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Punicalagin alleviates hypercholesterolemia in mice through modulating farnesoid X receptor signaling and modulating gut microbiota

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Food science and Human Wellness 2025年第1期14卷 175-189页

作者： Huanhuan Liu Hongli Liu Chunhong Yan Jiaxiu Liu Yu Cao Guopeng Li Xiaodong Xia State Key Laboratory of Marine Food Processing and Safety Control National Engineering Research Center of SeafoodSchool of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Punicalagin has been demonstrated to exhibit anti-oxidant and anti-inflammatory properties,but whether and how it could impact hypercholesterolemia remains not fully *** aim of this study was to investigate the influence of punicalagin on hypercholesterolemia in mice and its related *** 6 weeks'intervention,punicalagin significantly reduced serum total cholesterol and low-density lipoprotein cholesterol(LDL-C)levels in mice fed a high-fat high-cholesterol(HFHC)***,punicalagin supplementation lowered hepatic cholesterol level,which corresponded to the down-regulation of cholesterol synthesis genes(Fdps,Cyp51)and up-regulated bile acid synthesis genes(Cyp7a1,Cyp27a1).In addition,bile acid reabsorption was retarded in punicalagin-fed mice through down-regulating ileal apical sodium-dependent BA transporter(ASBT).Furthermore,intestinal farnesoid X receptor(FXR)-fibroblast growth factor 15(Fgf15)pathway was inhibited while hepatic FXR-small heterodimeric partner(SHP)pathway was activated in punicalagin *** analysis and targeted metabolomics showed that punicalagin decreased the abundance of bile-salt hydrolase(BSH)-producing bacteria(Clostridiaceae and Bifidobacteriaceae)and the ratio of primary BAs to secondary *** conclusion,the cholesterol-lowering effect of punicalagin partly through down-regulating cholesterol synthesis and increasing cholesterol catabolism,which could be achieved by regulating gut microbiota,altering bile acid composition and modulating FXR signaling *** findings indicate the potential application of punicalagin-related products as an alternative strategy for hypercholesterolemia prevention and mitigation.

关键词： Punicalagin Hypercholesterolemia Farnesoid X receptor Bile acid metabolism Gut microbiota

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Strong π-Metal Interaction Enables Liquid Interfacial Nanoarray-Molecule Co-assembly for Raman Sensing of Ultratrace Fentanyl Doped in Heroin, Ketamine, Morphine, and Real Urine

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ACS Applied Materials and Interfaces 2023年第9期15卷 12570-12579页

作者： Ding, Zhongxiang Wang, Chao Song, Xin Li, Ning Zheng, Xinyong Wang, Chenxue Su, Mengke Liu, Honglin China Light Industry Key Laboratory of Meat Microbial Control and Utilization School of Food and Biological Engineering Hefei University of Technology Hefei230009 China National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei230027 China Hefei Public Security Bureau Hefei230009 China

Toward the challenge on reliable determination of trace fentanyl to avoid opioid overdose death in drug crisis, here we realize rapid and direct detection of trace fentanyl in real human urine without pretreatment by a portable surface enhanced Raman spectroscopy (SERS) strategy on liquid/liquid interfacial (LLI) plasmonic arrays. It was observed that fentanyl could interact with the gold nanoparticles (GNPs) surface, facilitate the LLI self-assembly, and consequently amplify the detection sensitivity with a limit of detection (LOD) as low as 1 ng/mL in aqueous solution and 50 ng/mL spiked in urine. Furthermore, we achieve multiplex blind sample recognition and classification of ultratrace fentanyl doped in other illegal drugs, which has extremely low LODs at mass concentrations of 0.02% (2 ng in 10 μg of heroin), 0.02% (2 ng in 10 μg of ketamine), and 0.1% (10 ng in 10 μg of morphine). A logic circuit of the AND gate was constructed for automatic recognition of illegal drugs with or without fentanyl doping. The data-driven analog soft independent modeling model could quickly distinguish fentanyl-doped samples from illegal drugs with 100% specificity. Molecular dynamics (MD) simulation elucidates the underlying molecular mechanism of nanoarray-molecule co-assembly through strong π-metal interactions and the differences in the SERS signal of various drug molecules. It paves a rapid identification, quantification, and classification strategy for trace fentanyl analysis, indicating broad application prospects in response to the opioid epidemic crisis. © 2023 American Chemical Society.

关键词： Molecules

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Time Delay Estimation Method for X-ray Pulsars Based on The Optimal Number of Bispectral Feature Points 3

Time Delay Estimation Method for X-ray Pulsars Based on The ...

