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Human umbilical cord mesenchymal stem cells derivedexosomes on VEGF-A in hypoxic-induced mice retinal astrocytes and mice model of retinopathy of prematurity

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International Journal of ophthalmology(English edition) 2024年第7期17卷 1238-1247页

作者： Xiao-Tian Zhang Bo-Wen Zhao Yuan-Long Zhang Song Chen Tianjin Eye Hospital Tianjin 300020China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin 300020China

AIM:To observe the effect of human umbilical cord mesenchymal stem cells(hUCMSCs)secretions on the relevant factors in mouse retinal astrocytes,and to investigate the effect of hUCMSCs on the expression of vascular endothelial growth factor-A(VEGF-A)and to observe the therapeutic effect on the mouse model of retinopathy of prematurity(ROP).METHODS:Cultured hUCMSCs and extracted exosomes from them and then retinal astrocytes were divided into control group and hypoxia *** assay,flow cytometry,reverse transcription-polymerase chain reaction(RT-PCR)and Western blot were used to detect related *** mechanisms by which hUCMSCs exosomes affect VEGF-A expression in hypoxia-induced mouse retinal astrocytes were *** last,the efficacy of exosomes of UCMSCs in a mouse ROP model was ***6 was used to comprehensively process data ***:The secretion was successfully extracted from the culture supernatant of hUCMSCs by gradient *** oxygen species(ROS)and hypoxia inducible factor-1α(HIF-1α)of mice retinal astrocytes under different hypoxia time and the expression level of VEGF-A protein and VEGF-A mRNA increased,and the ROP cell model was established after 6h of *** secretions of medium and high concentrations of hUCMSCs can reduce ROS and HIF-1α,the expression levels of VEGF-A protein and VEGF-A mRNA are statistically significant and concentration *** with the ROP cell model group,the expression of phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)signal pathway related factors in the hUCMSCs exocrine group is significantly *** intravitreal injection of the secretions of medium and high concentrations of hUCMSCs can reduce VEGF-A and HIF-1αin ROP model *** staining shows that the number of retinal neovascularization in ROP mice decreases with the increase of the dose of hUCMSCs ***:In a hypoxia induced

关键词： human umbilical cord mesenchymal stem cells retinal astrocytes retinopathy of prematurity vascular endothelial growth factor hypoxia inducible factor

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Symmetry of upper eyelid after unilateral blepharoptosis repair with minimally invasive conjoint fascial sheath suspension technique

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International Journal of ophthalmology(English edition) 2024年第1期17卷 53-60页

作者： Yianzhu Liu Wenli Chen Xia Chen Tianjin Eye Hospital Tianjin 300020China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin 300020China

AIM:To investigate the symmetry of upper eyelid in patients with unilateral mild and moderate blepharoptosis who underwent unilateral minimally invasive combined fascia sheath(CFS)***:A retrospective study of patients who underwent unilateral minimally invasive CFS suspension surgery between January 2018 and December *** criteria included unilateral mild and moderate ptosis,good levator muscle function(>9 mm)and follow-up of at least ***-and post-operative symmetry was graded subjectively for marginal reflex distance 1(MRD1),tarsal platform show(TPS)and eyebrow fat span(BFS).A t-test was used to evaluate MRD1,TPS and BFS asymmetry by calculating delta *** Bézier curve tool of the Image J software was used to extract the upper eyelid contours,where the symmetry was measured by the percentage of overlapping curvatures(POC).RESULTS:Totally 105 patients(105 eyelids)were included(mild group,n=84;moderate group,n=21).Postoperatively,all patients increased MRD1 and decreased TPS in the ptotic eye while maintaining unchanged *** asymmetric delta value for MRD1 was measured to be 1.48±0.86 preoperatively,and it decreased to 0.58±0.67 postoperatively in all cases(P=0.0004).In patients with mild ptosis,the asymmetry value of TPS fell significantly from 1.15±0.62 to 0.68±0.38(P=0.0187).The symmetry of the upper eyelid contour increased in all subgroups of patients,with a POC of 59.39%±13.45%preoperatively and POC of 78.29%±13.80%***:Minimally invasive CFS suspension is proved to be an effective means of improving the symmetry of unilateral ptosis in terms of MRD1(all subgroups),POC(all subgroups)and TPS(only mild group),whereas BFS is unaffected.

