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Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

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Acta Pharmaceutica Sinica B 2024年第1期14卷 1-19页

作者： Weile Ye Jiaojiao Wang Peter JLittle Jiami Zou Zhihua Zheng Jing Lu Yanjun Yin Hao Liu Dongmei Zhang Peiqing Liu Suowen Xu Wencai Ye Zhiping Liu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Pharmacy Australia Centre of Excellence School of PharmacyUniversity of QueenslandWoolloongabba QLD 4102Australia Sunshine Coast Health Institute and School of Health and Behavioural Sciences University of the Sunshine CoastBirtinya QLD 4575Australia National-Local Joint Engineering Lab of Druggability and New Drugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China School of Pharmacy Bengbu Medical CollegeBengbu 233030China Institute of Endocrine and Metabolic Diseases the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of *** biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for *** studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease *** clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia ***,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and *** highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(NADPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIRT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and ***,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis.

关键词： Cardiovascular disease Atherosclerosis Ginkgo biloba Ginkgolide B Endothelial dysfunction LOX-1 PCSK9 PAF-R antagonist

Development of Novel Ionic Covalent Organic Frameworks Composite Nanofiltration Membranes for Dye/Salt Separation

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SSRN 2023年

Covalent organic frameworks (COF) have desirable properties such as high porosity, low mass density, excellent heat resistance and regulatable structure, making them an ideal candidate for membrane material. Traditional methods for preparing covalent organic framework composite membranes, such as interfacial polymerization, vacuum filtration, and covalent organic framework abrasive coating. Stand-alone COF membranes produced by the above methods usually suffer from problems such as poor mechanical properties. Here, we fabricated high performance COF composite membranes by modified casting-precipitation-evaporation method. The designed composite membranes consisted of the ionic COF (iCOF) selective layer and the support layer are applied in dye/salt separation. The high permeability (~68 L h-1 m-2 bar-1), high dyes rejection (97% for Rose Bengal), and low salts rejection (~2.86% for NaCl) are achieved by the iCOF layer. The as-prepared composite membranes have a hydrophilic and highly smooth surface, making them have good anti-fouling performance. In addition, the rigid pore structure of iCOF selective layer endows the composite membranes with excellent stability, the composite membranes maintain original structure under high pressure (6 bar) and ultrasonic treatment (16 kHz for 60 min). This work may open up a novel path to fabricate iCOF composite membranes, which exhibit great potential in dye/salt separation. © 2023, The Authors. All rights reserved.

关键词： Sodium chloride

Subway rail transit monitoring by built-in sensor platform of smartphone

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Frontiers of Information technology & Electronic engineering 2020年第8期21卷 1226-1238页

作者： Jian-li CONG Ming-yuan GAO Yuan WANG Rong CHEN Ping WANG School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China Key Laboratory of High-speed Railway Engineering Ministry of EducationChengdu 610031China College of Engineering and Technology Southwest UniversityChongqing 400716China National&Local Joint Engineering Laboratory of Intelligent Transmission and Control Technology Chongqing 400716China School of System Design and Intelligent Manufacturing Southern University of Science and TechnologyShenzhen 518055China

Smartphone,as a smart device with multiple built-in sensors,can be used for collecting information(e.g.,vibration and location).In this paper,we propose an approach for using the smartphone as a sensing platform to obtain real-time data on vehicle acceleration,velocity,and location through the development of the corresponding application software and thereby achieve the green concept based monitoring of the track condition during subway rail *** tests are conducted to verify the accuracy of smartphones in terms of the obtained data’s standard deviation(SD),Sperling index(SI),and International Organization for Standardization(ISO)-2631 weighted acceleration index(WAI).A vehicle-positioning method,together with the coordinate alignment algorithm for a Global Positioning System(GPS)free tunnel environment,is *** the time-domain integration method,the relationship between the longitudinal acceleration of a vehicle and the subway location is established,and the distance between adjacent stations of the subway is calculated and compared with the actual *** effectiveness of the method is verified,and it is confirmed that this approach can be used in the GPS-free subway tunnel *** is also found that using the proposed vehicle-positioning method,the integral error of displacement of a single subway section can be controlled to within 5%.This study can make full use of smartphones and offer a smart and eco-friendly approach for human life in the field of intelligent transportation systems.

关键词： Acceleration signals Smart monitoring Embedded sensors Smartphones Subway

The influence of mixing technology on the uniformity and strength of cement stabilized macadam mixture 57

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The influence of mixing technology on the uniformity and str...

