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The palomar transient factory core-collapse supernova host-galaxy sample. I. Host-galaxy distribution functions and environment-dependence of CCSNe

arXiv

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arXiv 2020年

作者： Schulze, Steve Yaron, Ofer Sollerman, Jesper Leloudas, Giorgos Gal, Amit Wright, Angus H. Lunnan, Ragnhild Gal-Yam, Avishay Ofek, eran O. Perley, Daniel A. Filippenko, Alexei V. Kasliwal, Mansi M. Kulkarni, Shri R. Nugent, Peter e. Quimby, Robert M. Sullivan, Mark Strothjohann, Nora Linn Arcavi, Iair Ben-Ami, Sagi Bianco, Federica Bloom, Joshua S. De, Kishalay Fraser, Morgan Fremling, Christoffer U. Horesh, Assaf Johansson, Joel Kelly, Patrick L. Knežević, Sladjana Maguire, Kate Nyholm, Anders Papadogiannakis, Seméli Petrushevska, Tanja Rubin, Adam Yan, Lin Yang, Yi Adams, Scott M. Bufano, Filomena Clubb, Kelsey I. Foley, Ryan J. Green, Yoav Harmanen, Jussi Ho, Anna Y.Q. Hook, Isobel M. Hosseinzadeh, Griffin Howell, D. Andrew Kong, Albert K.H. Kotak, Rubina Matheson, Thomas McCully, Curtis Milisavljevic, Dan Pan, Yen-Chen Poznanski, Dovi Shivvers, Isaac van Velzen, Sjoert Department of Particle Physics and Astrophysics Weizmann Institute of Science 234 Herzl St Rehovot76100 Israel Department of Astronomy Oskar Klein Centre Stockholm University AlbaNova Stockholm10691 Sweden DTU Space National Space Institute Technical University of Denmark Elektrovej 327 Kgs. LyngbyDK-2800 Denmark Department of Physics of Complex Systems Weizmann Institute of Science 234 Herzl St Rehovot76100 Israel Ruhr-Universität Bochum Astronomisches Institut German Centre for Cosmological Lensing Universitätsstr. 150 Bochum44801 Germany Astrophysics Research Institute Liverpool John Moores University 146 Brownlow Hill LiverpoolL3 5RF United Kingdom Department of Astronomy University of California BerkeleyCA94720-3411 United States Miller Senior Fellow Miller Institute for Basic Research in Science University of California BerkeleyCA94720 United States Division of Physics Mathematics and Astronomy California Institute of Technology PasadenaCA91125 United States Cahill Center for Astrophysics California Institute of Technology 1200 E. California Blvd PasadenaCA91125 United States Lawrence Berkeley National Laboratory 1 Cyclotron Road MS 50B-4206 BerkeleyCA94720 United States Department of Astronomy / Mount Laguna Observatory San Diego State University 5500 Campanile Drive San DiegoCA92812-1221 United States University of Tokyo Institutes for Advanced Study University of Tokyo KashiwaChiba277-8583 Japan School of Physics and Astronomy University of Southampton SouthamptonSO17 1BJ United Kingdom School of Physics and Astronomy Tel Aviv University Tel Aviv69978 Israel CIFAR Azrieli Global Scholars program CIFAR Toronto Canada Department of Physics and Astronomy University of Delaware NewarkDE19716 United States Joseph R. Biden Jr. School of Public Policy and Administration University of Delaware NewarkDE19716 United States Data Science Institute University of Delaware NewarkDE19716 United States Center for Urban

Several thousand core-collapse supernovae (CCSNe) of different flavors have been discovered so far. However, identifying their progenitors has remained an outstanding open question in astrophysics. Studies of SN host galaxies have proven to be powerful in providing constraints on the progenitor populations. In this paper, we present all CCSNe detected between 2009 and 2017 by the Palomar Transient Factory. This sample includes 888 SNe of 12 distinct classes out to redshift z ≈ 1. We present the photometric properties of their host galaxies from the far-ultraviolet to the mid-infrared and model the host-galaxy spectral energy distributions to derive physical properties. The galaxy mass functions of Type Ic, Ib, IIb, II, and IIn SNe ranges from 105 to 1011.5 M☉, probing the entire mass range of star-forming galaxies down to the least-massive star-forming galaxies known. Moreover, the galaxy mass distributions are consistent with models of star-formation-weighted mass functions. Regular CCSNe are hence direct tracers of star formation. Small but notable differences exist between some of the SN classes. Type Ib/c SNe prefer galaxies with slightly higher masses (i.e., higher metallicities) and star-formation rates than Type IIb and II SNe. These differences are less pronounced than previously thought. H-poor SLSNe and SNe Ic-BL are scarce in galaxies above 1010 M☉. Their progenitors require environments with metallicities of Copyright © 2020, The Authors. All rights reserved.

关键词： Galaxies

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evidence for Late-stage eruptive Mass-loss in the Progenitor to SN2018gep, a Broad-lined Ic Supernova: Pre-explosion emission and a Rapidly Rising Luminous Transient