关键词： symmetry unilateral blepharoptosis minimally invasive combined fascia sheath suspension

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Observation of the Curative Effect of the Dexamethasone Vitreous Cavity Implant for the Treatment of Irvine-Gass Syndrome

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Biomedical and Environmental sciences 2023年第8期36卷 725-731页

作者： MAO Yu GAO Li Qin JIA Li Yun HOU Si Meng XIAO Yuan Yuan JI Xi Wen WANG Shuang Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Objective To investigate the clinical efficacy of dexamethasone vitreous cavity implants(Ozurdex)for the treatment of macular edema(Irvine-Gass Syndrome)after cataract *** Eight patients(eight eyes)with Irvine-Gass syndrome were enrolled for vitreous injections with *** patients included six men(six eyes)and two women(two eyes)with a mean age of 67.12±11.92 *** in the patients best-corrected visual acuity(BCVA),central macular thickness(CMT),and intraocular pressure were compared before and after *** The mean visual acuity BCVA of the patients was 0.81±0.26 before implantation,which improved to 0.20±0.12,0.13±0.09,and 0.15±0.13 at 2 weeks,1 month,and 3 months after implantation,respectively(P<0.001).The patient’s mean CMT before implantation was 703.00±148.88μm,and it reduced to 258.87±37.40μm,236.25±28.74μm,and 278.00±76.82μm at 2 weeks,1 month,and 3 months after implantation,respectively(P<0.001).Conclusion The dexamethasone vitreous cavity implant(Ozurdex)is a safe and effective treatment,which can effectively improve patient’s visual acuity and reduce macular edema associated with cataract surgery.

关键词： Irvine-Gass Syndrome Macular edema Dexamethasone Vitreous injection

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The Effect of Intense Pulsed Light Treatment for Chronic Hordeolum

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Biomedical and Environmental sciences 2023年第11期36卷 1005-1014页

作者： YANG Ke WEN Ya ZHU Lei BAO Jia Yu LI Shang WANG Ying Hui FENG Jun TIAN Lei JIE Ying Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Science Key LabBeijing 100730China

Objective To evaluate the effect of intense pulsed light(IPL)in the treatment of chronic *** Patients with chronic hordeolum who underwent IPL treatment were enrolled in this *** to the severity of hordeolum,the patients were treated with IPL 3 to 5 ***’satisfaction and visual analog scale scores for ocular discomfort symptoms before and after treatment were *** number,congestion,long diameter,short diameter and area of nodules were also recorded and ***,eyelid margin signs,meibum quality,meibomian gland expressibility,meibomian gland dropout,tear meniscus height,and corneal fluorescein staining were *** 20 patients were enrolled in this *** eyelid margins were congestive and swollen,with blunt rounding or *** meibum was cloudy or *** meibomian gland expressibility,meibomian gland dropout and tear meniscus height were *** cornea showed scattered fluorescein *** treatment,score of visual analog scale,congestion and size of nodules were significantly *** margin signs,meibum quality,meibomian gland expressibility,tear meniscus height and corneal fluorescein staining scores were *** gland dropout had no significant *** side effects occurred during *** IPL is beneficial for the treatment of chronic hordeolum.

