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Immune oppression array elucidating immune escape and survival mechanisms in uveal melanoma

International Journal of ophthalmology(English edition) 2016年第12期9卷 1701-1712页

作者： Fang Hou Qi-Ming Huang Dan-Ning Hu Jost B.Jonas Wen-Bin Wei Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Science Key Lab Departments of Ophthalmology and Pathology New York Eye and Ear Infirmary of Mount Sinai Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University

AIM： To examine the genetic profile of primary uveal melanoma （UM） as compared to UM in immune ***： Dendritic cells （DC） loaded with lysates of UM cells of high metastatic potential were used to stimulate CTLs（CTLs）. When CTLs co-cultured with the UM cells, most UM cells could be eliminated. Survival UM cells grew slowly and were considered to be survival variants and examined by a microarray analysis. These differential genes were analyzed further with Venn Diagrams and functions related to immune escape. We additionally examined transcriptional changes of manually selected survival variants of UM cells and of clinical UM samples by quantitative real-time polymerase chain reaction （qRT-PCR）, and analyzed the correlation of these expressions and patients’ ***： Gene expression analyses revealed a marked up-regulation of SLAMF7 and CCL22 and a significant down-regulation of KRT10, FXYD3 and ABCC2. The expression of these genes in the relapsed UM was significantly greater than those in primary UM. UM patients with overexpression of these genes had a shorter survival period as compared with those of their ***： Gene expression, in particular of SLAMF7, CCL22, KRT10, FXYD3 and ABCC2, differed between primary UM cells and survival variants of UM cells.

关键词： uveal melanoma dendritic cells immuneescape gene expression profile b＂~2

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Single self-leading suture technique for iridodialysis repairment

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International Journal of ophthalmology(English edition) 2024年第9期17卷 1752-1754页

作者： Jing-Wen Hui Quan-Hong Han Yong Tang Ying Wang Tianjin Eye Hospital Tianjin 300020China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin 300020China Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China

Dear Editor,We described an innovative“single self-leading suture technique”for repairing *** of moving the needle forth and back,our method is easier to manipulate in the narrow surgical space between the cornea and lens,which will decrease the unnecessary complications related to iatrogenic *** provide an economical friendly and less time-taking method,which improves the suture accuracy.

关键词： dialysis needle suture

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Combined Accelerated Crosslinking with Laser In Situ Keratomileusis (LASIK) for Myopic Patients: A Systematic Review and Meta-Analysis

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American Journal of ophthalmology 2025年

作者： He Tian Le Chang Min Yang Yan Wang Clinical College of Ophthalmology Tianjin Medical University Tianjin China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Tianjin Eye Hospital Tianjin China Nankai University Eye Institute Nankai University Affiliated Eye Hospital Nankai University Tianjin China School of Medicine Nankai University Tianjin China

Purpose To compare laser in situ keratomileusis (LASIK) and Simultaneous LASIK and accelerated Crosslinking (LASIK Xtra) for myopia correction. Design Systematic review and meta-analysis. Methods A search of PubMed, EMBASE, Web of science, the Cochrane Library, and China National Knowledge Internet was conducted up to October 1, 2024 to identify studies comparing LASIK and LASIK Xtra for myopia correction. The outcome of visual acuity and refraction, safety, efficiency, predictability, stability, postoperative corneal thickness and endothelial cell count were measure. Results A total of 1,647 eyes (836 LASIK, 811 LASIK Xtra) from 15 studies were included. LASIK demonstrated superior postoperative uncorrected distance visual acuity (UDVA) compared to LASIK Xtra, with a mean difference (MD) of -0.03 (8 studies, n = 750 eyes; 95% confidence interval [CI]: -0.04 to -0.01, P = 0.007) at one month and (7 studies, n = 672 eyes; MD= -0.01 95% CI: -0.02 to 0.00, P  = 0.02) for long-term results (≥6 months). No significant differences were found in corrected distance visual acuity (CDVA; 6 studies, n= 530 eyes; MD= 0.00, 95% CI: -0.01, 0.00, P  = 0.32), spherical equivalent (14 studies, n= 1639 eyes; MD = 0.03, 95% CI: −0.03, 0.08; P =0.40), safety (8 studies, n= 779 eyes; odds ratios[OR]= 0.70; 95% CI: 0.39, 1.26; P  = 0.23), efficiency (11 studies, n= 921 eyes; OR= 0.75, 95% CI: 0.54, 1.05, P  = 0.10), predictability (11 studies, n= 971 eyes; OR= 1.03, 95% CI: 0.72, 1.47, P  = 0.86), stability (3 studies, n= 90 eyes; OR= 0.70, 95% CI: 0.21, 2.28, P  = 0.55). Subgroup analysis indicated a higher risk of postoperative CDVA loss in the Ectasia Risk Group undergoing LASIK-Xtra (OR= 0.20, 95% CI: 0.04 to 0.97, P =0.05). The 30 mW/cm² for 90 seconds (2.7 J/cm²) irradiation protocol in LASIK Xtra may resulted in worse UDVA compared to LASIK (MD= -0.01, 95% CI: -0.03 to -0.001, P =0.05). The certainty of evidence for the outcomes ranged from "low to very low". Conclusions Current e

