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Dietary supplementation with N‑acetyl‑L‑cysteine ameliorates hyperactivated ERK signaling in the endometrium that is linked to poor pregnancy outcomes following ovarian stimulation in pigs

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Journal of Animal science and Biotechnology 2025年第1期16卷 167-181页

作者： Linghua Cheng Zhicheng Shi Yuan Yue Yue Wang Yusheng Qin Wei Zhao Yupei Hu Qin Li Min Guo Lei An Shumin Wang Jianhui Tian Frontiers Science Center for Molecular Design Breeding(MOE) State Key Laboratory of Animal Biotech BreedingKey Laboratory of Animal GeneticsBreeding and Reproduction of the Ministry of Agriculture and Rural AffairsNational Engineering Laboratory for Animal BreedingCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193People’s Republic of China

Background Exogenous gonadotropin-controlled ovarian stimulation is the critical step in animal reproductive management,such as pig,sheep,bovine and other *** helps synchronize ovulation or stimulate multiple ***,a number of evidence indicated an unexpected decrease in pregnancy outcomes following ovarian *** study aimed to explore the underlying mechanism of the pregnancy defect and develop a practical rescue *** Compared with those in the control group,gilts that underwent ovarian stimulation showed a decrease in pregnancy rate,farrowing rate,and total number of piglets *** gilts also showed an increase in estra-diol(E_(2))*** supraphysiologicalE_(2) level was correlated with the decrease in the number of piglets ***,we found that high levels ofE_(2) impair uterine receptivity,as shown by the overproliferation of endo-metrial epithelial *** vitro mechanistic studies demonstrated that high levels ofE_(2) hyperactivate FGF-FGFR-ERK signaling cascade in the uterine endometrium,and in turn induces overproliferation of endometrial epithelial *** note,N-acetyl-L-cysteine(NAC)supplementation effectively inhibits ERK hyperphosphorylation and ameliorates endometrial epithelial ***,in vivo experiments indicated that dietary NAC supplementa-tion,compared with ovarian stimulation group,improves the uterine receptivity in gilts,and significantly increases the pregnancy rate and total number of piglets *** Ovarian stimulation-induced supraphysiological levels ofE_(2) impairs uterine receptivity by hyperactivat-ing FGF-FGFR-ERK signaling cascade,thereby reducing pregnancy rate and litter *** NAC to a con-ventional diet for gilts ameliorates hyperactivated ERK signaling and improves uterine receptivity,thus rescuing adverse pregnancy outcomes following ovarian stimulation.

关键词： Estradiol Gonadotropin Implantation N-acetyl-L-cysteine Ovarian stimulation Uterine receptivity

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Tailoring conductive network Zn@NPC@MWCNTs nanocomposites derived from ZIF-8 as high-performance electromagnetic absorber for the whole X-Band

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Defence technology（防务技术） 2023年第5期23卷 189-200页

作者： Shi-bin Lu Ying Meng Hai-bo Wang Xian-wei Jiang Jin Yang Ning Wei Lin Jin Li-juan Wan Hao Tang Qian-qian Hou Anhui Province Key Laboratory of Simulation and Design for Electronic Information System Hefei Normal UniversityHefei230601PR China Universities Joint Key Laboratory of Photoelectric Detection Science and Technology in Anhui Province Hefei Normal UniversityHefei230601PR China

A porous 3D cross-linked conductive network pierced by multi-wall carbon nanotubes(MWCNTs) was successfully designed from zeolitic imidazolate framework-8(ZIF-8). Zn@NPC@MWCNTs composites were tailored by the facile regulating the mass ratios and thermal annealing treatment. Due to the combination of less eddy current loss and dielectric loss together with multiple reflection attenuation caused by a unique structure. With a 10 wt% filler loading, the Zn@NPC@MWCNTs composites carbonized at 800℃ show two high reflection loss(RL) values with different thicknesses. An RL value is-53.18 dB with 4.09 mm thickness in the C-Band(4-8 GHz), and a minimum RL can reach-74.83 d B(10.8 GHz)with a matching thickness of 2.749 mm. The effective absorption bandwidth is 4 GHz(from 8 to 12 GHz,RL ≤-10 d B), which just covers the full X-band. Low cost and easy preparation can also provide advantages to develop MOF-based materials as effective EMW absorbents.