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3rd IEEE International Conference on Computer Communication and Artificial Intelligence, CCAI 2023

作者： Huang, Zhiwei Zong, Hua Xie, Yujia Xu, Nuoqi Beijing Aerospace Automatic Control Institute National Key Laboratory of Science and Technology on Aerospace Intelligent Control Beijing China Beijing Electronic Technology Vocational College School of Economics and Management Beijing China

ISBN: (纸本)9798350335262

To enhance the accuracy and efficiency of X-ray pulsars time delay estimation, a novel time delay estimation method for X-ray pulsars based on the optimal number of bispectral feature points is proposed. The approach establishes the relationship between the time delay estimation error and the number of bispectral feature points used under different signalto-noise ratios, and gives a method to determine the optimal number of bispectral feature points involved in the estimation. We conduct simulation experiments for HXMT-Insight satellite observations of the Crab pulsar on Matlab R2017b. Results indicate that the average running time of the proposed algorithm is 50ms and the average error during observation intervals below 50s is 99. 0083us. Compared to the traditional bispectrum method, the proposed algorithm exhibits slightly higher accuracy and significantly improved running time. © 2023 IEEE.

关键词： Timing circuits

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Loading Effects of the Human Body on An Ultrawideband Wearable Textile Antenna 12

Loading Effects of the Human Body on An Ultrawideband Wearab...

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12th IEEE Asia-Pacific Conference on Antennas and Propagation, APCAP 2024

作者： Xu, Ziang Gao, Xiang Mao, Zhuzhang Tang, Wenfei Guo, Kun Beijing Institute of Technology School of Cyberspace Science and Technology Beijing100081 China National Key Laboratory of Science and Technology on Space-Born Intelligent Information Processing Beijing100081 China Beijing Institute of Technology School of Integrated Circuits and Electronics Beijing100081 China Beijing Institute of Technology School of Information and Electronics Beijing100081 China

ISBN: (纸本)9798350351019

This paper presents an ultrawideband wearable textile antenna for emergency communication applications, and investigates the loading effects of the human body on radiation performance of the antenna. The proposed antenna has a measured operating bandwidth from 0.31 to 1.2 GHz and an average realized gain of 3.32 dBi in free space. Furthermore, the results show that the antenna gain can effectively be improved by properly adjusting the distance between the human body and the antenna. © 2024 IEEE.

关键词： Wearable antennas

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Predefined-Time Distributed Fault-Tolerant control for Nonlinear Multiagent Systems Suffering From Nonaffine Faults

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IEEE Transactions on Systems, Man, and Cybernetics: Systems 2025年第5期55卷 3300-3311页

作者： Cheng, Shuai Xin, Bin Chen, Jie Deng, Fang Qingdao University School of Automation Qingdao266071 China Beijing Institute of Technology School of Automation Beijing100081 China Beijing Institute of Technology National Key Laboratory of Autonomous Intelligent Unmanned Systems Beijing100081 China Shanghai Research Institute for Intelligent Autonomous Systems Tongji University Department of Control Science and Engineering Shanghai200092 China

This article investigates the distributed predefined-time (PT) fault-tolerant control for nonlinear multiagent systems (NNMSs) with nonaffine faults. A novel distributed PT control scheme is proposed based on a new PT theorem. The switching functions are introduced into distributed control signals to avoid the singularity problem. The second-order filter technology is designed to solve "explosion of complexity" issues. The newly designed PT compensation signals are utilized to eliminate filter errors. The proposed distributed PT controller based on local information can guarantee that all signals of the closed-loop system are PT bounded, and consensus errors of NNMSs can be enforced to a small region around the origin within a predefined time. Compared with the finite/fixed time, the predefined time is an exact value given in advance, which remains constant regardless of initial states and control parameters. Finally, two comparative simulations are provided to demonstrate the presented strategy. © 2013 IEEE.

关键词： Adaptive control systems

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A Novel Principal Component Analysis Algorithm for Fault Detection

A Novel Principal Component Analysis Algorithm for Fault Det...

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第43届中国控制会议

作者： Wang Shenhang Tian Kun Zheng Wei Liu Mengyu National Key Laboratory of Science and Technology on Aerospace Intelligent Control

ISBN: (数字)9789887581581

ISBN: (纸本)9798350366907

In modern industry,fault detection is very important in high-cost and safety-critical *** component analysis(PCA) is an effective data-driven approach which is widely used in this *** PCA is time-invariant,which often lead to false *** order to overcome the false alarms,recursive PCA algorithms have been proposed for adaptive ***,the amount of calculation of the algorithm is very great because of frequently updated *** this paper,a novel recursive PCA method is proposed for solving the question by introducing the standard residual *** standard residual method serves as an indicator of the level of consistency among data,which is used to decide whether or not to update the PCA *** proposed method is applied to fault detection and experiment results demonstrate the effectiveness of the method.

