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Lycium barbarum polysaccharide inhibits retinal neovascularization and inflammation in vitro and in vivo

International Journal of ophthalmology(English edition) 2025年第2期18卷 216-221页

作者： Bin Wu Xue Wang Wei Zhang Xin Wang Qi-Miao Wang Ya-Ju Pang Yi-Chun Kong Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteClinical College of Ophthalmology Tianjin Medical UniversityTianjin 300102China Department of Ophthalmology Tianjin Hospital of Integrated Traditional Chinese and Western MedicineTianjin 300100China

AIM:To explore the effect and mechanism of Lycium barbarum polysaccharide(LBP)inhibiting retinal ***:In vitro tests were performed on human retinal microvascular endothelial cells(HRECs)from three groups,including control group(normal oxygen),hypoxic group(hypoxia at 37℃,1%O_(2),5%CO_(2),and 94%N_(2)),and LBP group(hypoxic group with LBP 100μg/mL).In vivo experiments,C57 mice were divided into three groups:control group(normal rearing group),the oxygen-induced ischemic retinopathy(OIR)group,and the OIR with 50 mg/kg LBP *** neovascularization was observed by fluorescein angiography and *** thickness was evaluated by Hematoxylin and eosin(HE)*** expression of epidermal growth factor receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),mammalian target of rapamycin(mTOR),phosphorylated mammalian target of rapamycin(p-mTOR),protein kinase B(AKT),phosphorylated protein kinase B(p-AKT),interleukin-1β(IL-1β),inducible nitric oxide synthase(iNOS),and tumor necrosis factor-α(TNF-α)in each group were analyzed by Western ***-1βlevel in retina was analyzed using immunohistochemical ***:The increased area of neovascular clusters in OIR mice was significantly decreased by *** thickness of OIR mice was significantly thinner compared with normal oxygenated mice and was increased in LBP *** with those in the hypoxic groups,Western blotting of HRECs and retinal tissues revealed that the expression of EGFR,PI3K,p-mTOR,p-AKT,IL-1β,iNOS,and TNF-αdecreased in the LBP group but was still greater than that in control ***,IL-1βwas reduced in retinal sections treated with *** the scratch test,the cell migration of the hypoxic group was significantly greater than that of the control group,while LBP treatment attenuated this increase in ***:LBP reduces retinal neovascularization and inflammation in vivo and inhibits the migration of HRECs in vitro by regulating the EGFR/PI3K/

关键词： Lycium barbarum polysaccharide neovascularization epidermal growth factor receptor retina

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visual outcomes and corneal biomechanical evaluation between LASIK and LASIK combined with accelerated corneal crosslinking

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International Journal of ophthalmology(English edition) 2025年第3期18卷 496-503页

作者： Li Zhang Yue-Hua Zhou Xiao-Rui Wang Yan Zheng Cai-Yun Fu Xiu-Mei Song Ya-Bin Hu Yue Wang Chang-Bin Zhai Beijing Tongren Eye Center Beijing Tongren Hospital Affiliated to Capital Medical UniversityBeijing Ophthalmology&Visual Science Key LabBeijing 100730China Beijing Ming Vision&Ophthalmology Beijing 100191China College of Ophthalmology Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina School of Optometry and Vision Sciences Cardiff UniversityCardiffCF244HQUK

AIM:To assess the visual outcomes and corneal biomechanical properties of myopia patients between laser in situ keratomileusis(LASIK)and LASIK combined with accelerated corneal crosslinking(LASIK Xtra).METHODS:This prospective study analyzed 52 consecutive myopia patients treated with LASIK Xtra and 45 consecutive myopia patients treated with *** the right eyes in the two groups were *** uncorrected distance visual acuity(UDVA),keratometry values,postoperative central corneal thickness(CCT),corneal demarcation line depth,the corneal compensated intraocular pressure(IOPcc),Goldmann-correlated IOP(IOPg),corneal resistance factor(CRF)and corneal hysteresis(CH)from Ocular Response Analyzer(ORA)were ***,the correlation between the demarcation line depth and ORA-related biomechanical parameters were ***:No significant differences in UDVA,postoperative CCT,or mean K values were found between the 2 groups at 1 to 12mo postoperative follow-up(all P>0.05).The changes of CRF was significantly lower in the LASIK Xtra group compared to the LASIK group(all P<0.05)at all the postoperative *** changes of CH were significantly higher in the LASIK Xtra group(all P<0.05).No significant differences were discovered regarding the changes of IOPcc and IOPg posperatively(all P>0.05).Out of 52 cases in the LASIK Xtra group,the demarcation line was present in 40 eyes(77%).The average depth of the demarcation was 220.73±42.70μm(136 to 288μm).No significant correlation was observed between the depth of the demarcation line and any of the ORA-related biomechanical parameters such as IOPcc,IOPg,CRF and CH at 12mo(all P>0.05).CONCLUSION:Both procedures demonstrate comparable outcomes in terms of visual acuity,refraction and ablation *** study confirms that corneal biomechanical properties of the included patients weakened after both procedures,but the cornea after LASIK Xtra are stiffer than conventional LASIK.