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Effects of higher-order aberrations on contrast sensitivity in normal eyes of a large myopic population

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International Journal of ophthalmology(English edition) 2017年第9期10卷 1407-1411页

作者： Peng-Fei Zhao Shi-Ming Li Jing Lu Hong-Min Song Jing Zhang Yue-Hua Zhou Ning-Li Wang Ophthalmic Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Sciences Key Lab Department of Ophthalmology Affiliated Hospital of Hebei Medical University College of Applied Arts and Science Beijing Union University

AIM：To study the relation between higher-order aberrations（HOAs）and contrast sensitivity（CS）in normal eyes among a population of laser in situ keratomileusis（LASIK）***：In 6629 eyes of 3315 LASIK candidates,CS were measured under dark environment at the spatial frequencies of 1.5,3,6,12 and 18 cycles per degree（c/d）,respectively,using an Optec 6500 visual function ***,ocular HOAs were measured for a 6.0 mm pupil with a Hartmann-Shack wavefront ***：In the study,the subjects with an average spherical equivalent of-4.86±2.07 D were *** decreased from the third to the sixth order aberrations with predominant aberrations of third-order coma,trefoil and fourth-order spherical *** low and moderate spatial frequencies,CS was negatively correlated with the third-order coma and trefoil aberrations,and decreased with increasing Z31,but increased with increasing Z3-3and *** high spatial frequencies,CS decreased with increasing Z3-3and increased with increasing ***：At a large pupil size of 6.0 mm,the thirdorder aberrations,but not the total aberrations,are the main factors affecting *** coma is negatively correlated with CS.

关键词： myopia contrast sensitivity higher-orderaberrations coma spherical aberration

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Strategies to control myopia in children:a review of the findings from the Anyang Childhood Eye Study

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Annals of Eye science 2018年第1期3卷 219-225页

作者： Shi-Ming Li Ningli Wang the Anyang Childhood Eye Study Group Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology&Visual Science Key LabBeijing Institute of OphthalmologyCapital Medical UniversityBeijing 100000China

Myopia in children remains a major public health problem worldwide,especially in some Asian countries such as China,Singapore and *** many interventions have been attempted,few has been proven to be effective in controlling onset and progression of myopia in *** factors,genetic susceptibility or ethnic differences can affect the efficacy of these ***,many questions remain unclear and even controversial for controlling *** has the biggest population with myopia,especially for children ***,it is of importance to present what achievements Chinese scientists have made in the field of myopia control in *** summarize the current findings on myopia control in children from the Anyang Childhood Eye Study,including epidemiological data,clinical trials,systematic reviews and meta-analyses,and compare them with studies in other countries to find potential clues for controlling myopia in children.

关键词： Children myopia time outdoors near work Chinese eye exercises spectacles

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Segmentaion of Parapapillary Atrophy in Retinal Images using HED 12

Segmentaion of Parapapillary Atrophy in Retinal Images using...