arXiv

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arXiv 2019年

作者： Ho, Anna Y.Q. Goldstein, Daniel A. Schulze, Steve Khatami, David K. Perley, Daniel A. ergon, Mattias Gal-Yam, Avishay Corsi, Alessandra Andreoni, Igor Barbarino, Cristina Bellm, eric C. Blagorodnova, Nadia Bright, Joe S. Burns, e. Cenko, S. Bradley Cunningham, Virginia De, Kishalay Dekany, Richard Dugas, Alison Fender, Rob P. Fransson, Claes Fremling, Christoffer Goldstein, Adam Graham, Matthew J. Hale, David Horesh, Assaf Hung, Tiara Kasliwal, Mansi M. M. Kuin, N. Paul Kulkarni, S.R. Kupfer, Thomas Lunnan, Ragnhild Masci, Frank J. Ngeow, Chow-Choong Nugent, Peter e. Ofek, eran O. Patterson, Maria T. Petitpas, Glen Rusholme, Ben Sai, Hanna Sfaradi, Itai Shupe, David L. Sollerman, Jesper Soumagnac, Maayane T. Tachibana, Yutaro Taddia, Francesco Walters, Richard Wang, Xiaofeng Yao, Yuhan Zhang, Xinhan Cahill Center for Astrophysics California Institute of Technology MC 249-17 1200 E California Boulevard PasadenaCA91125 United States Department of Particle Physics and Astrophysics Weizmann Institute of Science 234 Herzl St Rehovot76100 Israel Department of Astronomy University of California BerkeleyCA94720 United States Astrophysics Research Institute Liverpool John Moores University IC2 Liverpool Science Park 146 Brownlow Hill LiverpoolL3 5RF United Kingdom The Oskar Klein Centre & Department of Astronomy Stockholm University AlbaNova StockholmSE-106 91 Sweden Department of Physics and Astronomy Texas Tech University Box 1051 LubbockTX79409-1051 United States DIRAC Institute Department of Astronomy University of Washington 3910 15th Avenue NE SeattleWA98195 United States Department of Astrophysics IMAPP Radboud University Nijmegen Netherlands Department of Physics University of Oxford Denys Wilkinson Building Keble Road OxfordOX1 3RH United Kingdom NASA Postdoctoral Program Fellow Goddard Space Flight Center GreenbeltMD20771 United States Astrophysics Science Division NASA Goddard Space Flight Center Mail Code 661 GreenbeltMD20771 United States Joint Space-Science Institute University of Maryland College ParkMD20742 United States Astronomy Department University of Maryland College ParkMD20742 United States Caltech Optical Observatories California Institute of Technology MC 11-17 1200 E. California Blvd. PasadenaCA91125 United States Division of Physics Mathematics and Astronomy California Institute of Technology PasadenaCA91125 United States Science and Technology Institute Universities Space Research Association HuntsvilleAL35805 United States Racah Institute of Physics Hebrew University Jerusalem91904 Israel Department of Astronomy and Astrophysics University of California Santa CruzCA95064 United States Mullard Space Science Laboratory University College London Holmbury St. Mary Dorking SurreyRH5 6NT Un

We present detailed observations of ZTF18abukavn (SN2018gep), discovered in high-cadence data from the Zwicky Transient Facility as a rapidly rising (1.4 ±0.1 mag/hr) and luminous (Mg,peak = −20 mag) transient. It is spectroscopically classified as a broad-lined stripped-envelope supernova (Ic-BL SN). The high peak luminosity (Lbol & 3×1044 erg s−1), the short rise time (trise = 3 day in g-band), and the blue colors at peak (g−r ∼ −0.4) all resemble the high-redshift Ic-BL iPTF16asu, as well as several other unclassified fast transients. The early discovery of SN2018gep (within an hour of shock breakout) enabled an intensive spectroscopic campaign, including the highest-temperature (Teff & 40, 000K) spectra of a stripped-envelope SN. A retrospective search revealed luminous (Mg ∼ Mr ≈ −14 mag) emission in the days to weeks before explosion, the first definitive detection of precursor emission for a Ic-BL. We find a limit on the isotropic gamma-ray energy release eγ,iso 10 day) light curve requires an additional energy source, which could be the radioactive decay of Ni-56. Copyright © 2019, The Authors. All rights reserved.

关键词： Shock waves

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Quantum computing at the frontiers of biological sciences

arXiv

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arXiv 2019年

作者： emani, Prashant S. Warrell, Jonathan Anticevic, Alan Bekiranov, Stefan Gandal, Michael McConnell, Michael J. Sapiro, Guillermo Aspuru-Guzik, Alán Baker, Justin Bastiani, Matteo McClure, Patrick Murray, John Sotiropoulos, Stamatios N. Taylor, Jacob Senthil, Geetha Lehner, Thomas Gerstein, Mark B. Harrow, Aram W. Program in Computational Biology and Bioinformatics Yale University New HavenCT06520 United States Department of Molecular Biophysics and Biochemistry Yale University New HavenCT06520 United States Yale School of Medicine Department of Psychiatry New HavenCT06511 United States University of Virginia School of Medicine Department of Biochemistry and Molecular Genetics CharlottesvilleVA22903 United States Department of Psychiatry Semel Institute David Geffen School of Medicine University of California–Los Angeles 695 Charles E. Young Drive South Los AngelesCA90095 United States Univ. of Virginia School of Medicine Department of Neuroscience CharlottesvilleVA22903 United States Department of Electrical and Computer Engineering Duke University DurhamNC27708 United States Department of Chemistry University of Toronto 80 St. George Street TorontoONM5S 3H6 Canada TorontoONM5S 1M1 Canada CIFAR Artificial Intelligence Research Chair Vector Institute TorontoONM5S 1M1 Canada Department of Computer Science University of Toronto 40 St. George Street TorontoONM5S 2E4 Canada Schizophrenia and Bipolar Disorder Program McLean Hospital BelmontMA02478 United States Department of Psychiatry Harvard Medical School BostonMA02114 United States Sir Peter Mansfield Imaging Centre School of Medicine University of Nottingham NottinghamNG7 2RD United Kingdom Machine Learning Team National Institute of Mental Health BethesdaMD20892 United States Section on Functional Imaging Methods National Institute of Mental Health BethesdaMD20892 United States Department of Psychiatry Yale University School of Medicine New HavenCT06511 United States Department of Physics Yale University New HavenCT06511 United States Joint Center for Quantum Information and Computer Science University of Maryland College ParkMD20742 United States National Institute of Standards and Technology GaithersburgMD20899 United States Office of Genomics Research Coordination N

The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems. Innovation in massively parallel, classical computing hardware and algorithms continues to address many of these challenges, but there is a need to simultaneously consider new paradigms to circumvent current barriers to processing speed. Accordingly, we articulate a view towards quantum computation and quantum information science, where algorithms have demonstrated potential polynomial and exponential computational speedups in certain applications, such as machine learning. The maturation of the field of quantum computing, in hardware and algorithm development, also coincides with the growth of several collaborative efforts to address questions across length and time scales, and scientific disciplines. We use this coincidence to explore the potential for quantum computing to aid in one such endeavor: the merging of insights from genetics, genomics, neuroimaging and behavioral phenotyping. By examining joint opportunities for computational innovation across fields, we highlight the need for a common language between biological data analysis and quantum computing. Ultimately, we consider current and future prospects for the employment of quantum computing algorithms in the biological sciences. Copyright © 2019, The Authors. All rights reserved.