关键词： ZIF-8 Electromagnetic wave absorption X-band C-Band

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Eco-friendly polysaccharide coatings for antifouling and dragreduction and potential application for marine devices

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Friction 2024年第4期12卷 726-744页

作者： Hao YANG Liguo QIN Wenhui ZHAO Fagla Jules MAWIGNON Hui GUO Yongkang WU Yali ZHANG Guangneng DONG Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Institute of Design Science and Basic ComponentsSchool of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Biomedical Information of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Department of Endocrinology First Affiliated Hospital of Medical CollegeXi'an Jiaotong UniversityXi’an 710061China

Traditional antifouling agents usually have a certain toxic effect on marine environments and non-target *** this study,Dictyophora indusiata polysaccharide(DIP)was applied as a natural antifouling surface modifier to prepare the surface coating for marine *** DIP coatings were prepared:*** spore polysaccharide(DISP),*** volva polysaccharide(DIVP),and *** embryonic body polysaccharide(DIEP).The antifouling,tribological,and anticorrosion behavior of the coatings were *** revealed that the three kinds of DIP coatings had excellent antifouling properties,which could effectively prevent the adhesion of Chlorella and the attachment of water-based and oily stains on the ***,the coatings showed great mechanical stability and could maintain an extremely low coefficient of friction(COF<0.05)after continuous *** drag reduction rate of the coated surfaces reached 5%,showing a powerful lubrication ***,the DIP coatings presented an outstanding corrosion resistance,where the equivalent circuit impedances were 4-9 orders of magnitude higher than the control *** research showed a promising prospect of surface coating fabrication with DIP for marine devices to achieve the purpose of antifouling and drag reduction.

关键词： Dictyophora indusiata polysaccharide(DIP)coating antifouling anticorrosion lubrication and drag reduction

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Research on Mitigation Measures for Severe Accident Source Terms of Small Modular reactor 23rd

Research on Mitigation Measures for Severe Accident Source T...

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23rd Pacific Basin Nuclear Conference, PBNC 2022

作者： Xu, Tao Han, Dujuan Zhang, Bin Wang, Junlong Liu, Jiajia Wu, Yirui Tian, Chao Xia, Mingming Ma, Haifu Science and Technology On Reactor System Design Technology Laboratory Nuclear Power Institute of China Sichuan Chengdu China School of Nuclear Science and Technology Xi’an Jiaotong University Shaanxi Xi’an China

ISBN: (纸本)9789811987793

Small modular reactor (ACP100), as a key scientific and technological project of third-generation nuclear power technology of china national Nuclear Corporation, must achieve the purpose of eliminating large-scale radioactive substances release. In order to meet this requirement, it is necessary to study the source term release and mitigation of small modular reactor in severe accident. In this paper, ISAA code is used to model the small modular reactor, and the typical severe accident sequence is selected to simulate the accident and calculate the source term. Containment spray and double containment model are set up respectively. The feasibility and effectiveness of the two measures on the source term mitigation are illustrated by comparing the source term results. The calculation results show that containment spray and double containment can significantly alleviate the release of radionuclides under severe accident conditions, and can play a role in reducing radioactivity. Meanwhile, for double containment, the leak rate from the inner containment to the annular space has a great impact on the mitigation of the source terms. To reduce the release of the source term to the environment, it should be reduced as far as possible. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Sensitivity analysis

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Development and Verification of a New Depletion, Activation and Radiation Source Term Calculation Code 23rd

Development and Verification of a New Depletion, Activation ...

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23rd Pacific Basin Nuclear Conference, PBNC 2022

作者： Wen, Xingjian Zhai, Zian Tang, Songqian Tian, Chao Liu, Zhouyu Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Sichuan Chengdu China Xi’an Jiaotong University Xi’anShaanxi China

ISBN: (纸本)9789819910229

Existing depletion and source term calculation codes lack flexible interfaces, which is difficult to meet the actual engineering design needs. Based on the Chebyshev rational approximation method, a new depletion, activation and source term calculation code TIST is developed and verified. Full-fidelity depletion library based on ENDF-VII.0 and EAF2010 contains 3837 isotopes is generated. Flexible interfaces are built-in to support cross sections from different sources for depletion and activation calculations. The EAF2010 library and the cross sections from the high-fidelity code NECP-X are adopted by TIST for the verification in this work. Based on the nuclide inventory of the depletion and activation calculation, the radiation source term calculation capability of TIST is developed, including the radioactivity, the decay heat, the neutron source and the photon source. The comparison results with NECP-X and FISPACT demonstrate good accuracy of TIST. © 2023, The Author(s).