关键词： myopia femto-laser in situ keratomileusis laser in situ keratomileusis combined with accelerated corneal crosslinking corneal biomechanics

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Safety evaluation after LASIK surgery based on the linear creep property:a finite element analysis

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International Journal of ophthalmology(English edition) 2025年第5期18卷 889-896页

作者： Ji-Xi Guo Xue-Feng Li Xin-Chao Wang Xin-Heng Zhao Yan Wang Li-Hua Fang Key Laboratory for Optoelectronic Information Perception and Instrumentation of Jiangxi Province Nanchang Hangkong UniversityNanchang 330063Jiangxi ProvinceChina Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye InstituteTianjin Eye HospitalNankai University Eye InstituteNankai UniversityClinical College of OphthalmologyTianjin Medical UniversityTianjin 300000China

AIM:To investigate the effect of the percent tissue altered(PTA)on the safety after laser-assisted in situ keratomileusis(LASIK)based on linear creep ***:The linear creep characteristics of the cornea were characterized by the generalized Kelvin-Voigt constitutive relationship with five ***,the displacement and stress distribution on the anterior and posterior surfaces of the cornea were analyzed by constructing the eye model with different ***:When PTA was above 39%,the vertex displacements under physiological intraocular pressure(IOP,15 mm Hg)exceeded that of the preoperative glaucoma under average *** is,an excessively high displacement value was *** addition,with the increase of PTA,the central cornea was stretched thinner and more obviously due to *** PTA was above 39%,the stress at the center of the anterior surface of the residual stroma was more than 20%larger than that of the normal human *** residual stroma was forced to stretch more severely due to excessive stress on the anterior *** resulted in deformation of the stroma and induced corneal ***,the postoperative vertex displacement increased with the decrease in viscosity ***:PTA less than 39%is the safe range for LASIK *** study may provide a reliable numerical basis for postoperative corneal dilatation and the outcomes after refractive surgery.

关键词： laser-assisted in situ keratomileusis finite element percent tissue altered vertex displacement

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Exosomal CCT3 as a biomarker for diagnosis and immune therapy response in patients diagnosed with hepatocellular carcinoma

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Digestive and Liver Disease 2025年第6期57卷 1315-1324页

作者： Liu, Tiange Cui, Yanyan Ouyang, Yiben Wang, Meilin Yue, Shijing School of Medicine Nankai University 94 Weijin Road Tianjin 300071 China Nankai University Affiliated Eye Hospital Nankai University Tianjin China Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Tianjin China The Affiliated Hospital of Chifeng University Inner Mongolia Chifeng China

Background: Hepatocellular carcinoma (HCC) is the dominant type of liver cancer and is associated with a high mortality rate. However, HCC lacks biomarkers for diagnosis and immune therapy response. Tumor-derived exosomes (TDEs) carcinogen-specific molecules have been used for screening multiple biomarkers. This study aimed to identify new biomarkers for the diagnosis of HCC and response to immune checkpoint blockade (ICB) therapy. Methods: Analysis of differentially expressed genes (DEGs) in HCC and normal tissues was integrated using The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and ExoCarta datasets. The expression of CCT3 was validated in samples from patients with HCC using quantitative polymerase chain reaction (qPCR), Western blotting, and immunohistochemistry (IHC) techniques. Results: Exosomal CCT3 was identified as a potential biomarker with significant impact. The expression of CCT3 in different tumor stages and normal tissues adjacent to the tumors (NATs) was validated using qPCR, western blotting, and IHC. CCT3 expression significantly increased the number of activated natural killer cells in HCC, as confirmed by qPCR and IHC. CCT3 expression significantly increases the expression of immune checkpoints in HCC. HCC-derived exosomes significantly increase the enrichment of CCT3. Conclusion: Exosomal CCT3 is a biomarker for diagnosis and ICB therapy of HCC via MYC pathway activation and immune infiltration. © 2025 Editrice Gastroenterologica Italiana S.r.l.

