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WGM-FP hybrid droplet-like microbubble resonator and application to all-optical tuning

Optics Letters 2025年第11期50卷 3704-3707页

作者： Chengfeng Xie Gan Lv Mengyu Wang Zhuang Guo Bin Wei Jiulin Shi Yan Wang Key Laboratory for Optoelectronic Information Perception and Instrumentation of Jiangxi Province Nanchang Hangkong University Nanchang 330063 China Jiangxi Engineering Laboratory for Optoelectronics Testing Technology Nanchang 330063 China mengyu@*** Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Nankai University Affiliated Eye Hospital Tianjin China Nankai University Eye Institute Nankai University Tianjin China Clinical College of Ophthalmology Tianjin Medical University Tianjin China wangyan7143@***

In this work, we present for the first time, to the best of our knowledge, a whispering gallery mode (WGM)-Fabry–Perot (FP) mixed-mode droplet-like microbubble resonator with a unique configuration that allows it to have both WGMs and FP resonances. We experimentally demonstrate its outstanding advantages in the field of all-optical tunability by increasing the control light power to bring its whispering gallery mode resonance wavelength tuning range to an astonishing 8.77 nm with a tuning sensitivity of 33.24 pm/mW. For FP interference, the tuning sensitivity reaches 62.84 pm/mW. This hybrid resonator is expected to be used in tunable lasers, filters, etc. The ability to excite multiple resonant modes at the same time is also extremely suitable for multi-parametric sensing.

关键词： Beam splitters Effective refractive index Optical filters Q factor Resonant modes Tunable lasers

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Limbus Compensation for Corneal Deformation Under Intraocular Pressure

SSRN

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SSRN 2025年

作者： Dai, Yongtao Peng, Qing Pan, Jinxin Wang, Li Liu, Xiaoming Wang, Kaijie LNM Institute of Mechanics Chinese Academy of Sciences Beijing100190 China School of Engineering Science UCAS Beijing100049 China Department of Applied Mechanics and Engineering Sun Yat-sen University Guangzhou510006 China Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Sciences Key Lab Beijing100730 China

The increasing need for corneal disease treatment necessitates a comprehensive understanding of corneal biomechanics. The limbus, located at the corneal boundary, is widely believed to help maintain the stability of central corneal curvature. However, experimental limitations have hindered a quantitative demonstration of contribution of limbus. By using the finite element method, this study aims to quantitatively assess the limbal influence on corneal refractive stability. A corneal mechanical model based on human corneal geometry and embedded fibers was developed to accurately capture the response in ex vivo inflation tests. By a developed procedure, we incorporate both the anterior and posterior surfaces to comprehensively assess refractive power, and quantitatively investigate the influence of limbal width on refractive power. In the ex vivo inflation test simulations, corneal deformation primarily occurs at the limbus, while the central cornea mostly undergoes positional shifts. Additionally, extreme intraocular pressure, whether high or low, causes refractive power deviations from normal levels. The limbus has a optimized width 1-2 mm, with which corneal refractive power fluctuations are minimized with intraocular pressure variations. The limbus functions as a dashpot, absorbing most of the deformation caused by intraocular pressure fluctuations, thereby ensuring corneal refractive stability. A limbus width of 1-2 mm provides optimal compensation for refractive power, resulting in maximum stability. This optimal width, corresponding to the typical human corneal limbus size, is likely an outcome of long-term human evolution. © 2025, The Authors. All rights reserved.

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Screening cognitive impairment in patients with atrial fibrillation: A deep learning model based on retinal fundus photographs

Heart Rhythm O2

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Heart Rhythm O2 2025年第5期6卷 678.0-686.0页