关键词： Principal component analysis fault detection standard residual method

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Inhomogeneous strain and doping of transferred CVD-grown graphene

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Rare Metals 2022年第5期41卷 1727-1734页

作者： Yu-Ting Niu Fang-Zhu Qing Xue-Song Li Bo Peng National Engineering Research Center of Electromagnetic Radiation Control Materials University of Electronic Science and Technology of ChinaChengdu 611731China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 611731China School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen 518110China

Chemical vapor deposition(CVD)-grown graphene on copper foils is subject to the Cu substrate, which affects the spatial distribution of strain and doping, thus influencing the electronic properties of graphene. However, plenty of electronic devices based on CVD-grown graphene require transfer process and the distribution of doping and strain in CVD-grown graphene transferred onto the insulating substrates remains elusive.

关键词： graphene transferred strain

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Predicting the Risk of Arterial Stiffness in Coal Miners Based on Different Machine Learning Models

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Biomedical and Environmental sciences 2024年第1期37卷 108-111页

作者： CHEN Qian Wei HUANG Xue Zan DING Yu ZHU Feng Ren WANG Jia ZOU Yuan Jie DU Yuan Zhen ZHANG Ya Jun HUI Zi Wen ZHU Feng Lin MU Min The Project was supported by Open Research Grant of Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHefei 232001AnhuiChina School of Public Health Anhui University of Science and TechnologyHefei 232001AnhuiChina Key Laboratory of Industrial Dust Prevention and Control Occupational Safety and HealthMinistry of EducationAnhui University of Science and TechnologyHefei 232001AnhuiChina Anhui Institute of Occupational Safety and Health Anhui University of Science and TechnologyHefei 232001AnhuiChina Joint Research Center of Occupational Medicine and Health Institute of Grand HealthHefei Comprehensive National Science CenterAnhui University of Science and TechnologyHefei 232001AnhuiChina Department of Occupational&Environmental Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina

Coal is one of the world’s main energy resources,accounting for approximately 68%of China’s current total power ***,several studies have demonstrated that dust,exhaust fumes,and other harmful factors in coal mines increase the risk of cardiovascular disease(CVD)among miners^([1]).Arterial stiffness(AS)is an independent risk factor of CVD,and epidemiological studies have shown that AS plays a vital role in assessing the risk of CVD^([2]).

关键词： Arterial cardiovascular assessing

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On-chip superconducting nanowire single-photon detectors integrated with pump rejection for entanglement characterization

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Photonics Research 2025年第4期13卷 1067-1073页

作者： ZHIYUN SHU YUCHI LI XIAOYU LIU HAILONG HAN YOU XIAO JIA HUANG HONGXIN XU WEI ZHANG LIXING YOU ZHEN WANG HAO LI Shanghai Key Laboratory of Superconductor Integrated Circuit Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Frontier Science Center for Quantum Information Electronic Engineering Department Tsinghua University Shanghai Research Center for Quantum Sciences

On-chip superconducting nanowire single-photon detectors (SNSPDs) are gaining traction in integrated quantum photonics due to their exceptional performance and the elimination of fiber coupling loss. However, off-chip high-rejection filters are commonly required to remove the intense pump light employed in quantum states generation, thus remaining the obstacle for embedding SNSPDs into quantum photonic circuits. Here, we explore the integration of SNSPDs with passive pump rejection filters, achieved by cascaded silicon Bragg gratings, on a single substrate.

关键词： Entanglement distribution Fiber losses Optical filters Ring resonators Subwavelength gratings Superconducting nanowire single photon detectors

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Spin–orbit torque in perpendicularly magnetized[Pt/Ni]multilayers

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Chinese Physics B 2023年第10期32卷 145-150页

作者：曹颖谢志成赵治源杨雨民雷娜缪冰锋魏大海 State Key Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China Fert Beijing Institute MIIT Key Laboratory of SpintronicsSchool of Integrated Circuit Science and EngineeringBeihang UniversityBeijing 100191China National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China

The performance of spin–orbit torque(SOT)in heavy metal/ferromagnetic metal periodic multilayers has attracted widespread *** this paper,we have successfully fabricated a series of perpendicular magnetized[Pt(2-t)/Ni(t)]_4 multilayers,and studied the SOT in the multilayers by varying the thickness of Ni layer *** current induced magnetization switching was achieved with a critical current density of 1×10^(7)A/cm^(2).The damping-like SOT efficiencyξ_(DL)was extracted from an extended harmonic Hall *** demonstrated that theξ_(DL)can be effectively modulated by t_(Pt)/t_(Ni)ratio of Pt and Ni in the *** SOT investigation about the[Pt/Ni]N multilayers might provide new material candidates for practical perpendicular SOT-MRAM devices.

关键词： spin–orbit torque perpendicular magnetic anisotropy spintronics

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