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SSRN 2024年

作者： Zheng, Yu Yang, Yang Ma, Ke Lin, Chuang Pei, Yajing Lu, Mingfeng Ji, Yi College of Automation College of Artificial Intelligence Nanjing University of Posts and Telecommunications Nanjing210023 China School of Mechanical Engineering and Automation Beihang University Beijing100191 China Beijing Institute of Ophthalmology Beijing TongRen Eye Center Beijing TongRen Hospital Capital Medical University Beijing Ophthalmology and Visual Sciences Key Lab Beijing100730 China Beijing Xianwei Medical Technology Company Co.Ltd. Beijing100083 China Department of Ophthalmology Shanxi Eye Hospital Affiliated to Shanxi Medical University Shanxi Taiyuan030002 China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou510060 China School of Automation Beijing Information Science & Technology University Beijing100192 China

Handheld manipulator offers a feasible way to relieve the challenge of continuous curvilinear capsulorhexis (CCC) by controlling peeling force actively. The precise identification and prediction of voluntary peeling force (0-2 Hz) form the basis of force controller design. However, achieving this goal is limited by species differences (experimental validation: animal model, clinical surgery: in-vivo human). This paper proposes a framework to relieve this problem. The proposed framework consists of a wavelet-based process module and a prediction module based on LSTM and the Transformer’s encoder. Peeling force measured from ex-vivo pig eyes (no treatment, treat with 0.1% and 0.5% sodium hypochlorite), in-vivo rabbit eyes, and ex-vivo human lens are utilized to validate the proposed framework. Experimental results show that the root mean square (RMS) error of identification is 0.37 mN. The RMS error of prediction is 0.41 mN (Steady) and 0.87 mN (Sharp, prediction time: 50 ms), respectively. The RMS prediction error of ex-vivo human samples is 0.36 mN (Steady) and 1.05 mN (Sharp) even all training data comes from animal models. © 2024, The Authors. All rights reserved.

关键词： Wavelet transforms

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WGM-FP hybrid droplet-like microbubble resonator and application to all-optical tuning

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Optics letters 2025年第11期50卷 3704-3707页

作者： Chengfeng Xie Gan Lv Mengyu Wang Zhuang Guo Bin Wei Jiulin Shi Yan Wang Key Laboratory for Optoelectronic Information Perception and Instrumentation of Jiangxi Province Nanchang Hangkong University Nanchang 330063 China Jiangxi Engineering Laboratory for Optoelectronics Testing Technology Nanchang 330063 China mengyu@*** Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Nankai University Affiliated Eye Hospital Tianjin China Nankai University Eye Institute Nankai University Tianjin China Clinical College of Ophthalmology Tianjin Medical University Tianjin China wangyan7143@***

In this work, we present for the first time, to the best of our knowledge, a whispering gallery mode (WGM)-Fabry-Perot (FP) mixed-mode droplet-like microbubble resonator with a unique configuration that allows it to have both WGMs and FP resonances. We experimentally demonstrate its outstanding advantages in the field of all-optical tunability by increasing the control light power to bring its whispering gallery mode resonance wavelength tuning range to an astonishing 8.77 nm with a tuning sensitivity of 33.24 pm/mW. For FP interference, the tuning sensitivity reaches 62.84 pm/mW. This hybrid resonator is expected to be used in tunable lasers, filters, etc. The ability to excite multiple resonant modes at the same time is also extremely suitable for multi-parametric sensing.

关键词： Beam splitters Effective refractive index Optical filters Q factor Resonant modes Tunable lasers

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Diagnostic value of genetic mutation analysis and mutation profiling of cell-free DNA in intraocular fluid for vitreoretinal lymphoma

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Cancer Communications 2022年第11期42卷 1217-1221页

作者： Xiaoqing Chen Yunwei Hu Wenru Su Shizhao Yang Xiaoxiao Wang Ping Zhang Xiaoyu Hong Chuqiao Liang Zhuyun Qian Ziqiang Li Yong Tao Huiqiang Huang Dan Liang State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhouGuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdongP.R.China Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijingP.R.China Nanjing Geneseeq Technology Inc. NanjingJiangsuP.R.China Beijing GIANTMED Medical Diagnostics Lab BeijingP.R.China

Dear editor,Vitreoretinal lymphoma(VRL)is a rare intraocular malignant lymphoma affecting the vitreous and/or *** diagnosis is *** biopsies have high risks of irreversible visual impairment(even blind-ness),which are not used in clinics for patients with residual visual *** limited cellular yield from vit-reous biopsies and the cell lysis also contribute to the low detection rates of VRL using cytopathology[1].

