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arXiv 2020年

作者： Cho, Kyuhyoun Lee, Jeongwoo Chae, Jongchul Wang, Haimin Ahn, Kwangsu Yang, Heesu Lim, Eun-Kyung Maurya, Ram Ajor Astronomy Program Department of Physics and Astronomy Seoul National University Seoul08826 Korea Republic of Space Weather Research Laboratory New Jersey Institute of Technology University Heights NewarkNJ07102-1982 United States Big Bear Solar Observatory Big Bear CityCA92314-9672 United States Korea Astronomy and Space Science Institute Daejeon305-348 Korea Republic of

Chromospheric activities prior to solar flares provide important clues to solar flare initiation, but are as yet poorly understood. We report a significant and rapid Hα line broadening before the solar flare SOL2011-09-29T18:08, that was detected using the unprecedented high-resolution Hα imaging spectroscopy with the Fast Imaging Solar Spectrograph (FISS) installed on the 1.6 m New Solar Telescope (NST) at Big Bear Solar Observatory. The strong Hα broadening extends as a blue excursion up to −4.5 Å and as a red excursion up to 2.0 Å which implies a mixture of velocities in the range of −130 km s−1 to 38 km s−1 by applying the cloud model, comparable to the highest chromospheric motions reported before. The Hα blueshifted broadening lasts for about 4 minutes, and is temporally and spatially correlated with the start of a rising filament, which is later associated with the main phase of the flare as detected by the Atmosphere Imaging Assembly (AIA) onboard Solar Dynamics Observatory (SDO). The potential importance of this Hα blueshifted broadening as a preflare chromospheric activity is briefly discussed within the context of the two-step eruption model. Copyright © 2020, The Authors. All rights reserved.

关键词： Chromophores

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Computer-aided drug discovery of a dual-target inhibitor for ovarian cancer: therapeutic intervention targeting CDK1/TTK signaling pathway and structural insights in the NCI-60

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Computers in biology and medicine 2025年 193卷 110445页

作者： Sung-Ling Tang Maryam Rachmawati Sumitra Yu-Cheng Kuo Han-Lin Hsu Muhamad Ansar Sheng-Liang Huang Shih-Yu Lee Hong-Jaan Wang Bashir Lawal Alexander T H Wu Lung-Ching Chen Hsu-Shan Huang School of Pharmacy National Defense Medical Center Taipei 11490 Taiwan. PhD Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan. Department of Pharmacology School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan School of Post-Baccalaureate Chinese Medicine College of Chinese Medicine China Medical University Taichung 40604 Taiwan. Graduate Institute of Clinical Medicine Taipei Medical University Taipei 11031 Taiwan Division of Pulmonary Medicine Department of Internal Medicine Wanfang Hospital Taipei Medical University Taipei 11031 Taiwan. Ph.D. Program in the Clinical Drug Development of Herbal Medicine Taipei Medical University Taipei 110301 Taiwan. Graduate Institute of Aerospace and Undersea Medicine National Defense Medical Center Taipei 11490 Taiwan. UPMC Hillman Cancer Center University of Pittsburgh Pittsburgh PA USA. Ph.D. Program of Translational Medicine College of Science and Technology Taipei Medical University Taipei 11031 Taiwan. Division of Cardiology Department of Internal Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 11101 Taiwan. School of Pharmacy National Defense Medical Center Taipei 11490 Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan Ph.D. Program in Biotechnology Research and Development College of Pharmacy Taipei Medical University Taipei 11031 Taiwan. Electronic address: huanghs99@tmu.edu.tw.

Ovarian cancer remains the third most prevalent and deadliest gynecologic malignancy worldwide, with most patients eventually developing resistance to platinum-based chemotherapy. This highlights a critical unmet need for innovative multitargeted therapies to address current treatment challenges. In this study, we identified 35 differentially expressed genes (DEGs) through integrated analysis of four GEO ovarian cancer datasets, with validation using TCGA data. Gene Ontology (GO) and KEGG enrichment analyses highlighted key tumor-associated pathways, and protein-protein interaction (PPI) network modeling prioritized CDK1 and TTK as high-value therapeutic targets. We evaluated the association between molecular genomic features and drug responses across the NCI-60 ovarian cancer cell line panel (IGROV1, OVCAR-3, OVCAR-4, OVCAR-5, OVCAR-8, NCI/ADR-RES, and SK-OV-3), using a series of salicylanilide-derived compounds and four FDA-approved drugs (cabozantinib, paclitaxel, rapamycin, and niclosamide) from the NCI Developmental Therapeutics program (DTP). Among these, NSC765690 (MCC22) emerged as the most promising candidate. It demonstrated potent antiproliferative activity, high target selectivity, and strong binding affinity to both CDK1 and TTK. Multi-omics integration, combined with AI-driven network modeling, further elucidated NSC765690's mechanism of action and its relevance to ovarian cancer pathogenesis. Additionally, ADMET and pharmacokinetic profiling confirmed its favorable drug-like properties and low predicted toxicity. Collectively, these findings establish NSC765690 as a potent dual-target inhibitor and exemplify a rational, data-driven drug discovery pipeline for overcoming chemotherapy resistance in ovarian cancer.

