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The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia program

Schizophrenia 2025年第1期11卷 1-14页

作者： Harms, Michael P. Cho, Kang-Ik K. Anticevic, Alan Bolo, Nicolas R. Bouix, Sylvain Campbell, Dylan Cannon, Tyrone D. Cecchi, Guillermo Goncalves, Mathias Haidar, Anastasia Hughes, Dylan E. Izyurov, Igor John, Omar Kapur, Tina Kim, Nicholas Kotler, Elana Kubicki, Marek Kuperman, Joshua M. Laulette, Kristen Lindberg, Ulrich Markiewicz, Christopher Ning, Lipeng Poldrack, Russell A. Rathi, Yogesh Romo, Paul A. Tamayo, Zailyn Wannan, Cassandra Wickham, Alana Yassin, Walid Zhou, Juan Helen Addington, Jean Alameda, Luis Arango, Celso Breitborde, Nicholas J. K. Broome, Matthew R. Cadenhead, Kristin S. Calkins, Monica E. Chen, Eric Yu Hai Choi, Jimmy Conus, Philippe Corcoran, Cheryl M. Cornblatt, Barbara A. Diaz-Caneja, Covadonga M. Ellman, Lauren M. Fusar-Poli, Paolo Gaspar, Pablo A. Gerber, Carla Glenthøj, Louise Birkedal Horton, Leslie E. Hui, Christy Lai Ming Kambeitz, Joseph Kambeitz-Ilankovic, Lana Keshavan, Matcheri S. Kim, Sung-Wan Koutsouleris, Nikolaos Kwon, Jun Soo Langbein, Kerstin Mamah, Daniel Mathalon, Daniel H. Mittal, Vijay A. Nordentoft, Merete Pearlson, Godfrey D. Perez, Jesus Perkins, Diana O. Powers, Albert R. Rogers, Jack Sabb, Fred W. Schiffman, Jason Shah, Jai L. Silverstein, Steven M. Smesny, Stefan Stone, William S. Strauss, Gregory P. Thompson, Judy L. Upthegrove, Rachel Verma, Swapna K. Wang, Jijun Wolf, Daniel H. Kahn, Rene S. Kane, John M. McGorry, Patrick D. Nelson, Barnaby Woods, Scott W. Shenton, Martha E. Wood, Stephen J. Bearden, Carrie E. Pasternak, Ofer Department of Psychiatry Washington University School of Medicine St. Louis MO United States Department of Psychiatry Brigham and Women’s Hospital Harvard Medical School Boston MA United States Department of Psychiatry Yale University School of Medicine New Haven CT United States Department of Psychiatry Beth Israel Deaconess Medical Center Harvard Medical School Boston MA United States Department of Software Engineering and Information Technology École de technologie supérieure Montréal QC Canada Department of Psychology Yale University New Haven CT United States T.J. Watson Research Laboratory IBM Research Yorktown Heights NY United States Department of Psychology Stanford University Stanford CA United States Department of Psychology University of California Los Angeles CA United States Department of Psychiatry and Psychotherapy Jena University Hospital Jena Germany Massachusetts General Hospital Harvard Medical School Boston MA United States Department of Radiology Brigham and Women’s Hospital Harvard Medical School Boston MA United States Department of Radiology University of California San Diego CA United States Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital - Rigshospitalet Glostrup Denmark Seaman Family MR Research Centre Calgary AB Canada Orygen Parkville VIC Australia Centre for Sleep and Cognition and Centre for Translational MR Research Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Department of Psychiatry Hotchkiss Brain Institute University of Calgary Calgary AB Canada General Psychiatry Service Treatment and Early Intervention in Psychosis Program Lausanne University Hospital and University of Lausanne Lausanne Switzerland Department of Child and Adolescent Psychiatry Institute of Psychiatry and Mental Health Hospital General Universitario Gregorio Marañón Instituto de Salud Carlos III School of Medicine Universidad Complutense Madrid Spain