关键词： lymphoma intraocular diagnosis

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Progression rate to primary angle closure following laser peripheral iridotomy in primary angle-closure suspects: a randomised study

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International Journal of ophthalmology(English edition) 2021年第8期14卷 1179-1184页

作者： Da-Peng Mou Yuan-Bo Liang Su-Jie Fan Yi Peng Ning-Li Wang Ravi Thomas Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Science Key LabBeijing 100730China Handan Eye Hospital Handan 056001Hebei ProvinceChina Queensland Eye Institute Brisbane 4343Australia University of Queensland Brisbane 4343Australia

AIM:To report the progression rate(PR)to primary angle closure(PAC)following laser peripheral iridotomy(LPI)in PAC suspects(PACS).METHODS:Prospective,randomized controlled interventional clinical trial conducted at the Handan Eye Hospital,*** 134 bilateral PACS,defined as non-visibility of the posterior trabecular meshwork for≥180 degrees on gonioscopy were randomly assigned to undergo LPI in one *** and Goldmann applanation tonometry were performed prior to,on day 7 and 12 mo post ***:Eighty of 134 patients(59.7%)could be followed up at one *** mean intraocular pressure(IOP)in treated eyes was 15.9±2.6 mm Hg at baseline,15.4±3.0 mm Hg on day 7;16.5±2.9 mm Hg at one month,and 15.5±2.9 mm Hg at 12 mo;the IOP in untreated eyes was similar(P=0.834).One or more quadrants of the angle opened in 93.7%of the LPI treated eyes,but 67.0%(53/79)remained closed in two or more *** PR to PAC in untreated eyes was 3.75%and one developed acute angleclosure glaucoma(AACG);the PR to PAC in treated eyes was 2.5%and none had developed peripheral anterior synechia(PAS)or ***:LPI can open some of the occludable angle in the majority of eyes with PACS,but 67%continue to have non-visibility of the trabecular meshwork for over 180 degrees.

关键词： primary angle-closure suspects anterior chamber angle laser peripheral iridotomy intraocular pressure

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PALM: Open Fundus Photograph Dataset with Pathologic Myopia Recognition and Anatomical Structure Annotation

arXiv

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arXiv 2023年

作者： Fang, Huihui Li, Fei Wu, Junde Fu, Huazhu Sun, Xu Orlando, José Ignacio Bogunović, Hrvoje Zhang, Xiulan Xu, Yanwu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China Intelligent Healthcare Unit Baidu Inc. Beijing China Institute of High Performance Computing Agency for Science Technology and Research Singapore Yatiris Group Pladema Institute Conicet Unicen Tandil Argentina Christian Doppler Lab for Artificial Intelligence in Retina Department of Ophthalmology and Optometry Medical University of Vienna Vienna Austria

Pathologic myopia (PM) is a common blinding retinal degeneration suffered by highly myopic population. Early screening of this condition can reduce the damage caused by the associated fundus lesions and therefore prevent vision loss. Automated diagnostic tools based on artificial intelligence methods can benefit this process by aiding clinicians to identify disease signs or to screen mass populations using color fundus photographs as inputs. This paper provides insights about PALM, our open fundus imaging dataset for pathological myopia recognition and anatomical structure annotation. Our databases comprises 1200 images with associated labels for the pathologic myopia category and manual annotations of the optic disc, the position of the fovea and delineations of lesions such as patchy retinal atrophy (including peripapillary atrophy) and retinal detachment. In addition, this paper elaborates on other details such as the labeling process used to construct the database, the quality and characteristics of the samples and provides other relevant usage notes. © 2023, CC BY-NC-ND.

关键词： Photography

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Fundus-Image-Based Retinal Vascular Analysis in Myopic Eyes 42

Fundus-Image-Based Retinal Vascular Analysis in Myopic Eyes

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42nd Chinese Control Conference, CCC 2023

作者： Shen, Jichen Zou, Haohan Wang, Yan Liu, Jinchao Yu, Ningbo College of Artificial Intelligence Nankai University Tianjin300350 China Clinical College of Ophthalmology Tianjin Medical University Tianjin300070 China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Tianjin Eye Hospital Nankai University Affiliated Eye Hospital Tianjin300020 China Nankai University Eye Institute Nankai University Tianjin300350 China Tianjin Key Laboratory of Intelligent Robotics Nankai University Tianjin300350 China Engineering Research Center of Trusted Behavior Intelligence Ministry of Education Nankai University Tianjin300350 China Institute of Intelligence Technology and Robotic Systems Shenzhen Research Institute of Nankai University Shenzhen518083 China

ISBN: (纸本)9789887581543

Myopia is prevalent worldwide and it is of great significance to prevent, control and intervene myopia in an early stage. The etiopathogenesis of myopia remains unclear and needs further research. Fundus photographs can show biomarkers and lesions of the retina in a non-invasive way directly. To discover some potential changes in myopic eyes, we extracted the retinal vascular features from vessel segmented results, and calculated the Spearman correlation coefficients between the retinal vascular features and the spherical refractive errors. The Kruskal-Wallis test was applied to explore the difference exists in the characteristics of retinal vessels among the mild, moderate and high myopia groups. The statistical analysis results indicated that the higher the degrees of myopia, the smaller the retinal vessels. This study found vascular changes in myopic eyes through fundus images, which could help to explain the mechanism of myopia and the damage caused by myopia. © 2023 Technical Committee on Control Theory, Chinese Association of Automation.

