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Effect of rigid gas permeable contact lens on keratoconus progression: a review

International Journal of ophthalmology(English edition) 2020年第7期13卷 1124-1131页

作者： Xiao-Han Zhang Xuan Li Clinical College of Ophthalmology Tianjin Medical UniversityTianjin Eye HospitalTianjin Eye InstituteTianjin Key Lab of Ophthalmology and Visual ScienceTianjinChina

The prevalence of keratoconus is 1/2000 in the general population and is high in *** is a progressive disease,which has a great impact on patients’quality of life and mental *** can be managed by surgical and non-surgical means,rigid gas permeable(RGP)contact lens as its main non-surgical method is widely used in *** efficacy of wearing RGP contact lens has been confirmed to some extent,but some studies have found that wearing RGP contact lens has adverse effects,which may promote disease *** this paper,the advantages and disadvantages of RGP contact lens in controlling keratoconus were reviewed to provide more suggestions and references for the clinical application of RGP contact lens.

关键词： rigid gas permeable keratoconus contact lens

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Large language models for diabetes training:a prospective study

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science Bulletin 2025年第6期70卷 934-942页

作者： Haoxuan Li Zehua Jiang Zhouyu Guan Yuqian Bao Yuexing Liu Tingting Hu Jiajia Li Ruhan Liu Liang Wu Di Cheng Hongwei Ji Yong Wang Ya-Xing Wang Carol Y.Cheung Yingfeng Zheng Jihong Wang Zhen Li Weibing Wu Cynthia Ciwei Lim Yong Mong Bee Hong Chang Tan Elif I.Ekinci David C.Klonoff Justin B.Echouffo-Tcheugui Nestoras Mathioudakis Leonor Corsino Rafael Simó Charumathi Sabanayagam Gavin Siew Wei Tan Ching-Yu Cheng Tien Yin Wong Huating Li Chun Cai Lijuan Mao Lee-Ling Lim Yih-Chung Tham Bin Sheng Weiping Jia Shanghai University of Sport Shanghai 200438China School of Clinical Medicine Beijing Tsinghua Changgung HospitalTsinghua MedicineTsinghua UniversityBeijing 100084China Beijing Visual Science and Translational Eye Research Institute(BERI) Tsinghua MedicineTsinghua UniversityBeijing 100084China Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Computer Science and EngineeringSchool of ElectronicInformationand Electrical EngineeringShanghai Jiao Tong UniversityDepartment of Endocrinology and MetabolismShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Diabetes InstituteShanghai Clinical Center for DiabetesShanghai 200240China MoE Key Lab of Artificial Intelligence Artificial Intelligence InstituteShanghai Jiao Tong UniversityShanghai 200240China Department of Cardiology the Affiliated Hospital of Qingdao UniversityQingdao 266011China CEMS NCMISHCMSMADISAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematics University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100049China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China k.Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong 999077China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060China Department of Renal Medicine Singapore General HospitalSingHealth-Duke Academic Medical CentreSingapore169

Diabetes poses a considerable global health challenge,with varying levels of diabetes knowledge among healthcare professionals,highlighting the importance of diabetes *** Language Models(LLMs)provide new insights into diabetes training,but their performance in diabetes-related queries remains uncertain,especially outside the English language like *** first evaluated the performance of ten LLMs:ChatGPT-3.5,ChatGPT-4.0,Google Bard,LlaMA-7B,LlaMA2-7B,Baidu ERNIE Bot,Ali Tongyi Qianwen,MedGPT,HuatuoGPT,and Chinese LlaMA2-7B on diabetes-related queries,based on the Chinese National Certificate Examination for Primary Diabetes Care in China(NCE-CPDC)and the English Specialty Certificate Examination in Endocrinology and Diabetes of Membership of the Royal College of Physicians of the United ***,we assessed the training of primary care physicians(PCPs)without and with the assistance of ChatGPT-4.0 in the NCE-CPDC examination to ascertain the reliability of LLMs as medical *** found that ChatGPT-4.0 outperformed other LLMs in the English examination,achieving a passing accuracy of 62.50%,which was significantly higher than that of Google Bard,LlaMA-7B,and *** the NCE-CPFC examination,ChatGPT-4.0,Ali Tongyi Qianwen,Baidu ERNIE Bot,Google Bard,MedGPT,and ChatGPT-3.5 successfully passed,whereas LlaMA2-7B,HuatuoGPT,Chinese LLaMA2-7B,and LlaMA-7B ***-4.0(84.82%)surpassed all PCPs and assisted most PCPs in the NCE-CPDC examination(improving by 1%–6.13%).In summary,LLMs demonstrated outstanding competence for diabetes-related questions in both the Chinese and English language,and hold great potential to assist future diabetes training for physicians globally.

