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arXiv 2022年

作者： Son, Jeongrak Talkner, Peter Thingna, Juzar Daejeon34126 Korea Republic of Department of Physics and Astronomy Seoul National University Seoul08826 Korea Republic of School of Physical and Mathematical Sciences Nanyang Technological University 639673 Singapore Institut für Physik Universität Augsburg Universitätsstraße 1 AugsburgD-86135 Germany Basic Science Program Korea University of Science and Technology Daejeon34113 Korea Republic of Department of Physics and Applied Physics University of Massachusetts LowellMA01854 United States

The charging of a quantum battery by a four-stroke quantum machine that works either as an engine or a refrigerator is investigated. The presented analysis provides the energetic behavior of the combined system in terms of the heat and workflows of the machine, the average, and variance of the battery’s energy as well as the coherent and incoherent parts of its ergotropy. To monitor the battery state its energy is measured either after the completion of any cycle or after a prescribed number of cycles is carried out. The resulting battery performances greatly differ for those two cases. During the first charging epoch with an engine, the regular measurements speed up the charging, whereas the gain of ergotropy is more pronounced in the absence of measurements. In a later stage, the engine fails to work as such while it still continues charging the battery that eventually reaches the maximally charged state in the absence of intermediate measurements and a suboptimally charged state for a periodically measured battery. For a refrigerator, the charging of the measured battery also proceeds faster during the first epoch. Only during the second stage when the machine fails to extract heat from the cold bath the influence of the measurements become less pronounced leading to rather similar asymptotic states for the two measurement scenarios. © 2022, CC BY.

关键词： engines

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Perylene tetracarboxylic acid-folate conjugated carbon quantum dots for targeted photodynamic therapy of prostate cancer

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Bioorganic chemistry 2025年 163卷 108631页

作者： eman Serag Sara A Abdel Gaber Ayman A Abdel-Shafi Mohamed e el-Khouly Nanoscience Program Institute of Basic and Applied Science Egypt-Japan University of Science and Technology (E-JUST) New Borg El-Arab City Alexandria Egypt Marine Pollution Department Environmental Division National Institute of Oceanography and Fisheries Alexandria Egypt. Nanomedicine Department Institute of Nanoscience and Nanotechnology Kafrelsheikh University Kafrelsheikh 33516 Egypt. Department of Chemistry Faculty of Science Ain Shams University 11566 Abbassia Cairo Egypt. Nanoscience Program Institute of Basic and Applied Science Egypt-Japan University of Science and Technology (E-JUST) New Borg El-Arab City Alexandria Egypt. Electronic address: mohamed.elkhouly@ejust.edu.eg.

This study reports the facile one-pot hydrothermal synthesis of water-soluble perylenetetracarboxylic dianhydride (PTCDA) conjugated carbon quantum dots (Per CDs) and their folate conjugate (PerFACDs), addressing the insolubility of PTCDA, a promising photosensitizer. Both CDs were thoroughly characterized using HRTeM, FTIR, Raman, and XPS techniques. Their singlet oxygen quantum yield (Φ), zeta potential, absorption and photoluminescence spectra were also studied. Their anti-human prostate cancer activity was tested using PC-3 cells as a model. The mode of cell death was investigated using flow cytometry, and their heamolytic activity and effect on the viability of normal peripheral blood mononuclear cells and were evaluated to assess the safety. The produced CDs were uniform spheres with diameters below 8 nm. At physiological pH, PerCDs exhibited a surface charge of -9 mV, while PerFACDs had -12 mV and a Φ of 0.22. The biocompatibility and cytotoxicity of the produced CDs were evaluated in vitro normal human fibroblast (HFF-1) cells, and peripheral blood cells. Both PerCDs and PerFACD showed negligible toxicity toward normal cells. To assess selective cytotoxicity, the selectivity index (SI) was calculated under dark conditions, yielding values of 1.47 for PerCDs and 2.4 for PerFACD, indicating significantly enhanced selectivity of PerFACD toward PC3 cells. Upon illumination using monochromatic 520 nm light-emitting diode (1.5 mW/cm), a total eradication of PC-3 cells was achieved within 60 min of irradiation using Per FA CD that was significantly more potent than Per CDs. Per FA CDs-PDT induced an apoptotic cell death mode at shorter irradiation times and a necrotic one at longer durations. These findings suggest that our synthesized third generation photosensitizer Per CDs and Per FA CD hold promise as safe and effective candidates for targeted PDT of prostate cancer.