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12th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2019

作者： Feng, Yunlong Li, Hanxiang Xu, Jie Li, Huiqi School of Information and Electronics Beijing Institute of Technology Beijing Ophthalmology and Visual Science Key Lab Beijing Institute of Ophthalmology Beijing Tongren Hospital Beijing China

ISBN: (纸本)9781728148526

Parapapillary atrophy (PPA) is a kind of atrophic abnormality of eyes, which lies on the retinal fundus adjacent to optic disc (OD). Clinically, PPA is correlated with several pathologies of eyes. For example, the area of PPA has a strong association with the severity of myopia. In this work, we developed a new segmentation algorithm aimed at PPA in retinal images. The frame work was derived from Holistically-Nested Edge Detection (HED), which originally deals with edge detection. Firstly, extracting region of interest (ROI) and normalizing datasets were performed in preprocessing stage. Next, an end-to-end model began to acquire rich hierarchical features with deep supervision on side outputs. We applied a new balance parameter to loss function for realization of the area segmentation. Finally, the holistic image predictions (PPA area segmented) were performed through full convolutional neural layers. The model training on retinal images with annotation from professional ophthalmologist achieves great performance on both adults and pupils datasets. Experiential results present the average F-score of 0.7910 on adults' test data (200 images) and 0.7478 on pupils' (50 images). MIoU of the segmentation reaches 0.7237 of adults and 0.6892 of pupils. © 2019 IEEE.

关键词： Convolution

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OCTA characteristics in non-arteritic central retinal artery occlusion and correlation with visual acuity

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International Journal of ophthalmology(English edition) 2024年第2期17卷 289-296页

作者： Hong-Xia Gong Bin Wu Shi-Yong Xie Wei Zhang Song Chen Tianjin Key Lab of Ophthalmology and Visual Science Department of Ophthalmology for Integrated Traditional Chinese and Western MedicineTianjin Eye HospitalTianjin 300020China Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300010China Eye Hospital Affiliated to Nankai University Tianjin 300020China

AIM:To observe the retinal and choroidal circulations in patients with non-arteritic permanent central retinal artery occlusion(NA-CRAO)via optical coherence tomography angiography(OCTA)and analyze their correlation with visual ***:Sixty-two eyes with clinically confirmed acute NA-CRAO were included in the study and divided into:A type(mild n=29),B type(moderate n=27)and C type(severe n=6)based on the degree of visual loss,retinal edema,and arterial blood flow delay in fundus fluorescence angiography(FFA).Contralateral healthy eyes were used as the control ***-corrected visual acuity(BCVA),slit lamp microscopy,indirect ophthalmoscopy,fundus color photography,OCTA,and FFA were ***’s correlation analysis was used to determine the correlations between retinal and choroidal vessels and visual ***:There were no statistically significant differences in age,gender,and intraocular pressure among the three types and the control group(P>0.05).Vessel density in deep capillary plexus(VD-DCP)significantly decreased(P<0.05)in all three types of NA-CRAO patients compared to the control *** density in superficial vascular plexus(VD-SVP)significantly decreased(P<0.05)in type A patients and choriocapillaris flow area significantly decreased(P<0.05)in type B and type C patients compared to the control group;while outer retinal flow areas significantly increased in the type A(P<0.05)and decreased in type C patients(P<0.05).The retinal thickness significantly increased in type C group(P<0.05).The VD-SVP at fovea in the type A was significantly lower than both of type B and *** VD-SVP at nasal parafovea in type A and B was significantly lower than type C(P<0.05).The logMAR BCVA of type A was significantly better than that of type B and C groups(P<0.05).Spearman’s correlation analysis showed that the logMAR BCVA was positively correlated with VD-SVP at fovea(r=0.679,P=0.031)and nasal parafovea(r=0.826,P=0.013).CONCLUSION:OCTA is valua

关键词： non-arteritic central retinal artery occlusion fundus fluorescence angiography optical coherence tomography angiography retinal vessel density visual acuity

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Refinement of Parapapillary Atrophy Segmentation Based on Conditional Random Field 12

Refinement of Parapapillary Atrophy Segmentation Based on Co...

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12th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2019

作者： Zhang, Xi Li, Hanxiang Xu, Jie Li, Huiqi School of Information and Electronics Beijing Institute of Technology Beijing Ophthalmology and Visual Science Key Lab Beijing Institute of Ophthalmology Beijing Tongren Hospital Beijing China

ISBN: (纸本)9781728148526

Parapapillary atrophy (PPA) is a crescent atrophic abnormality adjacent to optic disk (OD). In clinical findings, PPA is highly related to glaucoma and high myopia, which makes it a potential indicator for ophthalmic diseases. Therefore, it is significant to develop an algorithm for automatic segmentation of PPA so as to aid the treatment and the prevention of eye diseases. A method that combines the confidence map with conditional random field (CRF) model is proposed in this paper to achieve the optimization of initial segmentation results from neural network. Holistically-Nested Edge Detection (HED) is applied to the segmentation of PPA and a confidence map is obtained. The CRF model is constructed with the confidence map and Maximum a posteriori (MAP) inference is implemented to conduct the segmentation. Post-processing is utilized to further refine the segmentation result. The proposed method has the advantage of robust performance when there is difference between training set and test set. The experimental results show that the average F-score is increased from 0.57 to 0.67, which shows a fair improvement effect. © 2019 IEEE.