关键词： Dual-target small molecule inhibitor Machine learning Molecular docking Molecular dynamics simulations NCI-60 panel Ovarian cancer

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ψ(2S) Suppression in Pb-Pb Collisions at the LHC

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Physical Review Letters 2024年第4期132卷 042301-042301页

作者： S. Acharya D. Adamová A. Adler G. Aglieri Rinella M. Agnello N. Agrawal Z. Ahammed S. Ahmad S. U. Ahn I. Ahuja A. Akindinov M. Al-Turany D. Aleksandrov B. Alessandro H. M. Alfanda R. Alfaro Molina B. Ali A. Alici N. Alizadehvandchali A. Alkin J. Alme G. Alocco T. Alt I. Altsybeev M. N. Anaam C. Andrei A. Andronic V. Anguelov F. Antinori P. Antonioli N. Apadula L. Aphecetche H. Appelshäuser C. Arata S. Arcelli M. Aresti R. Arnaldi I. C. Arsene M. Arslandok A. Augustinus R. Averbeck M. D. Azmi A. Badalà J. Bae Y. W. Baek X. Bai R. Bailhache Y. Bailung A. Balbino A. Baldisseri B. Balis D. Banerjee Z. Banoo R. Barbera F. Barile L. Barioglio M. Barlou G. G. Barnaföldi L. S. Barnby V. Barret L. Barreto C. Bartels K. Barth E. Bartsch F. Baruffaldi N. Bastid S. Basu G. Batigne D. Battistini B. Batyunya D. Bauri J. L. Bazo Alba I. G. Bearden C. Beattie P. Becht D. Behera I. Belikov A. D. C. Bell Hechavarria F. Bellini R. Bellwied S. Belokurova V. Belyaev G. Bencedi S. Beole A. Bercuci Y. Berdnikov A. Berdnikova L. Bergmann M. G. Besoiu L. Betev P. P. Bhaduri A. Bhasin M. A. Bhat B. Bhattacharjee L. Bianchi N. Bianchi J. Bielčík J. Bielčíková J. Biernat A. P. Bigot A. Bilandzic G. Biro S. Biswas N. Bize J. T. Blair D. Blau M. B. Blidaru N. Bluhme C. Blume G. Boca F. Bock T. Bodova A. Bogdanov S. Boi J. Bok L. Boldizsár A. Bolozdynya M. Bombara P. M. Bond G. Bonomi H. Borel A. Borissov A. G. Borquez Carcamo H. Bossi E. Botta Y. E. M. Bouziani L. Bratrud P. Braun-Munzinger M. Bregant M. Broz G. E. Bruno D. Budnikov H. Buesching S. Bufalino O. Bugnon P. Buhler Z. Buthelezi S. A. Bysiak M. Cai H. Caines A. Caliva E. Calvo Villar J. M. M. Camacho P. Camerini F. D. M. Canedo M. Carabas A. A. Carballo F. Carnesecchi R. Caron J. Castillo Castellanos F. Catalano C. Ceballos Sanchez I. Chakaberia P. Chakraborty S. Chandra S. Chapeland M. Chartier S. Chattopadhyay T. G. Chavez T. Cheng C. Cheshkov B. Cheynis V. Chibante Barroso D. D. Chinellato E. S. Chizzali J. Cho S. Cho P. Chochula P. Christakoglou C. H. Christensen P. Christianse Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France Nuclear Physics Institute of the Czech Academy of Sciences Husinec-Řež Czech Republic Johann-Wolfgang-Goethe Universität Frankfurt Institut für Informatik Fachbereich Informatik und Mathematik Frankfurt Germany European Organization for Nuclear Research (CERN) Geneva Switzerland Dipartimento DISAT del Politecnico and Sezione INFN Turin Italy INFN Sezione di Bologna Bologna Italy Variable Energy Cyclotron Centre Homi Bhabha National Institute Kolkata India Department of Physics Aligarh Muslim University Aligarh India Korea Institute of Science and Technology Information Daejeon Republic of Korea Faculty of Science P.J. Šafárik University Košice Slovak Republic Affiliated with an institute covered by a cooperation agreement with CERN Research Division and ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Darmstadt Germany INFN Sezione di Torino Turin Italy Central China Normal University Wuhan China Instituto de Física Universidad Nacional Autónoma de México Mexico City Mexico Dipartimento di Fisica e Astronomia dell’Università and Sezione INFN Bologna Italy University of Houston Houston Texas USA Department of Physics and Technology University of Bergen Bergen Norway INFN Sezione di Cagliari Cagliari Italy Institut für Kernphysik Johann Wolfgang Goethe-Universität Frankfurt Frankfurt Germany Horia Hulubei National Institute of Physics and Nuclear Engineering Bucharest Romania Westfälische Wilhelms-Universität Münster Institut für Kernphysik Munster Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany INFN Sezione di Padova Padova Italy Lawrence Berkeley National Laboratory Berkeley California USA SUBATECH IMT Atlantique Nantes Université CNRS-IN2P3 Nantes France Laboratoire de Physique Subatomique et de Cosmologie Université Grenoble-Alpes CNRS-IN2P3 Grenoble France Department of Physics University of Oslo