Neuroimaging with MRI has been a frequent component of studies of individuals at clinical high risk (CHR) for developing psychosis, with goals of understanding potential brain regions and systems impacted in the CHR state and identifying prognostic or predictive biomarkers that can enhance our ability to forecast clinical outcomes. To date, most studies involving MRI in CHR are likely not sufficiently powered to generate robust and generalizable neuroimaging results. Here, we describe the prospective, advanced, and modern neuroimaging protocol that was implemented in a complex multi-site, multi-vendor environment, as part of the large-scale Accelerating Medicines Partnership® Schizophrenia program (AMP® SCZ), including the rationale for various choices. This protocol includes T1- and T2-weighted structural scans, resting-state fMRI, and diffusion-weighted imaging collected at two time points, approximately 2 months apart. We also present preliminary variance component analyses of several measures, such as signal- and contrast-to-noise ratio (SNR/CNR) and spatial smoothness, to provide quantitative data on the relative percentages of participant, site, and platform (i.e., scanner model) variance. Site-related variance is generally small (typically <10%). For the SNR/CNR measures from the structural and fMRI scans, participant variance is the largest component (as desired;40–76%). However, for SNR/CNR in the diffusion scans, there is substantial platform-related variance (>55%) due to differences in the diffusion imaging hardware capabilities of the different scanners. Also, spatial smoothness generally has a large platform-related variance due to inherent, difficult to control, differences between vendors in their acquisitions and reconstructions. These results illustrate some of the factors that will need to be considered in analyses of the AMP SCZ neuroimaging data, which will be the largest CHR cohort to date. Watch Dr. Harms discuss this article at https://vimeo.

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A point design for a LEU composite NTP system: Superb use of Low Enriched Uranium (SULEU)

A point design for a LEU composite NTP system: Superb use of...

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2016 nuclear and Emerging Technologies for Space, NETS 2016

作者： Venneri, Paolo F. Eades, Michael J. Kim, Yonghee Ultra-Safe Nuclear Corporation Los AlamosNM87544 United States Department of Nuclear and Quantum Engineering Korea Advanced Institute of Science and Technology Daejeon64141 Korea Republic of Nuclear Engineering Program Ohio State University ColumbusOH43201 United States

ISBN: (纸本)9781510843431

This work presents the initial point design and development of the Superb Use of Low Enriched Uranium (SULEU) nuclear thermal propulsion core. The core design is based off the heritage NERVA design, retaining the graphite-composite fuel elements (the only difference being the enrichment level), the presence of the moderator elements in the core (albeit with a varied configuration and an increase in the size of the moderator sleeve), and the core peripherals including the reflector, control drums, and axial components of the core. The core is unique at this point by the fact that is able to match the existing NASA DRA 5.0 style mission requirements while having a similar mass as existing NTP core designs. The performance parameters achieved by this preliminary design are as follows. It has a mass of 2498 kg (excluding the shield), a nominal Isp of 898 seconds, a nominal thrust of 155.7 kN (35,000 lbf.), and a peak fuel temperature of 2850 K. It should be noted that in order to achieve these performance values, the inlet pressure for the core is higher than other LEU-NTP designs, requiring 8 MPa at the core inlet and consequently higher pressure drop across the core of 3 MPa. Furthermore, SULEU, has a total fissile mass of 235U that is well below that of other cores of the same class. In direct contrast with existing LEU-NTP cores, SULEU has only 18.1 kg of 235U. This establishes it as the current best in class in terms of reduction of fissile material, particularly when compared with tungsten CERMET LEU-NTP cores. In this work we have done a basic neutronic and performance analysis of the core and identified various methods and areas where it can be further improved upon.

关键词： NASA

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Standardised formats and open-source analysis tools for the MAGIC telescopes data