关键词： Chemical activation

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Determining the nuclear temperature dependence on source neutron-proton asymmetry in heavy-ion reactions at intermediate energy

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Chinese Physics C 2023年第5期47卷 152-159页

作者：曲国峰黄宇郑华刘星泉 R.Wada 林炜平黄美容韩纪锋任培培杨振雷张鑫冷强钟 Key Laboratory of Radiation Physics and Technology of the Ministry of Education Sichuan UniversityChengdu 610064China Institute of Nuclear Science and Technology Sichuan UniversityChengdu 610064China School of Physics and Information Technology Shaanxi Normal UniversityXi'an 710119China Cyclotron Institute Texas A&M UniversityCollege StationTexas 77843USA College of Physics and Electronics information Inner Mongolia University for NationalitiesTongliao 028000China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610213China

In this article,we investigate the dependence of nuclear temperature on emitting source neutron-proton(N/Z)asymmetry with light charged particles(LCPs)and intermediate mass fragments(IMFs)generated from intermediate-velocity sources in thirteen reaction systems with different N/Z asymmetries,^(64)Zn on^(112)Sn,and^(70)Zn,^(64)Ni on^(112,124)Sn,^(58,64)Ni,^(197)Au,and^(232)Th at 40 MeV/*** apparent temperature values of LCPs and IMFs from different systems are deduced from the measured yields using two helium-related and eight carbon-related double isotope ratio thermometers,***,the sequential decay effect on the experimental apparent temperature deduction with the double isotope ratio thermometers is quantitatively corrected explicitly with the aid of the quantum statistical *** present treatment is an improvement compared to our previous studies in which an indirect method was adopted to qualitatively consider the sequential decay effect.A negligible N/Z asymmetry dependence of the real temperature after the correction is quantitatively addressed in heavy-ion reactions at the present intermediate energy,where a change of o.1 units in source N/Z asymmetry corresponds to an absolute change in temperature of an order of 0.03 to 0.29 MeV on average for LCPs and *** conclusion is in close agreement with that inferred qualitatively via the indirect method in our previous studies.

关键词： nuclear temperature N/Z asymmetry dependence Albergo thermometer sequential decay correction heavy-ion reactions at intermediate energy

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Force Analysis of the Overconstrained Mechanisms Based on Equivalent Stiffness Considering Limb Axial Deformation

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Chinese Journal of Mechanical Engineering 2023年第1期36卷 292-304页

作者： Jinwei Guo Yongsheng Zhao Bo Chen Guoxing Zhang Yundou Xu Jiantao Yao Parallel Robot and Mechatronic System Laboratory of Hebei Province Yanshan UniversityQinhuangdao066004China Key Laboratory of Advanced Forging&Stamping Technology and Science of Ministry of National Education Yanshan UniversityQinhuangdao066004China

Overconstrained mechanism has the advantages of large bearing capacity and high motion reliability,but its force analysis is complex and difficult because the mechanism system contains *** the limb axial deformation,taking typical 2SS+P and 7-SS passive overconstrained mechanisms,2SPS+P and 7-SPS active overconstrained mechanisms,and 2SPS+P and 7-SPS passive-input overconstrained mechanisms as examples,a new force analysis method based on the idea of equivalent stiffness is *** equivalent stiffness matrix of passive overconstrained mechanism is derived by combining the force balance and deformation compatibility equations with consideration of axial elastic limb *** relationship between the constraint wrench magnitudes and the external force,limb stiffness is *** equivalent stiffness matrix of active overconstrained mechanism is derived by combining the force balance and displacement compatibility ***,the relationship between the magnitudes of the actuated wrenches and the external force,limb stiffness is *** with the equivalent stiffness of the passive overconstrained mechanism,an analytical relationship between the actuated forces of passive-input overconstrained mechanism and the output displacement,limb stiffness is ***,adaptability of the equivalent stiffness to overconstrained mechanisms is discussed,and the effect of the limb stiffness on overconstrained mechanisms force distribution is *** research results provide a theoretical reference for the design,research and practical application of overconstrained mechanism.

关键词： Active overconstrained Passive overconstrained Passive-input overconstrained Equivalent stiffness Force distribution

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design of Static Semantic Analyzer for Code Generator Applied in Safety-Level I&C of NPPs 7th

Design of Static Semantic Analyzer for Code Generator Applie...