The production of the ψ(2S) charmonium state was measured with ALICE in Pb-Pb collisions at sNN=5.02 TeV, in the dimuon decay channel. A significant signal was observed for the first time at LHC energies down to zer... 详细信息

关键词： Color confinement Relativistic heavy-ion collisions Quarkonia

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Front Cover: Emergence of Non-photoresponsive Catalytic Techniques for Environmental Remediation and Energy Generation (Chem. Asian J. 9/2023)

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Chemistry – An Asian Journal 2023年第9期18卷

作者： Manish Kumar Sharma Dr. Imran Khan Kuldeep Kaswan Dr. Snigdha Roy Barman Prof. Dr. Subhajit Saha Wu-Chiao Hsieh Prof. Dr. Yu-Lun Chueh Prof. Dr. Yu-Lin Wang Prof. Dr. Sangmin Lee Prof. Dr. Dukhyun Choi Prof. Dr. Zong-Hong Lin Department of Materials Science and Engineering National Tsing Hua University Hsinchu 30013 Taiwan Institute of NanoEngineering and Microsystems National Tsing Hua University Hsinchu 30013 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu 30013 Taiwan Department of Renewable Energy Maulana Abul Kalam Azad University of Technology West Bengal 741249 India Department of Obstetrics and Gynecology Chang Gung Memorial Hospital and College of Medicine Chang Gung University Taoyuan 333 Taiwan Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu 30013 Taiwan School of Mechanical Engineering Chung-Ang University Seoul 06974 South Korea Department of Mechanical Engineering Sungkyunkwan University Suwon 16419 South Korea Department of Biomedical Engineering National Taiwan University Taipei 10617 Taiwan

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First Measurement of Antideuteron Number Fluctuations at Energies Available at the Large Hadron Collider

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Physical Review Letters 2023年第4期131卷 041901-041901页