arXiv

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arXiv 2024年

作者： Abe, S. Abhir, J. Abhishek, A. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Aniello, T. Ansoldi, S. Antonelli, L.A. Engels, A. Arbet Arcaro, C. Artero, M. Asano, K. Babić, A. de Almeida, U. Barres Barrio, J.A. Batković, I. Bautista, A. Baxter, J. González, J. Becerra Bednarek, W. Bernardini, E. Bernete, J. Berti, A. Besenrieder, J. Bigongiari, C. Biland, A. Blanch, O. Bonnoli, G. Bošnjak, Ž. Bronzini, E. Burelli, I. Busetto, G. Campoy-Ordaz, A. Carosi, A. Carosi, R. Carretero-Castrillo, M. Castro-Tirado, A.J. Cerasole, D. Ceribella, G. Chai, Y. Cifuentes, A. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Amico, G. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. de Menezes, R. Delfino, M. Delgado, J. Di Pierro, F. Di Tria, R. Di Venere, L. Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Elsaesser, D. Escudero, J. Fariña, L. Fattorini, A. Foffano, L. Font, L. Fröse, S. Fukami, S. Fukazawa, Y. López, R.J. García Garczarczyk, M. Gasparyan, S. Gaug, M. Paiva, J.G. Giesbrecht Giglietto, N. Giordano, F. Gliwny, P. Gradetzke, T. Grau, R. Green, D. Green, J.G. Günther, P. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Llorente, J. Herrera Hrupec, D. Hütten, M. Imazawa, R. Ishio, K. Martínez, I. Jiménez Jormanainen, J. Kayanoki, T. Kerszberg, D. Kluge, G.W. Kobayashi, Y. Kouch, P.M. Kubo, H. Kushida, J. Láinez, M. Lamastra, A. Leone, F. Lindfors, E. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Lorini, A. Lyard, E. de Oliveira Fraga, B. Machado Majumdar, P. Makariev, M. Maneva, G. Manganaro, M. Mangano, S. Mannheim, K. Mariotti, M. Martínez, M. Martínez-Chicharro, M. Mas-Aguilar, A. Mazin, D. Menchiari, S. Mender, S. Miceli, D. Miener, T. Miranda, J.M. Mirzoyan, R. González, M. Molero Molina, E. Mondal, H.A. Moralejo, A. Morcuende, D. Nakamori, T. Nanci, C. Neustroev, V. Nickel, L. Rosillo, M. Nievas Nigro, C. Nikolić, L. Nishijima, K. Ekoume, T. Njoh Noda, K. Nozaki, S. Ohtani, Y. Okumura, A. Otero-Santos, J. The University of Tokyo Chiba Kashiwa277-8582 Japan ETH Zürich ZürichCH-8093 Switzerland Università di Siena INFN Pisa SienaI-53100 Italy Bellaterra BarcelonaE-08193 Spain Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain RomeI-00136 Italy Università di Udine INFN Trieste UdineI-33100 Italy Max-Planck-Institut für Physik GarchingD-85748 Germany Università di Padova INFN PadovaI-35131 Italy Zagreb10000 Croatia URCA RJ Rio de Janeiro22290-180 Brazil IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain Instituto de Astrofísica de Canarias Dpto. de Astrofísica Universidad de La Laguna La Laguna TenerifeE-38200 Spain University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Università di Pisa INFN Pisa PisaI-56126 Italy INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica dell’Università e del Politecnico di Bari BariI-70125 Italy Department for Physics and Technology University of Bergen Norway INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy Croatian MAGIC Group University of Rijeka Faculty of Physics Rijeka51000 Croatia Universität Würzburg WürzburgD-97074 Germany Technische Universität Dortmund DortmundD-44221 Germany Japanese MAGIC Group: Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan ZeuthenD-15738 Germany Armenian MAGIC Group: ICRANet-Armenia Yerevan0019 Armenia Croatian MAGIC Group Josip Juraj Strossmayer University of Osijek Department of Physics Osijek31000 Croatia Finnish MAGIC Group Finnish Cent

Instruments for gamma-ray astronomy at Very High Energies (E > 100 GeV) have traditionally derived their scientific results through proprietary data and software. Data standardisation has become a prominent issue in this field both as a requirement for the dissemination of data from the next generation of gamma-ray observatories and as an effective solution to realise public data legacies of current-generation instruments. Specifications for a standardised gamma-ray data format have been proposed as a community effort and have already been successfully adopted by several instruments. We present the first production of standardised data from the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) telescopes. We converted 166 h of observations from different sources and validated their analysis with the open-source software Gammapy. We consider six data sets representing different scientific and technical analysis cases and compare the results obtained analysing the standardised data with open-source software against those produced with the MAGIC proprietary data and software. Aiming at a systematic production of MAGIC data in this standardised format, we also present the implementation of a database-driven pipeline automatically performing the MAGIC data reduction from the calibrated down to the standardised data level. In all the cases selected for the validation, we obtain results compatible with the MAGIC proprietary software, both for the manual and for the automatic data productions. Part of the validation data set is also made publicly available, thus representing the first large public release of MAGIC data. This effort and this first data release represent a technical milestone toward the realisation of a public MAGIC data legacy. © 2024, CC BY.

关键词： Cosmology

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Constraints on Lorentz invariance violation from the extraordinary Mrk 421 flare of 2014 using a novel analysis method