关键词： Machine learning

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Detection of RS Oph with LST-1 and modelling of its He/VHe gamma-ray emission

arXiv

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arXiv 2025年

作者： Abe, K. Abe, S. Abhishek, A. Acero, F. Aguasca-Cabot, A. Agudo, I. Alispach, C. Crespo, N. Alvarez Ambrosino, D. Antonelli, L.A. Aramo, C. Arbet-engels, A. Arcaro, C. Asano, K. Aubert, P. Baktash, A. Balbo, M. Bamba, A. Larriva, A. Baquero de Almeida, U. Barres Barrio, J.A. Jiménez, L. Barrios Batkovic, I. Baxter, J. González, J. Becerra Bernardini, e. Bernete, J. Berti, A. Bezshyiko, I. Bhattacharjee, P. Bigongiari, C. Bissaldi, e. Blanch, O. Bonnoli, G. Bordas, P. Borkowski, G. Brunelli, G. Bulgarelli, A. Bunse, M. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Castrejón, N. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chon, G. Chytka, L. Cicciari, G.M. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Da Vela, P. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. de Menezes, R. Del Burgo, R. Del Peral, L. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dore, D. Dorner, D. Doro, M. eisenberger, L. elsässer, D. emery, G. escudero, J. Fallah Ramazani, V. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukazawa, Y. Garcia López, R. Gasbarra, C. Gasparrini, D. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, D. Green, J. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Herrera Llorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Inoue, S. Ioka, K. Iori, M. Iuliano, A. Jahanvi, J. Jimenez Martinez, I. Jimenez Quiles, J. Jurysek, J. Kagaya, M. Kalashev, O. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lacave, B. Lainez, M. Lamanna, G. Lamastra, A. Lemoigne, L. Department of Physics Tokai University 4-1-1 Kita-Kaname Kanagawa Hiratsuka259-1292 Japan Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Chiba Kashiwa277-8582 Japan Sezione di Fisica Via Roma 56 Siena53100 Italy Université Paris-Saclay Université Paris Cité CEA CNRS AIM Gif-sur-YvetteF-91191 Cedex France FSLAC IRL 2009 CNRS/IAC Tenerife La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 Barcelona08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Department of Astronomy University of Geneva Chemin d’Ecogia 16 VersoixCH-1290 Switzerland IPARCOS-UCM Instituto de Física de Partículas y del Cosmos EMFTEL Department Universidad Complutense de Madrid Ciudad Universitaria Plaza de Ciencias 1 Madrid28040 Spain INFN Sezione di Napoli Via Cintia ed. G Napoli80126 Italy INAF - Osservatorio Astronomico di Roma Via di Frascati 33 Monteporzio Catone00040 Italy Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany INFN Sezione di Padova Università degli Studi di Padova Via Marzolo 8 Padova35131 Italy Univ. Savoie Mont Blanc CNRS Laboratoire d’Annecy de Physique des Particules - IN2P3 Annecy74000 France Universität Hamburg Institut für Experimentalphysik Luruper Chaussee 149 Hamburg22761 Germany Graduate School of Science University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan Faculty of Science and Technology Universidad del Azuay Cuenca Ecuador Centro Brasileiro de Pesquisas Físicas Rua Xavier Sigaud 150 RJ Rio de Janeiro22290-180 Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna C. Vía Láctea s/n Santa Cruz de Tenerife La Laguna38205 Spain CIEMAT Avda. Complutense 40 Madrid28040 Spain University of Geneva Département de physique nucléaire et corpusculaire 24 Quai Ernest Ansernet

Context. The recurrent nova RS Ophiuchi (RS Oph) underwent a thermonuclear eruption in August 2021. In this event, RS Oph was detected by the High energy Stereoscopic System (H.e.S.S.), the Major Atmospheric Gamma Imaging Cherenkov (MAGIC), and the first Large-Sized Telescope (LST-1) of the future Cherenkov Telescope Array Observatory (CTAO) at very-high gamma-ray energies above 100 GeV. This means that novae are a new class of very-high-energy (VHe) gamma-ray emitters. Aims. We report the analysis of the RS Oph observations with LST-1. We constrain the particle population that causes the observed emission in hadronic and leptonic scenarios. Additionally, we study the prospects of detecting further novae using LST-1 and the upcoming LST array of CTAO-North. Methods. We conducted target-of-opportunity observations with LST-1 from the first day of this nova event. The data were analysed in the framework of cta-lstchain and Gammapy, the official CTAO-LST reconstruction and analysis packages. One-zone hadronic and leptonic models were considered to model the gamma-ray emission of RS Oph using the spectral information from Fermi-LAT and LST-1, together with public data from the MAGIC and H.e.S.S. telescopes. Results. RS Oph was detected at 6.6σ with LST-1 in the first 6.35 hours of observations following the eruption. The hadronic scenario is preferred over the leptonic scenario considering a proton energy spectrum with a power-law model with an exponential cutoff whose position increases from (0.26 ± 0.08) TeV on day 1 up to (1.6 ± 0.6) TeV on day 4 after the eruption. The deep sensitivity and low energy threshold of the LST-1/LST array will allow us to detect faint novae and increase their discovery rate. © 2025, CC BY.