作者： S. Acharya D. Adamová A. Adler G. Aglieri Rinella M. Agnello N. Agrawal Z. Ahammed S. Ahmad S. U. Ahn I. Ahuja A. Akindinov M. Al-Turany D. Aleksandrov B. Alessandro H. M. Alfanda R. Alfaro Molina B. Ali Y. Ali A. Alici N. Alizadehvandchali A. Alkin J. Alme G. Alocco T. Alt I. Altsybeev M. N. Anaam C. Andrei A. Andronic V. Anguelov F. Antinori P. Antonioli C. Anuj N. Apadula L. Aphecetche H. Appelshäuser S. Arcelli R. Arnaldi I. C. Arsene M. Arslandok A. Augustinus R. Averbeck S. Aziz M. D. Azmi A. Badalà Y. W. Baek X. Bai R. Bailhache Y. Bailung R. Bala A. Balbino A. Baldisseri B. Balis D. Banerjee Z. Banoo R. Barbera L. Barioglio M. Barlou G. G. Barnaföldi L. S. Barnby V. Barret L. Barreto C. Bartels K. Barth E. Bartsch F. Baruffaldi N. Bastid S. Basu G. Batigne D. Battistini B. Batyunya D. Bauri J. L. Bazo Alba I. G. Bearden C. Beattie P. Becht D. Behera I. Belikov A. D. C. Bell Hechavarria R. Bellwied S. Belokurova V. Belyaev G. Bencedi S. Beole A. Bercuci Y. Berdnikov A. Berdnikova L. Bergmann M. G. Besoiu L. Betev P. P. Bhaduri A. Bhasin I. R. Bhat M. A. Bhat B. Bhattacharjee L. Bianchi N. Bianchi J. Bielčík J. Bielčíková J. Biernat A. Bilandzic G. Biro S. Biswas J. T. Blair D. Blau M. B. Blidaru N. Bluhme C. Blume G. Boca F. Bock T. Bodova A. Bogdanov S. Boi J. Bok L. Boldizsár A. Bolozdynya M. Bombara P. M. Bond G. Bonomi H. Borel A. Borissov H. Bossi E. Botta L. Bratrud P. Braun-Munzinger M. Bregant M. Broz G. E. Bruno M. D. Buckland D. Budnikov H. Buesching S. Bufalino O. Bugnon P. Buhler Z. Buthelezi J. B. Butt A. Bylinkin S. A. Bysiak M. Cai H. Caines A. Caliva E. Calvo Villar J. M. M. Camacho R. S. Camacho P. Camerini F. D. M. Canedo M. Carabas F. Carnesecchi R. Caron J. Castillo Castellanos F. Catalano C. Ceballos Sanchez I. Chakaberia P. Chakraborty S. Chandra S. Chapeland M. Chartier S. Chattopadhyay T. G. Chavez T. Cheng C. Cheshkov B. Cheynis V. Chibante Barroso D. D. Chinellato E. S. Chizzali S. Cho P. Chochula P. Christakoglou C. H. Christensen P. Christiansen T. Chujo M. Ciacco C. Cicalo L. C Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France Variable Energy Cyclotron Centre Homi Bhabha National Institute Kolkata India Nuclear Physics Institute of the Czech Academy of Sciences Husinec-Řež Czech Republic Johann-Wolfgang-Goethe Universität Frankfurt Institut für Informatik Fachbereich Informatik und Mathematik Frankfurt Germany European Organization for Nuclear Research (CERN) Geneva Switzerland Dipartimento DISAT del Politecnico and Sezione INFN Turin Italy INFN Sezione di Bologna Bologna Italy Department of Physics Aligarh Muslim University Aligarh India Korea Institute of Science and Technology Information Daejeon Republic of Korea Faculty of Science P.J. Šafárik University Košice Slovak Republic Affiliated with an institute covered by a cooperation agreement with CERN Research Division and ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Darmstadt Germany INFN Sezione di Torino Turin Italy Central China Normal University Wuhan China Instituto de Física Universidad Nacional Autónoma de México Mexico City Mexico COMSATS University Islamabad Islamabad Pakistan Dipartimento di Fisica e Astronomia dell’Università and Sezione INFN Bologna Italy University of Houston Houston Texas USA Department of Physics and Technology University of Bergen Bergen Norway INFN Sezione di Cagliari Cagliari Italy Institut für Kernphysik Johann Wolfgang Goethe-Universität Frankfurt Frankfurt Germany Horia Hulubei National Institute of Physics and Nuclear Engineering Bucharest Romania Westfälische Wilhelms-Universität Münster Institut für Kernphysik Münster Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany INFN Sezione di Padova Padova Italy Lawrence Berkeley National Laboratory Berkeley California USA SUBATECH IMT Atlantique Nantes Université CNRS-IN2P3 Nantes France Department of Physics University of Oslo Oslo Norway Yale University New Haven Connecticut USA L

The first measurement of event-by-event antideuteron number fluctuations in high energy heavy-ion collisions is presented. The measurements are carried out at midrapidity (|η|<0.8) as a function of collision centrality in Pb-Pb collisions at sNN=5.02 TeV using the ALICE detector. A significant negative correlation between the produced antiprotons and antideuterons is observed in all collision centralities. The results are compared with a state-of-the-art coalescence calculation. While it describes the ratio of higher order cumulants of the antideuteron multiplicity distribution, it fails to describe quantitatively the magnitude of the correlation between antiproton and antideuteron production. On the other hand, thermal-statistical model calculations describe all the measured observables within uncertainties only for correlation volumes that are different with respect to those describing proton yields and a similar measurement of net-proton number fluctuations.