关键词： Carbon quantum dots Folic acid Perylene derivative Photodynamic therapy Prostate cancer treatment

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In-situ growth of novel iron oxide/iron organic framework composites as efficient electroactive materials of battery supercapacitor hybrids

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Journal of energy Storage 2024年 97卷

作者： Kuo, Tsung-Rong Saukani, Muhammad Kuo, Tsung-Rong Kubendhiran, Subbiramaniyan Wang, Yu-Min Tai, Po-Chun Wu, Chang-Feng Lin, Lu-Yin Kongvarhodom, Chutima Kongvarhodom, Chutima Husain, Sadang Yougbaré, Sibidou Chen, Hung-Ming International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Chemical Engineering University of New Brunswick FrederictonNBE3B5A3 Canada Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Iron oxide (Fe2O3) with a high theoretical capacitance, wide potential ranges and easy availability has attracted much attentions as the electrode material of battery supercapacitor hybrids (BSH). Metal–organic framework (MOF) is one of the promising potential energy storage materials due to its large surface area and controllable pore structures. In this work, novel iron oxide/iron organic framework composites (Fe2O3/FeMOF) are in-situ grown on the Ni foam as efficient energy storage electrodes of BSH. By tuning the solvothermal durations, the morphology changes from random sizes of sheets, regular grown vertical sheets, to flower-like structures. The d-spacing also increases for the Fe2O3/FeMOF synthesized using longer solvothermal durations. The optimal Fe2O3/FeMOF electrode synthesized using 9 h shows a high areal capacitance of 10.97 F/cm2 along with an areal capacity of 5.49 F/cm2 at the current density of 35 mA/cm2, owing to the most regular growth of sheets, the large d-spacing, and the smallest charge-transfer resistances. A BSH composed of the Fe2O3/FeMOF positive electrode and a graphene negative electrode shows a maximum energy density of 0.76 mWh/cm2 at 22.5 mW/cm2. The excellent long-term cycling stability with the capacitance retention of 85% and Coulombic efficiency of 98% are also achieved after 10,000 charge/discharge cycles. © 2024 elsevier Ltd

关键词： Supercapacitor

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Supplier Selection of Companies Providing Micro Mobility Service Under Type-2 Neutrosophic Number Based Decision Making Model

SSRN

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SSRN 2023年

作者： Önden, İsmail Deveci, Muhammet Kara, Karahan Yalçın, Galip Cihan Önden, Abdullah eker, Mert Hasseb, Mouad Smart System Research Group of TUBITAK TUSSIDE Turkey Department of Industrial Engineering Turkish Naval Academy National Defence University Turkey The Bartlett School of Sustainable Construction University College London LondonWC1E 6BT United Kingdom Artvin Çoruh Universty Hopa Vocational School Logistics Program Artvin Turkey Kırıkkale University Faculty of Mathematics Institute of Science and Technology Kırıkkale Turkey Department of International Trade and Finance Yalova University Turkey Fabrikod Yalova University Turkey

environmental approaches play an active role in the production platform as well as in the supply chain. Studies that deal with supplier selection problems in the supply chain with a green focus have recently intensified. In this research, the supplier selection problem of companies providing "last mile" service, which is seen as the last step of transportation, is handled with a green focus. The supplier selection problem of these companies is differentiated according to strategic and non-strategic product groups. In this study, a green-oriented supplier selection proposal is presented for both the strategic product group and the non-strategic product group. The supplier selection problem is accepted as a multi-criteria decision making problem (MCDM). Thus, the type-2 neutrosophic numbers (T2NNs) - based CRiteria Importance Through Intercriteria Correlation (CRITIC) – based Multi-Attributive Border Approximation Area Comparison (-MABAC) hybrid model is applied to evaluate the green-oriented supplier. The motivation of the study is to determine the best alternative supplier type for strategic and non-strategic products groups. In this context, two cases are created, ten criteria are selected, and three supplier types are determined. Supplier types are as follows: (i) Classical suppliers, (ii) Classical to green centric suppliers, and (iii) Start-Ups & green centric suppliers. In addition, the findings are strengthened by creating twenty-two sensitivity analysis scenarios. As a result of the research, solution proposals for both product groups of the last mile service company are developed. © 2023, The Authors. All rights reserved.