arXiv

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arXiv 2024年

作者： Abe, S. Abhir, J. Abhishek, A. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Aniello, T. Ansoldi, S. Antonelli, L.A. Engels, A. Arbet Arcaro, C. Artero, M. Asano, K. Babić, A. Baquero, A. de Almeida, U. Barres Barrio, J.A. Batković, I. Bautista, A. Baxter, J. González, J. Becerra Bednarek, W. Bernardini, E. Bernete, J. Berti, A. Besenrieder, J. Bigongiari, C. Biland, A. Blanch, O. Bonnoli, G. Bošnjak, Ž. Bronzini, E. Burelli, I. Busetto, G. Campoy-Ordaz, A. Carosi, A. Carosi, R. Carretero-Castrillo, M. Castro-Tirado, A.J. Cerasole, D. Ceribella, G. Chai, Y. Cifuentes, A. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Amico, G. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. de Menezes, R. Del Popolo, A. Delfino, M. Delgado, J. Mendez, C. Delgado Di Pierro, F. Di Tria, R. Di Venere, L. Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Elsaesser, D. Emery, G. Escudero, J. Fariña, L. Fattorini, A. Foffano, L. Font, L. Fröse, S. Fukami, S. Fukazawa, Y. López, R.J. García Garczarczyk, M. Gasparyan, S. Gaug, M. Paiva, J.G. Giesbrecht Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Gradetzke, T. Grau, R. Green, D. Green, J.G. Günther, P. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Herrera, J. Hrupec, D. Hütten, M. Imazawa, R. Ishio, K. Martínez, I. Jiménez Jormanainen, J. Kayanoki, T. Kerszberg, D. Kluge, G.W. Kobayashi, Y. Kouch, P.M. Kubo, H. Kushida, J. Láinez, M. Lamastra, A. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Lorini, A. Lyard, E. de Oliveira Fraga, B. Machado Majumdar, P. Makariev, M. Maneva, G. Manganaro, M. Mangano, S. Mannheim, K. Mariotti, M. Martínez, M. Martínez-Chicharro, M. Mas-Aguilar, A. Mazin, D. Menchiari, S. Mender, S. Miceli, D. Miener, T. Miranda, J.M. Mirzoyan, R. González, M. Molero Molina, E. Mondal, H.A. Moralejo, A. Morcuende, D. Nakamori, T. Nanci, C. Neustroev, V. Nickel, L. Rosillo, M. Nievas Nigro, C. Nikolić, L. The University of Tokyo Chiba Kashiwa277-8582 Japan ETH Zürich ZürichCH-8093 Switzerland Università di Siena INFN Pisa SienaI-53100 Italy Instituto de Astrofísica de Canarias and Dpto. de Astrofísica Universidad de La Laguna Tenerife La LagunaE-38200 Spain Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain RomeI-00136 Italy Università di Udine INFN Trieste UdineI-33100 Italy Max-Planck-Institut für Physik GarchingD-85748 Germany Università di Padova INFN PadovaI-35131 Italy Bellaterra BarcelonaE-08193 Spain Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Università di Pisa INFN Pisa PisaI-56126 Italy INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica dell’Università e del Politecnico di Bari BariI-70125 Italy Department for Physics and Technology University of Bergen Norway INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy INFN MAGIC Group INFN Sezione di Catania Dipartimento di Fisica e Astronomia University of Catania CataniaI-95123 Italy Croatian MAGIC Group University of Rijeka Faculty of Physics Rijeka51000 Croatia Universität Würzburg WürzburgD-97074 Germany Technische Universität Dortmund DortmundD-44221 Germany University of Geneva Chemin d’Ecogia 16 VersoixCH-1290 Switzerland Japanese MAGIC Group: Physics Program Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8526 Japan ZeuthenD-15738 Germany Armenia

The Lorentz Invariance Violation (LIV), a proposed consequence of certain quantum gravity (QG) scenarios, could instigate an energy-dependent group velocity for ultra-relativistic particles. This energy dependence, although suppressed by the massive QG energy scale EQG, expected to be on the level of the Planck energy 1.22 × 1019 GeV, is potentially detectable in astrophysical observations. In this scenario, the cosmological distances traversed by photons act as an amplifier for this effect. By leveraging the observation of a remarkable flare from the blazar Mrk 421, recorded at energies above 100 GeV by the MAGIC telescopes on the night of April 25 to 26, 2014, we look for time delays scaling linearly and quadratically with the photon energies. Using for the first time in LIV studies a binned-likelihood approach we set constraints on the QG energy scale. For the linear scenario, we set 95% lower limits EQG > 2.7×1017 GeV for the subluminal case and EQG > 3.6×1017 GeV for the superluminal case. For the quadratic scenario, the 95% lower limits for the subluminal and superluminal cases are EQG > 2.6 × 1010 GeV and EQG > 2.5 × 1010 GeV, respectively. Copyright © 2024, The Authors. All rights reserved.

关键词： Gamma rays

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Corrosion testing of TiN on steel substrates for use in waste packages

Corrosion testing of TiN on steel substrates for use in wast...

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2016 Transactions of the American nuclear Society Annual Meeting, ANS 2016

作者： Echols, John R. Fusco, Michael A. Casey, Abigail H.M. Winfrey, A. Leigh Department of Materials Science and Engineering University of Florida GainesvilleFL32611 United States Department of Nuclear Engineering North Carolina State University Raleigh NC27695 United States Nuclear Engineering Program University of Florida GainesvilleFL32611 United States