关键词： Hadron-hadron interactions

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To and fro in the archipelago: Repeated inter-island dispersal and New Guinea's orogeny affect diversification of Delias, the world's largest butterfly genus

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Molecular Phylogenetics and Evolution 2024年 194卷 108022页

作者： Liang, Weijun Nunes, Renato Leong, Jing V. Carvalho, Ana Paula S. Müller, Chris J. Braby, Michael F. Pequin, Olivier Hoshizaki, Sugihiko Morinaka, Sadaharu Peggie, Djunijanti Badon, Jade Aster T. Mohagan, Alma B. Beaver, Ethan Hsu, Yu-Feng Inayoshi, Yutaka Monastyrskii, Alexander Vlasanek, Petr Toussaint, Emmanuel F.A. Benítez, Hugo A. Kawahara, Akito Y. Pierce, Naomi E. Lohman, David J. Department of Biology City College of New York City University of New York United States PhD Program in Biology Graduate Center City University of New York New York NY United States Biology Centre of the Czech Academy of Sciences Branisovska 31 Ceske Budejovice Czech Republic Faculty of Science Department of Zoology University of South Bohemia Ceske Budejovice Czech Republic McGuire Center for Lepidoptera and Biodiversity Florida Museum of Natural History University of Florida Gainesville FL United States Australian Museum Sydney NSW Australia Division of Ecology and Evolution Research School of Biology The Australian National University Acton ACT Australia Australian National Insect Collection Canberra ACT Australia 5 Avenue du Port Sibouliere Dinard France Department of Agricultural and Environmental Biology Graduate School of Agricultural and Life Sciences The University of Tokyo Yayoi Tokyo Bunkyo-ku Japan Saitama Study Center The Open University of Japan Ômiya-ku Japan Museum Zoologicum Bogoriense Research Center for Biosystematics and Evolution National Research and Innovation Agency Cibinong-Bogor Indonesia Animal Biology Division Institute of Biological Sciences University of the Philippines Los Baños Laguna Philippines Department of Biology College of Arts and Sciences and Center for Biodiversity Research & Extension in Mindanao Central Mindanao University Musuan Maramag Bukidnon Philippines College of Life Science National Taiwan Normal University Taipei Taiwan Sritana Condominium 2 96/173 Huay Kaeo Rd. T. Suthep A. Muang Chiang Mai Thailand Vietnam National Museum of Nature Vietnam Academy of Science and Technology Cau Giay Hanoi Viet Nam T.G. Masaryk Water Research Institute Prague Czech Republic Department of Entomology Natural History Museum of Geneva Geneva Switzerland Laboratorio de Ecología y Morfometría Evolutiva Centro de Investigación de Estudios Avanzados del Maule Universidad Católica del Maule Talca Chile Entomolo

The world's largest butterfly genus Delias, commonly known as Jezebels, comprises ca. 251 species found throughout Asia, Australia, and Melanesia. Most species are endemic to islands in the Indo-Australian Archipelago or to New Guinea and nearby islands in Melanesia, and many species are restricted to montane habitats over 1200 m. We inferred an extensively sampled and well-supported molecular phylogeny of the group to better understand the spatial and temporal dimensions of its diversification. The remarkable diversity of Delias evolved in just ca. 15–16 Myr (crown age). The most recent common ancestor of a clade with most of the species dispersed out of New Guinea ca. 14 Mya, but at least six subsequently diverging lineages dispersed back to the island. Diversification was associated with frequent dispersal of lineages among the islands of the Indo-Australian Archipelago, and the divergence of sister taxa on a single landmass was rare and occurred only on the largest islands, most notably on New Guinea. We conclude that frequent inter-island dispersal during the Neogene—likely facilitated by frequent sea level change—sparked much diversification during that period. Many extant New Guinea lineages started diversifying 5 Mya, suggesting that orogeny facilitated their diversification. Our results largely agree with the most recently proposed species group classification system, and we use our large taxon sample to extend this system to all described species. Finally, we summarize recent insights to speculate how wing pattern evolution, mimicry, and sexual selection might also contribute to these butterflies’ rapid speciation and diversification. © 2024 Elsevier Inc.