关键词： Intense pulsed light Hordeolum Chronic

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Technique of using Cionni-modified capsular tension ring in the management of severely traumatic lens subluxation

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International Journal of ophthalmology(English edition) 2023年第7期16卷 1078-1083页

作者： Hao Jiang Wei Zhang Yan-Hua Chu Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteClinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China

AIM:To investigate the effect of Cionni-modified capsular tension ring(CTR)implantation in patients with severely traumatic subluxated ***:All patients who totally had traumatic cataracts and lost zonule support and underwent cataract surgery were retrospectively *** distance visual acuity(CDVA),extent of zonulysis,intraocular lens(IOL)position,intraoperative presentation,and complications were *** primary outcomes included IOL centration stability and other postoperative ***:Twenty patients(20 eyes)were included in this *** mean age in this study was 58.0±11.3y,and the average follow-up time was 17.3±*** bags were saved by Cionni-modified *** eyes(45%)underwent simultaneously anterior vitrectomy due to the presence of vitreous in the anterior *** preoperative mean CDVA was 0.83±0.24 log MAR,and the postoperative average CDVA was 0.23±0.30 log MAR(P<0.05).The horizontal and vertical IOL decentration after surgery was 0.27±0.12 mm and 0.41±0.19 mm,respectively;the vertical and horizontal IOL tilt after surgery was 5.5°±2.5°and 6.1°±2.2°,*** of the eyes had obvious IOL decentration during the follow-up *** eyes(40%)had posterior capsule opacification(PCO)that was severe enough to cause poor ***:YAG laser capsulotomy were performed on these eyes when the CTR was ***:With the help of Cionni-modified CTR,capsular bag preservation and better IOL concentration can be achieved without major complications in patients with severely traumatic subluxated cataracts.

关键词： Cionni-modified capsular tension ring subluxated traumatic cataracts surgical technique intraocular lens decentration intraocular lens tilt

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Lycium barbarum polysaccharide inhibits retinal neovascularization and inflammation in vitro and in vivo

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International Journal of ophthalmology(English edition) 2025年第2期18卷 216-221页

作者： Bin Wu Xue Wang Wei Zhang Xin Wang Qi-Miao Wang Ya-Ju Pang Yi-Chun Kong Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteClinical College of Ophthalmology Tianjin Medical UniversityTianjin 300102China Department of Ophthalmology Tianjin Hospital of Integrated Traditional Chinese and Western MedicineTianjin 300100China

AIM:To explore the effect and mechanism of Lycium barbarum polysaccharide(LBP)inhibiting retinal ***:In vitro tests were performed on human retinal microvascular endothelial cells(HRECs)from three groups,including control group(normal oxygen),hypoxic group(hypoxia at 37℃,1%O_(2),5%CO_(2),and 94%N_(2)),and LBP group(hypoxic group with LBP 100μg/mL).In vivo experiments,C57 mice were divided into three groups:control group(normal rearing group),the oxygen-induced ischemic retinopathy(OIR)group,and the OIR with 50 mg/kg LBP *** neovascularization was observed by fluorescein angiography and *** thickness was evaluated by Hematoxylin and eosin(HE)*** expression of epidermal growth factor receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),mammalian target of rapamycin(mTOR),phosphorylated mammalian target of rapamycin(p-mTOR),protein kinase B(AKT),phosphorylated protein kinase B(p-AKT),interleukin-1β(IL-1β),inducible nitric oxide synthase(iNOS),and tumor necrosis factor-α(TNF-α)in each group were analyzed by Western ***-1βlevel in retina was analyzed using immunohistochemical ***:The increased area of neovascular clusters in OIR mice was significantly decreased by *** thickness of OIR mice was significantly thinner compared with normal oxygenated mice and was increased in LBP *** with those in the hypoxic groups,Western blotting of HRECs and retinal tissues revealed that the expression of EGFR,PI3K,p-mTOR,p-AKT,IL-1β,iNOS,and TNF-αdecreased in the LBP group but was still greater than that in control ***,IL-1βwas reduced in retinal sections treated with *** the scratch test,the cell migration of the hypoxic group was significantly greater than that of the control group,while LBP treatment attenuated this increase in ***:LBP reduces retinal neovascularization and inflammation in vivo and inhibits the migration of HRECs in vitro by regulating the EGFR/PI3K/