关键词： ophthalmology

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Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy

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Neural Regeneration Research 2024年第2期19卷 425-433页

作者： Feng Chen Xi Dong Zhenhuan Wang Tongrui Wu Liangpeng Wei Yuanyuan Li Kai Zhang Zengguang Ma Chao Tian Jing Li Jingyu Zhao Wei Zhang Aili Liu Hui Shen Laboratory of Neurobiology School of Biomedical EngineeringTianjin Medical UniversityTianjinChina Institute for Translational Neuroscience the Second Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Institute for Translational Brain Research Fudan UniversityShanghaiChina Department of Radiology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinanChina Department of Anesthesiology Tianjin Medical University General HospitalTianjinChina Department of Orthopaedics Tianjin Medical University General HospitalTianjinChina Tianjin Eye Hospital Tianjin Eye InstituteTianjin Key Lab of Ophthalmology and Visual ScienceTianjinChina Laboratory of Neurobiology School of Basic Medical SciencesTianjin Medical UniversityTianjinChina

Temporal lobe epilepsy is a multifactorial neurological dysfunction syndrome that is refractory,resistant to antiepileptic drugs,and has a high recurrence *** pathogenesis of temporal lobe epilepsy is complex and is not fully *** calcium dynamics have been implicated in temporal lobe ***,the effect of fluctuating calcium activity in CA1 pyramidal neurons on temporal lobe epilepsy is unknown,and no longitudinal studies have investigated calcium activity in pyramidal neurons in the hippocampal CA1 and primary motor cortex M1 of freely moving *** this study,we used a multichannel fiber photometry system to continuously record calcium signals in CA1 and M1 during the temporal lobe epilepsy *** found that calcium signals varied according to the grade of temporal lobe epilepsy *** particular,cortical spreading depression,which has recently been frequently used to represent the continuously and substantially increased calcium signals,was found to correspond to complex and severe behavioral characteristics of temporal lobe epilepsy ranging from gradeⅡto gradeⅤ.However,vigorous calcium oscillations and highly synchronized calcium signals in CA1 and M1 were strongly related to convulsive motor *** inhibition of pyramidal neurons in CA1 significantly attenuated the amplitudes of the calcium signals corresponding to gradeⅠ*** addition,the latency of cortical spreading depression was prolonged,and the above-mentioned abnormal calcium signals in CA1 and M1 were also significantly ***,it was possible to rescue the altered intracellular calcium *** simultaneous analysis of calcium signals and epileptic behaviors,we found that the progression of temporal lobe epilepsy was alleviated when specific calcium signals were reduced,and that the end-point behaviors of temporal lobe epilepsy were *** results indicate that the calcium dynamic between CA1 and M1 may reflect sp

关键词： Ca^(2+) calcium signals chemogenetic methods hippocampus primary motor cortex pyramidal neurons temporal lobe epilepsy

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Loratadine-associated cystoid macular edema: A case report

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American Journal of ophthalmology Case Reports 2022年 26卷 101477-101477页

作者： Tang, Yong Dou, Rui Liu, Yuyan Xie, Shiyong Han, Quanhong Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Nankai University Affiliated Eye Hospital Clinical College of Ophthalmology Tianjin Medical University Tianjin China

Purpose: To report the first known case of bilateral cystoid macular edema in a patient undergoing long-term loratadine treatment. Observations: A 49-year-old Chinese woman who had been undergoing treatment with loratadine for the past 6 years presented with decreased visual acuity and bilateral cystoid macular edema (CME). Upon cessation of loratadine, macular edema partially resolved, and visual acuity markedly improved. Fundus autofluorescence (FAF), optical coherence tomography (OCT), and fluorescence fundus angiography (FFA) were used to document the severity of CME and its subsequent resolution after cessation of loratadine therapy. Conclusions and Importance: Long-term use of loratadine might cause CME that partially resolves with discontinuation of the drug. The pathophysiology of drug-induced CME without leakage remains unclear. Dysfunction of histamine receptor1-expressed retinal neurons and the associated signal transduction, toxicity to Müller cells or RPE cells with subsequent intracellular fluid accumulation, and subclinical damage to the blood-retina barrier leading to leakage of extracellular fluid, have been proposed. © 2022 The Authors