关键词： Diabetes Diabetestraining Largelanguagemodels Primarydiabetescare Prospectivestudy

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Comparison of correcting myopia and astigmatism with SMILE or FS-LASIK and postoperative higher-order aberrations

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International Journal of ophthalmology(English edition) 2021年第4期14卷 523-528页

作者： Peng-Fei Zhao Ya-Bin Flu Yue Wang Cai-Yun Fu Jing Zhang Chang-Bin Zhai Beijing Tongren Hospital Affiliated to Capital Medical University Beijing Tongren Eye CenterBeijing Ophthalmology&Visual Science Key LabBeijing 100730China Beijing Vision Optometry Beijing 100191China College of Ophthalmology Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina

AIM:To compare the effect of myopia and astigmatism correction and postoperative change in higher-order aberration as results of receiving small-incision lenticule extraction(SMILE)and femtosecond laser-assisted in situ keratomileusis(FS-LASIK).METHODS:A prospective and non-randomized controlled study was *** subjects are divided into two groups according to different operations received:229 eyes of 116 patients in the SMILE group and 168 eyes of 86 patients in the FS-LASIK *** subjects were followed up for 3 mo by monitoring their uncorrected visual acuity(UCVA),best-corrected visual acuity(BCVA),spherical equivalent,higher-order aberrations,and the preoperative and postoperative ***:At 1 wk,1,and 3 mo post-surgery,224 eyes(97.8%),227 eyes(99.1%)and 229 eyes(100%)had UCVA≥20/20 in the SMILE group,while 165 eyes(98.2%),167 eyes(99.4%)and 167 eyes(99.4%)had UCVA≥20/20 in the FS-LASIK group,respectively(χ^(2)=0.146,2.135,and 1.124;all P>0.05).BCVA reduction was not observed in both groups at 1 and 3 mo of post-surgery(χ^(2)=0.734 and 1.898,P>0.05).There was no statistically significant difference in the spherical equivalent between the two groups at 1 and 3 mo post-surgery,though the percentage of the spherical equivalent within±0.50 D at 3 mo postsurgery was 98%in the SMILE group,which was higherthan that of the FS-LASIK group(92%,χ^(2)=1.872,P>0.05).The root mean square(RMS)values of total high-order aberration,coma,and spherical aberration of the two groups increased significantly in the early postoperative period and decreased after 3 mo,but the values were still higher than the preoperative levels(P<0.05);there was no significant difference between the two groups in the RMS values of total higher-order aberrations and specific higherorder aberrations(P>0.05).The incidence of complications in the SMILE group was lower than that in the FS-LASIK group(χ^(2)=14.52,P<0.05).CONCLUSION:SMILE and FS-LASIK can effectively treat myopia,sig

关键词： myopia femtosecond laser in situ keratomileusis small incision lenticule extraction high order aberrations

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Corneal Biomechanics as a Causal Factor in Myopia and Astigmatism: Evidence from Mendelian Randomization

Ophthalmology Science

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ophthalmology science 2025年第5期5卷 100738-100738页

作者： Wei, Pinghui Han, Guoge Su, Qi Jia, Lanbo Xue, Chao Wang, Yan Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science Tianjin China Nankai University Eye Institute Nankai University Affiliated Eye Hospital Nankai University Tianjin China Clinical College of Ophthalmology Tianjin Medical University Tianjin China