关键词： CCT3 Exosome Hepatocellular carcinoma MYC pathway NK cell

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An innovative external drainage device for suprachoroidal fluid: the puncture needle with drainage groove

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International Journal of ophthalmology(English edition) 2025年第5期18卷 962-964页

作者： Jing-Wen Hui Xiao-Li Li Bo Xiao Quan-Hong Han Ying Wang Tianjin Eye Hospital Tianjin 300020China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin 300020China Clinical College of Ophthalmology Tianjin Medical University Tianjin Medical UniversityTianjin 300020China

Dear Editor,We introduce a novel surgical instrument designed to overcome the challenges in draining fluid from the suprachoroidal space in patients with choroidal *** the evolving landscape of ophthalmic surgeries,procedures that were once considered complex,such as those for choroidal detachment,are becoming increasingly *** of subchoroidal fluid was derived from 1985[1]with indirect visualization during scleral buckle surgery[2-4].

关键词： surgical instrument scleral buckle surgery draining fluid innovative external drainage device choroidal detachmentare indirect visualization choroidal detachmentin subchoroidal fluid

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A topological-aware automatic grading model corneal epithelial damage evaluation from full Corneal Fluorescence Staining images

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Computers in Biology and Medicine 2025年 184卷 109451-109451页

作者： Ren, Zi-Kai Feng, Jun Tian, Lei Wang, Kai-Ni Wang, Jing-Yi Shu, Yuan-Chao Hao, Yi-Ran Jie, Ying Zhou, Guang-Quan School of Biological Science and Medical Engineering Southeast University Nanjing210096 China Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Science Key Lab Beijing100730 China College of Control Science and Engineering Zhejiang University Hangzhou310027 China

Corneal Fluorescence Staining (CFS) imaging is commonly employed for assessing corneal epithelial damage. Automating the grading of CFS images can minimize subjectivity in clinical evaluations and enhance diagnostic efficiency. Existing methods typically depend on the texture and morphological information extracted from whole CFS images, often neglecting the spatial and distribution information between stained regions. This oversight hinders the accurate evaluation of corneal epithelial injury states. This study proposes a three-stage automatic corneal epithelial damage assessment model for full CFS images, optimizing grading by considering topological features among detected stained regions, which are crucial for accurately interpreting the spatial properties of objects within an image. Accurate corneal localization, robust to variations in contrast, is first achieved by integrating CFS images’ intensity and phase information, subsequently by a multi-scale morphological top-hat operator concerning their prior shape to detect the stained regions. Finally, a multi-scale graph structure is constructed based on the detected stained areas, and distance-weighted topological features, along with textural and morphological features, are extracted into an automatic grading model based on an ensemble model. Experiments on an in-house dataset of CFS images annotated with six categories of Ocular Surface Staining (OSS) scores reveal that incorporating topological features achieves the highest Accuracy (0.7589), F1 score (0.7449), and AUC (0.9335). Moreover, topological features outperformed other individual features. These findings underscore the effectiveness of our proposed model in CFS grading, indicating its potential for assessing corneal epithelial damage. Additionally, the valuable insights provided by topological features into the spatial distribution patterns of staining suggest promising applications for enhancing disease classification and supporting more informed c

关键词： Damage detection

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Large language models for diabetes training:a prospective study

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science Bulletin 2025年第6期70卷 934-942页