关键词： Supply chains

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Correction: Spatial organization of B lymphocytes and prognosis prediction in patients with gastric cancer

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Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2025年 2025 May 16页

作者： Ryan Yong Kiat Tay Manavi Sachdeva Haoran Ma Young-Woo Kim Myeong-Cherl Kook Hyunki Kim Jae-Ho Cheong Lindsay C Hewitt Katharina Nekolla Günter Schmidt Takaki Yoshikawa Takashi Oshima Tomio Arai Supriya Srivastava Ming Teh Xuewen Ong Su Ting Tay Taotao Sheng Joseph J Zhao Patrick Tan Heike I Grabsch Raghav Sundar Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road Singapore 119228 Singapore. Department of Haematology-Oncology National University Cancer Institute National University Hospital Singapore Singapore. Cancer and Stem Cell Biology Program Duke-NUS Medical School Singapore Singapore. Department of Cancer Policy and Population Health National Cancer Center Graduate School of Cancer Science and Policy and Center for Gastric Cancer and Department of Surgery National Cancer Center Goyang Republic of Korea. Center for Gastric Cancer Department of Pathology National Cancer Center Goyang Republic of Korea. Department of Pathology Yonsei University College of Medicine Seoul Republic of Korea. Department of Surgery Yonsei University College of Medicine Seoul Republic of Korea. Department of Pathology GROW Research Institute for Oncology and Reproduction Maastricht University Medical Center+ Maastricht The Netherlands. Department of Precision Medicine GROW School for Oncology and Reproduction Maastricht University Center+ Maastricht The Netherlands. Computational Pathology Oncology R&D AstraZeneca Munich Germany. Department of Surgery Kanagawa Cancer Center Yokohama Japan. Department of Surgery Yokohama City University Yokohama Japan. Department of Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan. Department of Pathology Tokyo Metropolitan Institute for Geriatrics and Gerontology Tokyo Japan. Department of Medicine National University of Singapore Singapore Singapore. Department of Pathology National University Hospital Singapore Singapore. Genome Institute of Singapore Agency for Science Technology and Research Singapore Singapore. Cancer Science Institute of Singapore National University of Singapore Singapore Singapore. Cellular and Molecular Research National Cancer Centre Singapore Singapore. Singhealth/Duke-NUS Institute of Precision Medicine National Heart Centre Singapore

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Identification of Groundwater Potential Zones in Samendeni Watershed in Sedimentary and Semi-Arid Contexts of Burkina Faso, Using Analytic Hierarchy Process (AHP) Method and GIS

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American Journal of Climate Change 2023年第1期12卷 172-203页

作者： Sadraki Yabre Youssouf Koussoubé Sauret Élie Serge Gaëtan Nicaise Yalo Stephen Silliman West African Science Service Centre on Climate Change and Adapted Land Use (WASCAL) Doctoral Research Program in Climate Change and Water Resources Institut National de l’eau Université d’Abomey Calavi Cotonou Bénin Laboratoire Géosciences et Environnement (LaGE) Département des Sciences de la Terre Université Joseph KI-ZERBO/Unité de Formation et de Recherche en Sciences de la Vie et de la Terre Ouagadougou Burkina Faso Centre National de Recherche Scientifique et Technologique Institut de l’Environnement et de Recherches Agricoles-Département Gestion des Ressources Naturelles/Systèmes de Productions DRREA-Ouest Station de Farako-ba Bobo-Dioulasso Burkina Faso Laboratoire d’Hydrologie Appliquée (LHA) Institut National de l’eau Université d’Abomey Calavi Cotonou Bénin School of Science Technology Engineering and Math Trevecca Nazarene University Nashville Tennessee USA