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A lower bound on intergalactic magnetic fields from time variability of 1ES 0229+200 from MAGIC and Fermi/LAT observations

arXiv

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arXiv 2022年

作者： Acciari, V.A. Agudo, I. Aniello, T. Ansoldi, S. Antonelli, L.A. Engels, A. Arbet Artero, M. Asano, K. Baack, D. Babić, A. Baquero, A. de Almeida, U. Barres Barrio, J.A. Batković, I. González, J. Becerra Bednarek, W. Bernardini, E. Bernardos, M. Berti, A. Besenrieder, J. Bhattacharyya, W. Bigongiari, C. Biland, A. Blanch, O. Bökenkamp, H. Bonnoli, G. Bošnjak, Ž. Burelli, I. Busetto, G. Carosi, R. Ceribella, G. Cerruti, M. Chai, Y. Chilingarian, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Amico, G. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. Del Popolo, A. Delfino, M. Delgado, J. Mendez, C. Delgado Depaoli, D. Di Pierro, F. Di Venere, L. Espiñeira, E. Do Souto Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Elsaesser, D. Ramazani, V. Fallah Fariña, L. Fattorini, A. Font, L. Fruck, C. Fukami, S. Fukazawa, Y. López, R.J. García Garczarczyk, M. Gasparyan, S. Gaug, M. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Green, J.G. Green, D. Hadasch, D. Hahn, A. Hassan, T. Heckmann, L. Herrera, J. Hrupec, D. Hütten, M. Inada, T. Iotov, R. Ishio, K. Iwamura, Y. Martínez, I. Jiménez Jormanainen, J. Jouvin, L. Kerszberg, D. Kobayashi, Y. Kubo, H. Kushida, J. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Linhoff, L. Liodakis, I. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Lorini, A. de Oliveira Fraga, B. Machado Maggio, C. Majumdar, P. Makariev, M. Mallamaci, M. Maneva, G. Manganaro, M. Mannheim, K. Mariotti, M. Martínez, M. Aguilar, A. Mas Mazin, D. Menchiari, S. Mender, S. Mićanović, S. Miceli, D. Miener, T. Miranda, J.M. Mirzoyan, R. Molina, E. Mondal, H.A. Moralejo, A. Morcuende, D. Moreno, V. Moretti, E. Nakamori, T. Nanci, C. Nava, L. Neustroev, V. Rosillo, M. Nievas Nigro, C. Nilsson, K. Nishijima, K. Noda, K. Nozaki, S. Ohtani, Y. Oka, T. Otero-Santos, J. Paiano, S. Palatiello, M. Paneque, D. Paoletti, R. Paredes, J.M. Pavletić, L. Peñil, P. Persic, M. Pihet, M. Instituto de Astrofísica de Canarias Dpto. de Astrofísica Universidad de La Laguna La Laguna TenerifeE-38200 Spain RomeI-00136 Italy Università di Udine INFN Trieste UdineI-33100 Italy Max-Planck-Institut für Physik MünchenD-80805 Germany Bellaterra BarcelonaE-08193 Spain The University of Tokyo Chiba Kashiwa277-8582 Japan Technische Universität Dortmund DortmundD-44221 Germany Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil Università di Padova INFN PadovaI-35131 Italy University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland ZeuthenD-15738 Germany ETH Zürich ZürichCH-8093 Switzerland Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Università di Pisa INFN Pisa PisaI-56126 Italy Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Armenian MAGIC Group A. Alikhanyan National Science Laboratory Yerevan0036 Armenia Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain Department for Physics and Technology University of Bergen Norway INFN MAGIC Group INFN Sezione di Catania Dipartimento di Fisica e Astronomia University of Catania CataniaI-95123 Italy INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica dell’Università e del Politecnico di Bari BariI-70125 Italy Croatian MAGIC Group University of Rijeka Department of Physics Rijeka51000 Croatia Universität Würzburg WürzburgD-97074 Germany Finnish MAGIC Group Finnish Centre for Astronomy with ESO University of Turku TurkuFI-20014 Finland Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Japanese MAGIC Group: Physics Program Graduate School of Advanced Science and E

Context. Extended and delayed emission around distant TeV sources induced by the effects of propagation of γ rays through the intergalactic medium can be used for the measurement of the intergalactic magnetic field (IGMF). Aims. We search for delayed GeV emission from the hard-spectrum TeV γ-ray emitting blazar 1ES 0229+200, with the goal to detect or constrain the IGMF-dependent secondary flux generated during the propagation of TeV γ rays through the intergalactic medium. Methods. We analyze the most recent MAGIC observations over a 5 year time span, and complement them with historic data of the H.E.S.S. and VERITAS telescopes along with a 12-year long exposure of the Fermi/LAT telescope. We use them to trace source evolution in the GeV-TeV band over one-and-a-half decade in time. We use Monte Carlo simulations to predict the delayed secondary γ-ray flux, modulated by the source variability, as revealed by TeV-band observations. We then compare these predictions for various assumed IGMF strengths to all available measurements of the γ-ray flux evolution. Results. We find that the source flux in the energy range above 200 GeV experiences variations around its average on the 14 years time span of observations. No evidence for the flux variability is found in 1 − 100 GeV energy range accessible to Fermi/LAT. Non-detection of variability due to delayed emission from electromagnetic cascade developing in the intergalactic medium imposes a lower bound of B > 1.8 × 10−17 G for long correlation length IGMF and B > 10−14 G for an IGMF of the cosmological origin. Though weaker than the one previously derived from the analysis of Fermi/LAT data, this bound is more robust, being based on a conservative intrinsic source spectrum estimate and accounting for the details of source variability in the TeV energy band. We discuss implications of this bound for cosmological magnetic fields which might explain the baryon asymmetry of the Universe. Copyright © 2022, The Authors. All ri