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7th International Symposium on Digital Instrumentation and Control technology for Nuclear Power Plant, SICPNPP 2023

作者： Lan, Lin Wang, Gang Tu, Jun Li, Zhe Huang, Di Zhang, Jia-Cheng Jiang, Wei Nuclear Power Institute of China Institute of Reactor Operation and Application Leshan Beijing China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of the China Chengdu Sichuan China

ISBN: (纸本)9789819934546

In the nuclear safety level I&C (Instrument and Control) area, the code generator plays an important role in developing the application software. The main function of the code generator is to translate the Lustre program corresponding to the graphical control algorithm into C code. Therefore, the reliability and quality of the code generator will directly affect the safe and reliable operation of nuclear power plants. In order to ensure the correctness of Lustre code, a static semantic analyzer is designed and developed to find the errors in source Lustre code. Its function is to check the correctness of the input source Lustre code, including identifier-checking declarations, identifier-checking programs, type-checking expressions and equations, clock-checking expressions and equations. According to the characteristics of Lustre language, the static semantic analyzer is designed and developed, and its function and correctness are verified by a large number of test cases. In this paper, mainly introducing the design and implementation of the static semantic analyzer. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Semantics

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Distributed Optimal Formation Control of Multiple Unmanned Surface Vehicles With Stackelberg Differential Graphical Game

IEEE Transactions on Artificial Intelligence

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IEEE Transactions on Artificial Intelligence 2024年第8期5卷 4058-4073页

作者： Yu, Kunting Li, Yongming Lv, Maolong Tong, Shaocheng Liaoning University of Technology College of Science Liaoning Jinzhou121001 China Dalian Maritime University Navigation College Liaoning Dalian116026 China Air Force Engineering University National Key Laboratory of Unmanned Aerial Vehicle Technology National Key Laboratory of Aerospace Power System and Plasma Technology College of Air Traffic Control and Navigation Shanxi Xi'an710051 China

In this work, a cooperative formation control methodology is proposed for multiple six-degree-of-freedom (six-DoF) unmanned surface vehicles (USVs) subject to input saturation. Our method includes several key steps. To begin, we formulate the optimal formation control problem for USVs as Stackelberg differential graphical games. According to this design principle, each USV is partitioned into a primary follower and a secondary follower. The primary followers coalesce into one team, while the secondary followers constitute another team independently. Second, a new type of barrier Lyapunov function (BLF) with a hyperbolic tangent function is introduced to indirectly constrain velocity vector. Third, an auxiliary system is established to compensate for the input saturation. Then, the Lyapunov stability theory is employed to prove that all closed-loop signals of multiple USVs are semiglobal uniform ultimate boundedness (SGUUB). Finally, we present the simulation results of our proposed control scheme. These results demonstrate the effectiveness and feasibility of our proposed methodology for cooperative formation control of multiple USVs. © 2020 IEEE.

关键词： Reinforcement learning

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Electrohydrodynamic printing for high resolution patterning of flexible electronics toward industrial applications

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InfoMat 2024年第2期6卷 28-56页

作者： Zhouping Yin Dazhi Wang Yunlong Guo Zhiyuan Zhao Liqiang Li Wei Chen Yongqing Duan State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhanthe People's Republic of China Optics Valley Laboratory Wuhanthe People's Republic of China Key Laboratory for Micro/Nano Technology and System of Liaoning Province Dalian University of TechnologyDalianthe People's Republic of China Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijingthe People's Republic of China Institute of Molecular Aggregation Sciences Tianjin UniversityTianjinthe People's Republic of China

Electrohydrodynamic(EHD)printing technique,which deposits micro/nanostructures through high electric force,has recently attracted significant research interest owing to their fascinating characteristics in high resolution(<1μm),wide material applicability(ink viscosity 1–10000 cps),tunable printing modes(electrospray,electrospinning,and EHD jet printing),and compatibility with flexible/wearable *** the laboratory level of the EHD printed electronics'resolution and efficiency is gradually approaching the commercial application level,an urgent need for developing EHD technique from laboratory into industrialization have been put ***,we first discuss the EHD printing technique,including the ink design,droplet formation,and key technologies for promoting printing efficiency/*** we summarize the recent progress of EHD printing in fabrication of displays,organic field-effect transistors(OFETs),transparent electrodes,and sensors and ***,a brief summary and the outlook for future research effort are presented.

关键词： display electrohydrodynamic printing flexible electronics organic field-effect transistor printhead

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