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检索条件"机构=Neuroscience Graduate Program and MD/PhD Program"
147 条 记 录,以下是11-20 订阅
排序:
Deep and shallow data science for multi-scale optical neuroscience
arXiv
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arXiv 2024年
作者: Mishne, Gal Charles, Adam Halıcıoğlu Data Science Institute Department of Electrical and Computer Engineering the Neurosciences Graduate Program UC San Diego 9500 Gilman Drive La Jolla CA92093 United States Department of Biomedical Engineering Kavli Neuroscience Discovery Institute Center for Imaging Science Department of Neuroscience Mathematical Institute for Data Science Johns Hopkins University BaltimoreMD21287 United States
Optical imaging of the brain has expanded dramatically in the past two decades. New optics, indicators, and experimental paradigms are now enabling in-vivo imaging from the synaptic to the cortex-wide scales. To match... 详细信息
来源: 评论
Modulation of microglial phenotypes improves sepsis-induced hippocampus-dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis (vol 134, pg 765, 2020)
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CLINICAL SCIENCE 2020年 第13期134卷 1677-1677页
作者: Michels, Monique Abatti, Mariane Vieira, Andriele Avila, Pricila Goulart, Amanda Indalecio Borges, Heloisa Corneo, Emily Dominguini, Diogo Barichello, Tatiana Dal-Pizzol, Felipe Laboratory of Experimental Pathophysiology Graduate Program in Health Sciences University of Southern Santa Catarina Criciúma SC Brazil Laboratory of Experimental Microbiology Graduate Program in Health Sciences Health Sciences Unit University of Southern Santa Catarina (UNESC) Criciúma SC Brazil Translational Psychiatry Program Department of Psychiatry and Behavioral Sciences McGovern Medical School The University of Texas Health Science Center at Houston (UTHealth) Houston TX U.S.A. Neuroscience Graduate Program The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston TX U.S.A.
Background: In order to modulate microglial phenotypes in vivo, M1 microglia were depleted by administration of gadolinium chloride and the expression of M2 microglia was induced by IL-4 administration in an animal mo... 详细信息
来源: 评论
Functional Connectome-Based Predictive Modeling in Autism
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BIOLOGICAL PSYCHIATRY 2022年 第8期92卷 626-642页
作者: Horien, Corey Floris, Dorothea L. Greene, Abigail S. Noble, Stephanie Rolison, Max Tejavibulya, Link O'Connor, David McPartland, James C. Scheinost, Dustin Chawarska, Katarzyna Lake, Evelyn M. R. Constable, R. Todd [a]Interdepartmental Neuroscience Program Yale School of Medicine New Haven Connecticut [b]MD-PhD Program Yale School of Medicine New Haven Connecticut [c]Department of Pediatrics Yale School of Medicine New Haven Connecticut [d]Department of Neurosurgery Yale School of Medicine New Haven Connecticut [e]Department of Radiology and Biomedical Imaging Yale School of Medicine New Haven Connecticut [f]Department of Biomedical Engineering Yale University New Haven Connecticut [g]Department of Psychology Yale University New Haven Connecticut [h]Department of Statistics and Data Science Yale University New Haven Connecticut [i]Yale Child Study Center New Haven Connecticut [j]Methods of Plasticity Research Department of Psychology University of Zürich Zurich Switzerland [k]Donders Center for Brain Cognition and Behavior Radboud University Nijmegen Nijmegen The Netherlands
Autism is a heterogeneous neurodevelopmental condition, and functional magnetic resonance imaging-based studies have helped advance our understanding of its effects on brain network activity. We review how predictive ... 详细信息
来源: 评论
A panoramic view of cell population dynamics in mammalian aging
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Science 2025年 第6731期387卷 eadn3949页
作者: Zhang, Zehao Schaefer, Chloe Jiang, Weirong Lu, Ziyu Lee, Jasper Sziraki, Andras Abdulraouf, Abdulraouf Wick, Brittney Haeussler, Maximilian Li, Zhuoyan Molla, Gesmira Satija, Rahul Zhou, Wei Cao, Junyue Laboratory of Single-Cell Genomics and Population Dynamics The Rockefeller University New York NY USA The David Rockefeller Graduate Program in Bioscience The Rockefeller University New York NY USA The Tri-Institutional MD-PhD Program New York NY USA UC Santa Cruz Genomics Institute University of California Santa Cruz CA USA New York Genome Center New York NY USA Center for Genomics and Systems Biology New York University New York NY USA
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling >20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes...