关键词： Lycium barbarum polysaccharide neovascularization epidermal growth factor receptor retina

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Single self-leading suture technique for iridodialysis repairment

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International Journal of ophthalmology(English edition) 2024年第9期17卷 1752-1754页

作者： Jing-Wen Hui Quan-Hong Han Yong Tang Ying Wang Tianjin Eye Hospital Tianjin 300020China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin 300020China Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China

Dear Editor,We described an innovative“single self-leading suture technique”for repairing *** of moving the needle forth and back,our method is easier to manipulate in the narrow surgical space between the cornea and lens,which will decrease the unnecessary complications related to iatrogenic *** provide an economical friendly and less time-taking method,which improves the suture accuracy.

关键词： dialysis needle suture

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OCTA characteristics in non-arteritic central retinal artery occlusion and correlation with visual acuity

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International Journal of ophthalmology(English edition) 2024年第2期17卷 289-296页

作者： Hong-Xia Gong Bin Wu Shi-Yong Xie Wei Zhang Song Chen Tianjin Key Lab of Ophthalmology and Visual Science Department of Ophthalmology for Integrated Traditional Chinese and Western MedicineTianjin Eye HospitalTianjin 300020China Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300010China Eye Hospital Affiliated to Nankai University Tianjin 300020China

AIM:To observe the retinal and choroidal circulations in patients with non-arteritic permanent central retinal artery occlusion(NA-CRAO)via optical coherence tomography angiography(OCTA)and analyze their correlation with visual ***:Sixty-two eyes with clinically confirmed acute NA-CRAO were included in the study and divided into:A type(mild n=29),B type(moderate n=27)and C type(severe n=6)based on the degree of visual loss,retinal edema,and arterial blood flow delay in fundus fluorescence angiography(FFA).Contralateral healthy eyes were used as the control ***-corrected visual acuity(BCVA),slit lamp microscopy,indirect ophthalmoscopy,fundus color photography,OCTA,and FFA were ***’s correlation analysis was used to determine the correlations between retinal and choroidal vessels and visual ***:There were no statistically significant differences in age,gender,and intraocular pressure among the three types and the control group(P>0.05).Vessel density in deep capillary plexus(VD-DCP)significantly decreased(P<0.05)in all three types of NA-CRAO patients compared to the control *** density in superficial vascular plexus(VD-SVP)significantly decreased(P<0.05)in type A patients and choriocapillaris flow area significantly decreased(P<0.05)in type B and type C patients compared to the control group;while outer retinal flow areas significantly increased in the type A(P<0.05)and decreased in type C patients(P<0.05).The retinal thickness significantly increased in type C group(P<0.05).The VD-SVP at fovea in the type A was significantly lower than both of type B and *** VD-SVP at nasal parafovea in type A and B was significantly lower than type C(P<0.05).The logMAR BCVA of type A was significantly better than that of type B and C groups(P<0.05).Spearman’s correlation analysis showed that the logMAR BCVA was positively correlated with VD-SVP at fovea(r=0.679,P=0.031)and nasal parafovea(r=0.826,P=0.013).CONCLUSION:OCTA is valua

关键词： non-arteritic central retinal artery occlusion fundus fluorescence angiography optical coherence tomography angiography retinal vessel density visual acuity

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Evaluation of dry eye disease symptomatology and mental health status among patients with different COVID-19 statuses

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International Journal of ophthalmology(English edition) 2024年第5期17卷 822-830页

作者： Fang Ruan Wen-Jun Kong Qian Fan Hong-Wei Dong Wei Zhang Wen-Bin Wei Ying Jie Department of Ophthalmology Beijing You’an HospitalCapital Medical UniversityBeijing Infectious Eye Disease Diagnosis and Treatment CenterBeijing 100069China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Institute of OphthalmologyBeijing Ophthalmology and Visual Sciences Key LabBeijing 100730China Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteNankai University Affiliated Eye HospitalNankai University Eye InstituteNankai UniversityClinical College of OphthalmologyTianjin Medical UniversityTianjin 300020China