Demand for water increases in Samendeni regarding the undertaken agricultural projects while pressure on surface water from global warming/evapotranspiration also increases. Thus, the need to evaluate the groundwater potential in the catchment is crucial as alternative supplier of water and resilience to climate hazards. The AHP was performed integrating ten influencing factors such as geomorphology, geology, soil, land use/land cover (lulc), slope, rainfall, drainage density, borehole rate & depth and piezometric level to generate groundwater potential zones (GWPZs) in Samendeni watershed (4420 km²). All the factors were processed and ranged into five (5) classes. Weight was assigned to each class of thematic layer. These thematic layers were then reclassified based on the normalized weight to be used in the calculation of groundwater potential zones (GWPZ). The final output, groundwater potential map, revealed a significant groundwater potential with very good (11%), good (31%), moderate (30%), poor (20%), and very poor (8%) of proportion. The interesting (very good, good) GWPZs in the study area are mostly in the central towards the east. The poor zones in term of groundwater potential are concentrated in the upper west region of the watershed. Besides the cross-validation with the relationship between different groundwater potential zones and the wells available in the study area, the overall accuracy was estimated to 88% provided from the result of the similarity analysis where 22 out of the 25 validation wells match with the expected yield classes of GWPZs. The statistics from that validation revealed the performance of AHP method to delineate groundwater potential zones at catchment level.

关键词： Climate Change Resilience Groundwater Potential Water Management Conjunctive Use AHP GIS Samendeni Watershed

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Thymine DNA glycosylase as a novel target for melanoma (vol 38, pg 3710, 2019)

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ONCOGeNe 2022年第23期41卷 3300-3301页

作者： Mancuso, Pietro Tricarico, Rossella Bhattacharjee, Vikram Cosentino, Laura Kadariya, Yuwaraj Jelinek, Jaroslav Nicolas, emmanuelle einarson, Margret Beeharry, Neil Devarajan, Karthik Katz, Richard A. Dorjsuren, Dorjbal G. Sun, Hongmao Simeonov, Anton Giordano, Antonio Testa, Joseph R. Davidson, Guillaume Davidson, Irwin Larue, Lionel Sobol, Robert W. Yen, Timothy J. Bellacosa, Alfonso Cancer Epigenetics Program Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 USA Department of Medical Biotechnologies Universita’ degli Studi di Siena Siena Italy Institut Curie PSL Research University INSERM U1021 Normal and Pathological Development of Melanocytes 91405 Orsay France Sbarro Institute for Cancer Research and Molecular Medicine Department of Biology College of Science and Technology Temple University Philadelphia PA 19122 USA Equipe Labellisée Ligue Contre le Cancer Orsay France University Paris-Sud University Paris-Saclay CNRS UMR3347 Orsay France Cancer Biology Program Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 USA Fels Institute for Cancer and Molecular Biology Temple University School of Medicine Philadelphia PA 19140 USA Department of Biostatistics Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 USA Division of Preclinical Innovation National Center for Advancing Translational Sciences National Institutes of Health Rockville MD 20850 USA Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS/INSERM/ULP 67404 Illkirch France Department of Oncologic Sciences Mitchell Cancer Institute University of South Alabama Mobile AL 36604 USA

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Four-hundred Very Metal-poor Stars Studied with LAMOST and Subaru. III. Dynamically Tagged Groups and Chemodynamical Properties

arXiv

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arXiv 2024年

作者： Zhang, Ruizhi Matsuno, Tadafumi Li, Haining Aoki, Wako Xue, Xiang-Xiang Suda, Takuma Zhao, Gang Chen, Yuqin Ishigaki, Miho N. Shi, Jianrong Xing, Qianfan Zhao, Jingkun CAS Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing100101 China Yuquan Road Shijingshan District Beijing100049 China Astronomisches Rechen-Institut Zentrum für Astronomie der Universität Heidelberg Mönchhofstraße 12-14 Heidelberg69120 Germany National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Astronomical Science Program The Graduate University for Advanced Studies SOKENDAI 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Department of Liberal Arts Tokyo University of Technology Nishi Kamata 5-23-22 Ota-ku Tokyo144-8535 Japan Research Center for the Early Universe The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan