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Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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Cell Reports 2023年 第1期42卷 111965页
作者: Orth-He, Elizabeth L. Huang, Hsin-Che Rao, Sahana D. Wang, Qinghui Chen, Qifeng Chui, Ashley J. Saoi, Michelle Griswold, Andrew R. Bhattacharjee, Abir Ball, Daniel P. Cross, Justin R. Bachovchin, Daniel A. Tri-Institutional PhD Program in Chemical Biology Memorial Sloan Kettering Cancer Center New York 10065 NY United States Chemical Biology Program Memorial Sloan Kettering Cancer Center New York 10065 NY United States Donald B. and Catherine C. Marron Cancer Metabolism Center Memorial Sloan Kettering Cancer Center New York 10065 NY United States Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program New York 10065 NY United States Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences Memorial Sloan Kettering Cancer Center New York 10065 NY United States
NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular danger signals and form inflammasomes. Both undergo autoproteolysis, generating N-terminal (NT) and C-terminal (CT) fragments.... 详细信息
来源: 评论
Genomic data processing with GenomeFlow
arXiv
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arXiv 2025年
作者: Park, Junseok Maury, Eduardo A. Oh, Changhoon Shin, Donghoon Denisko, Danielle Lee, Eunjung Alice Division of Genetics and Genomics Boston Children’s Hospital 3 Blackfan Circle BostonMA United States Department of Pediatrics Harvard Medical School 25 Shattuck St BostonMA United States Bioinformatics Integrative Genomics Program Harvard/MIT MD-PHD Program Harvard Medical School BostonMA United States Program in Medical and Population Genetics Broad Institute of MIT and Harvard CambridgeMA United States Graduate School of Information Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul Korea Republic of Department of Human Centered Design and Engineering University of Washington SeattleWA United States Department of Biomedical Informatics Harvard Medical School BostonMA United States
Advances in genome sequencing technologies generate massive amounts of sequence data that are increasingly analyzed and shared through public repositories. On-demand infrastructure services on cloud computing platform... 详细信息
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The hypothalamus for whole-body physiology:from metabolism to aging
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Protein & Cell 2022年 第6期13卷 394-421页
作者: Tiemin Liu Yong Xu Chun-Xia Yi Qingchun Tong Dongsheng Cai State Key Laboratory of Genetic Engineering Department of Endocrinology and MetabolismInstitute of Metabolism and Integrative BiologyHuman Phenome Instituteand Collaborative Innovation Center for Genetics and DevelopmentZhongshan HospitalSchool of Life SciencesFudan UniversityShanghai 200438China Children’s Nutrition Research Center Department of PediatricsDepartment of Molecular and Cellular BiologyBaylor College of MedicineOne Baylor PlazaHoustonTX 77030USA Department of Endocrinology and Metabolism Amsterdam University Medical CentersAmsterdam Gastroenterology Endocrinology MetabolismUniversity of AmsterdamMeibergdreef 91105AZ AmsterdamNetherlands Brown Foundation Institute of Molecular Medicine Department of Neurobiology and AnatomyUniversity of Texas McGovern Medical SchoolGraduate Program in Neuroscience of MD Anderson UTHealth Graduate School of Biomedical SciencesHoustonTX 77030USA Department of Molecular Pharmacology Albert Einstein College of MedicineBronxNew YorkNY 10461USA
Obesity and aging are two important epidemic factors for metabolic syndrome and many other health issues,which contribute to devastating diseases such as cardiovascular diseases,stroke and *** brain plays a central ro... 详细信息
来源: 评论
The mystery of phospho-Drp1 with four adaptors in cell cycle: when mitochondrial fission couples to cell fate decisions
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Cell Cycle 2023年 第21-22期22卷 2485-2503页