Purpose: The causal relationship between refractive errors and corneal biomechanical properties remains uncertain. This study aimed to clarify this relationship using Mendelian randomization (MR), offering new insights into the prevention and treatment of refractive errors. Design: A bidirectional, 2-sample MR analysis. Participants: Corneal biomechanical data were obtained from 97 653 European participants in the UK Biobank, whereas refractive error data were sourced from the UK Biobank and FinnGen consortia. Methods: The exposures in this study were identified as corneal biomechanical parameters, specifically corneal hysteresis (CH) and the corneal resistance factor (CRF). The outcomes were defined as refractive errors, including myopia, hyperopia, and astigmatism, along with refractive power, encompassing both spherical and cylindrical power. A meta-analysis was performed to combine the MR estimates from both UK Biobank and FinnGen consortia, with heterogeneity assessed using the Q test and I² statistics. Additionally, a reverse MR analysis was conducted to examine the potential causal effect of the refractive status on corneal biomechanics. Main Outcome Measures: Corneal hysteresis and CRF as causal factors in myopia and astigmatism. Results: Data from UK Biobank revealed that CH and CRF were protective against the development of myopia (CH: odds ratio (OR) = 0.9936, P = 7.79 × 10⁻⁴;CRF: OR = 0.9946, P = 2.41 × 10⁻³) and astigmatism (CH: OR = 0.9975, P = 0.02;CRF: OR = 0.9977, P = 0.017). Conversely, increased corneal-compensated intraocular pressure was a risk factor for myopia development (OR = 1.0091, P = 2.07 × 10⁻²). The meta-analysis, which combined data from both sources, supported a causal relationship between CH and CRF and the development of myopia, although no significant causal link was found for hyperopia. Reverse MR analysis demonstrated a causal effect of spherical power on CH (OR = 1.0664, P

关键词： Astigmatism Corneal biomechanics Hyperopia Mendelian randomization Myopia

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Machine learning models for outcome prediction of Chinese uveal melanoma patients: A 15-year follow-up study

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Cancer Communications 2022年第3期42卷 273-276页

作者： Yu-Ning Chen Yi-Ning Wang Meng-Xi Chen Kai Zhang Rong-Tian Chen Rui Fang Heng Wang Hai-Han Zhang Yi-Ning Huang Yu Feng Jing-Ting Luo Yin-Jun Lan Yue-Ming Liu Yang Li Wen-Bin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730P.R.China InferVision Healthcare Science and Technology Limited Company Shanghai 200030P.R.China

Dear Editor Uveal melanoma(UM)is the most frequent primary malig-nant intraocular tumor in adults with an estimated inci-dence of 4-5 per million per year in western countries[1].About 50%of UM patients eventually develop *** a previous study,the prognosis of Chinese UM was mainly correlated with visual clinical features and gene sequencing *** designed to predict UM prognosis have been previously described[2],but these studies were based on Caucasians,not Chinese.

关键词： melanoma patients prognosis

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Multi-scale Spatio-temporal Transformer-based Imbalanced Longitudinal Learning for Glaucoma Forecasting from Irregular Time Series Images

arXiv

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arXiv 2024年

作者： Yang, Xikai Wu, Jian Wang, Xi Yuan, Yuchen Wang, Ning Li Heng, Pheng-Ann The Zhejiang Lab Hangzhou China The Department of Computer Science and Engineering The Chinese University of Hong Kong Hong Kong The Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing China The Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing China

Glaucoma is one of the major eye diseases that leads to progressive optic nerve fiber damage and irreversible blindness, afflicting millions of individuals. Glaucoma forecast is a good solution to early screening and intervention of potential patients, which is helpful to prevent further deterioration of the disease. It leverages a series of historical fundus images of an eye and forecasts the likelihood of glaucoma occurrence in the future. However, the irregular sampling nature and the imbalanced class distribution are two challenges in the development of disease forecasting approaches. To this end, we introduce the Multi-scale Spatio-temporal Transformer Network (MST-former) based on the transformer architecture tailored for sequential image inputs, which can effectively learn representative semantic information from sequential images on both temporal and spatial dimensions. Specifically, we employ a multi-scale structure to extract features at various resolutions, which can largely exploit rich spatial information encoded in each image. Besides, we design a time distance matrix to scale time attention in a non-linear manner, which could effectively deal with the irregularly sampled data. Furthermore, we introduce a temperature-controlled Balanced Softmax Cross-entropy loss to address the class imbalance issue. Extensive experiments on the Sequential fundus Images for Glaucoma Forecast (SIGF) dataset demonstrate the superiority of the proposed MST-former method, achieving an AUC of 98.6% for glaucoma forecasting. Besides, our method shows excellent generalization capability on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) MRI dataset, with an accuracy of 90.3% for mild cognitive impairment and Alzheimer’s disease prediction, outperforming the compared method by a large margin. A series of ablation studies further verify the contribution of our proposed components in addressing the irregular sampled and class imbalanced problems. Copyright © 2024, The Aut