AIM:To evaluate dry eye disease(DED)symptomatology and mental health status in different COVID-19 ***:A cross-sectional observational design was *** 123 eligible adults(46.34%of men,age range,18-59y)with COVID-19 included in the study from August to November,*** Surface Disease Index(OSDI),Five-item Dry Eye Questionnaire(DEQ-5),Hospital Anxiety and Depression Scale(HADS),and Pittsburgh Sleep Quality Index(PSQI)were used in this ***:OSDI scores were 6.82(1.25,15.91)in asymptomatic carriers,7.35(2.50,18.38)in mild cases,and 16.67(4.43,28.04)in recurrent cases,with 30.00%,35.56%,and 57.89%,respectively evaluated as having DED symptoms(χ2=7.049,P=0.029).DEQ-5 score varied from 2.00(0,6.00)in asymptomatic carriers,3.00(0,8.00)in mild cases,and 8.00(5.00,10.00)in recurrent cases,with 27.50%,33.33%,and 55.26%,respectively assessed as having DED symptoms(χ2=8.532,P=0.014).The prevalence of clinical anxiety(50.00%)and depression(47.37%)symptoms were also significantly higher in patients with recurrent infection(χ2=24.541,P<0.001;χ2=30.871,P<0.001).Recurrent infection was a risk factor for high OSDI scores[odds ratio,2.562;95%confidence interval(CI),1.631-7.979;P=0.033]and DEQ-5 scores(odds ratio,3.353;95%CI,1.038-8.834;P=0.043),whereas having a fixed occupation was a protective factor for OSDI scores(odds ratio,0.088;95%CI,0.022-0.360;P=0.001)and DEQ-5 scores(odds ratio,0.126;95%CI,0.039-0.405;P=0.001).CONCLUSION:Patients with recurrent COVID-19 have more severe symptoms of DED,anxiety,and depression.

关键词： COVID-19 dry eye disease recurrent infection mental health

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Safety evaluation after LASIK surgery based on the linear creep property:a finite element analysis

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International Journal of ophthalmology(English edition) 2025年第5期18卷 889-896页

作者： Ji-Xi Guo Xue-Feng Li Xin-Chao Wang Xin-Heng Zhao Yan Wang Li-Hua Fang Key Laboratory for Optoelectronic Information Perception and Instrumentation of Jiangxi Province Nanchang Hangkong UniversityNanchang 330063Jiangxi ProvinceChina Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye InstituteTianjin Eye HospitalNankai University Eye InstituteNankai UniversityClinical College of OphthalmologyTianjin Medical UniversityTianjin 300000China

AIM:To investigate the effect of the percent tissue altered(PTA)on the safety after laser-assisted in situ keratomileusis(LASIK)based on linear creep ***:The linear creep characteristics of the cornea were characterized by the generalized Kelvin-Voigt constitutive relationship with five ***,the displacement and stress distribution on the anterior and posterior surfaces of the cornea were analyzed by constructing the eye model with different ***:When PTA was above 39%,the vertex displacements under physiological intraocular pressure(IOP,15 mm Hg)exceeded that of the preoperative glaucoma under average *** is,an excessively high displacement value was *** addition,with the increase of PTA,the central cornea was stretched thinner and more obviously due to *** PTA was above 39%,the stress at the center of the anterior surface of the residual stroma was more than 20%larger than that of the normal human *** residual stroma was forced to stretch more severely due to excessive stress on the anterior *** resulted in deformation of the stroma and induced corneal ***,the postoperative vertex displacement increased with the decrease in viscosity ***:PTA less than 39%is the safe range for LASIK *** study may provide a reliable numerical basis for postoperative corneal dilatation and the outcomes after refractive surgery.

关键词： laser-assisted in situ keratomileusis finite element percent tissue altered vertex displacement

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