关键词： Gamma radiography

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Publisher Correction: Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020

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eye (London, england) 2024年第11期38卷 2229-2231页

作者： Konrad Pesudovs Hugh R. Taylor Tabassom Sedighi Rupert R. A. Bourne Shahina Pardhan Van Charles Lansingh John H. Kempen Ian Tapply Arthur G. Fernandes Maria Vittoria Cicinelli Alessandro Arrigo Nicolas Leveziel Serge Resnikoff Seth Flaxman Mukkharram M. Bikbov Tasanee Braithwaite Alain Bron Ching-Yu Cheng Monte A. Del Monte Joshua R. ehrlich Leon B. ellwein David Friedman João M. Furtado Gus Gazzard Ronnie George M. elizabeth Hartnett Jost B. Jonas Rim Kahloun Moncef Khairallah Rohit C. Khanna Janet Leasher Julie-Anne Little Vinay Nangia Michal Nowak Tunde Peto Pradeep Ramulu Fotis Topouzis Mitiadis Tsilimbaris Ya Xing Wang Ningli Wang Paul Svitil Briant Theo Vos Katrin Burkart Kaleb Coberly Xiaochen Dai Stephen S. Lim Tomislav Mestrovic Ali H. Mokdad Christopher J. L. Murray Jaimie D. Steinmetz Awoke Misganaw Yohannes Habtegiorgis Abate Mohammad Abdollahi Mozhan Abdollahi Ayele Mamo Abebe Olumide Abiodun Richard Gyan Aboagye Woldu Aberhe Abrha Hasan Abualruz Hiwa Abubaker Ali eman Abu-Gharbieh Salahdein Aburuz Tadele Girum Girum Adal Mesafint Molla Adane Isaac Yeboah Addo Qorinah estiningtyas Sakilah Adnani Muhammad Sohail Afzal Muhammad Umair Shahin Aghamiri Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Ali Ahmadi Siamak Sabour Ayman Ahmed Haroon Ahmed Ahmad Samir Alfaar Abid Ali Syed Shujait Shujait Ali Awais Altaf Hubert Amu emmanuel Manu Sofia Androudi Rodrigo Anguita Abhishek Anil Rimple Jeet Kaur Muhammad Aaqib Shamim Saeid Anvari Anayochukwu edward Anyasodor Francis Appiah Jalal Arabloo Haleh Ayatollahi Mosab Arafat Damelash Areda Reza Arefnezhad Brhane Berhe Aregawi Akeza Awealom Asgedom Tahira Ashraf Seyyed Shamsadin Athari Bantalem Tilaye Tilaye Atinafu Birhan Tsegaw Taye Maha Moh’d Wahbi Atout Alok Atreya Ahmed Y. Azzam Hassan Babamohamadi Sara Bagherieh Yogesh Bahurupi Atif Amin Baig Shumaila Nargus Biswajit Banik Mainak Bardhan Saurav Basu Kavita Batra Nebiyou Simegnew Bayileyegn Fatemeh Bazvand Addisu Shunu Beyene Awoke Masrie Asrat Derese Devidas S. Bhagat Akshaya Srikanth Bhagavathula Pankaj Bh Medicine & Health University of New South Wales Sydney NSW Australia School of Optometry and Vision Science University of New South Wales Sydney NSW Australia School of Population and Global Health University of Melbourne Carlton VIC Australia Vision and Eye Research Institute Anglia Ruskin University Cambridge UK HelpMeSee Instituto Mexicano de Oftalmologia Santiago de Querétaro Mexico University of Miami Gables FL USA University of Utah Salt Lake City UT USA Chief Medical Office HelpMeSee New York NY USA Mexican Institute of Ophthalmology Queretaro Mexico Department of Ophthalmology Massachusetts Eye and Ear/Shepens Eye Research Institute/Harvard Medical School Boston MA USA Eye Unit MyungSung Christian Medical Center (MCM) Comprehensive Specialized Hospital and MyungSun Medical College Addis Ababa Ethiopia Department of Ophthalmology Addis Ababa University Addis Ababa Ethiopia Sight for Souls Bellevue WA USA Department of Ophthalmology Harvard University Boston MA USA Eye Unit MyungSung Medical College Addis Ababa Ethiopia Addenbrooke’s Hospital Cambridge UK Department of Ophthalmology Cambridge University Hospitals Cambridge UK Federal University of Sao Paolo Sao Paolo SP Brazil University of Calgary Calgary AB Canada Department of Ophthalmology and Visual Sciences Federal University of São Paulo Sao Paulo Brazil School of Medicine Vita-Salute San Raffaele University Milan Italy Department of Ophthalmology IRCCS San Raffaele Scientific Institute Milan Italy Department of Ophthalmology San Raffaele Scientific Institute Milano Italy IRCCS San Raffaele Scientific Institute Vita-Salute University Milan Italy Scientific Institute San Raffaele Hospital Vita-Salute University Milan Italy University of Poitiers Poitiers France CHU de Poitiers Poitiers France Ophthalmology Department CHU de Poitiers (Poitiers University Hospital) Poitiers France Unité 1084 National Institute of Health and Medical Research (INSERM) Poitiers France

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Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat Sajeewa S.N.Maharachchikumbura Walter Rossi Marco Leonardi Hyang Burm Lee Hye Yeon Mun Jos Houbraken Thuong T.T.Nguyen Sun Jeong Jeon Jens Christian Frisvad Dhanushka N.Wanasinghe Robert Lucking Andre Aptroot Marcela e.S.Caceres Samantha C.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak Nimali Ide Silva Kasun M.Thambugala Ruvishika S.Jayawardena Indunil C.Senanayake Saranyaphat Boonmee Jie Chen Zong-Long Luo Chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson Campos Rosado Buyck Bart emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene Mayrada Silva Soares Helio Longoni Plautz Jr Helen Maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira Bezerra Thays Gabrielle Linsde Oliveira Cristina Mariade Souza-Motta Oliane Maria Correia Magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.Manawasinghe Wei Dong Sheng-Nan Zhang Dan-Feng Bao Milan C.Samarakoon Dhandevi Pem Anuruddha Karunarathna Chuan-Gen Lin Jing Yang Rekhani H.Perera Vinit Kumar Shi-Ke Huang Monika C.Dayarathne Anusha H.ekanayaka Subashini C.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula Niskanen Kare Liimatainen Yu-Cheng Dai Xiao-Hong Ji Xue-Mei Tian Armin Mesic Sanjay K.Singh Kunthida Phutthacharoen Lei Cai Touny Sorvongxay Vinodhini Thiyagaraja Chada Norphanphoun Napalai Chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage Ming Zeng Thilini Chethana Deping Wei Martina Reblova Jacques Fournier Jana Nekvindova Renan do Nascimento Barbosa Jose ewerton Felintodos Santos Neiva Tintide Oliveira Guo-Jie Li Damien ertz Qiu-Ju Shang Alan J.L.Phillips Chang-Hsin Kuo erio Camporesi Timur S.Bulgakov Saisamorn Lumyong e.B.Gareth Jones Putarak Chomnunti eleni Gentekaki Frank Bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-Chi Wen Paras Nath Singh Yusufjon Gafforov Itthayakorn Promputtha erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul M Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly Department of Botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Biotechnology and Biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark Botanischer Garten und Botanisches Museum Berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany Laboratorio de Botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil Departamento de Biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key Laboratory of Microbial