作者： Haoxuan Li Zehua Jiang Zhouyu Guan Yuqian Bao Yuexing Liu Tingting Hu Jiajia Li Ruhan Liu Liang Wu Di Cheng Hongwei Ji Yong Wang Ya-Xing Wang Carol Y.Cheung Yingfeng Zheng Jihong Wang Zhen Li Weibing Wu Cynthia Ciwei Lim Yong Mong Bee Hong Chang Tan Elif I.Ekinci David C.Klonoff Justin B.Echouffo-Tcheugui Nestoras Mathioudakis Leonor Corsino Rafael Simó Charumathi Sabanayagam Gavin Siew Wei Tan Ching-Yu Cheng Tien Yin Wong Huating Li Chun Cai Lijuan Mao Lee-Ling Lim Yih-Chung Tham Bin Sheng Weiping Jia Shanghai University of Sport Shanghai 200438China School of Clinical Medicine Beijing Tsinghua Changgung HospitalTsinghua MedicineTsinghua UniversityBeijing 100084China Beijing Visual Science and Translational Eye Research Institute(BERI) Tsinghua MedicineTsinghua UniversityBeijing 100084China Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Computer Science and EngineeringSchool of ElectronicInformationand Electrical EngineeringShanghai Jiao Tong UniversityDepartment of Endocrinology and MetabolismShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Diabetes InstituteShanghai Clinical Center for DiabetesShanghai 200240China MoE Key Lab of Artificial Intelligence Artificial Intelligence InstituteShanghai Jiao Tong UniversityShanghai 200240China Department of Cardiology the Affiliated Hospital of Qingdao UniversityQingdao 266011China CEMS NCMISHCMSMADISAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematics University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100049China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China k.Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong 999077China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060China Department of Renal Medicine Singapore General HospitalSingHealth-Duke Academic Medical CentreSingapore169

Diabetes poses a considerable global health challenge,with varying levels of diabetes knowledge among healthcare professionals,highlighting the importance of diabetes *** Language Models(LLMs)provide new insights into diabetes training,but their performance in diabetes-related queries remains uncertain,especially outside the English language like *** first evaluated the performance of ten LLMs:ChatGPT-3.5,ChatGPT-4.0,Google Bard,LlaMA-7B,LlaMA2-7B,Baidu ERNIE Bot,Ali Tongyi Qianwen,MedGPT,HuatuoGPT,and Chinese LlaMA2-7B on diabetes-related queries,based on the Chinese National Certificate Examination for Primary Diabetes Care in China(NCE-CPDC)and the English Specialty Certificate Examination in Endocrinology and Diabetes of Membership of the Royal College of Physicians of the United ***,we assessed the training of primary care physicians(PCPs)without and with the assistance of ChatGPT-4.0 in the NCE-CPDC examination to ascertain the reliability of LLMs as medical *** found that ChatGPT-4.0 outperformed other LLMs in the English examination,achieving a passing accuracy of 62.50%,which was significantly higher than that of Google Bard,LlaMA-7B,and *** the NCE-CPFC examination,ChatGPT-4.0,Ali Tongyi Qianwen,Baidu ERNIE Bot,Google Bard,MedGPT,and ChatGPT-3.5 successfully passed,whereas LlaMA2-7B,HuatuoGPT,Chinese LLaMA2-7B,and LlaMA-7B ***-4.0(84.82%)surpassed all PCPs and assisted most PCPs in the NCE-CPDC examination(improving by 1%–6.13%).In summary,LLMs demonstrated outstanding competence for diabetes-related questions in both the Chinese and English language,and hold great potential to assist future diabetes training for physicians globally.

关键词： Diabetes Diabetestraining Largelanguagemodels Primarydiabetescare Prospectivestudy

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Corneal Biomechanics as a Causal Factor in Myopia and Astigmatism: Evidence from Mendelian Randomization

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ophthalmology science 2025年第5期5卷 100738-100738页

作者： Wei, Pinghui Han, Guoge Su, Qi Jia, Lanbo Xue, Chao Wang, Yan Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science Tianjin China Nankai University Eye Institute Nankai University Affiliated Eye Hospital Nankai University Tianjin China Clinical College of Ophthalmology Tianjin Medical University Tianjin China

Purpose: The causal relationship between refractive errors and corneal biomechanical properties remains uncertain. This study aimed to clarify this relationship using Mendelian randomization (MR), offering new insights into the prevention and treatment of refractive errors. Design: A bidirectional, 2-sample MR analysis. Participants: Corneal biomechanical data were obtained from 97 653 European participants in the UK Biobank, whereas refractive error data were sourced from the UK Biobank and FinnGen consortia. Methods: The exposures in this study were identified as corneal biomechanical parameters, specifically corneal hysteresis (CH) and the corneal resistance factor (CRF). The outcomes were defined as refractive errors, including myopia, hyperopia, and astigmatism, along with refractive power, encompassing both spherical and cylindrical power. A meta-analysis was performed to combine the MR estimates from both UK Biobank and FinnGen consortia, with heterogeneity assessed using the Q test and I² statistics. Additionally, a reverse MR analysis was conducted to examine the potential causal effect of the refractive status on corneal biomechanics. Main Outcome Measures: Corneal hysteresis and CRF as causal factors in myopia and astigmatism. Results: Data from UK Biobank revealed that CH and CRF were protective against the development of myopia (CH: odds ratio (OR) = 0.9936, P = 7.79 × 10⁻⁴;CRF: OR = 0.9946, P = 2.41 × 10⁻³) and astigmatism (CH: OR = 0.9975, P = 0.02;CRF: OR = 0.9977, P = 0.017). Conversely, increased corneal-compensated intraocular pressure was a risk factor for myopia development (OR = 1.0091, P = 2.07 × 10⁻²). The meta-analysis, which combined data from both sources, supported a causal relationship between CH and CRF and the development of myopia, although no significant causal link was found for hyperopia. Reverse MR analysis demonstrated a causal effect of spherical power on CH (OR = 1.0664, P

