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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Kaustav Nandy Prabhakar R. Gudla Ryan Amundsen Karen J. Meaburn Tom Misteli Stephen J. Lockett Optical Microscopy and Analysis Laboratory Advanced Technology program SAIC-Frederick Inc. Electrical Engineering and Computer Science Department University of Michigan Cell Biology of Gene Expression National Cancer Institute National Institutes of Health

ISBN: (纸本)9781424441211

Accurate segmentation of cell nuclei in microscope images of tissue sections is a key step in a number of biological and clinical applications. Often such applications require analysis of large image datasets for which manual segmentation becomes subjective and time consuming. Hence automation of the segmentation steps using fast, robust and accurate image analysis and pattern classification techniques is necessary for high throughput processing of such datasets. We describe a supervised learning framework, based on artificial neural networks (ANNs), to identify well-segmented nuclei in tissue sections from a multistage watershed segmentation algorithm. The successful automation was demonstrated by screening over 1400 well segmented nuclei from 9 datasets of human breast tissue section images and comparing the results to a previously used stacked classifier based analysis framework.

关键词： tissue section Cell nucleus Semi-supervised Learning Nucleus Dataset image analysis MULTISTAGE Artificial neural networks Frameworks nuclei (nuclear physics) segmentation Segmentation Automation pattern classification method

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X-photon 3D lithography by fs-oscillators:wavelength-independent and photoinitiator-free

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Light(Advanced Manufacturing) 2024年第4期5卷 89-101页

作者： Dimitra Ladika Antanas Butkus Vasileia Melissinaki Edvinas Skliutas Elmina Kabouraki Saulius Juodkazis Maria Farsari Mangirdas Malinauskas Institute of Electronic Structure and Laser Foundation for Research and Technology-Hellas70013 HeraklionGreece Department of Materials Science and Technology University of Crete70013HeraklionCrete Laser Research Center Faculty of PhysicsVilnius UniversitySaulėtekio Ave.10LT-10223 VilniusLithuania Optical Sciences Centre and ARC Training Centre in Surface Engineering for Advanced Materials(SEAM) School of ScienceSwinburne University of TechnologyMelbourneAustralia WRH Program International Research Frontiers Initiative(IRFI)Tokyo Institute of Technology Nagatsuta-choMidori-kuYokohamaJapan

Laser direct writing employing multi-photon 3D polymerisation is a scientific and industrial tool used in various fields such as micro-optics,medicine,metamaterials,programmable materials,etc.,due to the fusion of highthroughput and fine features down to hundreds of *** limitations of technology applicability emerge from photo-resin properties,however any material modifications can strongly affect its printability,as photoexcitation conditions alter as *** we present wavelength-independent 3D polymerisation using low peak power laser *** pulse repetition rate and fast laser direct writing was employed for advancing additive manufacturing out of the SZ2080^(TM)photo-resist without any *** of 517 nm,780 nm,and 1035 nm are shown to be suitable for producing 300 nm polymerized features even at high-up to 10^(5)μm/s-writing *** of organic-inorganic ratio in hybrid material results in shift and decrease of the dynamic fabrication window,yet not prohibiting the *** energy deposition per focal volume is achieved due to localized heating enabling efficient 3D *** spatio-selective photo-chemical crosslinking widens optical manufacturing capacity of non-photo-sensitive materials.

关键词： 3D polymerisation Nonlinear absorption Multi-photon absorption Laser direct writing Additive manufacturing Material engineering Organic-inorganic polymers SZ2080^(TM) Photosensitizer

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Lattice vibration modes in type-II superlattice InAs/GaSb with no-common-atom interface and overlapping vibration spectra

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Physical Review B 2015年第23期91卷 235317-235317页

作者： Henan Liu Naili Yue Yong Zhang Pengfei Qiao Daniel Zuo Ben Kesler Shun Lien Chuang Jae-Hyun Ryou James D. Justice Russell Dupuis Optical Science and Engineering Graduate Program University of North Carolina at Charlotte Charlotte North Carolina USA Department of Electrical and Computer Engineering University of North Carolina at Charlotte Charlotte North Carolina USA Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign Champaign Illinois USA Center for Compound Semiconductors and School of Electrical and Computer Engineering Georgia Institute of Technology Atlanta Georgia USA

Heterostructures like InAs/GaSb superlattices (SLs) are distinctly different from well-studied ones like GaAs/AlAs SLs in terms of band alignment, common interface atom, and phonon spectrum overlapping of the constituents, which manifests as stark differences in their electronic and vibrational properties. This paper reports a comprehensive examination of all four types of phonon modes (confined, quasiconfined, extended, and interface) that have long been predicted for the InAs/GaSb SL, with the observation and interpretation of a set of phonon modes by performing cleaved edge μ-Raman study with polarization analysis. Furthermore, we show a signature of symmetry reduction from D2d for GaAs/AlAs SL to C2v for InAs/GaSb SL revealed as a phonon-polariton effect.

