

作者： X Zhang B Tang S R Zhang State Key Laboratory of Multi-Spectral Absorbing Materials and Structures of Ministry of Education University of electronic Science and Technology of China Chengdu 610054 PR China National Engineering Research Center of Electromagnetic Radiation Control Materials University of Electronic Science and Technology of China Chengdu 610054 PR China

In this study, the ZnO doping Li3Mg2TaO6 were prepared by solid state reaction method. The correlations between microstructure and microwave dielectric characterizations of Li3Mg2-x Zn x TaO6(x = 0~0.5) ceramics were systematically investigated. All the samples showed the single phase of Li3Mg2TaO6 with orthorhombic structure in Fddd (70) space group, and the structure refinement results showed the increase of the cell volume with the increasing x. The SEM images indicated that the dense structures were obtained in the range of 0~0.3, and a small amount of ZnO impurity phase was observed in grain boundaries because of the evaporation of ZnO in the high sintering temperature. The r and τ f increased as the ZnO content increased. The Q × f value increase firstly with the increasing x, to the maximum at x = 0.3, and then decreased. As sintered at 1270 °C for 4h, the Li3Mg1.7Zn0.3TaO6 (x = 0.3) ceramics showed the excellent microwave properties: r = 20.61, Q × f = 106,863 GHz and τf = -21.6 ppm/°C.

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Unsupervised feature learning architecture with multi-clustering integration RBM

arXiv

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arXiv 2018年

作者： Chu, Jielei Wang, Hongjun Liu, Jing Gong, Zhiguo Li, Tianrui Institute of Artificial Intelligence School of Information Science and Technology Southwest Jiaotong University Chengdu611756 China National Engineering Laboratory of Integrated Transportation Big Data Application Technology Southwest Jiaotong University Chengdu611756 China School of Business Sichuan University ChengduSichuan610065 China State Key Laboratory of Internet of Things for Smart City Department of Computer and Information Science University of Macau China

In this paper, we present a novel unsupervised feature learning architecture, which consists of a multi-clustering integration module and a variant of RBM termed multi-clustering integration RBM (MIRBM). In the multi-clustering integration module, we apply three unsupervised K-means, affinity propagation and spectral clustering algorithms to obtain three different clustering partitions (CPs) without any background knowledge or label. Then, an unanimous voting strategy is used to generate a local clustering partition (LCP). The novel MIRBM model is a core feature encoding part of the proposed unsupervised feature learning architecture. The novelty of it is that the LCP as an unsupervised guidance is integrated into one step contrastive divergence (CD1) learning to guide the distribution of the hidden layer features. For the instance in the same LCP cluster, the hidden and reconstructed hidden layer features of the MIRBM model in the proposed architecture tend to constrict together in the training process. Meanwhile, each LCP center tends to disperse from each other as much as possible in the hidden and reconstructed hidden layer during training. The experiments demonstrate that the proposed unsupervised feature learning architecture has more powerful feature representation and generalization capability than the state-of-the-art graph regularized RBM (GraphRBM) for clustering tasks in the Microsoft Research Asia Multimedia (MSRA-MM)2.0 dataset. Copyright © 2018, The Authors. All rights reserved.

关键词： Integration

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