关键词： Edge detection

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Retinal nerve fiber layer thickness and retinal vascular caliber alterations in coal miners in northern China:a community-based observational study

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International Journal of ophthalmology(English edition) 2022年第1期15卷 135-140页

作者： Jing-Yan Yang Wen-Jia Zhou Qian Wang Yang Li Yan-Ni Yan Ya-Xing Wang Shou-Ling Wu Wen-Bin Wei Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Science Key LabBeijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China Cardiology Department Kailuan General HospitalTangshan 063000Hebei ProvinceChina

AIM:To evaluate retinal nerve fiber layer thickness and retinal vascular caliber alterations in coal mine ***:The community-based observational crosssectional study included 4004 participants of a subpopulation of the Kailuan *** the study participants underwent structured interviews with a standardized questionnaire,fundus photography and spectral-domain optical coherence tomography(OCT)examinations performed by trained ***:The retinal nerve fiber layer thickness was significantly higher(P=0.006)and the central macular thickness was lower in coal miners(n=659,51.0±7.8 y)as compared to the control(working above the ground;n=477,51.8±7.5 y;P=0.032).Additionally,the downhole workers showed a significantly thicker retinal artery(P=0.012)and vein diameters(P<0.001).In multivariable regression,a thicker retinal nerve fiber layer was associated with a higher cumulative silica dust exposure(P=0.005)after adjusting for younger age and larger spherical *** a reverse pattern,a higher cumulative silica dust exposure(P=0.004)was significantly associated with a thicker retinal nerve fiber layer after adjusting for age,high-density lipoproteins and uric *** retinal vein diameters were associated with higher cumulative silica dust exposure(P=0.036)after adjusting for younger age and larger spherical ***:The retinal vessels diameters and retinal nerve fiber layer thickness are significantly thicker in long term of coal *** results of our study indicate that underground working environment may lead to retinal vessel dilation and ***,ocular examination might be needed within coal miners in order to monitor the occupational eye health as well as the incidence and progression of eye diseases.

关键词： retinal vessels diameter retinal nerve fiber layer thickness cumulative silica dust exposure

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The transcorneal electrical stimulation as a novel therapeutic strategy against retinal and optic neuropathy: a review of experimental and clinical trials

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International Journal of ophthalmology(English edition) 2016年第6期9卷 914-919页

作者： Ye Tao Tao Chen Bei Liu Li-Qiang Wang Guang-Hua Peng Li-Min Qin Zhong-Jun Yan Yi-Fei Huang Department of Ophthalmology Ophthalmology & Visual Science Key Lab of PLAGeneral Hospital of Chinese PLA Department of Clinical Aerospace Medicine the Fourth Military Medical University Department of Neurosurgery and Institute for Functional Brain Disorders Tangdu Hospitalthe Fourth Military Medical University

Transcorneal electrical stimulation （TES） is a novel therapeutic approach to activate the retina and related downstream structures. TES has multiple advantages over traditional treatments, such as being minimally invasive and readily applicable in a routine manner. Series of animal experiments have shown that TES protects the retinal neuron from traumatic or genetic induced degeneration. These laboratory evidences support its utilization in ophthalmological therapies against various retinal and optical diseases including retinitis pigmentosa （RP）, traumatic optic neuropathy, anterior ischemic optic neuropathy （AION）, and retinal artery occlusions （RAOs）. Several pioneering explorations sought to clarify the functional mechanism underlying the neuroprotective effects of TES. It seems that the neuroprotective effects should not be attributed to a solitary pathway, on the contrary, multiple mechanisms might contribute collectively to maintain cellular homeostasis and promote cell survival in the retina. More precise evaluations y/a functional and morphological techniques would determine the exact mechanism underlying the remarkable neuroprotective effect of TES. Further studies to determine the optimal parameters and the long-term stability of TES are crucial to justify the clinical significance and to establish TES as a popularized therapeutic modality against retinal and optic neuropathy.

关键词： transcorneal electrical stimulation therapeutic strategy retinal disease optic neuropathy

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