关键词： Aposematism Biogeographic stochastic mapping Divergence dating Indo-Australian archipelago Lepidoptera Sequence capture

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Correction: Biomass derived nitrogen functionalized carbon nanodots for nanomolar determination of levofloxacin in pharmaceutical and water samples

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Mikrochimica acta 2023年第7期190卷 269页

作者： Velusamy Arul Natarajan Sampathkumar Sindhuja Kotteeswaran Ponnusamy Arul Ahmed Muteb Aljuwayid Mohamed A Habila Mani Govindasamy Department of Chemistry Sri Eshwar College of Engineering (Autonomous) Coimbatore 641 202 Tamil Nadu India. kvarulchem6@***. Department of Chemistry Korea University 145 Anam-Ro Seongbuk-Gu Seoul South Korea. kvarulchem6@***. Department of Chemistry SSM College of Arts and Science Dindigul 624002 Tamil Nadu India. International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. Department of Chemical Engineering and Biotechnology Institute of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei 106 Taiwan ROC. vpsarul@***. Department of Chemistry College of Science King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia. International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. govindasamy420700@***. Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. govindasamy420700@***. Department of Research and Innovation Saveetha School of Engineering SIMATS 602105 Chennai India. govindasamy420700@***.

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Restoring Prohealing/Remodeling-Associated M2a/c Macrophages Using ON101 Accelerates Diabetic Wound Healing

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JID Innovations 2022年第5期2卷 100138-100138页

作者： Lin, Ching-Wen Chen, Chih-Chiang Huang, Wen-Yen Chen, Yen-Yu Chen, Shiou-Ting Chou, Hung-Wen Hung, Chien-Ming Chen, Wan-Jiun Lu, Chia-Sing Nian, Shi-Xin Chen, Shyi-Gen Chang, Hsuen-Wen Chang, Vincent H.S. Liu, Li-Ying Kuo, Ming-Liang Chang, Shun-Cheng Oneness Biotech Co. Ltd. Taipei Taiwan Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan Department of Dermatology School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Microbio Co. Ltd Taipei Taiwan NTU YongLin Institute of Health National Taiwan University Taipei Taiwan Division of Plastic and Reconstructive Surgery Department of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan TMU Laboratory Animal Center Office of Research and Development Taipei Medical University Taipei Taiwan Department of Physiology School of Medicine Taipei Medical University Taipei Taiwan The PhD Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Microbio Shanghai Co. Ltd. Shanghai China Division of Plastic Surgery Integrated Burn & Wound Care Center Department of Surgery Shuang-Ho Hospital Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei Taiwan

Diabetic wounds exhibit chronic inflammation and delayed tissue proliferation or remodeling, mainly owing to prolonged proinflammatory (M1) macrophage activity and defects in transition to prohealing/proremodeling (M2a/M2c;CD206⁺ and/or CD163⁺) macrophages. We found that topical treatment with ON101, a plant-based potential therapeutic for diabetic foot ulcers, increased M2c-like (CD163⁺ and CD206⁺) cells and suppressed M1-like cells, altering the inflammatory gene profile in a diabetic mouse model compared with that in the controls. An in vitro macrophage-polarizing model revealed that ON101 directly suppressed CD80⁺ and CD86⁺ M1-macrophage polarization and M1-associated proinflammatory cytokines at both protein and transcriptional levels. Notably, conditioned medium collected from ON101-treated M1 macrophages reversed the M1-conditioned medium‒mediated suppression of CD206⁺ macrophages. Furthermore, conditioned medium from ON101-treated adipocyte progenitor cells significantly promoted CD206⁺ and CD163⁺ macrophages but strongly inhibited M1-like cells. ON101 treatment also stimulated the expression of GCSF and CXCL3 genes in human adipocyte progenitor cells. Interestingly, treatment with recombinant GCSF protein enhanced both CD206⁺ and CD163⁺ M2 markers, whereas CXCL3 treatment only stimulated CD163⁺ M2 macrophages. Depletion of cutaneous M2 macrophages inhibited ON101-induced diabetic wound healing. Thus, ON101 directly suppressed M1 macrophages and facilitated the GCSF- and CXCL3-mediated transition from M1 to M2 macrophages, lowering inflammation and leading to faster diabetic wound healing. © 2022 The Authors

关键词： ADPC adipocyte progenitor cell CM conditioned medium HFD high-fat diet HG high-glucose IHC immunohistochemistry iNOS inducible nitric oxide synthase M1-CM M1-associated conditioned medium m-Clo mannosylated clodronate STAT3 signal transducer and activator of transcription 3

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The ALMA Survey of 70 μm Dark High-mass Clumps in Early Stages (ASHES). IX. Physical Properties and Spatial Distribution of Cores in IRDCs

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Astrophysical Journal 2023年第2期950卷 148-148页