作者： Wang, Zhen Li, Mingxiao Xia, Peng Jiang, Chao Shen, Ting Ma, Jiaming Bai, Yu Zhang, Suhui Lai, Yiwei Li, Sitong Xu, Hui Xu, Yang Ma, Tong Ju, Lie He, Liu Dong, Li Sang, Caihua Long, Deyong Chen, Yuzhong Du, Xin Ge, Zongyuan Dong, Jianzeng Wei, Wen-Bin Ma, Changsheng Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing China Engineering Research Center of Medical Devices for Cardiovascular Diseases Ministry of Education Capital Medical University Beijing China National Clinical Research Center for Cardiovascular Diseases Beijing China Beijing Airdoc Technology Co. Ltd. Beijing China Department of Electrical and Computer Systems Engineering Faculty of Engineering Monash University Clayton Australia Yale School of Medicine New Haven Connecticut United States School of Clinical Medicine Peking Union Medical College and Chinese Academy of Medical Science Beijing China Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology & Visual Sciences Key Lab Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology Beijing Tongren Hospital Capital Medical University Beijing China Monash e-Research Center Monash University Clayton Australia

Background: Patients with atrial fibrillation (AF) have a higher risk of cognitive impairment (CI). However, complexity of CI diagnosis and lack of simple screening approaches limited early screening and intervention of CI in AF patients. Objective: Our study aimed to develop deep learning models based on fundus photographs for easy screening of CI in AF patients. Methods: From May 2021 to April 2023, patients who completed fundus examination and cognitive function evaluation in the Chinese Atrial Fibrillation Registry Study were included. The training and validation sets were randomly split at an 8:2 ratio. Participants from the Beijing Eye Study served as the external validation set. Different deep learning models were trained, and their CI detection ability was validated. Results: A total of 899 patients in the Chinese Atrial Fibrillation Registry Study were included. In the validation set, the vision-ensemble model based on fundus images alone had an area under the receiver-operating characteristic curve (AUROC) of 0.855 (95% confidence interval 0.816–0.894) for CI screening. The multimodal model (AUROC 0.861, 95% confidence interval 0.823–0.898), based on fundus photographs and 4 clinical variables, performed comparably to the vision-ensemble model. The AUROC of the vision-ensemble model for CI screening achieved 0.773 (95% confidence interval 0.709–0.837) in the external test set. In the saliency map, the vision-ensemble model focused on areas around retinal vessels and the optic disc. Conclusion: A vision-ensemble model based on fundus images might be practical for preliminary screening of CI in AF patients. © 2025 Heart Rhythm Society

关键词： Artificial intelligence Atrial fibrillation Cognitive impairment Deep learning Fundus photography

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Macular Perfusion Changes and Ganglion Cell Complex Loss in Patients with Silicone Oil-related visual Loss

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Biomedical and Environmental sciences 2020年第3期33卷 151-157页

作者： MA Ya ZHU Xiao Qing PENG Xiao Yan Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Objective The aim of this study was to investigate macular perfusion changes and ganglion cell complex(GCC)loss in patients with unexplained visual loss following vitrectomy and silicone oil(SO)tamponade,and to evaluate the correlation between retinal blood flow and GCC loss using optical coherence tomography angiography(OCTA)and optical coherence tomography(OCT).Methods This retrospective study included seven eyes(seven patients)with unexpected visual loss after vitrectomy and SO *** was used to evaluate the alterations in retinal vessel density(VD)in the superficial capillary plexus(SCP),deep capillary plexus(DCP),and radial peripapillary capillary plexus(RPCP).OCT was used to measure the thickness of GCC and retinal nerve fiber layer(RNFL).Medical records of patients were *** Quantitative analysis of OCTA images revealed a significant reduction in SCP VD in the affected eyes compared with the controls(all sections P<0.05).No difference was found in GCC thickness,but FLV(focal loss volume)and GLV(global loss volume)were significantly higher in the affected eyes(both P<0.001).SCP VD was inversely correlated with FLV and *** Silicone oil-related severe visual loss was associated with superficial retinal microvasculature damage and ganglion cell apoptosis.