关键词： Forecasting

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Human congenital cataract mutation in MYH9 alters F-actin organization and cell functions

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International Journal of ophthalmology(English edition) 2025年第6期18卷 969-977页

作者： Hao Yuan Zhen-Yu Wang Jia-Rui Yang Chen Huang Liang Zhu Xue-Min Li Department of Ophthalmology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Beijing 100191China Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Science Key LabCapital Medical UniversityBeijing 100191China Medical Research Center Peking University Third HospitalBeijing 100191China Wu Zuze Foundation for Sci-tech Development Beijing 100191China

AIM:To explore the role of a previously-found MYH9 tail domain mutation(p.E1384Q)in the pathogenesis of congenital ***:The cell experiments were conducted in ***-type(WT)MYH9 and p.E1384Q mutant fragments were constructed,which was then transiently transfected into Hek293T cell *** blotting and quantitative real time polymerase chain reaction(qRT-PCR)were used to analyze the protein and mRNA level of non-muscle myosin IIA(NM IIA)and F-actin in transfected cells,and fluorescence microscopy was applied to explore the subcellular localization of NM IIA and *** counting kit-8(CCK8),woundhealing and double staining flow cytometry assays were performed to evaluate the proliferation,migration and apoptosis function of transfected cells,*** electron microscope was conducted to observe the alteration of organelle ***:The transiently-transfected WT and p.E1384Q mutant Hek293T cell lines was *** blot demonstrated that,comparing with MYH9WT group,the relative protein amount of NM IIA and F-actin significantly decreased in MYH9E1384Q cells(P<0.001).qRT-PCR analysis revealed that the relative mRNA amount of NM IIA and F-actin also significantly reduced in MYH9E1384Q cells when compared with *** immunofluorescence microscopy showed that the fluorescence signal of NM IIA and F-actin significantly decreased in E1384Q *** diffuse cytoplasmic distribution of NM IIA in MYH9WT was changed to be clumped distribution,presenting a“speckled”pattern characterized by aggregates of small size in *** study revealed that the E1384Q mutation significantly inhibited cell proliferation(P=0.003)and migration(P<0.001),and promoted apoptosis(P<0.001).Electron microscope showed that the mutation remarkably decreased the number of mitochondria(P<0.001)and changed the phenotype of ***:The missense gene mutation in MYH9(p.E1384Q)causing congenital cataract results i

关键词： congenital cataract MYH9 F-actin cell function mitochondria

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Mesenchymal stem cell-derived exosomes inhibit the VEGF-A expression in human retinal vascular endothelial cells induced by high glucose

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International Journal of ophthalmology(English edition) 2021年第12期14卷 1820-1827页

作者： Guang-Hui He Ying-Xue Ma Meng Dong Song Chen Yu-Chuan Wang Xiang Gao Bin Wu Jian Wang Jun-Hua Wang Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300070China Tianjin Eye Hospital Tianjin Eye InstituteTianjin Key Lab of Ophthalmology and Visual ScienceTianjin 300020China Ophthalmic Center of Xinjiang Production and Construction Corps Hospital Urumqi 830002Xinjiang Uygur Autonomous RegionChina Medical College of NanKai University Tianjin 300000China

AIM:To determine the effect of exosomes derived from human umbilical cord blood mesenchymal stem cells(hUCMSCs)on the expression of vascular endothelial growth factor A(VEGF-A)in human retinal vascular endothelial cells(HRECs).METHODS:Exosomes were isolated from hUCMSCs using cryogenic ultracentrifugation and characterized by transmission electron microscopy,Western blotting and nanoparticle tracking *** were randomly divided into a normal control group(group A),a high glucose model group(group B),a high glucose group with 25μg/mL(group C),50μg/mL(group D),and 100μg/mL exosomes(group E).Twenty-four hours after coculture,the cell proliferation rate was detected using flow cytometry,and the VEGF-A level was detected using *** coculture 8,16,and 24h,the expression levels of VEGF-A in each group were detected using PCR and Western ***:The characteristic morphology(membrane structured vesicles)and size(diameter between 50 and 200 nm)were observed under transmission electron *** average diameter of 122.7 nm was discovered by nanoparticle tracking analysis(NTA).The exosomal markers CD9,CD63,and HSP70 were strongly *** proliferation rate of the cells in group B increased after 24h of *** analyses revealed that the upregulation of VEGF-A expression in HRECs stimulated by high glucose could be downregulated by cocultured hUCMSC-derived exosomes(F=39.03,P<0.01).The upregulation of VEGF-A protein(group C:F=7.96;group D:F=17.29;group E:F=11.89;8h:F=9.45;16h:F=12.86;24h:F=42.28,P<0.05)and mRNA(group C:F=4.137;group D:F=13.64;group E:F=22.19;8h:F=7.253;16h:F=16.98;24h:F=22.62,P<0.05)in HRECs stimulated by high glucose was downregulated by cocultured hUCMSC-derived exosomes(P<0.05).CONCLUSION:hUCMSC-derived exosomes downregulate VEGF-A expression in HRECs stimulated by high glucose in time and concentration dependent manner.