Very metal-poor (VMP) stars record the signatures of early accreted galaxies, making them essential tools for unraveling the early stages of Galaxy formation. Understanding the origin of VMP stars requires comprehensive studies of their chemical compositions and kinematics, which are currently lacking. Hence, we conduct a chemodynamical analysis of 352 VMP stars selected from one of the largest uniform high-resolution VMP star samples, jointly obtained from LAMOST and Subaru. We apply a friends-of-friends clustering algorithm to the master catalog of this high-resolution sample, which consists of 5778 VMP stars. It results in 131 dynamically tagged groups with 89 associated with known substructures in the Milky Way, including Gaia-Sausage-enceladus (GSe), Thamnos, Helmi streams, Sequoia, Wukong, Pontus, and the very metal-poor disk (VMPD). Our findings are: (i) the VMPD shows lower Zn abundances than the rest, which indicates that it could be a relic of small stellar systems;(ii) Sequoia shows moderately high r-process abundances;(iii) Helmi streams show deficiencies in carbon and light neutron-capture elements;(iv) the fraction of carbon-enhanced metal-poor stars with no enhancement in heavy elements (CeMP-no stars) seems low in the VMPD and the Helmi streams;and (v) a subgroup in GSe exhibits a very high fraction of r-process enhanced stars, with four out of five showing [eu/Fe]> +1.0. The abundance patterns of other elements in VMP substructures largely match the whole VMP sample. We also study large-scale correlations between abundance ratios and kinematics without classifying stars into substructures, but it does not yield significant correlations once the overall chemical evolution is considered for most elements. © 2024, CC BY.

关键词： Stars

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The magnetic field in quiescent star-forming filament G16.96+0.27

arXiv

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arXiv 2024年

作者： Gu, Qi-Lao Liu, Tie Shen, Zhi-Qiang Jiao, Sihan Montillaud, Julien Juvela, Mika Lu, Xing Lee, Chang Won Liu, Junhao Li, Pak Shing Liu, Xunchuan Johnstone, Doug Kwon, Woojin Kim, Kee-Tae Tatematsu, Ken’ichi Sanhueza, Patricio Ristorcelli, Isabelle Koch, Patrick Zhang, Qizhou Pattle, Kate Hirano, Naomi Alina, Dana Di Francesco, James Shanghai Astronomical Observatory Chinese Academy of Sciences No.80 Nandan Road Xuhui Shanghai200030 China National Astronomical Observatories Chinese Academy of Sciences A20 Datun Road Chaoyang Beijing100101 China Université de Franche-Comté CNRS Institut UTINAM OSU THETA BesançonF-25000 France Department of Physics University of Helsinki PO box 64 FI-00014 Finland Korea Astronomy and Space Science Institute 776 Daedeokdae-ro Yuseong-gu Daejeon34055 Korea Republic of University of Science and Technology 217 Gajeong-ro Yuseong-gu Daejeon34113 Korea Republic of National Astronomical Observatory of Japan 2-21-1 Osawa Tokyo Mitaka181-8588 Japan NRC Herzberg Astronomy and Astrophysics 5071 West Saanich Rd VictoriaBCV9E 2E7 Canada Department of Physics and Astronomy University of Victoria VictoriaBCV8P 5C2 Canada Department of Earth Science Education Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of SNU Astronomy Research Center Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of The Center for Educational Research Seoul National University 1 Gwanak-ro Gwanak-gu Seoul08826 Korea Republic of Nobeyama Radio Observatory National Astronomical Observatory of Japan National Institutes of Natural Sciences Nobeyama Minamimaki Minamisaku Nagano384-1305 Japan Astronomical Science Program Graduate Institute for Advanced Studies SOKENDAI 2-21-1 Osawa Tokyo Mitaka181-8588 Japan IRAP Université de Toulouse CNRS 9 avenue du Colonel Roche BP 44346 Toulouse31028 Cedex 4 France Academia Sinica Institute of Astronomy and Astrophysics No. 1 Section 4 Roosevelt Road Taipei10617 Taiwan Center for Astrophysics Harvard & Smithsonian 60 Garden Street CambridgeMA02138 United States Department of Physics and Astronomy University College London Gower Street LondonWC1E 6BT United Kingdom Department of Physics School of Science and Technology Nazarbayev University Astana010000 Kazakhs

We present 850 µm thermal dust polarization observations with a resolution of 14.4′′(∼ 0.13 pc) towards an infrared dark cloud G16.96+0.27 using JCMT/POL-2. The average magnetic field orientation, which roughly agrees with the larger-scale magnetic field orientation traced by the Planck 353 GHz data, is approximately perpendicular to the filament structure. The estimated plane-of-sky magnetic field strength is ∼ 96 µG and ∼ 60 µG using two variants of the Davis-Chandrasekhar-Fermi methods. We calculate the virial and magnetic critical parameters to evaluate the relative importance of gravity, the magnetic field, and turbulence. The magnetic field and turbulence are both weaker than gravity, but magnetic fields and turbulence together are equal to gravity, suggesting that G16.96+0.27 is in a quasi-equilibrium state. The cloud-magnetic-field alignment is found to have a trend moving away from perpendicularity in the dense regions, which may serve as a tracer of potential fragmentation in such quiescent filaments. © 2024, CC BY.