关键词： Silicone oil visual loss Optical coherence tomography angiography Ganglion cell complex

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Observation of the Curative Effect of the Dexamethasone Vitreous Cavity Implant for the Treatment of Irvine-Gass Syndrome

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Biomedical and Environmental sciences 2023年第8期36卷 725-731页

作者： MAO Yu GAO Li Qin JIA Li Yun HOU Si Meng XIAO Yuan Yuan JI Xi Wen WANG Shuang Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Objective To investigate the clinical efficacy of dexamethasone vitreous cavity implants(Ozurdex)for the treatment of macular edema(Irvine-Gass Syndrome)after cataract *** Eight patients(eight eyes)with Irvine-Gass syndrome were enrolled for vitreous injections with *** patients included six men(six eyes)and two women(two eyes)with a mean age of 67.12±11.92 *** in the patients best-corrected visual acuity(BCVA),central macular thickness(CMT),and intraocular pressure were compared before and after *** The mean visual acuity BCVA of the patients was 0.81±0.26 before implantation,which improved to 0.20±0.12,0.13±0.09,and 0.15±0.13 at 2 weeks,1 month,and 3 months after implantation,respectively(P<0.001).The patient’s mean CMT before implantation was 703.00±148.88μm,and it reduced to 258.87±37.40μm,236.25±28.74μm,and 278.00±76.82μm at 2 weeks,1 month,and 3 months after implantation,respectively(P<0.001).Conclusion The dexamethasone vitreous cavity implant(Ozurdex)is a safe and effective treatment,which can effectively improve patient’s visual acuity and reduce macular edema associated with cataract surgery.

关键词： Irvine-Gass Syndrome Macular edema Dexamethasone Vitreous injection

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Addressing underestimation and explanation of retinal fundus photo-based cardiovascular disease risk score: Algorithm development and validation

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Computers in Biology and Medicine 2025年 189卷 109941-109941页

作者： Lin, Zhihong Liu, Chi Shi, Danli Wang, Yueye Hu, Wenyi Henwood, Jacqueline Kiburg, Katerina van Wijngaarden, Peter Clark, Malcolm Shang, Xianwen Han, Xiaotong Zhang, Lei He, Mingguang Ge, Zongyuan The AIM for Health Lab Monash University Melbourne Australia Faculty of Engineering Monash University Melbourne Australia Faculty of Data Science City University of Macau China Centre for Eye Research Australia University of Melbourne Melbourne Australia Ophthalmology Department of Surgery University of Melbourne Melbourne Australia School of Optometry The Hong Kong Polytechnic University Hong Kong Department of General Practice University of Melbourne Melbourne Australia State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangdong Provincial Clinical Research Center for Ocular Diseases Guangdong Guangzhou China Central Clinical School Faculty of Medicine Monash University Australia Clinical Medical Research Center Children's Hospital of Nanjing Medical University China The Hong Kong Polytechnic University Hong Kong Faculty of Information Technology Monash University Melbourne Australia

Objective: To resolve the underestimation problem and investigate the mechanism of the AI model which employed to predict cardiovascular disease (CVD) risk scores from retinal fundus photos. Methods: An ordinal regression Deep Learning (DL) model was proposed to predict 10-year CVD risk scores. The mechanism of the DL model in understanding CVD risk was explored using methods such as transfer learning and saliency maps. Results: Model development was performed using data from 34,652 participants with good-quality fundus photographs from the UK Biobank and a dataset for external validation collected in Australia comprised of 1376 fundus photos of 401 participants with a desktop retinal camera and a portable retinal camera. The mean [SD] risk-level accuracies across cross-validation folds was 0.772 [0.008], while AUROC for over moderate risk was 0.849 [0.005] and the AUROC for high risk was 0.874 [0.007] on the UK Biobank dataset. The risk-level accuracy for images acquired with the desktop camera data was 0.715, and the accuracy for portable camera data was 0.656 on the external dataset. Conclusions: The DL model described in this study has minimized the underestimation problem. Our analysis confirms that the DL model learned CVD risk score prediction primarily from age- and sex-related image representation. Model performance was only slightly degraded when features such as the retinal vessels and colours were removed from the images. Our analysis identified some image features associated with high CVD risk status, such as the peripheral small vessels and the macula areas. © 2025

关键词： ophthalmology

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Transfection with CXCR4 potentiates homing of mesenchymal stem cells in vitro and therapy of diabetic retinopathy in vivo

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International Journal of ophthalmology(English edition) 2018年第5期11卷 766-772页