关键词： Astigmatism Corneal biomechanics Hyperopia Mendelian randomization Myopia

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WGM-FP hybrid droplet-like microbubble resonator and application to all-optical tuning

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Optics Letters 2025年第11期50卷 3704-3707页

作者： Chengfeng Xie Gan Lv Mengyu Wang Zhuang Guo Bin Wei Jiulin Shi Yan Wang Key Laboratory for Optoelectronic Information Perception and Instrumentation of Jiangxi Province Nanchang Hangkong University Nanchang 330063 China Jiangxi Engineering Laboratory for Optoelectronics Testing Technology Nanchang 330063 China mengyu@*** Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Nankai University Affiliated Eye Hospital Tianjin China Nankai University Eye Institute Nankai University Tianjin China Clinical College of Ophthalmology Tianjin Medical University Tianjin China wangyan7143@***

In this work, we present for the first time, to the best of our knowledge, a whispering gallery mode (WGM)-Fabry–Perot (FP) mixed-mode droplet-like microbubble resonator with a unique configuration that allows it to have both WGMs and FP resonances. We experimentally demonstrate its outstanding advantages in the field of all-optical tunability by increasing the control light power to bring its whispering gallery mode resonance wavelength tuning range to an astonishing 8.77 nm with a tuning sensitivity of 33.24 pm/mW. For FP interference, the tuning sensitivity reaches 62.84 pm/mW. This hybrid resonator is expected to be used in tunable lasers, filters, etc. The ability to excite multiple resonant modes at the same time is also extremely suitable for multi-parametric sensing.

关键词： Beam splitters Effective refractive index Optical filters Q factor Resonant modes Tunable lasers

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Limbus Compensation for Corneal Deformation Under Intraocular Pressure

SSRN

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SSRN 2025年

作者： Dai, Yongtao Peng, Qing Pan, Jinxin Wang, Li Liu, Xiaoming Wang, Kaijie LNM Institute of Mechanics Chinese Academy of Sciences Beijing100190 China School of Engineering Science UCAS Beijing100049 China Department of Applied Mechanics and Engineering Sun Yat-sen University Guangzhou510006 China Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Sciences Key Lab Beijing100730 China

The increasing need for corneal disease treatment necessitates a comprehensive understanding of corneal biomechanics. The limbus, located at the corneal boundary, is widely believed to help maintain the stability of central corneal curvature. However, experimental limitations have hindered a quantitative demonstration of contribution of limbus. By using the finite element method, this study aims to quantitatively assess the limbal influence on corneal refractive stability. A corneal mechanical model based on human corneal geometry and embedded fibers was developed to accurately capture the response in ex vivo inflation tests. By a developed procedure, we incorporate both the anterior and posterior surfaces to comprehensively assess refractive power, and quantitatively investigate the influence of limbal width on refractive power. In the ex vivo inflation test simulations, corneal deformation primarily occurs at the limbus, while the central cornea mostly undergoes positional shifts. Additionally, extreme intraocular pressure, whether high or low, causes refractive power deviations from normal levels. The limbus has a optimized width 1-2 mm, with which corneal refractive power fluctuations are minimized with intraocular pressure variations. The limbus functions as a dashpot, absorbing most of the deformation caused by intraocular pressure fluctuations, thereby ensuring corneal refractive stability. A limbus width of 1-2 mm provides optimal compensation for refractive power, resulting in maximum stability. This optimal width, corresponding to the typical human corneal limbus size, is likely an outcome of long-term human evolution. © 2025, The Authors. All rights reserved.

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