This article is the tenth series of the Fungal Diversity Notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideomycetes),five new genera(Caatingomyces,Cryptoschizotrema,Neoacladium,Paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,Blackwellomyces lateris,Boubovia gelatinosa,Buellia viridula,Caatingomyces brasiliensis,Calophoma humuli,Camarosporidiella mori,Canalisporium dehongense,Cantharellus brunneopallidus,***,Castanediella meliponae,Coprinopsis psammophila,Cordyceps succavus,Cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium chiangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,Micarea squamulosa,Muriphaeosphaeria angustifoliae,Neoacladium indicum,Neodidymelliopsis sambuci,Neosetophoma miscanthi,***,Nodulosphaeria aquilegiae,***,Paramassaria samaneae,Penicillium circulare,***,***-pumilae,***,***,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium chiangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatomyces chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,Prolixandromyces australi,***,***,***,P.

关键词： 71 new taxa Ascomycota Basidiomycota Dothideomycetes eurotiomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Taxonomy

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Monitoring the morphology of M87∗ in 2009–2017 with the event Horizon Telescope

arXiv

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arXiv 2020年

作者： Wielgus, Maciek Akiyama, Kazunori Blackburn, Lindy Chan, Chi-Kwan Dexter, Jason Doeleman, Sheperd S. Fish, Vincent L. Issaoun, Sara Johnson, Michael D. Krichbaum, Thomas P. Lu, Ru-Sen Pesce, Dominic W. Wong, George N. Bower, Geoffrey C. Broderick, Avery e. Chael, Andrew Chatterjee, Koushik Gammie, Charles F. Georgiev, Boris Hada, Kazuhiro Loinard, Laurent Markoff, Sera Marrone, Daniel P. Plambeck, Richard Weintroub, Jonathan Dexter, Matthew MacMahon, David H.e. Wright, Melvyn Alberdi, Antxon Alef, Walter Asada, Keiichi Azulay, Rebecca Baczko, Anne-Kathrin Ball, David Baloković, Mislav Barausse, enrico Barrett, John Bintley, Dan Boland, Wilfred Bouman, Katherine L. Bremer, Michael Brinkerink, Christiaan D. Brissenden, Roger Britzen, Silke Broguiere, Dominique Bronzwaer, Thomas Byun, Do-Young Carlstrom, John e. Chatterjee, Shami Chen, Ming-Tang Chen, Yongjun Cho, Ilje Christian, Pierre Conway, John e. Cordes, James M. Crew, Geoffrey B. Cui, Yuzhu Davelaar, Jordy de Laurentis, Mariafelicia Deane, Roger Dempsey, Jessica Desvignes, Gregory Dzib, Sergio A. eatough, Ralph P. Falcke, Heino Fomalont, ed Fraga-encinas, Raquel Friberg, Per Fromm, Christian M. Galison, Peter García, Roberto Gentaz, Olivier Goddi, Ciriaco Gold, Roman Gómez, José L. Gómez-Ruiz, Arturo I. Gu, Minfeng Gurwell, Mark Hecht, Michael H. Hesper, Ronald Ho, Luis C. Ho, Paul Honma, Mareki Huang, Chih-Wei L. Huang, Lei Hughes, David H. Inoue, Makoto James, David J. Jannuzi, Buell T. Janssen, Michael Jeter, Britton Jiang, Wu Jimenez-Rosales, Alejandra Jorstad, Svetlana Jung, Taehyun Karami, Mansour Karuppusamy, Ramesh Kawashima, Tomohisa Keating, Garrett K. Kettenis, Mark Kim, Jae-Young Kim, Junhan Kim, Jongsoo Kino, Motoki Koay, Jun Yi Koch, Patrick M. Koyama, Shoko Kramer, Michael Kramer, Carsten Kuo, Cheng-Yu Lauer, Tod R. Lee, Sang-Sung Li, Yan-Rong Li, Zhiyuan Lindqvist, Michael Lico, Rocco Liu, Kuo Liuzzo, elisabetta Lo, Wen-Ping Lobanov, Andrei P. Lonsdale, Colin MacDonald, Nicholas R. Mao, Jirong Marchili, Nicola Marscher, Alan P. Martí-Vidal, Iv Black Hole Initiative at Harvard University 20 Garden Street CambridgeMA02138 United States Center for Astrophysics Harvard & Smithsonian 60 Garden Street CambridgeMA02138 United States National Radio Astronomy Observatory 520 Edgemont Rd CharlottesvilleVA22903 United States Massachusetts Institute of Technology Haystack Observatory 99 Millstone Road WestfordMA01886 United States National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Steward Observatory and Department of Astronomy University of Arizona 933 N. Cherry Ave. TucsonAZ85721 United States Data Science Institute University of Arizona 1230 N. Cherry Ave. TucsonAZ85721 United States JILA Department of Astrophysical and Planetary Sciences University of Colorado BoulderCO80309 United States Radboud University P.O. Box 9010 Nijmegen6500 GL Netherlands Max-Planck-Institut für Radioastronomie Auf dem Hügel 69 BonnD-53121 Germany Shanghai Astronomical Observatory Chinese Academy of Sciences 80 Nandan Road Shanghai200030 China Department of Physics University of Illinois 1110 West Green St UrbanaIL61801 United States CCS-2 Los Alamos National Laboratory P.O. Box 1663 Los AlamosNM87545 United States Institute of Astronomy and Astrophysics Academia Sinica 645 N. A’ohoku Place HiloHI96720 United States Perimeter Institute for Theoretical Physics 31 Caroline Street North WaterlooONN2L 2Y5 Canada Department of Physics and Astronomy University of Waterloo 200 University Avenue West WaterlooONN2L 3G1 Canada Waterloo Centre for Astrophysics University of Waterloo WaterlooONN2L 3G1 Canada Princeton Center for Theoretical Science Jadwin Hall Princeton University PrincetonNJ08544 United States NASA Hubble Fellowship Program Einstein Fellow Anton Pannekoek Institute for Astronomy University of Amsterdam Science Park 904 Amsterdam1098 XH Netherlands Department of Astronomy University of Illinois at Urbana-Champaign 1002 West Green Street Urba