作者： Jian Wang Wei Zhang Guang-Hui He Bin Wu Song Chen Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteClinical College of Ophthalmology Tianjin Medical University

AIM：To investigate the effect of the overexpression of C-X-C chemokine receptor type 4（CXCR4） on homing of mesenchymal stem cells（MSCs） in vitro and therapeutic effects of diabetic retinopathy（DR） in ***：MSCs were infected by lentivirus constructed with *** expression of CXCR4 was examined by immunofluorescence,Western blot,and quantitative polymerase chain ***4-overexpressing MSCs were cultured in vitro to evaluate their chemotaxis,migration,and apoptotic ***4-overexpressing MSCs were intravitreally injected to observe and compare their effects in a mouse model of *** histological structure of DR in rats was inspected by hematoxylin and eosin *** expression of rhodopsin,neuron-specific enolase（NSE）,and inflammatory cytokines interleukin（IL）-6 and tumor necrosis factor（TNF）-α was examined by Western blot and immunohistochemical ***：The transduction of MSCs by lentivirus was effective,and the transduced MSCs had high expression levels of CXCR4 gene and *** migration activities were observed in CXCR4-overexpressing ***,reduced retinal damage,upregulation of rhodopsin and NSE protein,and downregulation of inflammatory cytokines IL-6 and TNF-α were observed in CXCR4-overexpressing MSCs in ***：The homing of MSCs can be enhanced by upregulating CXCR4 levels,possibly improving histological structures of ***4-overexpressing MSCs can be a novel strategy for treating DR.

关键词： chemokine receptor type 4 diabetic retinopathy mesenchymal stem cells transplantation

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Evaluation of a rat meibomian gland dysfunction model induced by closure of meibomian gland orifices

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International Journal of ophthalmology(English edition) 2018年第7期11卷 1077-1083页

作者： Zi-Yi Dong Ming Ying Jie Zheng Lan-Jun Hu Jiang-Yan Xie Yi Ma Department of Ophthalmology Tianjin Union Medical Center Tianjin Eye Hospital Tianjin Eye Institute Tianjin Key Lab of Ophthalmology and Visual Science

AIM： To find a stable, inexpensive, and reliable method to produce a rat meibomian gland dysfunction（MGD） model. METHODS： We inserted slim guidewires into the meibomian gland orifices of twelve Brown Norway rats and fulgurized every guidewire to destroy part of the meibomian gland. We then observed the morphological changes in the eyelid margin, and compared the data of tear breakup time（TBUT）, Schirmer I test, and the corneal fluorescence staining scores at different times（1, 2, 4, and 6 wk）. We observed pathological changes of the cornea, conjunctiva and meibomian gland, and we used real-time polymerase chain reaction to analyze epithelial growth factor（EGF）, interleukin-6（IL-6）, IL-8, tumor necrosis factor-α（TNF-α）, and Ki67. RESULTS： In the fourth week, compared with the control group, the TBUT of the model group began to decreased（P〈0.05）. The tear secretion remained stable（P〉0.05）. The corneal dots were significantly increased in the fourth week when the fusion stain began to appear（P〈0.05）. In the fourth week, partial meibomian gland openings had hoary secretions blocked, orifices were expanded, and there was a partial convex deformation. In the sixth week, the tissue section showed that the number of conjunctival goblet cells was decreased, epithelial cells were irregular, the epithelium was detached and rough, and meibomian glands were lost. The expressions of EGF, IL-6, IL-8, and TNF-α in corneal, conjunctival, and meibomian tissues were highly increased（P〈0.05）, but no statistical difference was found in the expression of Ki67 in corneal and conjunctival tissues（P〉0.05）. CONCLUSION： The MGD rat model, produced via electrocauterization of meibomian gland orifices, matched clinical manifestations and cytokine levels. Our research provides a new method of achieving an MGD animal model.