关键词： Stars

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Associations of cord plasma per- and polyfluoroakyl substances (PFAS) with neonatal and child body composition and adiposity: The GUSTO study

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environment International 2024年 183卷 108340页

作者： Chen, Ling-Wei Ng, Sharon Tint, Mya-Thway Michael, Navin Sadananthan, Suresh Anand Ong, Yi Ying Yuan, Wen Lun Chen, Ze-Ying Chen, Chia-Yang Godfrey, Keith M. Tan, Kok Hian Gluckman, Peter D. Chong, Yap-Seng eriksson, Johan G. Yap, Fabian Lee, Yung Seng Fortier, Marielle V. Velan, Sendhil S. Chan, Shiao-Yng Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University No. 17 Xu-Zhou Road Taipei10055 Taiwan Master of Public Health Program College of Public Health National Taiwan University No. 17 Xu-Zhou Road Taipei10055 Taiwan Singapore Institute for Clinical Sciences Agency for Science Technology and Research 30 Medical Drive 117609 Singapore Human Potential Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore Department of Paediatrics Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road 119228 Singapore Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health BostonMA United States ParisF-75004 France Institute of Food Safety and Health College of Public Health National Taiwan University No. 17 Xu-Zhou Road Taipei10055 Taiwan MRC Lifecourse Epidemiology Centre & NIHR Southampton Biomedical Research Centre University of Southampton & University Hospital Southampton NHS Foundation Trust Tremona Road SO16 6YD Southampton United Kingdom Duke-NUS Medical School 8 College Road 169857 Singapore Department of Reproductive Medicine KK Women's and Children Hospital Singapore Singapore Liggins Institute University of Auckland 85 Park Rd Grafton Auckland1023 New Zealand Department of Obstetrics & Gynaecology Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road 119228 Singapore Department of General Practice and Primary Health Care University of Helsinki Haartmaninkatu 8 Helsinki00290 Finland Folkhälsan Research Center Topeliusgatan 20 Helsinki00250 Finland Department of Pediatric Endocrinology KK Women's and Children's Hospital 100 Bukit Timah Road 229899 Singapore Khoo Teck Puat-National University Children's Medical Institute National University Health System 1E Kent Ridge Road 119228 Singapore Department of Diagnostic & Interventional Imaging KK Women's and Childre

Background: The influence of prenatal exposure to per- and poly- fluoroalkyl substances (PFAS) on birth size and offspring adiposity is unclear, especially for the newer, shorter-chained replacement PFAS. Methods: In the GUSTO multi-ethnic Singaporean mother-offspring cohort, 12 PFAS were measured in 783 cord plasma samples using ultra-performance-liquid chromatography-tandem-mass-spectrometer (UPLC-MS/MS). Outcomes included offspring anthropometry, other indicators of body composition/metabolic health, and MRI-derived abdominal adiposity (subset) at birth and 6 years of age. PFAS were modeled individually, in categories of long-chain and short-chain PFAS, and as scores of three principal components (PC) derived using PC analysis (PC1, PC2, and PC3 reflect predominant exposure patterns to "very-long-PFAS", "long-PFAS", and "short-PFAS", respectively). Associations with outcomes were assessed using multivariable linear regressions, adjusted for important covariates such as maternal sociodemographic and lifestyle factors. Results: Overall, cord PFAS levels showed either no or positive associations (mostly for long-chain PFAS) with birth weight, length and head circumference. In general, PFAS were associated with higher neonatal abdominal adiposity, driven by shorter-chain PFAS. Perfluoroheptanoic acid (PFHpA) was associated with higher volumes of superficial subcutaneous adipose tissue (sSAT) (3.75 [1.13, 6.37] mL per SD increase in PFAS) and internal adipose tissue (IAT) (1.39 [0.41, 2.38] mL). Higher levels of perfluorobutanesulfonic acid (PFBS), short-chain PFAS, and PC3 were associated with higher IAT volume (β range 1.22–1.41 mL/SD, all P © 2023 The Authors

关键词： Tissue

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