The event Horizon Telescope (eHT) has recently delivered the first resolved images of M87∗, the supermassive black hole in the center of the M87 galaxy. These images were produced using 230 GHz observations performed in 2017 April. Additional observations are required to investigate the persistence of the primary image feature – a ring with azimuthal brightness asymmetry – and to quantify the image variability on event horizon scales. To address this need, we analyze M87∗ data collected with prototype eHT arrays in 2009, 2011, 2012, and 2013. While these observations do not contain enough information to produce images, they are sufficient to constrain simple geometric models. We develop a modeling approach based on the framework utilized for the 2017 eHT data analysis and validate our procedures using synthetic data. Applying the same approach to the observational data sets, we find the M87∗ morphology in 2009–2017 to be consistent with a persistent asymmetric ring of ∼40 µas diameter. The position angle of the peak intensity varies in time. In particular, we find a significant difference between the position angle measured in 2013 and 2017. These variations are in broad agreement with predictions of a subset of general relativistic magnetohydrodynamic simulations. We show that quantifying the variability across multiple observational epochs has the potential to constrain the physical properties of the source, such as the accretion state or the black hole spin. Copyright © 2020, The Authors. All rights reserved.

关键词： Black holes

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SYMBA: An end-to-end VLBI synthetic data generation pipeline Simulating event Horizon Telescope observations of M87

arXiv

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arXiv 2020年

作者： Roelofs, F. Janssen, M. Natarajan, I. Deane, R. Davelaar, J. Olivares, H. Porth, O. Paine, S.N. Bouman, K.L. Tilanus, R.P.J. van Bemmel, I.M. Falcke, H. Akiyama, K. Alberdi, A. Alef, W. Asada, K. Azulay, R. Baczko, A. Ball, D. Baloković, M. Barrett, J. Bintley, D. Blackburn, L. Boland, W. Bower, G.C. Bremer, M. Brinkerink, C.D. Brissenden, R. Britzen, S. Broderick, A.e. Broguiere, D. Bronzwaer, T. Byun, D. Carlstrom, J.e. Chael, A. Chan, C. Chatterjee, S. Chatterjee, K. Chen, M. Chen, Y. Cho, I. Christian, P. Conway, J.e. Cordes, J.M. Crew, G.B. Cui, Y. de Laurentis, M. Dempsey, J. Desvignes, G. Dexter, J. Doeleman, S.S. eatough, R.P. Fish, V.L. Fomalont, e. Fraga-encinas, R. Friberg, P. Fromm, C.M. Gómez, J.L. Galison, P. Gammie, C.F. García, R. Gentaz, O. Georgiev, B. Goddi, C. Gold, R. Gu, M. Gurwell, M. Hada, K. Hecht, M.H. Hesper, R. Ho, L.C. Ho, P. Honma, M. Huang, C.L. Huang, L. Hughes, D.H. Ikeda, S. Inoue, M. Issaoun, S. James, D.J. Jannuzi, B.T. Jeter, B. Jiang, W. Johnson, M.D. Jorstad, S. Jung, T. Karami, M. Karuppusamy, R. Kawashima, T. Keating, G.K. Kettenis, M. Kim, J. Kim, J. Kim, J. Kino, M. Koay, J.Y. Koch, P.M. Koyama, S. Kramer, M. Kramer, C. Krichbaum, T.P. Kuo, C. Lauer, T.R. Lee, S. Li, Y. Li, Z. Lindqvist, M. Lico, R. Liu, K. Liuzzo, e. Lo, W. Lobanov, A.P. Loinard, L. Lonsdale, C. Lu, R. MacDonald, N.R. Mao, J. Markoff, S. Marrone, D.P. Marscher, A.P. Martí-Vidal, I. Matsushita, S. Matthews, L.D. Medeiros, L. Menten, K.M. Mizuno, Y. Mizuno, I. Moran, J.M. Moriyama, K. Moscibrodzka, M. Müller, C. Nagai, H. Nagar, N.M. Nakamura, M. Narayan, R. Narayanan, G. Neri, R. Ni, C. Noutsos, A. Okino, H. Olivares, H. Ortiz-León, G.N. Oyama, T. Özel, F. Palumbo, D.C.M. Patel, N. Pen, U. Pesce, D.W. Piétu, V. Plambeck, R. PopStefanija, A. Prather, B. Preciado-López, J.A. Psaltis, D. Pu, H. Ramakrishnan, V. Radboud University P.O. Box 9010 Nijmegen6500 GL Netherlands Centre for Radio Astronomy Techniques and Technologies Department of Physics and Electronics Rhodes University Grahamstown6140 South Africa Department of Physics University of Pretoria Lynnwood Road Hatfield Pretoria0083 South Africa Institut für Theoretische Physik Goethe-Universität Frankfurt Max-von-Laue-Straße 1 Frankfurt am MainD-60438 Germany Anton Pannekoek Institute for Astronomy University of Amsterdam Science Park 904 Amsterdam1098 XH Netherlands Center for Astrophysics Harvard & Smithsonian 60 Garden Street CambridgeMA02138 United States Black Hole Initiative at Harvard University 20 Garden Street CambridgeMA02138 United States California Institute of Technology 1200 East California Boulevard PasadenaCA91125 United States Leiden Observatory-Allegro Leiden University P.O. Box 9513 Leiden2300 RA Netherlands Postbus 93138 Den Haag2509 AC Netherlands Oude Hoogeveensedijk 4 PD Dwingeloo7991 Netherlands National Radio Astronomy Observatory 520 Edgemont Rd CharlottesvilleVA22903 United States Massachusetts Institute of Technology Haystack Observatory 99 Millstone Road WestfordMA01886 United States National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n GranadaE-18008 Spain Max-Planck-Institut für Radioastronomie Auf dem Hügel 69 BonnD-53121 Germany Institute of Astronomy and Astrophysics Academia Sinica 11F of Astronomy-Mathematics Building AS/NTU No. 1 Sec. 4 Roosevelt Rd Taipei10617 Taiwan Departament d'Astronomia i Astrofísica Universitat de València C. Dr. Moliner 50 Burjassot ValènciaE-46100 Spain Observatori Astronòmic Universitat de València C. Catedrático José Beltrán 2 Paterna ValènciaE-46980 Spain Steward Observatory and Department of Astronomy University of Arizona 933 N. Cherry Ave. TucsonAZ85721 United States East Asian Observatory