关键词： Monte Carlo methods

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Simulated Gamma doses to coating materials for use in high level waste packages

Simulated Gamma doses to coating materials for use in high l...

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2016 Transactions of the American nuclear Society Annual Meeting, ANS 2016

作者： Casey, Abigail H.M. Behar, Lucienne Kerrigan, Sean P. Winfrey, A. Leigh Department of Materials Science and Engineering University of Florida GainesvilleFL32611-6400 United States Nuclear Engineering Program University of Florida GainesvilleFL32611-6400 United States

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Classification of Major Depressive Disorder Using Vertex-Wise Brain Sulcal Depth, Curvature, and Thickness with a Deep and a Shallow Learning Model

arXiv

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arXiv 2023年

作者： Goya-Maldonado, Roberto Erwin-Grabner, Tracy Zeng, Ling-Li Ching, Christopher R.K. Aleman, Andre Amod, Alyssa R. Basgoze, Zeynep Benedetti, Francesco Besteher, Bianca Brosch, Katharina Bülow, Robin Colle, Romain Connolly, Colm G. Corruble, Emmanuelle Couvy-Duchesne, Baptiste Cullen, Kathryn Dannlowski, Udo Davey, Christopher G. Dols, Annemiek Ernsting, Jan Evans, Jennifer W. Fisch, Lukas Fuentes-Claramonte, Paola Gonul, Ali Saffet Gotlib, Ian H. Grabe, Hans J. Groenewold, Nynke A. Grotegerd, Dominik Hahn, Tim Hamilton, J. Paul Han, Laura K.M. Harrison, Ben J. Ho, Tiffany C. Jahanshad, Neda Jamieson, Alec J. Karuk, Andriana Kircher, Tilo Klimes-Dougan, Bonnie Koopowitz, Sheri-Michelle Lancaster, Thomas Leenings, Ramona Li, Meng Linden, David E.J. MacMaster, Frank P. Mehler, David M.A. Meinert, Susanne Melloni, Elisa Mueller, Bryon A. Mwangi, Benson Nenadić, Igor Ojha, Amar Okamoto, Yasumasa Oudega, Mardien L. Penninx, Brenda W.J.H. Poletti, Sara Pomarol-Clotet, Edith Portella, Maria J. Pozzi, Elena Radua, Joaquim Rodríguez-Cano, Elena Sacchet, Matthew D. Salvador, Raymond Schrantee, Anouk Sim, Kang Soares, Jair C. Solanes, Aleix Stein, Dan J. Stein, Frederike Stolicyn, Aleks Thomopoulos, Sophia I. Toenders, Yara J. Uyar-Demir, Aslihan Vieta, Eduard Vives-Gilabert, Yolanda Völzke, Henry Walter, Martin Whalley, Heather C. Whittle, Sarah Winter, Nils Wittfeld, Katharina Wright, Margaret J. Wu, Mon-Ju Yang, Tony T. Zarate, Carlos Veltman, Dick J. Schmaal, Lianne Thompson, Paul M. Georg-August University Göttingen Germany College of Intelligence Science and Technology National University of Defense Technology Changsha410073 China Imaging Genetics Center Mark & Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California Marina del ReyCA90274 United States Department of Biomedical Sciences of Cells and Systems University Medical Center Groningen University of Groningen Groningen Netherlands Department of Psychiatry & Mental Health Neuroscience Institute University of Cape Town Cape Town South Africa Department of Psychiatry and Behavioral Science University of Minnesota Medical School MinneapolisMN United States Division of Neuroscience IRCCS Scientific Institute Ospedale San Raffaele Milano Italy Department of Psychiatry and Psychotherapy Jena University Hospital Jena Germany Department of Psychiatry and Psychotherapy University of Marburg Rudolf Bultmann Str. 8 Marburg35039 Germany Institute for Radiology and Neuroradiology University Medicine Greifswald Greifswald Germany MOODS Team CESP INSERM U1018 Faculté de Médecine Univ Paris-Saclay Le Kremlin Bicêtre94275 France Service Hospitalo Universitaire de Psychiatrie de Bicêtre Hôpitaux Universitaires Paris-Saclay Assistance Publique-Hôpitaux deParis Hôpital de Bicêtre Le Kremlin BicêtreF-94275 France Department of Biomedical Sciences Florida State University TallahasseeFL United States Sorbonne University Paris Brain Institute - ICM CNRS Inria Inserm AP-HP Hôpital de la Pitié Salpêtrière ParisF-75013 France Institute for Molecular Bioscience the University of Queensland St LuciaQLD Australia Institute for Translational Psychiatry University of Münster Münster Germany Melbourne Neuropsychiatry Centre Department of Psychiatry the University of Melbourne ParkvilleVIC Australia Department of Psychiatry Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam Neuroscience Amsterdam Public Health Research Institute Am

Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD, likely due to the heterogeneity of this disorder. The application of deep learning tools to neuroimaging data, capable of capturing complex non-linear patterns, has the potential to provide diagnostic and predictive biomarkers for MDD. However, previous attempts to demarcate MDD patients and healthy controls (HC) based on segmented cortical features via linear machine learning approaches have reported low accuracies. In this study, we used globally representative data from the ENIGMA-MDD working group containing 7,012 participants from 30 sites (N=2,772 MDD and N=4,240 HC), which allows a comprehensive analysis with generalizable results. Based on the hypothesis that integration of vertex-wise cortical features can improve classification performance, we evaluated the classification of a DenseNet and a Support Vector Machine (SVM), with the expectation that the former would outperform the latter. As we analyzed a multi-site sample, we additionally applied the ComBat harmonization tool to remove potential nuisance effects of site. We found that both classifiers exhibited close to chance performance (balanced accuracy DenseNet: 51%;SVM: 53%), when estimated on unseen sites. Slightly higher classification performance (balanced accuracy DenseNet: 58%;SVM: 55%) was found when the cross-validation folds contained subjects from all sites, indicating site effect. In conclusion, the integration of vertex-wise morphometric features and the use of the non-linear classifier did not lead to the differentiability between MDD and HC. Our results support the notion that MDD classification on this combination of features and classifiers is unfeasible. Future studies are needed to determine whether more sophisticated integration of information from ot

关键词： Support vector machines

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Leveraging correlation to reduce uncertainty in efficiency measurements for low pressure ratio fans

Leveraging correlation to reduce uncertainty in efficiency m...

引用

ASME Turbo Expo 2016: Turbomachinery Technical Conference and Exposition, GT 2016

作者： Ferrar, Anthony M. Schneck, William C. O'Brien, Walter F. B and e Applied Research and Science Lab Nuclear Engineering Program University of Florida GainesvilleFL United States TurboLab Mechanical Engineering Virginia Tech BlacksburgVA United States

ISBN: (纸本)9780791849699

This paper presents the often-neglected correlation terms for uncertainty propagation and shows their importance for rigorous uncertainty analysis. It shows that these terms can be leveraged, often through simple experimental design changes to substantially reduce uncertainty. The efficiency equation is particularly suited to this approach, with order of magnitude uncertainty reductions possible. The paper will present this effect from both a theoretical study and from data measured behind a transonic fan during a distortion response program. The efficiency equation is particularly suited to improving uncertainty by leveraging the correlation terms because the temperature uncertainty contributes most of the overall uncertainty. Systematic error sources usually dominate thermocouple measurement uncertainty because the slow time response leads to small random errors. The partial derivatives with respect to inlet and outlet total temperature have opposite signs. Correlations between these systematic errors are relatively easy to force through using a single data acquisition system and in-situ calibration standard. This paper presents performance comparisons of these effects for thermocouples. For a 1.35 pressure ratio, 85% efficiency fan, the uncertainty can be reduced by correlation from 85% ± 6.7% to 85% ± 0.48% for typical K-type thermocouples. © 2016 by ASME.

关键词： Systematic errors

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Constraints on Cosmic Strings Using Data from the Third Advanced LIGO–Virgo Observing Run

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Physical Review Letters 2021年第24期126卷 241102-241102页