关键词： SUPERLATTICES HETEROJUNCTIONS VIBRATIONAL spectra PHONON spectra RAMAN spectroscopy

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Enhancement of photonic density of states in finite graphene multilayers

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Physical Review B 2013年第19期88卷 195411-195411页

作者： Ashley M. DaSilva You-Chia Chang Ted Norris Allan H. MacDonald Department of Physics The University of Texas at Austin Austin Texas 78712-1192 USA Applied Physics Program The University of Michigan Ann Arbor Michigan 48109 USA Center for Ultrafast Optical Science The University of Michigan Ann Arbor Michigan 48109 USA Department of Electrical Engineering and Computer Science The University of Michigan Ann Arbor Michigan 48109 USA

We consider the optical properties of finite systems composed of a series of graphene sheets separated by thin dielectric layers. Because these systems respond as conductors to electric fields in the plane of the graphene sheets and as insulators to perpendicular electric fields, they can be expected to have properties similar to those of hyperbolic metamaterials. We show that under typical experimental conditions graphene/dielectric multilayers have enhanced Purcell factors, and enhanced photonic densities of states in both the terahertz (THz) and midinfrared (mid-IR) frequency range. These behaviors can be traced to the coupled plasmon modes of the multilayer graphene system. We show that these results can be obtained with just a few layers of graphene.

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Passively Q-switching cylindrical vector beam fiber laser operating in high-order mode

arXiv

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arXiv 2018年

作者： Li, Hongxun Yan, Ke Zhang, Yimin Dong, Zhipeng Gu, Chun Yao, Peijun Xu, Lixin Zhang, Rui Su, Jingqin Chen, Wei Zhu, Yonggang Zhan, Qiwen Department of Optics and Optical Engineering University of Science and Technology of China Hefei230026 China Research Center of Laser Fusion China Academy of Engineering Physics Mianyang621900 China Science and Technology on Plasma Physics Laboratory Mianyang621900 China Shanghai Jiaotong University Shanghai200240 China Jiangsu Hengtong Optical Fiber Technology Com.Ltd Jiangsu215000 China Electro-Optics Program University of Dayton DaytonOH45469 United States

We experimentally demonstrate a linear-cavity all-fiber passively Q-switching cylindrical vector beam (CVB) laser operating in high-order mode. This CVB fiber laser operates without any mode converter which always leads to high insertion loss, and it can realize high efficiency. In this fiber laser, the stable Q-switching pulse is achieved with a slope efficiency of 39%. By properly adjusting the polarization controllers, radially polarized and azimuthally polarized beams can be obtained. Our work proves the feasibility of achieving the stable Q-switching CVB pulse with high-order mode directly oscillating, and it may have an enormous potential for enhancing the efficiency. Copyright © 2018, The Authors. All rights reserved.

关键词： Fiber lasers

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Hyperchromatic Structural Color for Perceptually Enhanced Colorimetric Sensing by the Naked Eye

Hyperchromatic Structural Color for Perceptually Enhanced Co...

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Conference on Lasers and Electro-Optics (CLEO)

作者： Tahmid H. Talukdar Bria McCoy Sarah Κ Timmins Taufiquar Khan Judson D. Ryckman Clemson University Clemson South Carolina Charles H. Townes Optical Science and Engineering Summer Program Clemson University Clemson South Carolina USA Clemson University Clemson South Carolina USA University of North Carolina Charlotte NC

We report a novel colorimetric sensing paradigm using multi-chromatic light from an RGB laser combined with a structural color sensor for fast, ultra-sensitive, and spatio-temporally resolved detection of surface biom... 详细信息

关键词： Surface emitting lasers Color Molecular biophysics Sensors Electrooptical waveguides

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Nanoscale porous silicon waveguides for biosensing applications

Nanoscale porous silicon waveguides for biosensing applicati...

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IEEE Photonics Conference (IPC)

作者： G. Rong X. Wei C. Kang M. Liscidini J. E. Sipe R. L. Mernaugh S. M. Weiss Department of Electrical Engineering and Computer Science Vanderbilt University Nashville TN USA Interdisciplinary Graduate Program in Materials Science Vanderbilt University Nashville TN USA Department of Physics and Institute for Optical Sciences University of Toronto Toronto ONT Canada Department of Biochemistry Vanderbilt University Nashville TN USA

Nanoscale porous silicon waveguides, both on silicon substrates and free-standing membranes, are explored for biosensing applications. Measured detection limits in the nanomolar range are reported for DNA sensing.