Context. Realistic synthetic observations of theoretical source models are essential for our understanding of real observational data. In using synthetic data, one can verify the extent to which source parameters can be recovered and evaluate how various data corruption effects can be calibrated. These studies are the most important when proposing observations of new sources, in the characterization of the capabilities of new or upgraded instruments, and when verifying model-based theoretical predictions in a direct comparison with observational data. Aims. We present the SYnthetic Measurement creator for long Baseline Arrays (SYMBA), a novel synthetic data generation pipeline for Very Long Baseline Interferometry (VLBI) observations. SYMBA takes into account several realistic atmospheric, instrumental, and calibration effects. Methods. We used SYMBA to create synthetic observations for the event Horizon Telescope (eHT), a millimetre VLBI array, which has recently captured the first image of a black hole shadow. After testing SYMBA with simple source and corruption models, we study the importance of including all corruption and calibration effects, compared to the addition of thermal noise only. Using synthetic data based on two example general relativistic magnetohydrodynamics (GRMHD) model images of M87, we performed case studies to assess the image quality that can be obtained with the current and future eHT array for different weather conditions. Results. Our synthetic observations show that the effects of atmospheric and instrumental corruptions on the measured visibilities are significant. Despite these effects, we demonstrate how the overall structure of our GRMHD source models can be recovered robustly with the eHT2017 array after performing calibration steps, which include fringe fitting, a priori amplitude and network calibration, and self-calibration. With the planned addition of new stations to the eHT array in the coming years, images could be reconstru

关键词： Telescopes

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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (vol 52, pg 1314, 2020)

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NATURe GeNeTICS 2021年第5期53卷 762-762页

作者： Surendran, Praveen Feofanova, elena V. Lahrouchi, Najim Ntalla, Ioanna Karthikeyan, Savita Cook, James Chen, Lingyan Mifsud, Borbala Yao, Chen Kraja, Aldi T. Cartwright, James H. Hellwege, Jacklyn N. Giri, Ayush Tragante, Vinicius Thorleifsson, Gudmar Liu, Dajiang J. Prins, Bram P. Stewart, Isobel D. Cabrera, Claudia P. eales, James M. Akbarov, Artur Auer, Paul L. Bielak, Lawrence F. Bis, Joshua C. Braithwaite, Vickie S. Brody, Jennifer A. Daw, e. Warwick Warren, Helen R. Drenos, Fotios Nielsen, Sune Fallgaard Faul, Jessica D. Fauman, eric B. Fava, Cristiano Ferreira, Teresa Foley, Christopher N. Franceschini, Nora Gao, He Giannakopoulou, Olga Giulianini, Franco Gudbjartsson, Daniel F. Guo, Xiuqing Harris, Sarah e. Havulinna, Aki S. Helgadottir, Anna Huffman, Jennifer e. Hwang, Shih-Jen Kanoni, Stavroula Kontto, Jukka Larson, Martin G. Li-Gao, Ruifang Lindstrom, Jaana Lotta, Luca A. Lu, Yingchang Luan, Jian'an Mahajan, Anubha Malerba, Giovanni Masca, Nicholas G. D. Mei, Hao Menni, Cristina Mook-Kanamori, Dennis O. Mosen-Ansorena, David Muller-Nurasyid, Martina Pare, Guillaume Paul, Dirk S. Perola, Markus Poveda, Alaitz Rauramaa, Rainer Richard, Melissa Richardson, Tom G. Sepulveda, Nuno Sim, Xueling Smith, Albert V. Smith, Jennifer A. Staley, James R. Stanakova, Alena Sulem, Patrick Theriault, Sebastien Thorsteinsdottir, Unnur Trompet, Stella Varga, Tibor V. Velez edwards, Digna R. Veronesi, Giovanni Weiss, Stefan Willems, Sara M. Yao, Jie Young, Robin Yu, Bing Zhang, Weihua Zhao, Jing-Hua Zhao, Wei Zhao, Wei evangelou, evangelos Aeschbacher, Stefanie Asllanaj, eralda Blankenberg, Stefan Bonnycastle, Lori L. Bork-Jensen, Jette Brandslund, Ivan Braund, Peter S. Burgess, Stephen Cho, Kelly Christensen, Cramer Connell, John de Mutsert, Renee Dominiczak, Anna F. Dorr, Marcus eiriksdottir, Gudny Farmaki, Aliki-eleni Gaziano, J. Michael Grarup, Niels Grove, Megan L. Hallmans, Goran Hansen, Torben Have, Christian T. Heiss, Gerardo Jorgensen, Marit e. Jousilahti, Pekka Kajantie, eero Kamat, Mihir Karajamaki, AnneMari Kar British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK British Heart Foundation Centre of Research Excellence University of Cambridge Cambridge UK Health Data Research UK Cambridge Wellcome Genome Campus and University of Cambridge Cambridge UK Rutherford Fund Fellow Department of Public Health and Primary Care University of Cambridge Cambridge UK MRC Biostatistics Unit University of Cambridge Cambridge UK National Institute for Health Research Cambridge Biomedical Research Centre University of Cambridge and Cambridge University Hospitals Cambridge UK MRC Integrative Epidemiology Unit (IEU) Population Health Sciences Bristol Medical School University of Bristol Bristol UK Robertson Centre for Biostatistics University of Glasgow Glasgow UK MRC Epidemiology Unit University of Cambridge School of Clinical Medicine Cambridge UK Department of Immunology and Inflammation Imperial College London London UK Centre for Non-communicable Disease Research (CNCR) Dhaka Bangladesh National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge Cambridge UK Department of Human Genetics Wellcome Sanger Institute Wellcome Genome Campus Hinxton Cambridge UK Department of Biostatistics and Epidemiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Center for Non-Communicable Diseases Karachi Pakistan Department of Genetics Novo Nordisk Research Centre Oxford Oxford UK Human Genetics Center Department of Epidemiology Human Genetics and Environmental Sciences School of Public Health University of Texas Health Science Center at Houston Houston TX USA Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Cardiovascular Research Center Center for Genomic Medicine