作者： R. Abbott T. D. Abbott S. Abraham F. Acernese K. Ackley A. Adams C. Adams R. X. Adhikari V. B. Adya C. Affeldt D. Agarwal M. Agathos K. Agatsuma N. Aggarwal O. D. Aguiar L. Aiello A. Ain P. Ajith T. Akutsu K. M. Aleman G. Allen A. Allocca P. A. Altin A. Amato S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Ando S. V. Angelova S. Ansoldi J. M. Antelis S. Antier S. Appert Koya Arai Koji Arai Y. Arai S. Araki A. Araya M. C. Araya J. S. Areeda M. Arène N. Aritomi N. Arnaud S. M. Aronson H. Asada Y. Asali G. Ashton Y. Aso S. M. Aston P. Astone F. Aubin P. Auclair P. Aufmuth K. AultONeal C. Austin S. Babak F. Badaracco M. K. M. Bader S. Bae Y. Bae A. M. Baer S. Bagnasco Y. Bai L. Baiotti J. Baird R. Bajpai M. Ball G. Ballardin S. W. Ballmer M. Bals A. Balsamo G. Baltus S. Banagiri D. Bankar R. S. Bankar J. C. Barayoga C. Barbieri B. C. Barish D. Barker P. Barneo S. Barnum F. Barone B. Barr L. Barsotti M. Barsuglia D. Barta J. Bartlett M. A. Barton I. Bartos R. Bassiri A. Basti M. Bawaj J. C. Bayley A. C. Baylor M. Bazzan B. Bécsy V. M. Bedakihale M. Bejger I. Belahcene V. Benedetto D. Beniwal M. G. Benjamin T. F. Bennett J. D. Bentley M. BenYaala F. Bergamin B. K. Berger S. Bernuzzi D. Bersanetti A. Bertolini J. Betzwieser R. Bhandare A. V. Bhandari D. Bhattacharjee S. Bhaumik J. Bidler I. A. Bilenko G. Billingsley R. Birney O. Birnholtz S. Biscans M. Bischi S. Biscoveanu A. Bisht B. Biswas M. Bitossi M.-A. Bizouard J. K. Blackburn J. Blackman C. D. Blair D. G. Blair R. M. Blair F. Bobba N. Bode M. Boer G. Bogaert M. Boldrini F. Bondu E. Bonilla R. Bonnand P. Booker B. A. Boom R. Bork V. Boschi N. Bose S. Bose V. Bossilkov V. Boudart Y. Bouffanais A. Bozzi C. Bradaschia P. R. Brady A. Bramley A. Branch M. Branchesi M. Breschi T. Briant J. H. Briggs A. Brillet M. Brinkmann P. Brockill A. F. Brooks J. Brooks D. D. Brown S. Brunett G. Bruno R. Bruntz J. Bryant A. Buikema T. Bulik H. J. Bulten A. Buonanno R. Buscicchio D. Buskulic L. Cadonati M. Caesar G. Cagnoli C. Cahillane H. W. Cain, III J. Calderón Bustillo J. D LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Louisiana State University Baton Rouge Louisiana 70803 USA Inter-University Centre for Astronomy and Astrophysics Pune 411007 India Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli Complesso Universitario di Monte S.Angelo I-80126 Napoli Italy OzGrav School of Physics and Astronomy Monash University Clayton 3800 Victoria Australia Christopher Newport University Newport News Virginia 23606 USA LIGO Livingston Observatory Livingston Louisiana 70754 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany University of Cambridge Cambridge CB2 1TN United Kingdom Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena D-07743 Jena Germany University of Birmingham Birmingham B15 2TT United Kingdom Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA) Northwestern University Evanston Illinois 60208 USA Instituto Nacional de Pesquisas Espaciais 12227-010 São José dos Campos São Paulo Brazil Gravity Exploration Institute Cardiff University Cardiff CF24 3AA United Kingdom Gran Sasso Science Institute (GSSI) I-67100 L’Aquila Italy INFN Laboratori Nazionali del Gran Sasso I-67100 Assergi Italy INFN Sezione di Pisa I-56127 Pisa Italy Università di Pisa I-56127 Pisa Italy International Centre for Theoretical Sciences Tata Institute of Fundamental Research Bengaluru 560089 India Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan California State University Fullerton Fullerton California 92831 USA NCSA University of Illi

We search for gravitational-wave signals produced by cosmic strings in the Advanced LIGO and Virgo full O3 dataset. Search results are presented for gravitational waves produced by cosmic string loop features such as cusps, kinks, and, for the first time, kink-kink collisions. A template-based search for short-duration transient signals does not yield a detection. We also use the stochastic gravitational-wave background energy density upper limits derived from the O3 data to constrain the cosmic string tension Gμ as a function of the number of kinks, or the number of cusps, for two cosmic string loop distribution models. Additionally, we develop and test a third model that interpolates between these two models. Our results improve upon the previous LIGO–Virgo constraints on Gμ by 1 to 2 orders of magnitude depending on the model that is tested. In particular, for the one-loop distribution model, we set the most competitive constraints to date: Gμ≲4×10−15. In the case of cosmic strings formed at the end of inflation in the context of grand unified theories, these results challenge simple inflationary models.

关键词： Cosmic strings & domain walls Gravitational waves

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