关键词： Silicon Biosensors optical waveguides Gratings Biomembranes Resonance DNA Biological materials optical materials optical surface waves

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The multi-objective optimisation design for a light guide rod

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International Journal of Industrial and Systems engineering 2015年第2期20卷 165-179页

作者： Yang, Yu-Sen Shih, Chun-Yao Chien, Hong-Yao Fung, Rong-Fong Depart. of Mechanical Automation Engineering National Kaohsiung First University of Science and Technology 1 University Road Yenchau Kaohsiung County824 Taiwan Graduate Institute of Electro-optical Engineering National Kaohsiung First University of Science and Technology 1 University Road Yenchau Kaohsiung County824 Taiwan Industrial Master Program on Advanced Headlamp Industry National Kaohsiung First University of Science and Technology 1 University Road Yenchau Kaohsiung County824 Taiwan

The light guide rod (LGR) has been popularly used for the vehicles, and the automobile lamp industries need mass production to match this trend. This paper aims to develop a systemic way to find the best parameters' combination for the LGR, and the parameters are usually restricted (existing October 11, 2012) to some levels and random values. In this paper, the LGR example with two optical performances of illuminance flux and uniformity is to be optimised by use of the real-coded genetic algorithm (RGA) and grey relational analysis (GRA). The illuminance flux and uniformity of the best parameters' combination are obtained and compared with the initial set. Comparisons with Taguchi-Grey can improve 5% of gain and comparisons with Pareto genetic algorithm (PaGA) can improve 1.7% of gain .The combined multi-objective optimisation can save 7% time and it is found that the new proposed method has positive gains in performances. Copyright © 2015 Inderscience Enterprises Ltd.

关键词： Multiobjective optimization

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Hamiltonian Hopping for Efficient Chiral Mode Switching in Encircling Exceptional Points

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Physical Review Letters 2020年第18期125卷 187403-187403页

作者： Aodong Li Jianji Dong Jian Wang Ziwei Cheng John S. Ho Dawei Zhang Jing Wen Xu-Lin Zhang C. T. Chan Andrea Alù Cheng-Wei Qiu Lin Chen Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China Department of Electrical and Computer Engineering National University of Singapore Singapore 117583 Singapore Engineering Research Center of Optical Instrument and Systems Ministry of Education and Shanghai Key Lab of Modern Optical System University of Shanghai for Science and Technology No. 516 Jungong Road Shanghai 200093 China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changchun 130012 China Department of Physics The Hong Kong University of Science and Technology Clear Water Bay Hong Kong 999077 China Photonics Initiative Advanced Science Research Center City University of New York New York New York 10031 USA Physics Program Graduate Center City University of New York New York New York 10016 USA

Dynamically encircling exceptional points (EPs) can lead to chiral mode switching as the system parameters are varied along a path that encircles EP. However, conventional encircling protocols result in low transmittance due to path-dependent losses. Here, we present a paradigm to encircle EPs that includes fast Hamiltonian variations on the parameter boundaries, termed Hamiltonian hopping, enabling ultrahigh-efficiency chiral mode switching. This protocol avoids path-dependent loss and allows us to experimentally demonstrate nearly 90% efficiency at 1550 nm in the clockwise direction, overcoming a long-standing challenge of non-Hermitian optical systems and powering up new opportunities for EP physics.

关键词： Open quantum systems & decoherence PT-symmetric quantum mechanics Photonics Waveguides

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Plasmonic Complex Fluids of Nematiclike and Helicoidal Self-Assemblies of Gold Nanorods with a Negative Order Parameter

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Physical Review Letters 2012年第8期109卷 088301-088301页

作者： Qingkun Liu Bohdan Senyuk Jianwei Tang Taewoo Lee Jun Qian Sailing He Ivan I. Smalyukh Department of Physics Material Science and Engineering Program Department of Electrical Computer & Energy Engineering and Liquid Crystal Materials Research Center University of Colorado Boulder Colorado 80309 USA Centre for Optical and Electromagnetic Research Zhejiang University Hangzhou 310058 People’s Republic of China Department of Electromagnetic Engineering Royal Institute of Technology S-100 44 Stockholm Sweden Renewable and Sustainable Energy Institute National Renewable Energy Laboratory and University of Colorado Boulder Colorado 80309 USA

We describe a soft matter system of self-organized oblate micelles and plasmonic gold nanorods that exhibit a negative orientational order parameter. Because of anisotropic surface anchoring interactions, colloidal gold nanorods tend to align perpendicular to the director describing the average orientation of normals to the discoidal micelles. Helicoidal structures of highly concentrated nanorods with a negative order parameter are realized by adding a chiral additive and are further controlled by means of confinement and mechanical stress. Polarization-sensitive absorption, scattering, and two-photon luminescence are used to characterize orientations and spatial distributions of nanorods. Self-alignment and effective-medium optical properties of these hybrid inorganic-organic complex fluids match predictions of a simple model based on anisotropic surface anchoring interactions of nanorods with the structured host medium.

关键词： PLASMONS (Physics) COMPLEX fluids MOLECULAR self-assembly GOLD nanoparticles PARAMETER estimation SOFT condensed matter

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