57th International Conference on Vibroengineering

作者： Wang, Jianhong Wang, Jinyong Wang, Quanlei Zhang, Dongchang Du, Bin Wang, Huoming Liang, Xuzhi Yunnan Dayong Expressway Co. Ltd. Yunnan Dali671000 China Road and Geotechnical Engineering Institute China Merchants Chongqing Communications Technology Research and Design Institute Co. Ltd. Chongqing400067 China National Local Joint Engineering Laboratory for Road Engineering and Disaster Prevention and Reduction Technology in Mountainous Areas Chongqing400067 China Chang’an University Highway School Shanxi Xi’an710064 China Zunyi Highway Administration Bureau of Guizhou Guizhou Zunyi563099 China

A comparison between the two strategies: secondary traditional mixing technology and secondary vibratory mixing technology is proposed based on aggregate sieving, cement EDTA titration and unconfined compressive strength tests to explore the influence of the uniformity and strength of cement stabilized macadam mixture in the paper. The results show that when the secondary vibratory mixing technology is adopted: (1) the standard deviations and coefficients of variation of the passing rates of key sieves of 19 mm, 13.2 mm, 9.5 mm, 4.75 mm and the cement dosage titration results decrease significantly, and the mixing uniformity of the mixture is significantly improved;(2) the 7-day and 28-day unconfined compressive strengths of the mixtures are significantly improved while the strength standard deviations and coefficients of variation are reduced, with an obvious trend along with the extension of the curing time (within 28 days). Copyright © 2022 Jianhong Wang, et al.

关键词： Mixtures

A Fractional Order Model Predictive Control Method for Electric-Hydrogen Hybrid Energy Storage System

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A Fractional Order Model Predictive Control Method for Elect...

Chinese Automation Congress (CAC)

作者： Xiaofeng Xu Zishun Peng Li Li Wen Zhou Zhenxing Zhao Yuxing Dai National-Local Joint Engineering Laboratory For Digitalize Electrical Design Technology Wenzhou University Wenzhou China Zhejiang CHINT Electrics Co. Ltd. Yueqing China Changsha Sunye Electric Co. Ltd. Changsha China College of Electrical & Information Engineering Hunan Institute of Engineering Changsha China

ISBN: (纸本)9781665426480

A Fractional order model predictive control (FO-MPC) method for electric-hydrogen combined hybrid energy storage system is proposed in this paper. This method can help the converter of HESS to smooth the fluctuations of DG’s output better, improve the control accuracy of the converter output current and improve the stability of DC microgrid. Firstly, the structure of electric-hydrogen combined HESS is illustrated and DC microgrid system is described. Secondly, the concept of fractional calculus is introduced and the predictive model of DC Converter based on fractional order differential equation is established. According to the predictive model, the next current state of bidirectional converter of battery-ultracapacitor and converter of electrolyzer and fuel cell is predicted precisely. Finally, the fractional order model predictive control approach is experimentally verified in Buck/Boost circuit and significantly reduce the current ripple on the DC bus of the microgrid.

关键词： Hydrogen Microgrids Power smoothing Predictive models Stability analysis Regulation Voltage control

Facile Preparation of Bimetallic Cobalt-Copper Selenide Nanosheets as Stable Cathode Materials for Rechargeable Magnesium Batteries

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SSRN 2023年

作者： Wang, Zhitao Zhang, Fuhao Gao, Shengbo Chen, Song Wang, Liyuan Liu, Xupo Li, Miao Shangguan, Enbo Henan Engineering Research Center of Design and Recycle for Advanced Electrochemical Energy Storage Material School of Materials Science and Engineering Henan Normal University Xinxiang453007 China Hebei Key Laboratory of Optic-Electronic Information and Materials National & Local Joint Engineering Laboratory of New Energy Photoelectric Devices College of Physics Science and Technology Hebei University Baoding071002 China

The pursuit of novel cathode materials with excellent performance is the key to promoting the application of rechargeable magnesium batteries (RMBs). Herein, bimetallic copper-cobalt selenide (CuCo2Se4) as a cathode material for RMBs, synthesized via a microwave-assisted method. Owing to the bimetallic synergistic effect, CuCo2Se4 exhibits a high reversible capacity of 108 mAh g−1 at 50 mA g−1 after 80 cycles, and a superior rate capability (90 mAh g−1 at 200 mA g−1). The crystal phase transition of the conversion electrode material during the cycles is analyzed using ex-situ XRD technology. The enhanced stability of bimetallic selenide provides a good experimental support for the preparation of high-performance rechargeable magnesium batteries based on bimetallic strategy. © 2023, The Authors. All rights reserved.