关键词： Cystoid macular edema Histamine Loratadine Optical coherence tomography

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Optical quality changes of the eye during peak SARS-CoV-2 pandemic in young adults

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Heliyon 2024年第23期10卷 e39497页

作者： Tian, He Fan, Qian Gao, Wenjing Wang, Yan Clinical College of Ophthalmology Tianjin Medical University Tianjin China Nankai University Eye Institute Nankai University Affiliated Eye Hospital Nankai University Tianjin China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin Eye Institute Tianjin Eye Hospital Tianjin China Beijing Friendship Hospital Capital Medical University Beijing China

Introduction: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects corneal morphology and optical quality. Methods: In this cross-sectional study, ophthalmological indicators were examined during the peak of SARS-CoV-2 infection after adjusting for public health control measures. Participants were divided into control (remained uninfected), A (infected during follow-up), and B (infected prior to the first consultation) groups. Effects of varying SARS-CoV-2 infection levels were determined using reverse transcription polymerase chain reaction. Changes in corneal morphology, backscatter, and aberrations were measured. Corneal parameters, such as flat keratometry, steep keratometry, and surface variance, vertical asymmetry, height asymmetry, and height decentration indices were considered. Results: Overall, 110 participants (208 eyes, 42.7 % male;age 17–31 years) were enrolled. Eighteen (16.3 %) were infection-free during the outbreak with unchanged corneal morphology, backscatter, and aberration. In group A, 34.73 ± 9.30 days after infection, the backscatter of the anterior corneal layer and central layer (both p = 0.000) decreased. Total low-order aberration, defocus, horizontal coma, and spherical aberration of the cornea increased (p < 0.05), while corneal morphology after infection did not change (p > 0.05). In group B, a decrease in backscattering in the corneal middle layer and an increase in horizontal coma (p < 0.05) were noted. Conclusion: Backscattering of the anterior and intermediate layers of the cornea decreased and corneal aberrations increased after SARS-CoV-2 infection, which affected corneal optical quality. However, corneal morphology and thickness remained unchanged. Ophthalmological indicators and optical quality should be monitored during SARS-CoV-2 infection. © 2024

关键词： Backscatter Corneal aberration Corneal morphology Coronavirus Optical quality

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Advances in myopia research anatomical findings in highly myopic eyes

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Eye and Vision 2020年第1期7卷 434-443页

作者： Jost B.Jonas Ya Xing Wang Li Dong Yin Guo Songhomitra Panda-Jonas Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karis-UniversityUniversitäts-AugenklinikTheodor-Kutzer-Ufer 1-368167 MannheimGermany Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Institute of OphthalmologyBeijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key LabBeijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Tongren HospitalCapital Medical UniversityBeijingChina Tongren Eye Care Center Beijing Tongren HospitalCapital Medical UniversityBeijingChina

Background:The goal of this review is to summarize structural and anatomical changes associated with high *** text:Axial elongation in myopic eyes is associated with retinal thinning and a reduced density of retinal pigment epithelium(RPE)cells in the equatorial *** of the retina and choriocapillaris and RPE cell density in the macula are independent of axial *** and scleral thickness decrease with longer axial length in the posterior hemisphere of the eye,most marked at the posterior *** any eye region,thickness of Bruch’s membrane(BM)is independent of axial *** opening,as the inner layer of the optic nerve head layers,is shifted in temporal direction in moderately elongated eyes(axial length<26.5 mm).It leads to an overhanging of BM into the intrapapillary compartment at the nasal optic disc side,and to an absence of BM at the temporal disc *** lack of BM at the temporal disc side is the histological equivalent of parapapillary gamma *** zone is defined as the parapapillary region without *** highly myopic eyes(axial length>26.5 mm),BM opening enlarges with longer axial *** leads to a circular gamma *** a parallel manner,the peripapillary scleral flange and the lamina cribrosa get longer and thinner with longer axial length in highly myopic *** elongated peripapillary scleral flange forms the equivalent of parapapillary delta zone,and the elongated lamina cribrosa is the equivalent of the myopic secondary *** prevalence of BM defects in the macular region increases with longer axial length in highly myopic *** staphylomas are characterized by marked scleral thinning and spatially correlated BM defects,while thickness and density of the choriocapillaris,RPE and BM do not differ markedly between staphylomatous versus non-staphylomatous eyes in the respective ***:High axial myopia is associated with a thinning of the sclera and choroid posteriorly and thinnin

关键词： High myopia Myopia Bruch’s membrane Optic nerve head Optic disc Parapapillary gamma zone Parapapillary delta zone Lamina cribrosa Anatomical changes

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