关键词： mesenchymal stem cells exosomes retinal vascular endothelial cells vascular endothelial growth factor A coculture

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A Concept-based Interpretable Model for the Diagnosis of Choroid Neoplasias using Multimodal Data

arXiv

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arXiv 2024年

作者： Wu, Yifan Liu, Yang Yang, Yue Yao, Michael S. Yang, Wenli Shi, Xuehui Yang, Lihong Li, Dongjun Liu, Yueming Gee, James C. Yang, Xuan Wei, Wenbin Gu, Shi University of Pennsylvania PhiladelphiaPA United States University of Electronic Science and Technology Chengdu China Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology and Visual Sciences Key Lab Beijing Tongren Hospital Capital Medical University Beijing China

Diagnosing rare diseases presents a common challenge in clinical practice, necessitating the expertise of specialists for accurate identification. The advent of machine learning offers a promising solution, while the development of such technologies is hindered by the scarcity of data on rare conditions and the demand for models that are both interpretable and trustworthy in a clinical context. Interpretable AI, with its capacity for human-readable outputs, can facilitate validation by clinicians and contribute to medical education. In the current work, we focus on choroid neoplasias—the most prevalent form of eye cancer in adults, albeit rare with 5.1 per million. We built the so-far largest dataset consisting of 750 patients, incorporating three distinct imaging modalities collected from 2004 to 2022. Our work introduces a concept-based interpretable model that distinguishes between three types of choroidal tumors, integrating insights from domain experts via radiological reports. Remarkably, this model not only achieves an F1 score of 0.91, rivaling that of black-box models, but also boosts the diagnostic accuracy of junior doctors by 42%. This study highlights the significant potential of interpretable machine learning in improving the diagnosis of rare diseases, laying a groundwork for future breakthroughs in medical AI that could tackle a wider array of complex health scenarios. Copyright © 2024, The Authors. All rights reserved.

关键词： Computer aided diagnosis

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Accuracy of intraocular lens power calculation formulae after laser refractive surgery in myopic eyes:a meta-analysis

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Eye and Vision 2020年第3期7卷 356-365页

作者： Hongyu Li Li Nan Jun Li Hui Song Clinical College of Ophthalmology Tianjin Medical UniversityTianjinChina Tianjin Eye Institute Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye HospitalNo.4 Gansu RoadHe-ping DistrictTianjin 300020China

Background:To compare the accuracy of intraocular lens power calculation formulae after laser refractive surgery in myopic ***:We searched the databases on PubMed,EMBASE,Web of science and the Cochrane library to select relevant studies published between Jan 1st,2009 and Aug 11th,*** outcomes were the percentages of refractive prediction error within±0.5 D and±1.0 ***:The final meta-analysis included 16 studies using seven common methods(ASCRS average,Barrett True-K no history,Double-K SRK/T,Haigis-L,OCT formula,Shammas-PL,and Wang-Koch-Maloney).ASCRS average yielded significantly higher percentage of refractive prediction error within±0.5 D than Haigis-L,Shammas-PL and WangKoch-Maloney(P=0.009,0.01,0.008,respectively).Barrett True-K no history also yielded significantly higher percentage of refractive prediction error within±0.5 D than Shammas-PL and Wang-Koch-Maloney(P=0.01,P<0.0001,respectively),and a similar result was found when comparing OCT formula with Haigis-L and Shammas-PL(P=0.03,P=0.01,respectively).Conclusion:The ASCRS average or Barrett True-K no history should be used to calculate the intraocular lens power in eyes after myopic laser refractive *** OCT formula if available,can also be a good alternative choice.

关键词： Myopic Laser Refractive IOL power calculation Meta-analysis

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