作者： Morii, Kaho Sanhueza, Patricio Nakamura, Fumitaka Zhang, Qizhou Sabatini, Giovanni Beuther, Henrik Lu, Xing Li, Shanghuo Garay, Guido Jackson, James M. Olguin, Fernando A. Tafoya, Daniel Tatematsu, Ken’ichi Izumi, Natsuko Sakai, Takeshi Silva, Andrea Department of Astronomy Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan National Astronomical Observatory of Japan National Institutes of Natural Sciences 2-21-1 Osawa Mitaka Tokyo 181-8588 Japan Astronomical Science Program The Graduate University for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo 181-8588 Japan Center for Astrophysics Harvard & Smithsonian 60 Garden Street Cambridge 02138 MA United States INAF—Istituto di Radioastronomia—Italian node of the ALMA Regional Centre (It-ARC) Via Gobetti 101 Bologna I-40129 Italy INAF Osservatorio Astrofisico di Arcetri Largo E. Fermi 5 Firenze I-50125 Italy Max Planck Institute for Astronomy Konigstuhl 17 Heidelberg D-69117 Germany Shanghai Astronomical Observatory Chinese Academy of Sciences 80 Nandan Road Shanghai 200030 China Departamento de Astronomía Universidad de Chile Las Condes Santiago 7550000 Chile Green Bank Observatory 155 Observatory Rd Green Bank 24944 WV United States Institute of Astronomy Department of physics National Tsing Hua University Hsinchu 30013 Taiwan Department of Space Earth and Environment Chalmers University of Technology Onsala Space Observatory Onsala SE-439 92 Sweden Academia Sinica Institute of Astronomy and Astrophysics 11F of AS/NTU Astronomy-Mathematics Building No.1 Section 4 Roosevelt Road Taipei 10617 Taiwan Graduate School of Informatics and Engineering The University of Electro-Communications Chofu Tokyo 182-8585 Japan

The initial conditions found in infrared dark clouds (IRDCs) provide insights on how high-mass stars and stellar clusters form. We have conducted high-angular resolution and high-sensitivity observations toward thirty-nine massive IRDC clumps, which have been mosaicked using the 12 and 7 m arrays from the Atacama Large Millimeter/submillimeter Array. The targets are 70 μm dark massive (220-4900 M _⊙), dense (>10⁴ cm⁻³), and cold (∼10-20 K) clumps located at distances between 2 and 6 kpc. We identify an unprecedented number of 839 cores, with masses between 0.05 and 81 M _⊙ using 1.3 mm dust continuum emission. About 55% of the cores are low-mass (<1 M _⊙), whereas ≲1% (7/839) are high-mass (≳27 M _⊙). We detect no high-mass prestellar cores. The most massive cores (MMC) identified within individual clumps lack sufficient mass to form high-mass stars without additional mass feeding. We find that the mass of the MMCs is correlated with the clump surface density, implying denser clumps produce more massive cores. There is no significant mass segregation except for a few tentative detections. In contrast, most clumps show segregation once the clump density is considered instead of mass. Although the dust continuum emission resolves clumps in a network of filaments, some of which consist of hub-filament systems, the majority of the MMCs are not found in the hubs. Our analysis shows that high-mass cores and MMCs have no preferred location with respect to low-mass cores at the earliest stages of high-mass star formation. © 2023. The Author(s). Published by the American Astronomical Society.

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Measurement of ω meson production in pp collisions at = 13 TeV

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Journal of High Energy Physics 2025年第4期2025卷 1-30页