关键词： meibomian gland dysfunction animal model epithelial growth factor interleukin-6 interleukin-8 tumornecrosis factor-α Ki67

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Differentiation of isolated human umbilical cord mesenchymal stem cells into neural stem cells

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International Journal of ophthalmology(English edition) 2016年第1期9卷 41-47页

作者： Song Chen Wei Zhang Ji-Ming Wang Hong-Tao Duan Jia-Hui Kong Yue-Xin Wang Meng Dong Xue Bi Jian Song Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Clinical College of Ophthalmology Tianjin Medical University

AIM：To investigate whether umbilical cord human mesenchymal stem cell（UC-MSC）was able to differentiate into neural stem cell and neuron.·METHODS：The umbilical cords were o btained from pregnant women with their written consent and the approval of the Clinic Ethnics ***-MSC were isolated by adherent culture in the medium contains 20%fetal bovine serum（FBS）,then they were maintained in the medium contain 10%FBS and induced to neural cells in neural differentiation *** investigated whether UC-MSC was able to differentiate into neural stem cell and neuron by using flow cytometry,reverse transcriptase-polymerase chain reaction（RT-PCR）and immunofluorescence（IF）analyzes.·R ESULTS：A substantial number of UC-MSC was harvested using the tissue explants adherent method at about *** cytometric study revealed that these cells expressed common markers of MSCs,such as CD105（SH2）,CD73（SH3）and *** induction of differentiation of neural stem cells,the cells began to form clusters;RT-PCR and IF showed that the neuron specific enolase（NSE）and neurogenic differentiation 1-positive cells reached 87.3%±14.7%and 72.6%±11.8%,*** showed neuronal cell differentiation after induced,including neuron-like protrusions,plump cell body,obviously and stronger ***-PCR and IF analysis showed that microtubule-associated protein 2（MAP2）and nuclear factor-M-positive cells reached 43.1%±10.3%and 69.4%±19.5%,respectively.·CONCLUSION：Human umbilical cord derived MSCs can be cultured and proliferated and differentiate into neural stem cells,which may be a valuable source for cell therapy of neurodegenerative eye diseases.

关键词： human umbilical cord mesenchymal stemcells neural stem cells neuron neurodegenerative eye diseases

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Optical Coherence Tomography Features of Tuberculous Serpiginous-like Choroiditis and Serpiginous Choroiditis

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Biomedical and Environmental sciences 2018年第5期31卷 327-334页

作者： wang xiao na you qi sheng zhao hui ying peng xiao yan Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key Lab Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Objective To investigate optical coherence tomography（OCT） characteristics of tuberculous serpiginous-like choroiditis（Tb-SLC） and serpiginous choroiditis（SC） and to perform OCT to differentiate between these *** This retrospective,case-control study examined consecutively enrolled patients with active Tb-SLC or *** underwent comprehensive ocular examinations and imaging（OCT,color fundus photography,autofluorescence imaging,fluorescein angiography,and indocyanine green angiography）.Findings were examined and compared between eyes with SC and *** Nine patients with active Tb-SLC（14 eyes） and 8 with active SC（12 eyes） were *** following OCT findings were observed significantly more often in the Tb-SLC group than in the SC group： vitreal hyper-reflective spots [5 Tb-SLC eyes（36%）,no SC eyes：P = 0.02],intraretinal edema [11 Tb-SLC eyes（79%）,3 SC eyes（25%）：P = 0.01],sub-retinal pigment epithelium（RPE） drusenoid deposits [11 Tb-SLC eyes（79%）,2 SC eyes（17%）：P 〈 0.01],and choroidal granulomas [8 Tb-SLC eyes（57%）,2 SC eyes（17%）：P = 0.03].A hyporeflective,wedge-shaped band was observed more often in the SC group [5 Tb-SLC eyes（36%）,9 SC eyes（75%）：P = 0.045] than in the Tb-SLC *** incidence of other OCT signs did not differ between the groups and included outer nuclear layer hyper-reflection,outer retinal tabulation,and choriocapillaris point-like *** Vitreal hyper-reflective spots,intraretinal fluid,sub-RPE drusenoid deposits,and choroidal granulomas on OCT images may indicate ***,a hyporeflective,wedge-shaped band may indicate ***,OCT is likely helpful in differentiating between Tb-SLC and SC.

关键词： Optical coherence tomography Choroiditis Serpiginous Tuberculosis

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