作者: Wu, Nian-Siou Ma, I-Chu Lin, Yi-Fan Ko, Huey-Jiun Loh, Joon-Khim Hong, Yi-Ren Department of Education Hsin-Chu Branch National Taiwan University Hospital Hsinchu Taiwan PhD Program in Molecular Medicine National Tsing Hua University Hsinchu Taiwan Division of Neurology China Medical University Hospital Taichung Taiwan Department of Education National Taiwan University Hospital Taipei Taiwan Department of Biochemistry College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Neurosurgery Kaohsiung Medical University Hospital Kaohsiung Taiwan Graduate Institutes of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Biological Sciences National Sun Yat-Sen University Kaohsiung Taiwan Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung Taiwan Center for Cancer Research Kaohsiung Medical University Kaohsiung Taiwan Neuroscience Research Center Kaohsiung Medical University Kaohsiung Taiwan
Recent study had deepened our knowledge of the mitochondrial dynamics to classify mitochondrial fission into two types. To further clarify the relationship between the two distinct fission machinery and the four major... 详细信息
来源: 评论
Sigma-1R–Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS
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Neurobiology of Disease 2025年 212卷 106992页
作者: Lin, Chun-Yu Wu, Hsuan-Cheng Fu, Ru-Huei Weng, Eddie Feng-Ju Hsieh, Wen-Chi Su, Tsung-Ping Wu, Hsiang-En Wang, Shao-Ming Neuroscience and Brain Disease Center China Medical University Taichung 404328 Taiwan School of Medicine College of Medicine China Medical University Taichung 404328 Taiwan Graduate Institute of Biomedical Sciences College of Medicine China Medical University Taichung 404328 Taiwan Ph.D. Program for Aging China Medical University Taichung 404328 Taiwan Translational Medicine Research Center China Medical University Hospital Taichung 40447 Taiwan Cellular Pathobiology Section Integrative Neuroscience Research Branch Intramural Research Program National Institute on Drug Abuse National Institutes of Health DHHS 333 Cassell Drive Baltimore 21224 MD United States
Nucleocytoplasmic transport disruption contributes to the pathogenesis of C9orf72-associated amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Among the dipeptide repeat proteins translated from G4C2-re... 详细信息
来源: 评论
Translational models of stress and resilience: An applied neuroscience methodology review
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neuroscience Applied 2024年 3卷
作者: Albayrak, Zeynep Seda Vaz, Andreia Bordes, Joeri Ünlü, Selen Sep, Milou S.C. Vinkers, Christiaan H. Pinto, Luisa Yapici-Eser, Hale Koç University Hospital Department of Child and Adolescent Psychiatry Istanbul Turkey Koç University Graduate School of Health Sciences Neuroscience PhD Program Koç University Istanbul Turkey Life and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Campus de Gualtar Braga 4710-057 Portugal ICVS/3B's–PT Government Associate Laboratory Braga 4710-057 Portugal Bn'ML Behavioral and Molecular Lab Campus de Gualtar Braga 4710-057 Portugal Neurocentre Magendie INSERM 1215 Université de Bordeaux Bordeaux France Koç University School of Medicine İstanbul Turkey Department of Psychiatry Amsterdam University Medical Centers Location Vrije Universiteit Amsterdam Netherlands GGZ InGeest Mental Health Care Amsterdam Netherlands Amsterdam Neuroscience Mood Anxiety Psychosis Sleep & Stress Program Amsterdam Netherlands Amsterdam Public Health Mental Health Program Amsterdam Netherlands Department of Psychiatry and Department of Anatomy and Neurosciences Amsterdam University Medical Center Location VUMC Amsterdam Netherlands Academic Working Place Depression GGZ InGeest Amsterdam Netherlands Amsterdam Neuroscience (Mood Anxiety Psychosis Stress & Sleep Program) and Amsterdam Public Health (Mental Health Program) Research Institutes Amsterdam Netherlands Koç University School of Medicine Department of Psychiatry İstanbul Turkey
Stress, encompassing psychological, physical, and physiological challenges, is an important factor affecting an individual's well-being and potentially leading to psychiatric, neurodegenerative, immune, and metabo... 详细信息
来源: 评论