关键词： Copper compounds

design of Three-Dimensional B-C-N Structures Via Tailoring Gnrs and Bnnrs

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SSRN 2023年

作者： Ma, Mengdong Zhu, Li Xiong, Mei Li, Baozhong Wu, Yingju Ying, Pan Zhao, Zhisheng He, Julong Kang, Zhenhui Macau University of Science and Technology Taipa999078 China State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao066004 China National-Local Joint Engineering Laboratory of Intelligent Manufacturing Oriented Automobile Die & Mould Tianjin University of Technology and Education Tianjin300222 China National Key Laboratory of Advanced Casting Technologies MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials Technology Engineering Research Center of Materials Behavior and Design Ministry of Education Nanjing University of Science and Technology Nanjing210094 China South China University of Technology China

A series of porous 3D Cx(BN)y crystal structures with full sp2 hybridization are obtained by polymerizing edge-functionalized graphene nanoribbons (GNRs) and boron nitride nanoribbons(BNNRs). Herein, the crystal structure and properties of Cx(BN)y are systematically and comprehensively investigated by first-principles calculations, deriving that it is feasible to achieve performance tuning by controlling the nanoribbon width. Thermodynamic stability, these structures have energy advantages with respect to the previously proposed B-C-N structures, and the thermodynamic stability of the structures deteriorates with the increase of the carbon content. electrical properties, the bandgap value is tunable between 0.1-1.1eV, and the bandgap value increases with the width of BNNRs at the same width of GNRs. Mechanical properties, these structures are mechanically stable, and exhibit unexpected superstretching properties, with tensile lengths up to 2.4 times the original length, bulk modulus tunable between 137-167GPa, shear modulus tunable between 81-115GPa, and the incompressibility of the structure decreases as the nanoribbon width increases. © 2023, The Authors. All rights reserved.

关键词： Energy gap

Catenated Cages Mediated by Enthalpic Reaction Intermediates

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CCS Chemistry 2021年第7期3卷 1838-1850页

作者： Shijun Xu Pan Li Zi-Ying Li Chunyang Yu Xiaoyun Liu Zhiqiang Liu Shaodong Zhang Key Laboratory of Specially Functional Polymeric Materials and Related Technology Ministry of EducationEast China University of Science and TechnologyShanghai 200237 School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Key Laboratory of Electrical Insulation and Thermal AgingShanghai Jiao Tong UniversityShanghai 200240 The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals Zhejiang University of TechnologyHangzhou 310014

Catenated cages are generally considered thermodynamically more stable than their constituent monomeric ***,the catenation mechanism is yet to be elucidated;it would require systematic investigation into the structural effects of the building blocks,their enthalpic and entropic contributions,and the effect of *** inspecting these factors,we rationalized some design principles for the efficient construction of catenated cages.

关键词： cage catenane enthalpic intermediate interlocked cages supramolecular chemistry

Bidirectional engineering of Ammonium Vanadate Enables High-Reversibility Hybrid Batteries

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SSRN 2025年

作者： Wang, Wenlong Tian, Miao Wang, Zhitao Si, Wenhui Fan, Shuang Zhang, Wenming Ying Yang, Hui Chen, Song Hebei Key Laboratory of Optic-Electronic Information and Materials National & Local Joint Engineering Laboratory of New Energy Photoelectric Devices College of Physics Science and Technology Hebei University Baoding071002 China Hebei Key Laboratory of Optic-electronic Information and Materials College of Physics Science and Technology Hebei University Baoding071002 China Henan Engineering Research Center of Design and Recycle for Advanced Electrochemical Energy Storage Material School of Materials Science and Engineering Henan Normal University Xinxiang453007 China School of Sino-German Intelligent Manufacturing Shenzhen City Polytechnic Shenzhen518100 China Pillar of Engineering Product Development Singapore University of Technology and Design 8 Somapah Road 487372 Singapore Singapore

Layered vanadium-based materials are promising for rechargeable magnesium batteries (rMBs) due to their tunable structures and high capacities. However, the strong electrostatic interactions between Mg2+ and cathode materials lead to sluggish ion diffusion and structural degradation, limiting their application. Herein, we propose an innovative bidirectional design strategy, incorporating oxygen vacancies and conductive polymer intercalation into layered ammonium vanadate (NH4V3O8), achieving excellent energy storage capability in Mg2+/Li+ hybrid batteries. First-principles calculations reveal that oxygen vacancies promote charge transfer, while the conductive polymer interlayer reduces ion diffusion barriers, thereby accelerating ion migration. Multiphysics simulations demonstrate that the ingenious architecture improves wettability and mitigates stress concentration, enhancing cycling stability. Moreover, dual-salt electrolyte optimization reduces Mg stripping/plating overpotential and improves interfacial stability. Ex-situ characterizations elucidate the dynamic evolution of vanadium valence states and the reversible Mg2+/Li+ insertion/extraction mechanism. This study provides a systematic framework for the development of advanced cathode materials towards high-performance and sustainable energy storage solutions. © 2025, The Authors. All rights reserved.

关键词： Electrolytes