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Genome-wide association study of long COVID

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Nature Genetics 2025年 1-16页

作者： Lammi, Vilma Nakanishi, Tomoko Jones, Samuel e. Andrews, Shea J. Karjalainen, Juha Cortés, Beatriz O’Brien, Heath e. Ochoa-Guzman, Ana Fulton-Howard, Brian e. Broberg, Martin Haapaniemi, Hele H. Kanai, Masahiro Pirinen, Matti Schmidt, Axel Mitchell, Ruth e. Mousas, Abdou Mangino, Massimo Huerta-Chagoya, Alicia Sinnott-Armstrong, Nasa Cirulli, elizabeth T. Vaudel, Marc Kwong, Alex S. F. Maiti, Amit K. Marttila, Minttu M. Posner, Daniel C. Rodriguez, Alexis A. Batini, Chiara Minnai, Francesca Dearman, Anna R. Warmerdam, C. A. Robert Sequeros, Celia B. Winkler, Thomas W. Jordan, Daniel M. Rešcenko, Raimonds Miano, Lorenzo Lane, Jacqueline M. Chung, Ryan K. Guillen-Guio, Beatriz Leavy, Olivia C. Carvajal-Silva, Laura Aguilar-Valdés, Kevin Frangione, erika Guare, Lindsay Vergasova, ekaterina Marouli, eirini Striano, Pasquale Zainulabid, Ummu Afeera Kumar, Ashutosh Ahmad, Hajar Fauzan edahiro, Ryuya Azekawa, Shuhei Maj, Carlo Pensel, Max C. Miller, Abigail Nöthen, Markus M. Behzad, Pari Schultz, Sonja Heggemann, Julia Balla, Daniella Morrison, David R. Mooser, Vincent Perley, Danielle Ragoussis, Jiannis Rousseau, Simon Shi, Fangyi Lathrop, G. Mark Yanishevsky, Solomia Laurent, Laetitia Auld, Daniel Bertrand, Mylene Boisclair, Ariane Bourque, Guillaume Bujold, David Durand, Madeleine Adra, Darin St-Cyr, Janick Niemi, Mari e. K. Iyengar, Sudha K. Cai, Tianxi Cho, Kelly Sarvadhavabhatla, Sannidhi Donaire, Maria Sophia Valenzuela-Jorquera, Héctor Lamoza, eduardo Arévalo, Tamara V. Retamales-Ortega, Rocío Sanhueza, Sergio Selman, Carolina S. Silva, Andrea X. Alarcon, Teresa A. Martínez, Matías F. Quiroga, Romina Zuñiga-Pacheco, Paula Zapata-Contreras, Daniela Yáñez, Cristian e. Quiñones, Luis A. Tobar-Calfucoy, eduardo A. Monardes-Ramírez, Virginia A. Signore, Iskra A. Guajardo, Lissette G. Figueroa, Alvaro Oróstica, Karen Y. Muñoz, Christian A. Fuentes-Guajardo, Macarena Bocchieri, Pamela Cabrera, Camilo echeverria, Cesar A. Cerpa, Leslie C. Donoso, Gerardo Gutiérrez-Richards, Scarlett Nova-Lamperti, estefania Saez Hidalgo Institute for Molecular Medicine Finland (FIMM) Helsinki Institute of Life Science (HiLIFE) University of Helsinki Helsinki Finland Department of Human Genetics McGill University Montreal QC Canada Centre for Clinical Epidemiology Department of Medicine Lady Davis Institute Jewish General Hospital McGill University Montreal QC Canada Kyoto-McGill International Collaborative Program in Genomic Medicine Graduate School of Medicine Kyoto University Kyoto Japan Department of Genome Informatics Graduate School of Medicine the University of Tokyo Tokyo Japan Research Fellow Japan Society for the Promotion of Science Tokyo Japan Department of Psychiatry and Behavioral Sciences University of California San Francisco San Francisco CA United States Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA United States Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge MA United States Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA United States Genomes for Life-GCAT Lab CORE Program Germans Trias i Pujol Research Institute (IGTP) Badalona Spain Grup de REcerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra) Barcelona Spain Sano Genetics Limited London United Kingdom Unidad de Biología Molecular y Medicina Genómica Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York City NY United States Broad Institute Cambridge MA United States Analytical and Translational Genetics Unit Massachusetts General Hospital Harvard Medical School Boston MA United States Department of Mathematics and Statistics University of Helsinki Helsinki Finland Department of Public Health University of Helsinki Helsinki Finland Institute of Human Genetics University of Bonn School of Medicine and University Hospital Bonn Bonn Germany MRC Integrat

Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID. © The Author(s) 2025.

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