作者： Acharya, S. Adamová, D. Agarwal, A. Aglieri Rinella, G. Aglietta, L. Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. Ahn, S. U. Ahuja, I. Akindinov, A. Akishina, V. Al-Turany, M. Aleksandrov, D. Alessandro, B. Alfanda, H. M. Alfaro Molina, R. Ali, B. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alocco, G. Alt, T. Altamura, A. R. Altsybeev, I. Alvarado, J. R. Anaam, M. N. Andrei, C. Andreou, N. Andronic, A. Andronov, E. Anguelov, V. Antinori, F. Antonioli, P. Apadula, N. Aphecetche, L. Appelshäuser, H. Arata, C. Arcelli, S. Aresti, M. Arnaldi, R. Arneiro, J. G. M. C. A. Arsene, I. C. Arslandok, M. Augustinus, A. Averbeck, R. Azmi, M. D. Baba, H. Badalà, A. Bae, J. Baek, Y. W. Bai, X. Bailhache, R. Bailung, Y. Bala, R. Balbino, A. Baldisseri, A. Balis, B. Banerjee, D. Banoo, Z. Barbasova, V. Barile, F. Barioglio, L. Barlou, M. Barman, B. Barnaföldi, G. G. Barnby, L. S. Barreau, E. Barret, V. Barreto, L. Bartels, C. Barth, K. Bartsch, E. Bastid, N. Basu, S. Batigne, G. Battistini, D. Batyunya, B. Bauri, D. Bazo Alba, J. L. Bearden, I. G. Beattie, C. Becht, P. Behera, D. Belikov, I. Bell Hechavarria, A. D. C. Bellini, F. Bellwied, R. Belokurova, S. Beltran, L. G. E. Beltran, Y. A. V. Bencedi, G. Bensaoula, A. Beole, S. Berdnikov, Y. Berdnikova, A. Bergmann, L. Besoiu, M. G. Betev, L. Bhaduri, P. P. Bhasin, A. Bhat, M. A. Bhattacharjee, B. Bianchi, L. Bianchi, N. Bielčík, J. Bielčíková, J. Bigot, A. P. Bilandzic, A. Biro, G. Biswas, S. Bize, N. Blair, J. T. Blau, D. Blidaru, M. B. Bluhme, N. Blume, C. Boca, G. Bock, F. Bodova, T. Bok, J. Boldizsár, L. Bombara, M. Bond, P. M. Bonomi, G. Borel, H. Borissov, A. Borquez Carcamo, A. G. Bossi, H. Botta, E. Bouziani, Y. E. M. Bratrud, L. Braun-Munzinger, P. Bregant, M. Broz, M. Bruno, G. E. Buckland, M. D. Budnikov, D. Buesching, H. Bufalino, S. Buhler, P. Burmasov, N. Buthelezi, Z. Bylinkin, A. Bysiak, S. A. Cabanillas Noris, J. C. Cabrera, M. F. T. Cai, M. Caines, H. Caliva, A. Calvo Villar, E. Camacho, J. M. M. Camerini, P. Canedo, F. D. M. Cantway, S. L. Carabas, M. Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France Nuclear Physics Institute of the Czech Academy of Sciences Husinec-Řež Czech Republic Variable Energy Cyclotron Centre Homi Bhabha National Institute Kolkata India European Organization for Nuclear Research (CERN) Geneva Switzerland Dipartimento di Fisica dell’Università and Sezione INFN Turin Italy Dipartimento DISAT del Politecnico and Sezione INFN Turin Italy Dipartimento di Fisica e Astronomia dell’Università and Sezione INFN Bologna Italy Department of Physics Aligarh Muslim University Aligarh India Korea Institute of Science and Technology Information Daejeon Republic of Korea Faculty of Science P.J. Šafárik University Košice Slovak Republic Frankfurt Institute for Advanced Studies Johann Wolfgang Goethe-Universität Frankfurt Frankfurt Germany Research Division and ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Darmstadt Germany INFN Sezione di Torino Turin Italy Central China Normal University Wuhan China Instituto de Física Universidad Nacional Autónoma de México Mexico City Mexico University of Houston Houston United States Sungkyunkwan University Suwon City Republic of Korea Department of Physics and Technology University of Bergen Bergen Norway INFN Sezione di Cagliari Cagliari Italy Institut für Kernphysik Johann Wolfgang Goethe-Universität Frankfurt Frankfurt Germany INFN Sezione di Bari Bari Italy Physik Department Technische Universität München Munich Germany High Energy Physics Group Universidad Autónoma de Puebla Puebla Mexico Horia Hulubei National Institute of Physics and Nuclear Engineering Bucharest Romania University of Derby Derby United Kingdom Universität Münster Institut für Kernphysik Münster Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany INFN Sezione di Padova Padova Italy INFN Sezione di Bologna Bologna Italy Lawrence Berkeley National Laboratory Berkeley United Sta

The pT-differential cross section of ω meson production in pp collisions at $$ \sqrt{s} $$ = 13 TeV at midrapidity (|y| < 0.5) was measured with the ALICE detector at the LHC, covering an unprecedented transverse-momentum range of 1.6 < pT < 50 GeV/c. The meson is reconstructed via the ω → π+π−π0 decay channel. The results are compared with various theoretical calculations: PYTHIA8.2 with the Monash 2013 tune overestimates the data by up to 50%, whereas good agreement is observed with Next-to-Leading Order (NLO) calculations incorporating ω fragmentation using a broken SU(3) model. The ω/π0 ratio is presented and compared with theoretical calculations and the available measurements at lower collision energies. The presented data triples the pT ranges of previously available measurements. A constant ratio of Cω/π0 = 0.578 ± 0.006 (stat.) ± 0.013 (syst.) is found above a transverse momentum of 4 GeV/c, which is in agreement with previous findings at lower collision energies within the systematic and statistical uncertainties.

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